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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis</title><author><name sortKey="De Almeida, Adriana B" sort="De Almeida, Adriana B" uniqKey="De Almeida A" first="Adriana B." last="De Almeida">Adriana B. De Almeida</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author><author><name sortKey="E Silva, Maria Carmelita Maia" sort="E Silva, Maria Carmelita Maia" uniqKey="E Silva M" first="Maria Carmelita Maia" last="E Silva">Maria Carmelita Maia E Silva</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author><author><name sortKey="Braga, Cynthia" sort="Braga, Cynthia" uniqKey="Braga C" first="Cynthia" last="Braga">Cynthia Braga</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author><author><name sortKey="Freedman, David O" sort="Freedman, David O" uniqKey="Freedman D" first="David O." last="Freedman">David O. Freedman</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">9529056</idno><idno type="pmc">108063</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC108063</idno><idno type="RBID">PMC:108063</idno><date when="1998">1998</date><idno type="wicri:Area/Pmc/Corpus">000B50</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000B50</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis</title><author><name sortKey="De Almeida, Adriana B" sort="De Almeida, Adriana B" uniqKey="De Almeida A" first="Adriana B." last="De Almeida">Adriana B. De Almeida</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author><author><name sortKey="E Silva, Maria Carmelita Maia" sort="E Silva, Maria Carmelita Maia" uniqKey="E Silva M" first="Maria Carmelita Maia" last="E Silva">Maria Carmelita Maia E Silva</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author><author><name sortKey="Braga, Cynthia" sort="Braga, Cynthia" uniqKey="Braga C" first="Cynthia" last="Braga">Cynthia Braga</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author><author><name sortKey="Freedman, David O" sort="Freedman, David O" uniqKey="Freedman D" first="David O." last="Freedman">David O. Freedman</name><affiliation><nlm:aff id="N0x8c7ea78.0x9db10f0"></nlm:aff></affiliation></author></analytic><series><title level="j">Infection and Immunity</title><idno type="ISSN">0019-9567</idno><idno type="eISSN">1098-5522</idno><imprint><date when="1998">1998</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Individuals with clinical manifestations of lymphatic filariasis may be currently infected or not. Twenty-five individuals from a <italic>Wuchereria bancrofti</italic>-endemic area of Brazil were classified as being asymptomatic microfilaremic individuals, antigenemic individuals with clinical filariasis, or nonantigenemic individuals with clinical filariasis. Intracellular cytokine staining of mitogen-stimulated peripheral blood mononuclear cells (PBMC) showed that the frequency of either gamma interferon (IFN-γ)- or interleukin-4 (IL-4)-producing cells was higher in the nonantigenemic individuals with clinical filariasis than in the asymptomatic microfilaremic individuals (geometric means, 22.1 versus 10.7% [<italic>P</italic> = 0.02] and 2.9 versus 1.4% [<italic>P</italic> = 0.01], respectively). When the asymptomatic microfilaremic individuals and antigenemic individuals with clinical filariasis were grouped together to constitute all actively infected individuals, the frequency of IFN-γ-producing cells was also lower than in the nonantigenemic individuals with clinical filariasis (<italic>P</italic> = 0.04). Likewise, the frequency of IL-4-producing cells in the actively infected individuals was also lower than in the nonantigenemic individuals with clinical filariasis (<italic>P</italic> = 0.02). No differences in the frequency of IFN-γ-, IL-4-, or IL-5-producing cells in purified CD4 T lymphocytes were found among the groups. These findings suggest that the presence of antigenemia, which is an indicator of current active infection, is closely associated with the frequency of IFN-γ- and IL-4-producing cells in lymphatic filariasis. The differences found in the frequency of cytokine-producing cells among the three groups appear to be due to a subset of cells other than CD4 T cells.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Infect Immun</journal-id><journal-id journal-id-type="publisher-id">INFECT IMMUN</journal-id><journal-title>Infection and Immunity</journal-title><issn pub-type="ppub">0019-9567</issn><issn pub-type="epub">1098-5522</issn><publisher><publisher-name>American Society for Microbiology</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">9529056</article-id><article-id pub-id-type="pmc">108063</article-id><article-id pub-id-type="publisher-id">0832</article-id><article-categories><subj-group subj-group-type="heading"><subject>Fungal and Parasitic Infections</subject></subj-group></article-categories><title-group><article-title>Differences in the Frequency of Cytokine-Producing Cells in Antigenemic and Nonantigenemic Individuals with Bancroftian Filariasis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>de Almeida</surname><given-names>Adriana B.</given-names></name><xref ref-type="aff" rid="N0x8c7ea78.0x9db10f0">1</xref><xref ref-type="author-notes" rid="FN150">*</xref></contrib><contrib contrib-type="author"><name><surname>e Silva</surname><given-names>Maria Carmelita Maia</given-names></name><xref ref-type="aff" rid="N0x8c7ea78.0x9db10f0">2</xref><xref ref-type="author-notes" rid="FN151">†</xref></contrib><contrib contrib-type="author"><name><surname>Braga</surname><given-names>Cynthia</given-names></name><xref ref-type="aff" rid="N0x8c7ea78.0x9db10f0">2</xref></contrib><contrib contrib-type="author"><name><surname>Freedman</surname><given-names>David O.</given-names></name><xref ref-type="aff" rid="N0x8c7ea78.0x9db10f0">1</xref></contrib></contrib-group><aff id="N0x8c7ea78.0x9db10f0"> Division of Geographic Medicine, The University of Alabama at Birmingham, Birmingham, Alabama,<sup>1</sup> and Centro de Pesquisas Aggeu Magalhães, Recife, Brazil<sup>2</sup></aff><author-notes><fn id="FN150"><label>*</label><p>Corresponding author. Mailing address: Division of Geographic Medicine, UAB Station, BBRB 544 Box 7, Birmingham, AL 35294-2170. Phone: (205) 975-7605. Fax: (205) 933-5671. E-mail: <email>dflab@geomed.dom.uab.edu</email>.</p></fn><fn id="FN151"><label>†</label><p>Present address: 6 Kenworthy Garth, Holt Park, Leeds, LS16 7QU, United Kingdom.</p></fn><fn><p>Editor: S. H. E. Kaufmann</p></fn></author-notes><pub-date pub-type="ppub"><month>4</month><year>1998</year></pub-date><volume>66</volume><issue>4</issue><fpage>1377</fpage><lpage>1383</lpage><history><date date-type="received"><day>1</day><month>7</month><year>1997</year></date><date date-type="rev-request"><day>2</day><month>10</month><year>1997</year></date><date date-type="accepted"><day>8</day><month>1</month><year>1998</year></date></history><copyright-statement>Copyright © 1998, American Society for Microbiology</copyright-statement><copyright-year>1998</copyright-year><abstract><p>Individuals with clinical manifestations of lymphatic filariasis may be currently infected or not. Twenty-five individuals from a <italic>Wuchereria bancrofti</italic>-endemic area of Brazil were classified as being asymptomatic microfilaremic individuals, antigenemic individuals with clinical filariasis, or nonantigenemic individuals with clinical filariasis. Intracellular cytokine staining of mitogen-stimulated peripheral blood mononuclear cells (PBMC) showed that the frequency of either gamma interferon (IFN-γ)- or interleukin-4 (IL-4)-producing cells was higher in the nonantigenemic individuals with clinical filariasis than in the asymptomatic microfilaremic individuals (geometric means, 22.1 versus 10.7% [<italic>P</italic> = 0.02] and 2.9 versus 1.4% [<italic>P</italic> = 0.01], respectively). When the asymptomatic microfilaremic individuals and antigenemic individuals with clinical filariasis were grouped together to constitute all actively infected individuals, the frequency of IFN-γ-producing cells was also lower than in the nonantigenemic individuals with clinical filariasis (<italic>P</italic> = 0.04). Likewise, the frequency of IL-4-producing cells in the actively infected individuals was also lower than in the nonantigenemic individuals with clinical filariasis (<italic>P</italic> = 0.02). No differences in the frequency of IFN-γ-, IL-4-, or IL-5-producing cells in purified CD4 T lymphocytes were found among the groups. These findings suggest that the presence of antigenemia, which is an indicator of current active infection, is closely associated with the frequency of IFN-γ- and IL-4-producing cells in lymphatic filariasis. The differences found in the frequency of cytokine-producing cells among the three groups appear to be due to a subset of cells other than CD4 T cells.</p></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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