The anti-neoplastic effects of coumarin: an emerging concept
Identifieur interne : 000996 ( Pmc/Corpus ); précédent : 000995; suivant : 000997The anti-neoplastic effects of coumarin: an emerging concept
Auteurs : Shailendra KapoorSource :
- Cytotechnology [ 0920-9069 ] ; 2013.
Abstract
The recent article by Liu et al. provided for highly interesting reading. Interestingly, recent data suggests that coumarin may exert significant anti-neoplastic effects in a number of systemic malignancies. Coumarin is also of clinical benefit in mammary malignancies. For instance, it attenuates the extent of extremity lymphedema following breast cancer surgery and radiation therapy. In one recent study, an almost 12.5 % decline in the volume of upper extremity lymphedema was noticed. As a result, quality of life is significantly improved. Similar attenuation of tumor growth has been seen in pulmonary malignancies. It mediates these anti-neoplastic effects by attenuating Bcl-2 expression within the tumor cells. On the other hand, Bax expression within the tumor cells is markedly accentuated. These changes have recently been confirmed in A549 cells.
Url:
DOI: 10.1007/s10616-013-9538-6
PubMed: 23340967
PubMed Central: 3967608
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">The anti-neoplastic effects of coumarin: an emerging concept</title><author><name sortKey="Kapoor, Shailendra" sort="Kapoor, Shailendra" uniqKey="Kapoor S" first="Shailendra" last="Kapoor">Shailendra Kapoor</name><affiliation><nlm:aff id="Aff1">74 Crossing Place, Mechanicsville, VA USA</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23340967</idno><idno type="pmc">3967608</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3967608</idno><idno type="RBID">PMC:3967608</idno><idno type="doi">10.1007/s10616-013-9538-6</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000996</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000996</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">The anti-neoplastic effects of coumarin: an emerging concept</title><author><name sortKey="Kapoor, Shailendra" sort="Kapoor, Shailendra" uniqKey="Kapoor S" first="Shailendra" last="Kapoor">Shailendra Kapoor</name><affiliation><nlm:aff id="Aff1">74 Crossing Place, Mechanicsville, VA USA</nlm:aff></affiliation></author></analytic><series><title level="j">Cytotechnology</title><idno type="ISSN">0920-9069</idno><idno type="eISSN">1573-0778</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The recent article by Liu et al. provided for highly interesting reading. Interestingly, recent data suggests that coumarin may exert significant anti-neoplastic effects in a number of systemic malignancies. Coumarin is also of clinical benefit in mammary malignancies. For instance, it attenuates the extent of extremity lymphedema following breast cancer surgery and radiation therapy. In one recent study, an almost 12.5 % decline in the volume of upper extremity lymphedema was noticed. As a result, quality of life is significantly improved. Similar attenuation of tumor growth has been seen in pulmonary malignancies. It mediates these anti-neoplastic effects by attenuating Bcl-2 expression within the tumor cells. On the other hand, Bax expression within the tumor cells is markedly accentuated. These changes have recently been confirmed in A549 cells.</p></div></front></TEI><pmc article-type="brief-report"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Cytotechnology</journal-id><journal-id journal-id-type="iso-abbrev">Cytotechnology</journal-id><journal-title-group><journal-title>Cytotechnology</journal-title></journal-title-group><issn pub-type="ppub">0920-9069</issn><issn pub-type="epub">1573-0778</issn><publisher><publisher-name>Springer Netherlands</publisher-name><publisher-loc>Dordrecht</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23340967</article-id><article-id pub-id-type="pmc">3967608</article-id><article-id pub-id-type="publisher-id">9538</article-id><article-id pub-id-type="doi">10.1007/s10616-013-9538-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Letter to the Editor</subject></subj-group></article-categories><title-group><article-title>The anti-neoplastic effects of coumarin: an emerging concept</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Kapoor</surname><given-names>Shailendra</given-names></name><address><phone>+865-607-1014</phone><fax>+865-678-6787</fax><email>shailendrakapoor@yahoo.com</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1">74 Crossing Place, Mechanicsville, VA USA</aff></contrib-group><pub-date pub-type="epub"><day>23</day><month>1</month><year>2013</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2013</year></pub-date><volume>65</volume><issue>5</issue><fpage>787</fpage><lpage>788</lpage><history><date date-type="received"><day>7</day><month>1</month><year>2013</year></date><date date-type="accepted"><day>9</day><month>1</month><year>2013</year></date></history><permissions><copyright-statement>© Springer Science+Business Media Dordrecht 2013</copyright-statement></permissions><abstract id="Abs1"><p>The recent article by Liu et al. provided for highly interesting reading. Interestingly, recent data suggests that coumarin may exert significant anti-neoplastic effects in a number of systemic malignancies. Coumarin is also of clinical benefit in mammary malignancies. For instance, it attenuates the extent of extremity lymphedema following breast cancer surgery and radiation therapy. In one recent study, an almost 12.5 % decline in the volume of upper extremity lymphedema was noticed. As a result, quality of life is significantly improved. Similar attenuation of tumor growth has been seen in pulmonary malignancies. It mediates these anti-neoplastic effects by attenuating Bcl-2 expression within the tumor cells. On the other hand, Bax expression within the tumor cells is markedly accentuated. These changes have recently been confirmed in A549 cells.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Coumarin</kwd><kwd>Breast cancer</kwd><kwd>Prostate cancer</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Science+Business Media Dordrecht 2013</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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