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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Appearance of spontaneously Ig secreting B cells in human peripheral blood after surgery.</title>
<author><name sortKey="Di Padova, F" sort="Di Padova, F" uniqKey="Di Padova F" first="F" last="Di Padova">F. Di Padova</name>
</author>
<author><name sortKey="Di Padova, C" sort="Di Padova, C" uniqKey="Di Padova C" first="C" last="Di Padova">C. Di Padova</name>
</author>
<author><name sortKey="Rovagnati, P" sort="Rovagnati, P" uniqKey="Rovagnati P" first="P" last="Rovagnati">P. Rovagnati</name>
</author>
<author><name sortKey="Tritapepe, R" sort="Tritapepe, R" uniqKey="Tritapepe R" first="R" last="Tritapepe">R. Tritapepe</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">3490939</idno>
<idno type="pmc">1542487</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1542487</idno>
<idno type="RBID">PMC:1542487</idno>
<date when="1986">1986</date>
<idno type="wicri:Area/Pmc/Corpus">001742</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001742</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Appearance of spontaneously Ig secreting B cells in human peripheral blood after surgery.</title>
<author><name sortKey="Di Padova, F" sort="Di Padova, F" uniqKey="Di Padova F" first="F" last="Di Padova">F. Di Padova</name>
</author>
<author><name sortKey="Di Padova, C" sort="Di Padova, C" uniqKey="Di Padova C" first="C" last="Di Padova">C. Di Padova</name>
</author>
<author><name sortKey="Rovagnati, P" sort="Rovagnati, P" uniqKey="Rovagnati P" first="P" last="Rovagnati">P. Rovagnati</name>
</author>
<author><name sortKey="Tritapepe, R" sort="Tritapepe, R" uniqKey="Tritapepe R" first="R" last="Tritapepe">R. Tritapepe</name>
</author>
</analytic>
<series><title level="j">Clinical and Experimental Immunology</title>
<idno type="ISSN">0009-9104</idno>
<idno type="eISSN">1365-2249</idno>
<imprint><date when="1986">1986</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p>Lymphoblastoid B cells, spontaneously secreting specific antibodies of IgG and IgA classes, are constantly detected after in-vivo immunization and represent a sensitive marker of a recent antigenic exposure. In this study we demonstrate that surgical trauma is followed, at a well-defined time after surgery, by the appearance of circulating lymphoblastoid B cells spontaneously secreting IgG and IgA. The kinetics and the functional behaviour of this B cell subset are identical to those of lymphoblastoid B cells observed after in-vivo immunization. Our data indicate that surgical trauma activates a humoral immune response. Antigens released by traumatized tissues or encountered through breaches in skin or mucous membranes might initiate the reaction.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Exp Immunol</journal-id>
<journal-title>Clinical and Experimental Immunology</journal-title>
<issn pub-type="ppub">0009-9104</issn>
<issn pub-type="epub">1365-2249</issn>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">3490939</article-id>
<article-id pub-id-type="pmc">1542487</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject>
</subj-group>
</article-categories>
<title-group><article-title>Appearance of spontaneously Ig secreting B cells in human peripheral blood after surgery.</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Di Padova</surname>
<given-names>F</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Di Padova</surname>
<given-names>C</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Rovagnati</surname>
<given-names>P</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Tritapepe</surname>
<given-names>R</given-names>
</name>
</contrib>
</contrib-group>
<pub-date pub-type="ppub"><month>9</month>
<year>1986</year>
</pub-date>
<volume>65</volume>
<issue>3</issue>
<fpage>582</fpage>
<lpage>588</lpage>
<abstract><p>Lymphoblastoid B cells, spontaneously secreting specific antibodies of IgG and IgA classes, are constantly detected after in-vivo immunization and represent a sensitive marker of a recent antigenic exposure. In this study we demonstrate that surgical trauma is followed, at a well-defined time after surgery, by the appearance of circulating lymphoblastoid B cells spontaneously secreting IgG and IgA. The kinetics and the functional behaviour of this B cell subset are identical to those of lymphoblastoid B cells observed after in-vivo immunization. Our data indicate that surgical trauma activates a humoral immune response. Antigens released by traumatized tissues or encountered through breaches in skin or mucous membranes might initiate the reaction.</p>
</abstract>
</article-meta>
</front>
</pmc>
</record>
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