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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Angiosarcoma Developing in a Vagal Schwannoma: A Rare Case Report</title>
<author><name sortKey="Mahajan, Vrushali" sort="Mahajan, Vrushali" uniqKey="Mahajan V" first="Vrushali" last="Mahajan">Vrushali Mahajan</name>
<affiliation><nlm:aff id="Aff1">Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rao, Seema" sort="Rao, Seema" uniqKey="Rao S" first="Seema" last="Rao">Seema Rao</name>
<affiliation><nlm:aff id="Aff1">Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gupta, Pallav" sort="Gupta, Pallav" uniqKey="Gupta P" first="Pallav" last="Gupta">Pallav Gupta</name>
<affiliation><nlm:aff id="Aff1">Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Munjal, Manish" sort="Munjal, Manish" uniqKey="Munjal M" first="Manish" last="Munjal">Manish Munjal</name>
<affiliation><nlm:aff id="Aff2">Department of ENT, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Agrawal, Sangeet" sort="Agrawal, Sangeet" uniqKey="Agrawal S" first="Sangeet" last="Agrawal">Sangeet Agrawal</name>
<affiliation><nlm:aff id="Aff2">Department of ENT, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25371276</idno>
<idno type="pmc">4542800</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4542800</idno>
<idno type="RBID">PMC:4542800</idno>
<idno type="doi">10.1007/s12105-014-0577-x</idno>
<date when="2014">2014</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Angiosarcoma Developing in a Vagal Schwannoma: A Rare Case Report</title>
<author><name sortKey="Mahajan, Vrushali" sort="Mahajan, Vrushali" uniqKey="Mahajan V" first="Vrushali" last="Mahajan">Vrushali Mahajan</name>
<affiliation><nlm:aff id="Aff1">Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Rao, Seema" sort="Rao, Seema" uniqKey="Rao S" first="Seema" last="Rao">Seema Rao</name>
<affiliation><nlm:aff id="Aff1">Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gupta, Pallav" sort="Gupta, Pallav" uniqKey="Gupta P" first="Pallav" last="Gupta">Pallav Gupta</name>
<affiliation><nlm:aff id="Aff1">Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Munjal, Manish" sort="Munjal, Manish" uniqKey="Munjal M" first="Manish" last="Munjal">Manish Munjal</name>
<affiliation><nlm:aff id="Aff2">Department of ENT, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Agrawal, Sangeet" sort="Agrawal, Sangeet" uniqKey="Agrawal S" first="Sangeet" last="Agrawal">Sangeet Agrawal</name>
<affiliation><nlm:aff id="Aff2">Department of ENT, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Head and Neck Pathology</title>
<idno type="ISSN">1936-055X</idno>
<idno type="eISSN">1936-0568</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
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<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p>Angiosarcoma arising in a schwannoma is extremely rare with only fourteen cases having been reported in the literature to the best of our knowledge. Amongst these fourteen, only five cases developed from vagal schwannoma. We describe a case of epithelioid angiosarcoma arising in a long standing vagal schwannoma in a 41 years male patient. Grossly the tumor was well encapsulated with variegated cut surface. On microscopy the tumor had two distinct components composed of benign schwannoma and malignant angiosarcoma which were further confirmed by immunohistochemistry. On further work up, he was found to have multiple distant metastases. This is the sixth reported case of angiosarcoma arising in a vagal schwannoma. The proposed histogenesis of this rare transformation, its prognostic factors and a review of literature regarding this entity is discussed.</p>
</div>
</front>
</TEI>
<pmc article-type="case-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Head Neck Pathol</journal-id>
<journal-id journal-id-type="iso-abbrev">Head Neck Pathol</journal-id>
<journal-title-group><journal-title>Head and Neck Pathology</journal-title>
</journal-title-group>
<issn pub-type="ppub">1936-055X</issn>
<issn pub-type="epub">1936-0568</issn>
<publisher><publisher-name>Springer US</publisher-name>
<publisher-loc>New York</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25371276</article-id>
<article-id pub-id-type="pmc">4542800</article-id>
<article-id pub-id-type="publisher-id">577</article-id>
<article-id pub-id-type="doi">10.1007/s12105-014-0577-x</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject>
</subj-group>
</article-categories>
<title-group><article-title>Angiosarcoma Developing in a Vagal Schwannoma: A Rare Case Report</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Mahajan</surname>
<given-names>Vrushali</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Rao</surname>
<given-names>Seema</given-names>
</name>
<address><email>seemarao1974@yahoo.co.in</email>
</address>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gupta</surname>
<given-names>Pallav</given-names>
</name>
<xref ref-type="aff" rid="Aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Munjal</surname>
<given-names>Manish</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Agrawal</surname>
<given-names>Sangeet</given-names>
</name>
<xref ref-type="aff" rid="Aff2"></xref>
</contrib>
<aff id="Aff1"><label></label>
Department of Histopathology, First Floor, SSRB Block, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</aff>
<aff id="Aff2"><label></label>
Department of ENT, Sir Ganga Ram Hospital, Rajinder Nagar, New Delhi, 110060 India</aff>
</contrib-group>
<pub-date pub-type="epub"><day>5</day>
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="collection"><month>9</month>
<year>2015</year>
</pub-date>
<volume>9</volume>
<issue>3</issue>
<fpage>405</fpage>
<lpage>411</lpage>
<history><date date-type="received"><day>6</day>
<month>8</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>25</day>
<month>10</month>
<year>2014</year>
</date>
</history>
<permissions><copyright-statement>© Springer Science+Business Media New York 2014</copyright-statement>
</permissions>
<abstract id="Abs1"><p>Angiosarcoma arising in a schwannoma is extremely rare with only fourteen cases having been reported in the literature to the best of our knowledge. Amongst these fourteen, only five cases developed from vagal schwannoma. We describe a case of epithelioid angiosarcoma arising in a long standing vagal schwannoma in a 41 years male patient. Grossly the tumor was well encapsulated with variegated cut surface. On microscopy the tumor had two distinct components composed of benign schwannoma and malignant angiosarcoma which were further confirmed by immunohistochemistry. On further work up, he was found to have multiple distant metastases. This is the sixth reported case of angiosarcoma arising in a vagal schwannoma. The proposed histogenesis of this rare transformation, its prognostic factors and a review of literature regarding this entity is discussed.</p>
</abstract>
<kwd-group xml:lang="en"><title>Keywords</title>
<kwd>Angiosarcoma</kwd>
<kwd>Immunohistochemistry</kwd>
<kwd>Schwannoma</kwd>
<kwd>Vagus nerve</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name>
<meta-value>© Springer Science+Business Media New York 2015</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
</record>
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