Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin.
Identifieur interne : 001272 ( Pmc/Corpus ); précédent : 001271; suivant : 001273Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin.
Auteurs : N. S. Mcnutt ; V. Fletcher ; M. A. ConantSource :
- The American Journal of Pathology [ 0002-9440 ] ; 1983.
Abstract
An aggressive variant of Kaposi's sarcoma (KS) has appeared in young homosexual men with evidence of systemic immunosuppression. The ultrastructure in biopsy specimens from 8 KS cases in young homosexual men has been compared with that in biopsy specimens from 4 KS cases in elderly heterosexuals and with that in biopsy specimens from 23 cases of benign vascular disorders of skin. In all cases of KS the small blood vessels lacked a prominent investment of pericytes and their processes, had a fragmented and often absent basal lamina, had frequent discontinuities in the endothelial lining, and had only a few small junctional densities between endothelial cells. Some clinically aggressive cases of KS also had necrosis of individual endothelial cells and had prominent cytoplasmic processes entrapping individual collagen fibers. The benign disorders lacked these features. These differences in the structure of the small vessels may be of diagnostic value in some early cases of KS. The loss of dendritic pericytes in blood capillaries in KS might relate to the telangiectasia which is a prominent feature of the early lesions of KS.
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PubMed: 6301283
PubMed Central: 1916204
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin.</title><author><name sortKey="Mcnutt, N S" sort="Mcnutt, N S" uniqKey="Mcnutt N" first="N. S." last="Mcnutt">N. S. Mcnutt</name></author><author><name sortKey="Fletcher, V" sort="Fletcher, V" uniqKey="Fletcher V" first="V." last="Fletcher">V. Fletcher</name></author><author><name sortKey="Conant, M A" sort="Conant, M A" uniqKey="Conant M" first="M. A." last="Conant">M. A. Conant</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">6301283</idno><idno type="pmc">1916204</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC1916204</idno><idno type="RBID">PMC:1916204</idno><date when="1983">1983</date><idno type="wicri:Area/Pmc/Corpus">001272</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">001272</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin.</title><author><name sortKey="Mcnutt, N S" sort="Mcnutt, N S" uniqKey="Mcnutt N" first="N. S." last="Mcnutt">N. S. Mcnutt</name></author><author><name sortKey="Fletcher, V" sort="Fletcher, V" uniqKey="Fletcher V" first="V." last="Fletcher">V. Fletcher</name></author><author><name sortKey="Conant, M A" sort="Conant, M A" uniqKey="Conant M" first="M. A." last="Conant">M. A. Conant</name></author></analytic><series><title level="j">The American Journal of Pathology</title><idno type="ISSN">0002-9440</idno><idno type="eISSN">1525-2191</idno><imprint><date when="1983">1983</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>An aggressive variant of Kaposi's sarcoma (KS) has appeared in young homosexual men with evidence of systemic immunosuppression. The ultrastructure in biopsy specimens from 8 KS cases in young homosexual men has been compared with that in biopsy specimens from 4 KS cases in elderly heterosexuals and with that in biopsy specimens from 23 cases of benign vascular disorders of skin. In all cases of KS the small blood vessels lacked a prominent investment of pericytes and their processes, had a fragmented and often absent basal lamina, had frequent discontinuities in the endothelial lining, and had only a few small junctional densities between endothelial cells. Some clinically aggressive cases of KS also had necrosis of individual endothelial cells and had prominent cytoplasmic processes entrapping individual collagen fibers. The benign disorders lacked these features. These differences in the structure of the small vessels may be of diagnostic value in some early cases of KS. The loss of dendritic pericytes in blood capillaries in KS might relate to the telangiectasia which is a prominent feature of the early lesions of KS.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 1</label><graphic xlink:href="amjpathol00193-0072-a" xlink:role="66"></graphic></fig><fig id="F2"><label>Figure 2</label><graphic xlink:href="amjpathol00193-0074-a" xlink:role="68"></graphic></fig><fig id="F3"><label>Figure 3</label><graphic xlink:href="amjpathol00193-0075-a" xlink:role="69"></graphic></fig><fig id="F4"><label>Figure 4</label><graphic xlink:href="amjpathol00193-0076-a" xlink:role="70"></graphic></fig><fig id="F5"><label>Figure 5</label><graphic xlink:href="amjpathol00193-0077-a" xlink:role="71"></graphic></fig><fig id="F6"><label>Figure 6</label><graphic xlink:href="amjpathol00193-0077-b" xlink:role="71"></graphic></fig><fig id="F7"><label>Figure 7</label><graphic xlink:href="amjpathol00193-0078-a" xlink:role="72"></graphic></fig><fig id="F8"><label>Figure 8</label><graphic xlink:href="amjpathol00193-0079-a" xlink:role="73"></graphic></fig><fig id="F9"><label>Figure 9</label><graphic xlink:href="amjpathol00193-0080-a" xlink:role="74"></graphic></fig><fig id="F10"><label>Figure 10</label><graphic xlink:href="amjpathol00193-0080-b" xlink:role="74"></graphic></fig><fig id="F11"><label>Figure 11</label><graphic xlink:href="amjpathol00193-0081-a" xlink:role="75"></graphic></fig></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id><journal-title>The American Journal of Pathology</journal-title><issn pub-type="ppub">0002-9440</issn><issn pub-type="epub">1525-2191</issn></journal-meta><article-meta><article-id pub-id-type="pmid">6301283</article-id><article-id pub-id-type="pmc">1916204</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Early lesions of Kaposi's sarcoma in homosexual men. An ultrastructural comparison with other vascular proliferations in skin.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>McNutt</surname><given-names>N. S.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Fletcher</surname><given-names>V.</given-names></name></contrib><contrib contrib-type="author"><name><surname>Conant</surname><given-names>M. A.</given-names></name></contrib></contrib-group><pub-date pub-type="ppub"><month>4</month><year>1983</year></pub-date><volume>111</volume><issue>1</issue><fpage>62</fpage><lpage>77</lpage><abstract><p>An aggressive variant of Kaposi's sarcoma (KS) has appeared in young homosexual men with evidence of systemic immunosuppression. The ultrastructure in biopsy specimens from 8 KS cases in young homosexual men has been compared with that in biopsy specimens from 4 KS cases in elderly heterosexuals and with that in biopsy specimens from 23 cases of benign vascular disorders of skin. In all cases of KS the small blood vessels lacked a prominent investment of pericytes and their processes, had a fragmented and often absent basal lamina, had frequent discontinuities in the endothelial lining, and had only a few small junctional densities between endothelial cells. Some clinically aggressive cases of KS also had necrosis of individual endothelial cells and had prominent cytoplasmic processes entrapping individual collagen fibers. The benign disorders lacked these features. These differences in the structure of the small vessels may be of diagnostic value in some early cases of KS. The loss of dendritic pericytes in blood capillaries in KS might relate to the telangiectasia which is a prominent feature of the early lesions of KS.</p><sec sec-type="scanned-figures"><title>Images</title><fig id="F1"><label>Figure 1</label><graphic xlink:href="amjpathol00193-0072-a" xlink:role="66"></graphic></fig><fig id="F2"><label>Figure 2</label><graphic xlink:href="amjpathol00193-0074-a" xlink:role="68"></graphic></fig><fig id="F3"><label>Figure 3</label><graphic xlink:href="amjpathol00193-0075-a" xlink:role="69"></graphic></fig><fig id="F4"><label>Figure 4</label><graphic xlink:href="amjpathol00193-0076-a" xlink:role="70"></graphic></fig><fig id="F5"><label>Figure 5</label><graphic xlink:href="amjpathol00193-0077-a" xlink:role="71"></graphic></fig><fig id="F6"><label>Figure 6</label><graphic xlink:href="amjpathol00193-0077-b" xlink:role="71"></graphic></fig><fig id="F7"><label>Figure 7</label><graphic xlink:href="amjpathol00193-0078-a" xlink:role="72"></graphic></fig><fig id="F8"><label>Figure 8</label><graphic xlink:href="amjpathol00193-0079-a" xlink:role="73"></graphic></fig><fig id="F9"><label>Figure 9</label><graphic xlink:href="amjpathol00193-0080-a" xlink:role="74"></graphic></fig><fig id="F10"><label>Figure 10</label><graphic xlink:href="amjpathol00193-0080-b" xlink:role="74"></graphic></fig><fig id="F11"><label>Figure 11</label><graphic xlink:href="amjpathol00193-0081-a" xlink:role="75"></graphic></fig></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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