Drug-induced proteolysis: a correlation with oedema-reducing ability.
Identifieur interne : 001534 ( Pmc/Corpus ); précédent : 001533; suivant : 001535Drug-induced proteolysis: a correlation with oedema-reducing ability.
Auteurs : N. B. PillerSource :
- British journal of experimental pathology [ 0007-1021 ] ; 1976.
Abstract
A very strong correlation has been shown to exist between acid and neutral protease activity levels in the skin, the acid protease activity level of the oedema fluid, and the oedema-reducing ability of the benzo-pyrones and related drugs. Macrophages, which are believed to be the main cells affected by the drugs, are very common in thermally injured tissues. Their lysosomal enzymes work at an acid pH. Since the main acid protease is cathepsin D, the overall acid protease levels are representative of changes in cathepsin D levels. Elevated levels are concomitant with more complete and rapid digestion of accumulated protein. The resulting fragments then can rapidly leave the injured tissues, freeing the oedema fluid. This form of proteolysis is very much different from that which is used by pharmacologists as a measure of inflammation. Normal proteolysis in inflammation represents an estimate of tissue derangement, but the proteolysis induced by drugs such as the benzo-pyrones represents a means of lessening some of the more injurious effects of this derangement. The results presented here strongly confirm this.
Url:
PubMed: 952727
PubMed Central: 2041068
Links to Exploration step
PMC:2041068Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Drug-induced proteolysis: a correlation with oedema-reducing ability.</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">952727</idno><idno type="pmc">2041068</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2041068</idno><idno type="RBID">PMC:2041068</idno><date when="1976">1976</date><idno type="wicri:Area/Pmc/Corpus">001534</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001534</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Drug-induced proteolysis: a correlation with oedema-reducing ability.</title><author><name sortKey="Piller, N B" sort="Piller, N B" uniqKey="Piller N" first="N. B." last="Piller">N. B. Piller</name></author></analytic><series><title level="j">British journal of experimental pathology</title><idno type="ISSN">0007-1021</idno><imprint><date when="1976">1976</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>A very strong correlation has been shown to exist between acid and neutral protease activity levels in the skin, the acid protease activity level of the oedema fluid, and the oedema-reducing ability of the benzo-pyrones and related drugs. Macrophages, which are believed to be the main cells affected by the drugs, are very common in thermally injured tissues. Their lysosomal enzymes work at an acid pH. Since the main acid protease is cathepsin D, the overall acid protease levels are representative of changes in cathepsin D levels. Elevated levels are concomitant with more complete and rapid digestion of accumulated protein. The resulting fragments then can rapidly leave the injured tissues, freeing the oedema fluid. This form of proteolysis is very much different from that which is used by pharmacologists as a measure of inflammation. Normal proteolysis in inflammation represents an estimate of tissue derangement, but the proteolysis induced by drugs such as the benzo-pyrones represents a means of lessening some of the more injurious effects of this derangement. The results presented here strongly confirm this.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Exp Pathol</journal-id><journal-title>British journal of experimental pathology</journal-title><issn pub-type="ppub">0007-1021</issn></journal-meta><article-meta><article-id pub-id-type="pmid">952727</article-id><article-id pub-id-type="pmc">2041068</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Drug-induced proteolysis: a correlation with oedema-reducing ability.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Piller</surname><given-names>N. B.</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>6</month><year>1976</year></pub-date><volume>57</volume><issue>3</issue><fpage>266</fpage><lpage>273</lpage><abstract><p>A very strong correlation has been shown to exist between acid and neutral protease activity levels in the skin, the acid protease activity level of the oedema fluid, and the oedema-reducing ability of the benzo-pyrones and related drugs. Macrophages, which are believed to be the main cells affected by the drugs, are very common in thermally injured tissues. Their lysosomal enzymes work at an acid pH. Since the main acid protease is cathepsin D, the overall acid protease levels are representative of changes in cathepsin D levels. Elevated levels are concomitant with more complete and rapid digestion of accumulated protein. The resulting fragments then can rapidly leave the injured tissues, freeing the oedema fluid. This form of proteolysis is very much different from that which is used by pharmacologists as a measure of inflammation. Normal proteolysis in inflammation represents an estimate of tissue derangement, but the proteolysis induced by drugs such as the benzo-pyrones represents a means of lessening some of the more injurious effects of this derangement. The results presented here strongly confirm this.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001534 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd -nk 001534 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Corpus
|type= RBID
|clé= PMC:2041068
|texte= Drug-induced proteolysis: a correlation with oedema-reducing ability.
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Corpus/RBID.i -Sk "pubmed:952727" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Corpus/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |