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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the General Practice Research Database</title><author><name sortKey="Burnham, J M" sort="Burnham, J M" uniqKey="Burnham J" first="J M" last="Burnham">J M Burnham</name></author><author><name sortKey="Shults, J" sort="Shults, J" uniqKey="Shults J" first="J" last="Shults">J. Shults</name></author><author><name sortKey="Weinstein, R" sort="Weinstein, R" uniqKey="Weinstein R" first="R" last="Weinstein">R. Weinstein</name></author><author><name sortKey="Lewis, J D" sort="Lewis, J D" uniqKey="Lewis J" first="J D" last="Lewis">J D Lewis</name></author><author><name sortKey="Leonard, M B" sort="Leonard, M B" uniqKey="Leonard M" first="M B" last="Leonard">M B Leonard</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">16627541</idno><idno type="pmc">1798264</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1798264</idno><idno type="RBID">PMC:1798264</idno><idno type="doi">10.1136/ard.2005.048835</idno><date when="2006">2006</date><idno type="wicri:Area/Pmc/Corpus">001343</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001343</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the General Practice Research Database</title><author><name sortKey="Burnham, J M" sort="Burnham, J M" uniqKey="Burnham J" first="J M" last="Burnham">J M Burnham</name></author><author><name sortKey="Shults, J" sort="Shults, J" uniqKey="Shults J" first="J" last="Shults">J. Shults</name></author><author><name sortKey="Weinstein, R" sort="Weinstein, R" uniqKey="Weinstein R" first="R" last="Weinstein">R. Weinstein</name></author><author><name sortKey="Lewis, J D" sort="Lewis, J D" uniqKey="Lewis J" first="J D" last="Lewis">J D Lewis</name></author><author><name sortKey="Leonard, M B" sort="Leonard, M B" uniqKey="Leonard M" first="M B" last="Leonard">M B Leonard</name></author></analytic><series><title level="j">Annals of the Rheumatic Diseases</title><idno type="ISSN">0003-4967</idno><idno type="eISSN">1468-2060</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>Childhood onset arthritis is associated with low bone mass and strength.</p></sec><sec><title>Objective</title><p>To determine whether childhood onset arthritis is associated with greater fracture risk.</p></sec><sec><title>Methods</title><p>In a retrospective cohort study all subjects with onset of arthritis between 1 and 19 years of age in the United Kingdom General Practice Research Database were identified. As controls, all sex and age matched subjects from a practice that included a subject with arthritis were included. Incidence rate ratios (IRRs) for first fracture were generated using Mantel‐Haenszel methods and Poisson regression.</p></sec><sec><title>Results</title><p>1939 subjects with arthritis (51% female) and 207 072 controls (53% female) were identified. The median age at arthritis diagnosis was 10.9 years. A total of 129 (6.7%) first fractures were noted in subjects with arthritis compared with 6910 (3.3%) in controls over a median follow up of 3.90 and 3.95 years in the subjects with arthritis and controls, respectively. The IRR (95% confidence interval) for first fracture among subjects with arthritis, compared with controls, according to the age at the start of follow up were 1.49 (0.91 to 2.31) for age <10 years, 3.13 (2.21 to 4.33) at 10–15 years, 1.75 (1.18 to 2.51) at 15–20 years, 1.40 (0.91 to 2.08) at 20–45 years, and 3.97 (2.23 to 6.59) at >45 years.</p></sec><sec><title>Conclusions</title><p>Childhood onset arthritis is associated with a clinically significant increased risk of fracture in children, adolescents and, possibly, adults. Studies are urgently needed to characterise the determinants of structural bone abnormalities in childhood arthritis and devise prevention and treatment strategies.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Ann Rheum Dis</journal-id><journal-title>Annals of the Rheumatic Diseases</journal-title><issn pub-type="ppub">0003-4967</issn><issn pub-type="epub">1468-2060</issn><publisher><publisher-name>BMJ Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">16627541</article-id><article-id pub-id-type="pmc">1798264</article-id><article-id pub-id-type="publisher-id">ar48835</article-id><article-id pub-id-type="doi">10.1136/ard.2005.048835</article-id><article-categories><subj-group subj-group-type="heading"><subject>Extended Report</subject></subj-group></article-categories><title-group><article-title>Childhood onset arthritis is associated with an increased risk of fracture: a population based study using the General Practice Research Database</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Burnham</surname><given-names>J M</given-names></name></contrib><contrib contrib-type="author"><name><surname>Shults</surname><given-names>J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Weinstein</surname><given-names>R</given-names></name></contrib><contrib contrib-type="author"><name><surname>Lewis</surname><given-names>J D</given-names></name></contrib><contrib contrib-type="author"><name><surname>Leonard</surname><given-names>M B</given-names></name></contrib></contrib-group><aff><bold>J M Burnham</bold>, Department of Pediatrics, Division of Rheumatology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA</aff><aff><bold>M B Leonard</bold>, Department of Nephrology, Children's Hospital of Philadelphia, University of Pennsylvania School of Medicine, USA</aff><aff><bold>J D Lewis</bold>, Department of Medicine, Division of Gastroenterology, Hospital of the University of Pennsylvania, University of Pennsylvania School of Medicine, USA</aff><aff><bold>J M Burnham</bold>,<bold>J Shults</bold>,<bold>R Weinstein</bold>,<bold>J D Lewis</bold>,<bold>M B Leonard</bold>, Center for Clinical Epidemiology and Biostatistics, University of Pennsylvania School of Medicine, USA</aff><author-notes><corresp>Correspondence to: Dr J M Burnham<break></break>Room 1579 CHOP North, 3535 Market Street, Philadelphia, PA 19104, USA; burnhams@
email.chop.edu</corresp><fn><p>Copyright © 2006 BMJ Publishing Group Ltd & European League Against Rheumatism</p></fn></author-notes><pub-date pub-type="ppub"><month>8</month><year>2006</year></pub-date><volume>65</volume><issue>8</issue><fpage>1074</fpage><lpage>1079</lpage><history><date date-type="accepted"><day>5</day><month>3</month><year>2006</year></date></history><permissions><copyright-statement>Copyright © 2006 BMJ Publishing Group Ltd & European League Against Rheumatism</copyright-statement></permissions><abstract><sec><title>Background</title><p>Childhood onset arthritis is associated with low bone mass and strength.</p></sec><sec><title>Objective</title><p>To determine whether childhood onset arthritis is associated with greater fracture risk.</p></sec><sec><title>Methods</title><p>In a retrospective cohort study all subjects with onset of arthritis between 1 and 19 years of age in the United Kingdom General Practice Research Database were identified. As controls, all sex and age matched subjects from a practice that included a subject with arthritis were included. Incidence rate ratios (IRRs) for first fracture were generated using Mantel‐Haenszel methods and Poisson regression.</p></sec><sec><title>Results</title><p>1939 subjects with arthritis (51% female) and 207 072 controls (53% female) were identified. The median age at arthritis diagnosis was 10.9 years. A total of 129 (6.7%) first fractures were noted in subjects with arthritis compared with 6910 (3.3%) in controls over a median follow up of 3.90 and 3.95 years in the subjects with arthritis and controls, respectively. The IRR (95% confidence interval) for first fracture among subjects with arthritis, compared with controls, according to the age at the start of follow up were 1.49 (0.91 to 2.31) for age <10 years, 3.13 (2.21 to 4.33) at 10–15 years, 1.75 (1.18 to 2.51) at 15–20 years, 1.40 (0.91 to 2.08) at 20–45 years, and 3.97 (2.23 to 6.59) at >45 years.</p></sec><sec><title>Conclusions</title><p>Childhood onset arthritis is associated with a clinically significant increased risk of fracture in children, adolescents and, possibly, adults. Studies are urgently needed to characterise the determinants of structural bone abnormalities in childhood arthritis and devise prevention and treatment strategies.</p></sec></abstract><kwd-group><kwd>children</kwd><kwd>arthritis</kwd><kwd>fracture</kwd><kwd>epidemiology</kwd><kwd>osteoporosis</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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