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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours</title><author><name sortKey="Holzapfel, Boris Michael" sort="Holzapfel, Boris Michael" uniqKey="Holzapfel B" first="Boris Michael" last="Holzapfel">Boris Michael Holzapfel</name><affiliation><nlm:aff id="Aff1">Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, Wuerzburg, 97072 Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059 Australia</nlm:aff></affiliation></author><author><name sortKey="Pilge, Hakan" sort="Pilge, Hakan" uniqKey="Pilge H" first="Hakan" last="Pilge">Hakan Pilge</name><affiliation><nlm:aff id="Aff4">Department of Orthopedics, University Hospital Duesseldorf, Moorenstr. 5, Duesseldorf, 40225 Germany</nlm:aff></affiliation></author><author><name sortKey="Prodinger, Peter Michael" sort="Prodinger, Peter Michael" uniqKey="Prodinger P" first="Peter Michael" last="Prodinger">Peter Michael Prodinger</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Toepfer, Andreas" sort="Toepfer, Andreas" uniqKey="Toepfer A" first="Andreas" last="Toepfer">Andreas Toepfer</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Mayer Wagner, Susanne" sort="Mayer Wagner, Susanne" uniqKey="Mayer Wagner S" first="Susanne" last="Mayer-Wagner">Susanne Mayer-Wagner</name><affiliation><nlm:aff id="Aff5">Department of Orthopedic Surgery, Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, Munich, 81377 Germany</nlm:aff></affiliation></author><author><name sortKey="Hutmacher, Dietmar Werner" sort="Hutmacher, Dietmar Werner" uniqKey="Hutmacher D" first="Dietmar Werner" last="Hutmacher">Dietmar Werner Hutmacher</name><affiliation><nlm:aff id="Aff2">Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff6">Institute for Advanced Study, Technical University Munich, Lichtenberg Str. 2a, Garching, 85748 Germany</nlm:aff></affiliation></author><author><name sortKey="Von Eisenhart Rothe, Ruediger" sort="Von Eisenhart Rothe, Ruediger" uniqKey="Von Eisenhart Rothe R" first="Ruediger" last="Von Eisenhart-Rothe">Ruediger Von Eisenhart-Rothe</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Rudert, Maximilian" sort="Rudert, Maximilian" uniqKey="Rudert M" first="Maximilian" last="Rudert">Maximilian Rudert</name><affiliation><nlm:aff id="Aff1">Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, Wuerzburg, 97072 Germany</nlm:aff></affiliation></author><author><name sortKey="Gradinger, Reiner" sort="Gradinger, Reiner" uniqKey="Gradinger R" first="Reiner" last="Gradinger">Reiner Gradinger</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Rechl, Hans" sort="Rechl, Hans" uniqKey="Rechl H" first="Hans" last="Rechl">Hans Rechl</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24658873</idno><idno type="pmc">4071499</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4071499</idno><idno type="RBID">PMC:4071499</idno><idno type="doi">10.1007/s00264-014-2314-1</idno><date when="2014">2014</date><idno type="wicri:Area/Pmc/Corpus">000B51</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B51</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours</title><author><name sortKey="Holzapfel, Boris Michael" sort="Holzapfel, Boris Michael" uniqKey="Holzapfel B" first="Boris Michael" last="Holzapfel">Boris Michael Holzapfel</name><affiliation><nlm:aff id="Aff1">Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, Wuerzburg, 97072 Germany</nlm:aff></affiliation><affiliation><nlm:aff id="Aff2">Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059 Australia</nlm:aff></affiliation></author><author><name sortKey="Pilge, Hakan" sort="Pilge, Hakan" uniqKey="Pilge H" first="Hakan" last="Pilge">Hakan Pilge</name><affiliation><nlm:aff id="Aff4">Department of Orthopedics, University Hospital Duesseldorf, Moorenstr. 5, Duesseldorf, 40225 Germany</nlm:aff></affiliation></author><author><name sortKey="Prodinger, Peter Michael" sort="Prodinger, Peter Michael" uniqKey="Prodinger P" first="Peter Michael" last="Prodinger">Peter Michael Prodinger</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Toepfer, Andreas" sort="Toepfer, Andreas" uniqKey="Toepfer A" first="Andreas" last="Toepfer">Andreas Toepfer</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Mayer Wagner, Susanne" sort="Mayer Wagner, Susanne" uniqKey="Mayer Wagner S" first="Susanne" last="Mayer-Wagner">Susanne Mayer-Wagner</name><affiliation><nlm:aff id="Aff5">Department of Orthopedic Surgery, Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, Munich, 81377 Germany</nlm:aff></affiliation></author><author><name sortKey="Hutmacher, Dietmar Werner" sort="Hutmacher, Dietmar Werner" uniqKey="Hutmacher D" first="Dietmar Werner" last="Hutmacher">Dietmar Werner Hutmacher</name><affiliation><nlm:aff id="Aff2">Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059 Australia</nlm:aff></affiliation><affiliation><nlm:aff id="Aff6">Institute for Advanced Study, Technical University Munich, Lichtenberg Str. 2a, Garching, 85748 Germany</nlm:aff></affiliation></author><author><name sortKey="Von Eisenhart Rothe, Ruediger" sort="Von Eisenhart Rothe, Ruediger" uniqKey="Von Eisenhart Rothe R" first="Ruediger" last="Von Eisenhart-Rothe">Ruediger Von Eisenhart-Rothe</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Rudert, Maximilian" sort="Rudert, Maximilian" uniqKey="Rudert M" first="Maximilian" last="Rudert">Maximilian Rudert</name><affiliation><nlm:aff id="Aff1">Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, Wuerzburg, 97072 Germany</nlm:aff></affiliation></author><author><name sortKey="Gradinger, Reiner" sort="Gradinger, Reiner" uniqKey="Gradinger R" first="Reiner" last="Gradinger">Reiner Gradinger</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author><author><name sortKey="Rechl, Hans" sort="Rechl, Hans" uniqKey="Rechl H" first="Hans" last="Rechl">Hans Rechl</name><affiliation><nlm:aff id="Aff3">Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</nlm:aff></affiliation></author></analytic><series><title level="j">International Orthopaedics</title><idno type="ISSN">0341-2695</idno><idno type="eISSN">1432-5195</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>We sought to analyse clinical and oncological outcomes of patients after guided resection of periacetabular tumours and endoprosthetic reconstruction of the remaining defect.</p></sec><sec><title>Methods</title><p>From 1988 to 2008, we treated 56 consecutive patients (mean age 52.5 years, 41.1 % women). Patients were followed up either until death or February 2011 (mean follow up 5.5 years, range 0.1–22.5, standard deviation ± 5.3). Kaplan–Meier analysis was used to estimate survival rates.</p></sec><sec><title>Results</title><p>Disease-specific survival was 59.9 % at five years and 49.7 % at ten and 20 years, respectively. Wide resection margins were achieved in 38 patients, whereas 11 patients underwent marginal and seven intralesional resection. Survival was significantly better in patients with wide or marginal resection than in patients with intralesional resection (<italic>p</italic> = 0.022). Survival for patients with secondary tumours was significantly worse than for patients with primary tumours (<italic>p</italic> = 0.003). In 29 patients (51.8 %), at least one reoperation was necessary, resulting in a revision-free survival of 50.5 % at five years, 41.1 % at ten years and 30.6 % at 20 years. Implant survival was 77.0 % at five years, 68.6 % at ten years and 51.8 % at 20 years. A total of 35 patients (62.5 %) experienced one or more complications after surgery. Ten of 56 patients (17.9 %) experienced local recurrence after a mean of 8.9 months. The mean postoperative Musculoskeletal Tumor Society (MSTS) score was 18.1 (60.1 %).</p></sec><sec><title>Conclusion</title><p>The surgical approach assessed in this study simplifies the process of tumour resection and prosthesis implantation and leads to acceptable clinical and oncological outcomes.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int Orthop</journal-id><journal-id journal-id-type="iso-abbrev">Int Orthop</journal-id><journal-title-group><journal-title>International Orthopaedics</journal-title></journal-title-group><issn pub-type="ppub">0341-2695</issn><issn pub-type="epub">1432-5195</issn><publisher><publisher-name>Springer Berlin Heidelberg</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24658873</article-id><article-id pub-id-type="pmc">4071499</article-id><article-id pub-id-type="publisher-id">2314</article-id><article-id pub-id-type="doi">10.1007/s00264-014-2314-1</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Paper</subject></subj-group></article-categories><title-group><article-title>Customised osteotomy guides and endoprosthetic reconstruction for periacetabular tumours</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Holzapfel</surname><given-names>Boris Michael</given-names></name><address><phone>+61-7-31386415</phone><fax>+61-7-31386030</fax><email>holzapfel@orthopaedic-oncology.net</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Pilge</surname><given-names>Hakan</given-names></name><xref ref-type="aff" rid="Aff4"></xref></contrib><contrib contrib-type="author"><name><surname>Prodinger</surname><given-names>Peter Michael</given-names></name><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Toepfer</surname><given-names>Andreas</given-names></name><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Mayer-Wagner</surname><given-names>Susanne</given-names></name><xref ref-type="aff" rid="Aff5"></xref></contrib><contrib contrib-type="author"><name><surname>Hutmacher</surname><given-names>Dietmar Werner</given-names></name><xref ref-type="aff" rid="Aff2"></xref><xref ref-type="aff" rid="Aff6"></xref></contrib><contrib contrib-type="author"><name><surname>von Eisenhart-Rothe</surname><given-names>Ruediger</given-names></name><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Rudert</surname><given-names>Maximilian</given-names></name><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Gradinger</surname><given-names>Reiner</given-names></name><xref ref-type="aff" rid="Aff3"></xref></contrib><contrib contrib-type="author"><name><surname>Rechl</surname><given-names>Hans</given-names></name><xref ref-type="aff" rid="Aff3"></xref></contrib><aff id="Aff1"><label></label>Orthopedic Center for Musculoskeletal Research, University of Wuerzburg, Koenig-Ludwig-Haus, Brettreichstr. 11, Wuerzburg, 97072 Germany</aff><aff id="Aff2"><label></label>Regenerative Medicine, Institute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, Brisbane, QLD 4059 Australia</aff><aff id="Aff3"><label></label>Department of Orthopedics and Orthopedic Sports Medicine, Technical University Munich, Klinikum Rechts der Isar, Ismaninger Str. 22, Munich, 81675 Germany</aff><aff id="Aff4"><label></label>Department of Orthopedics, University Hospital Duesseldorf, Moorenstr. 5, Duesseldorf, 40225 Germany</aff><aff id="Aff5"><label></label>Department of Orthopedic Surgery, Campus Grosshadern, Ludwig-Maximilians-University Munich, Marchioninistr. 15, Munich, 81377 Germany</aff><aff id="Aff6"><label></label>Institute for Advanced Study, Technical University Munich, Lichtenberg Str. 2a, Garching, 85748 Germany</aff></contrib-group><pub-date pub-type="epub"><day>23</day><month>3</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2014</year></pub-date><volume>38</volume><issue>7</issue><fpage>1435</fpage><lpage>1442</lpage><history><date date-type="received"><day>6</day><month>1</month><year>2014</year></date><date date-type="accepted"><day>23</day><month>2</month><year>2014</year></date></history><permissions><copyright-statement>© Springer-Verlag Berlin Heidelberg 2014</copyright-statement></permissions><abstract id="Abs1"><sec><title>Purpose</title><p>We sought to analyse clinical and oncological outcomes of patients after guided resection of periacetabular tumours and endoprosthetic reconstruction of the remaining defect.</p></sec><sec><title>Methods</title><p>From 1988 to 2008, we treated 56 consecutive patients (mean age 52.5 years, 41.1 % women). Patients were followed up either until death or February 2011 (mean follow up 5.5 years, range 0.1–22.5, standard deviation ± 5.3). Kaplan–Meier analysis was used to estimate survival rates.</p></sec><sec><title>Results</title><p>Disease-specific survival was 59.9 % at five years and 49.7 % at ten and 20 years, respectively. Wide resection margins were achieved in 38 patients, whereas 11 patients underwent marginal and seven intralesional resection. Survival was significantly better in patients with wide or marginal resection than in patients with intralesional resection (<italic>p</italic> = 0.022). Survival for patients with secondary tumours was significantly worse than for patients with primary tumours (<italic>p</italic> = 0.003). In 29 patients (51.8 %), at least one reoperation was necessary, resulting in a revision-free survival of 50.5 % at five years, 41.1 % at ten years and 30.6 % at 20 years. Implant survival was 77.0 % at five years, 68.6 % at ten years and 51.8 % at 20 years. A total of 35 patients (62.5 %) experienced one or more complications after surgery. Ten of 56 patients (17.9 %) experienced local recurrence after a mean of 8.9 months. The mean postoperative Musculoskeletal Tumor Society (MSTS) score was 18.1 (60.1 %).</p></sec><sec><title>Conclusion</title><p>The surgical approach assessed in this study simplifies the process of tumour resection and prosthesis implantation and leads to acceptable clinical and oncological outcomes.</p></sec></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Periacetabular tumours</kwd><kwd>Three-dimensional planning</kwd><kwd>Rapid prototyping</kwd><kwd>Guided osteotomy</kwd><kwd>Patient-specific implants</kwd><kwd>Endoprosthetic reconstruction</kwd><kwd>Custom made</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© SICOT aisbl 2014</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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