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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Prediction and evaluation of resting energy expenditure in a large group of obese outpatients</title><author><name sortKey="Marra, M" sort="Marra, M" uniqKey="Marra M" first="M" last="Marra">M. Marra</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Cioffi, I" sort="Cioffi, I" uniqKey="Cioffi I" first="I" last="Cioffi">I. Cioffi</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Sammarco, R" sort="Sammarco, R" uniqKey="Sammarco R" first="R" last="Sammarco">R. Sammarco</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Montagnese, C" sort="Montagnese, C" uniqKey="Montagnese C" first="C" last="Montagnese">C. Montagnese</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Naccarato, M" sort="Naccarato, M" uniqKey="Naccarato M" first="M" last="Naccarato">M. Naccarato</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Amato, V" sort="Amato, V" uniqKey="Amato V" first="V" last="Amato">V. Amato</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Contaldo, F" sort="Contaldo, F" uniqKey="Contaldo F" first="F" last="Contaldo">F. Contaldo</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Pasanisi, F" sort="Pasanisi, F" uniqKey="Pasanisi F" first="F" last="Pasanisi">F. Pasanisi</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">28163316</idno><idno type="pmc">5418562</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5418562</idno><idno type="RBID">PMC:5418562</idno><idno type="doi">10.1038/ijo.2017.34</idno><date when="2017">2017</date><idno type="wicri:Area/Pmc/Corpus">000924</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000924</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Prediction and evaluation of resting energy expenditure in a large group of obese outpatients</title><author><name sortKey="Marra, M" sort="Marra, M" uniqKey="Marra M" first="M" last="Marra">M. Marra</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Cioffi, I" sort="Cioffi, I" uniqKey="Cioffi I" first="I" last="Cioffi">I. Cioffi</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Sammarco, R" sort="Sammarco, R" uniqKey="Sammarco R" first="R" last="Sammarco">R. Sammarco</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Montagnese, C" sort="Montagnese, C" uniqKey="Montagnese C" first="C" last="Montagnese">C. Montagnese</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Naccarato, M" sort="Naccarato, M" uniqKey="Naccarato M" first="M" last="Naccarato">M. Naccarato</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Amato, V" sort="Amato, V" uniqKey="Amato V" first="V" last="Amato">V. Amato</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Contaldo, F" sort="Contaldo, F" uniqKey="Contaldo F" first="F" last="Contaldo">F. Contaldo</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author><author><name sortKey="Pasanisi, F" sort="Pasanisi, F" uniqKey="Pasanisi F" first="F" last="Pasanisi">F. Pasanisi</name><affiliation><nlm:aff id="aff1"><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></nlm:aff></affiliation></author></analytic><series><title level="j">International Journal of Obesity (2005)</title><idno type="ISSN">0307-0565</idno><idno type="eISSN">1476-5497</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background/Objectives:</title><p>The aim of this study was to compare resting energy expenditure (REE) measured (MREE) by indirect calorimetry (IC) and REE predicted (PREE) from established predictive equations in a large sample of obese Caucasian adults.</p></sec><sec><title>Subjects/Methods:</title><p>We evaluated 1851 obese patients (body mass index (BMI)>30 kg m<sup>−</sup><sup>2</sup>) aged between 18a and 65 years. Data were obtained by comparing MREE with PREE, derived from different equations, within and between normal weight and obese groups. The mean differences between PREE and MREE as well as the accuracy prediction within ±10% level were investigated in the whole sample and in three subgroups, classified by BMI (Group 1=30–39.9 kg m<sup>−</sup><sup>2</sup>; Group 2=40–49.9 kg m<sup>−</sup><sup>2</sup>; Group 3>50 kg m<sup>−</sup><sup>2</sup>).</p></sec><sec><title>Results:</title><p>We observed that FAO, Henry and Muller3 (body composition (BC)) equations provided good mean PREE–MREE (bias −0.7, −0.3 and 0.9% root mean standard error (RMSE) 273, 263 and 269 kcal per day, respectively); HB and Henry equations were more accurate individually (57 and 56.9%). Only the Muller1 (BC) equation gave the lowest PREE–MREE difference (bias −1.7% RMSE 228 kcal per day) in females, while Johnstone and De Lorenzo equations were the most accurate (55.1 and 54.8%). When the sample was split into three subgroups according to BMI, no differences were found in males; however, the majority of the equations included in this study failed to estimate REE in severely obese females (BMI>40 kg m<sup>−</sup><sup>2</sup>). Overall, prediction accuracy was low (~55%) for all predictive equations, regardless of BMI.</p></sec><sec><title>Conclusions:</title><p>Different established equations can be used for estimating REE at the population level in both sexes. However, the accuracy was very low for all predictive equations used, particularly among females and when BMI was high, limiting their use in clinical practice. Our findings suggest that the validation of new predictive equations would improve the accuracy of REE prediction, especially for severely obese subjects (BMI>40 kg m<sup>−</sup><sup>2</sup>).</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Obes (Lond)</journal-id><journal-id journal-id-type="iso-abbrev">Int J Obes (Lond)</journal-id><journal-title-group><journal-title>International Journal of Obesity (2005)</journal-title></journal-title-group><issn pub-type="ppub">0307-0565</issn><issn pub-type="epub">1476-5497</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">28163316</article-id><article-id pub-id-type="pmc">5418562</article-id><article-id pub-id-type="pii">ijo201734</article-id><article-id pub-id-type="doi">10.1038/ijo.2017.34</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Prediction and evaluation of resting energy expenditure in a large group of obese outpatients</article-title><alt-title alt-title-type="running">Evaluation of REE in obese outpatients</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Marra</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="caf1">*</xref><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0002-3258-7374</contrib-id></contrib><contrib contrib-type="author"><name><surname>Cioffi</surname><given-names>I</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sammarco</surname><given-names>R</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Montagnese</surname><given-names>C</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Naccarato</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Amato</surname><given-names>V</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Contaldo</surname><given-names>F</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Pasanisi</surname><given-names>F</given-names></name><xref ref-type="aff" rid="aff1">1</xref><contrib-id contrib-id-type="orcid">http://orcid.org/0000-0003-4224-7821</contrib-id></contrib><aff id="aff1"><label>1</label><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Naples,<country>Italy</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label><institution>Internal Medicine and Clinical Nutrition Unit, Department of Clinical Medicine and Surgery, Interuniversity Centre for Obesity and Eating Disorders (CISRODCA), Federico II University of Naples</institution>, Via S. Pansini 5, Naples 80131, <country>Italy</country>. E-mail: <email>marra@unina.it</email></corresp></author-notes><pub-date pub-type="ppub"><month>05</month><year>2017</year></pub-date><pub-date pub-type="epub"><day>28</day><month>02</month><year>2017</year></pub-date><volume>41</volume><issue>5</issue><fpage>697</fpage><lpage>705</lpage><history><date date-type="received"><day>22</day><month>06</month><year>2016</year></date><date date-type="rev-recd"><day>03</day><month>01</month><year>2017</year></date><date date-type="accepted"><day>22</day><month>01</month><year>2017</year></date></history><permissions><copyright-statement>Copyright © 2017 The Author(s)</copyright-statement><copyright-year>2017</copyright-year><copyright-holder>The Author(s)</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs 4.0 International License. The images or other third party material in this article are included in the article's Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-nd/4.0/">http://creativecommons.org/licenses/by-nc-nd/4.0/</ext-link></license-p></license></permissions><abstract><sec><title>Background/Objectives:</title><p>The aim of this study was to compare resting energy expenditure (REE) measured (MREE) by indirect calorimetry (IC) and REE predicted (PREE) from established predictive equations in a large sample of obese Caucasian adults.</p></sec><sec><title>Subjects/Methods:</title><p>We evaluated 1851 obese patients (body mass index (BMI)>30 kg m<sup>−</sup><sup>2</sup>) aged between 18a and 65 years. Data were obtained by comparing MREE with PREE, derived from different equations, within and between normal weight and obese groups. The mean differences between PREE and MREE as well as the accuracy prediction within ±10% level were investigated in the whole sample and in three subgroups, classified by BMI (Group 1=30–39.9 kg m<sup>−</sup><sup>2</sup>; Group 2=40–49.9 kg m<sup>−</sup><sup>2</sup>; Group 3>50 kg m<sup>−</sup><sup>2</sup>).</p></sec><sec><title>Results:</title><p>We observed that FAO, Henry and Muller3 (body composition (BC)) equations provided good mean PREE–MREE (bias −0.7, −0.3 and 0.9% root mean standard error (RMSE) 273, 263 and 269 kcal per day, respectively); HB and Henry equations were more accurate individually (57 and 56.9%). Only the Muller1 (BC) equation gave the lowest PREE–MREE difference (bias −1.7% RMSE 228 kcal per day) in females, while Johnstone and De Lorenzo equations were the most accurate (55.1 and 54.8%). When the sample was split into three subgroups according to BMI, no differences were found in males; however, the majority of the equations included in this study failed to estimate REE in severely obese females (BMI>40 kg m<sup>−</sup><sup>2</sup>). Overall, prediction accuracy was low (~55%) for all predictive equations, regardless of BMI.</p></sec><sec><title>Conclusions:</title><p>Different established equations can be used for estimating REE at the population level in both sexes. However, the accuracy was very low for all predictive equations used, particularly among females and when BMI was high, limiting their use in clinical practice. Our findings suggest that the validation of new predictive equations would improve the accuracy of REE prediction, especially for severely obese subjects (BMI>40 kg m<sup>−</sup><sup>2</sup>).</p></sec></abstract></article-meta></front><body><sec><title>Introduction</title><p>Obesity is a state of energy imbalance. As such, the assessment of resting energy expenditure (REE) provides useful information for body weight management. As a matter of fact, knowledge of the individual energy expenditure appears to be necessary for providing adequate dietary advice since REE generally contributes 60–70% of total energy expenditure.<sup><xref ref-type="bibr" rid="bib1">1</xref></sup> In clinical practice, the evaluation of REE in obese subjects provides the background to prescribe appropriate energy-restricted diets,<sup><xref ref-type="bibr" rid="bib2">2</xref></sup> thus improving long-term patient compliance.</p><p>REE can be measured by indirect calorimetry (IC) or estimated from predictive equations. The measurement of REE by IC is a non-invasive method that measures oxygen consumption and carbon dioxide production. IC is generally considered the gold standard in clinical practice. However, potential drawbacks such as the high cost of equipment, the time required to take correct measurements and the lack of qualified staff have prevented the widespread use of IC in most clinical settings.</p><p>Alternatively, predictive equations are widely used to estimate REE. These equations are typically based on anthropometric variables; however, many variables such as age, sex, weight, height and body composition (FM: fat mass and FFM: fat-free mass) as well as ethnicity, environmental temperature, drug treatment and so on can affect REE prediction.</p><p>Although several equations have been developed, data show conflicting results on which is the most appropriate to use for predicting REE in obese subjects, especially for severely obese people (body mass index (BMI)>40 kg m<sup>−</sup><sup>2</sup>). Some of the most commonly used predictive equations were generated in normal-weight populations<sup><xref ref-type="bibr" rid="bib3">3</xref>, <xref ref-type="bibr" rid="bib4">4</xref>, <xref ref-type="bibr" rid="bib5">5</xref></sup> that included few or no obese<sup><xref ref-type="bibr" rid="bib6">6</xref></sup> or severely obese subjects.<sup><xref ref-type="bibr" rid="bib7">7</xref></sup> It can be assumed that most of the established REE predictive equations do no accurately predict REE in obese subjects.<sup><xref ref-type="bibr" rid="bib8">8</xref></sup> For example, Horie <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib9">9</xref></sup> formulated a new equation specifically to estimate REE in 120 obese subjects (BMI>35 kg m<sup>−</sup><sup>2</sup>) as no published equation accurately predicted REE in this population when compared to REE measured by IC. Therefore, much research is still needed in this area.</p><p>It is also unclear whether body composition variables, such as FFM and FM, could enhance the accuracy of REE predictive equations in severely obese people. For example, when body composition variables were assessed by bioelectrical impendence analysis (BIA), the accuracy of REE was highly dependent on the equations used to calculate percent FFM.<sup><xref ref-type="bibr" rid="bib7">7</xref>, <xref ref-type="bibr" rid="bib10">10</xref></sup></p><p>Thus, in the present study, we sought to compare REE measured (MREE) by IC and REE predicted (PREE) by commonly cited predictive equations in a sample of 1851 obese, Caucasian adults. In addition to assessing the accuracy of these prediction equations in the entire sample, we also tested whether splitting our sample into three subgroups according to BMI could improve the accuracy of REE prediction.</p></sec><sec><title>Materials and methods</title><sec><title>Patients</title><p>A group of 1851 Caucasian Italian obese patients, 1181 females and 670 males, aged between 18 and 65 years old with BMI >30 kg m<sup>−</sup><sup>2</sup> were recruited for the study. Exclusion criteria were as follows: current participation in a weight loss program, presence of metabolic, inflammatory and/or endocrine diseases, pregnancy, lactation or daily use of prescription medication or drugs known to influence energy metabolism.</p><p>Data were collected between 2005 and 2015 from outpatients undergoing routine procedures to evaluate nutritional status (including full biochemistry, bio-impedance analysis and IC) at the Internal Medicine and Clinical Nutrition Unit of the Federico II University Hospital in Naples, Italy. The study was conducted in according to the Declaration of Helsinki and received the approval of the Local Ethical Committee; in addition, informed consent was obtained from all patients.</p><p>All measurements were performed early in the morning after a fasting period of 10–12 h according to standardized conditions, that is, abstention from alcohol, smoking and rigorous physical activity for 24 h prior to the assessment. According to the protocol, smoking was not allowed for occasional smokers on the day of the test; however, to avoid any confounding factors, current smokers asked to keep their current smoking habits.<sup><xref ref-type="bibr" rid="bib11">11</xref></sup></p><p>Data were excluded from analysis if the respiratory quotient was outside the expected physiological range (0.71–1.00), when measured REE was ±3 s.d.'s outside the mean REE or in the presence of peripheral oedema.</p></sec><sec><title>Anthropometry</title><p>Body weight and height were measured to the nearest 0.1 kg and 0.5 cm, respectively. Measurements were taken while the subject wore light clothes and no shoes using a platform beam scale with a built-in stadiometer (Seca 709; Seca, Hamburg, Germany). BMI was calculated as body weight expressed as kilograms divided by squared height reported in meters.</p></sec><sec><title>Body composition</title><p>Body composition (BC) was evaluated by bioelectrical impedance analysis (BIA)<sup><xref ref-type="bibr" rid="bib12">12</xref></sup> performed at 50 kHz (Human Im Plus II, DS Medica, Milan, Italy) at room temperature (22–25 °C). Measurements were carried out on the non-dominant side of the body, in the post-absorptive state, and after being in the supine position for 20 min. Subjects voided prior to measurements. The measured BIA variables were resistance (<italic>R</italic>) and reactance (<italic>X</italic>c),<sup><xref ref-type="bibr" rid="bib13">13</xref></sup> while FFM and FM were estimated using the predictive equation developed by Kushner.<sup><xref ref-type="bibr" rid="bib14">14</xref></sup></p></sec><sec><title>Indirect calorimetry</title><p>REE was measured by IC<sup><xref ref-type="bibr" rid="bib15">15</xref></sup> using a canopy system (V max29, Sensor Medics, Anaheim, CA, USA) at an ambient temperature of 23–25 °C. The instrument was checked by burning ethanol, while oxygen and carbon dioxide analyzers were calibrated using nitrogen and standardized gases (mixtures of nitrogen, carbon dioxide and oxygen) on test day. Women were evaluated in the follicular phase to avoid any potential effects of the menstrual cycle on REE. Subjects lay down on the bed, in a quiet environment for a 15-min adaptation period. Afterwards, oxygen consumption and carbon dioxide production were measured for 45 min. The interday coefficient of variation (as determined in six obese individuals on consecutive days) was less than 3%. Energy expenditure was calculated using the abbreviated Weir's formula, neglecting protein oxidation.<sup><xref ref-type="bibr" rid="bib16">16</xref></sup></p></sec><sec><title>REE predictive equations</title><p>The majority of REE prediction equations commonly used for adults (15 based on anthropometric parameters and 10 on BC) were selected as follows: predictive equations for normal-weight subjects (Harris and Benedict,<sup><xref ref-type="bibr" rid="bib3">3</xref></sup> Schofield,<sup><xref ref-type="bibr" rid="bib4">4</xref></sup> FAO/WHO/UNU,<sup><xref ref-type="bibr" rid="bib5">5</xref></sup> Henry<sup><xref ref-type="bibr" rid="bib17">17</xref></sup> and Muller <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib18">18</xref></sup>), for both normal-weight and obese subjects (Mifflin <italic>et al.</italic>,<sup><xref ref-type="bibr" rid="bib6">6</xref></sup> Muller <italic>et al.</italic>,<sup><xref ref-type="bibr" rid="bib18">18</xref></sup> De Lorenzo <italic>et al.</italic>,<sup><xref ref-type="bibr" rid="bib19">19</xref></sup> Owen <italic>et al.</italic>,<sup><xref ref-type="bibr" rid="bib20">20</xref>, <xref ref-type="bibr" rid="bib21">21</xref></sup> Korth <italic>et al.</italic>,<sup><xref ref-type="bibr" rid="bib22">22</xref></sup> Johnstone <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib23">23</xref></sup> and Livingstone and Kohlstadt<sup><xref ref-type="bibr" rid="bib24">24</xref></sup>) and for obese subjects only (Lazzer <italic>et al.</italic>,<sup><xref ref-type="bibr" rid="bib7">7</xref></sup> Muller <italic>et al.</italic>,<sup><xref ref-type="bibr" rid="bib18">18</xref></sup> Huang <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib25">25</xref></sup> and Bernstein <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib26">26</xref></sup>; see <xref ref-type="supplementary-material" rid="sup1">Supplementary Appendix</xref>). We applied all the equations, regardless of the weight status of the patient.</p></sec><sec><title>Data analysis</title><p>All data are presented as means±s.d.'s. Statistical significance is defined as <italic>P</italic><0.05. One-way analysis of variance was used to compare data between sexes. Accuracy of the predictive equations at both the population and individual levels were calculated. Bias, or the average percent difference between the PREE and MREE, was defined at ±5% and used as a measure of accuracy at the group level.<sup><xref ref-type="bibr" rid="bib27">27</xref>, <xref ref-type="bibr" rid="bib28">28</xref></sup></p><p>The percentage of patients with a predicted REE within 90–110% of the measured REE was used as a measure of accuracy at the individual level. Specifically, values lower than 90% were classified as underpredictions, and values higher than 110% as overpredictions. The root mean squared error (RMSE) was used to define the predictions obtained with this model. Comparisons of measured versus calculated REE were performed while taking into account the Bland–Altman plots to estimate limits of agreement.<sup><xref ref-type="bibr" rid="bib29">29</xref></sup> All statistical analyses were performed using SPSS IBM ver.18 (Chicago, IL, USA).</p></sec></sec><sec><title>Results</title><p>Significant differences in anthropometric, body composition and MREE data of the full study group as well as the BMI subgroups (Group 1=30–39.9 kg m<sup>−</sup><sup>2</sup>; Group 2=40–49.9 kg m<sup>−</sup><sup>2</sup>; Group 3 >50 kg m<sup>−</sup><sup>2</sup>) are summarized in <xref rid="tbl1" ref-type="table">Table 1</xref>.</p><p>We evaluated differences in the following measures: PREE–MREE in kcal per day, percent bias, the maximum values for negative and positive error, the RMSE in kcal per day, percent accurate predictions, percent underpredictions and percent overpredictions. Bland–Altman plots of PREE–MREE differences versus mean PREE–MREE were performed.</p><p>The Muller3 (BC) equation revealed the lowest PREE–MREE difference in both males (−22 kcal per day) and females (+47 kcal per day). In males, we observed that FAO/WHO/UNU, Henry and Muller3 (BC) equations had bias percentages under 1% (bias −0.7, −0.3 and 0.9% RMSE 273, 263 and 269 kcal per day, respectively; <xref rid="tbl2a" ref-type="table">Table 2a</xref>). In females, none of the predictive equations considered in this study showed a percent bias lower than 1%. Of those equations tested, Muller1 (BC) gave the lowest value (−1.7% RMSE 228 kcal per day; <xref rid="tbl2b" ref-type="table">Table 2b</xref>).</p><p>Generally, only a few equations showed an accuracy within the ±10% range and included more than 55% of the REE values. These equations were HB, Henry, Schofield, FAO/WHO/UNU, De Lorenzo and Korth equations in males (<xref ref-type="fig" rid="fig1">Figure 1a</xref>) and only the Johnstone (BC) equation in females (<xref ref-type="fig" rid="fig1">Figure 1b</xref>).</p><sec><title>PREE–MREE differences, bias, RMSE and percentage of accurate predictions in Group 1</title><p>The smallest PREE–MREE difference was +35 kcal per day from the Muller3 (BC) equation in males and −9 kcal per day using the Lazzer (BC) equation in females. The lowest percentage bias was found for the Korth equation in males (−0.4%, RMSE 224 kcal per day), whereas the FAO/WHO/UNU and Lazzer-BC equations showed the smallest percentage of bias in females (−0.5, 0.9% RMSE 177, 173 kcal per day, respectively; <xref rid="tbl3a" ref-type="table">Tables 3a</xref> and <xref rid="tbl3b" ref-type="table">b</xref>).</p><p>We found that HB, Henry, Schofield, FAO and Korth equations showed higher accuracy of predictions in males (57.4%, 57.8%, 56.6%, 57.8% and 56.6%, respectively; <xref ref-type="fig" rid="fig2">Figure 2a</xref>), while the FAO/WHO/UNU, De Lorenzo, Korth, Johnstone and Lazzer-BC equations resulted in the most accurate predictions in females (57.1%, 58.3%, 57.5%, 59.3% and 58.9%, respectively; <xref ref-type="fig" rid="fig2">Figure 2b</xref>).</p></sec><sec><title>PREE–MREE difference, bias, RMSE and percentage of accurate predictions in Group 2</title><p>The smallest PREE–MREE difference was found in males using the Muller2 equation (+29 kcal per day) and in females with the Muller3 (BC) equation (+11 kcal per day). As previously shown, Henry, FAO/WHO/UNU and Muller3 (BC) equations had bias values lower than 1% in males (−0.1, −0.9 and 0.1% RMSE 273, 285 and 287 kcal per day), while none of the equations evaluated gave an accurate prediction of REE in females (<xref rid="tbl3a" ref-type="table">Tables 3a</xref> and <xref rid="tbl3b" ref-type="table">b</xref>).</p><p>The HB, Henry, Schofield, FAO/WHO/UNU and De Lorenzo equations predicted REE with higher accuracy (56.7%, 57.4%, 56.4%, 55.3% and 55%, respectively) in males (<xref ref-type="fig" rid="fig2">Figure 2a</xref>). The Muller3 (BC) equation resulted in the most accurate predictions in females, with 54.6% accuracy (<xref ref-type="fig" rid="fig2">Figure 2b</xref>).</p></sec><sec><title>PREE–MREE differences, bias, RMSE and percentage of accurate predictions in Group 3</title><p>In group 3 (BMI>50 kg m<sup>−</sup><sup>2</sup>), the lowest PREE–MREE difference was −11 kcal per day for males (FAO/WHO/UNU) and 16 kcal per day for females (Muller2). Bias percentages lower than 1% were found for the HB, Muller2, Schofield and FAO/WHO/UNU equations in males (−0.5%, −0.2%, −0.3% zand 0.7%, respectively) and for the Muller3 (BC) equation in females (−0.4% <xref rid="tbl3a" ref-type="table">Tables 3a</xref> and <xref rid="tbl3b" ref-type="table">b</xref>). The Muller equation<xref ref-type="bibr" rid="bib15"><sup>15</sup></xref> for overweight and obese subjects, including body composition, gave the most accurate predictions in both sexes (59 and 64% in males; 58.2 and 59.3 in females, respectively), as shown in <xref ref-type="fig" rid="fig2">Figure 2.</xref></p></sec><sec><title>Bland–Altman plots of PREE–MREE differences</title><p>Bland–Altman plots of PREE–MREE differences versus mean PREE–MREE values were performed for each equation; eight of these (four for males, four for females) demonstrated the best agreement for PREE and MREE and have been shown in <xref ref-type="fig" rid="fig3">Figure 3</xref>. The selected plots highlight the best agreement.</p></sec></sec><sec><title>Discussion</title><p>The present study compared REE measured by IC with REE estimated from several predictive equations in a large sample of obese, Caucasian patients. Accuracy of predictions in the whole sample as well as within BMI subgroups was assessed for each equation. Our findings showed that some of the predictive equations<sup><xref ref-type="bibr" rid="bib3">3</xref>, <xref ref-type="bibr" rid="bib4">4</xref>, <xref ref-type="bibr" rid="bib5">5</xref>, <xref ref-type="bibr" rid="bib7">7</xref>, <xref ref-type="bibr" rid="bib18">18</xref></sup> can be used for estimating REE at the population level if the BMI is lower than 40 kg m<sup>−</sup><sup>2</sup>. However, none of them can be used to assess individual differences, as they provide inaccurate results for clinical use.</p><p>According to the literature, the Mifflin equation<sup><xref ref-type="bibr" rid="bib6">6</xref></sup> is the best predictive equation for estimating REE in obese people with a BMI range between 30 and 40 kg m<sup>−</sup><sup>2</sup>, but no literature was found with a recommendation for predicting REE in severely obese subjects (BMI>40 kg m<sup>−</sup><sup>2</sup>). In fact, a recent systematic review by Madden <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib30">30</xref></sup> reported that the Mifflin equation is recommended for people with BMI values between 30 and 39.9 kg m<sup>−</sup><sup>2</sup>, although errors exceed 10 in 25% of those assessed. Overall, no single predictive equation provides accurate REE estimations for all obese adults. This finding was in accordance with a previous systematic review by Frankenfield <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib27">27</xref></sup> who suggested that the Mifflin St Jeor equation<sup><xref ref-type="bibr" rid="bib6">6</xref></sup> may be used for overweight and obese subjects (BMI 25–40 kg m<sup>−</sup><sup>2</sup>) but not for those who are severely obese, despite limited data supporting this claim. Similarly, Weijs <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib31">31</xref></sup> found that the Mifflin equation was accurate in estimating REE in overweight and obese adults in the United States (BMI 25–40 kg m<sup>−</sup><sup>2</sup>), although there currently appears to be no accurate equation for predicting REE in Dutch adults. Despite many studies supporting the use of the Mifflin equation, our results showed that HB,<sup><xref ref-type="bibr" rid="bib3">3</xref></sup> Henry,<sup><xref ref-type="bibr" rid="bib17">17</xref></sup> Schofield,<sup><xref ref-type="bibr" rid="bib4">4</xref></sup> Muller,<sup><xref ref-type="bibr" rid="bib18">18</xref></sup> FAO/WHO/UNU<sup><xref ref-type="bibr" rid="bib5">5</xref></sup> and De Lorenzo<sup><xref ref-type="bibr" rid="bib19">19</xref></sup> equations were all suitable for predicting REE in our obese population when considering an acceptable PREE–MREE difference as lower than 5% however, none of these equations showed an accurate prediction (~55%) at the individual level. Similar results were previously observed in obese adolescents, which showed that, although some predictive equations, such as the Lazzer equation, were suitable for predicting REE at the population level, the accuracy of these predictions did not reach 50% at the individual level.<sup><xref ref-type="bibr" rid="bib32">32</xref></sup></p><p>On the basis of our results, and in light of the findings reported by other investigators, it can be concluded that obese-specific equations do not necessarily predict the REE of an obese population more accurately than those obtained from normal-weight subjects. In addition, despite what previous studies have suggested, we observed that including body composition variables, such FM and FFM assessed by BIA, did not significantly improve the accuracy of predictions.<sup><xref ref-type="bibr" rid="bib10">10</xref>, <xref ref-type="bibr" rid="bib31">31</xref></sup> With obesity, especially severe obesity, there can be variance in the distribution of FM (central versus peripheral, android versus gynoid)<sup><xref ref-type="bibr" rid="bib33">33</xref></sup> and fluid distribution (edema, lymphedema) that results in body segments that are not cylindrical, which contradicts the primary assumption of BIA measurements.<sup><xref ref-type="bibr" rid="bib34">34</xref></sup> In these cases, tissue hydration status is not constant across BMI categories, further contradicting the second assumption of BIA measurements.<sup><xref ref-type="bibr" rid="bib34">34</xref></sup> In fact, obesity is associated with a state of general ‘overhydration', with excess total body water and an altered ratio of extracellular water to intracellular water. Elevated total body water and extracellular water result in overestimations of FFM and thereby underestimate FM with an increasingly lower accuracy for higher levels of obesity.<sup><xref ref-type="bibr" rid="bib34">34</xref>, <xref ref-type="bibr" rid="bib35">35</xref></sup></p><p>When the study population was split into three groups according to BMI, prediction accuracy was further reduced in the two heaviest groups, especially in females. As a result, none of the predictive equations specifically obtained from obese subjects<sup><xref ref-type="bibr" rid="bib7">7</xref>, <xref ref-type="bibr" rid="bib25">25</xref>, <xref ref-type="bibr" rid="bib26">26</xref></sup> were well fitted to our female sample, with the exception of the Muller equation,<sup><xref ref-type="bibr" rid="bib18">18</xref></sup> which was accurate in 55 and 59% of obese females (Groups 2 and 3, respectively). Comparatively, the Lazzer equation,<sup><xref ref-type="bibr" rid="bib7">7</xref></sup> which was developed in obese Italian females, was accurate only in Group 1 (BMI=30–39.9 kg m<sup>−</sup><sup>2</sup>). Recently, Jesus <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib36">36</xref></sup> showed that the Muller equation<sup><xref ref-type="bibr" rid="bib18">18</xref></sup> gave a high percentage of accurate predictions (~64%) in patients with BMIs higher than 40 kg m<sup>−</sup><sup>2</sup>. However, the highest accuracy was achieved by the Huang equation<sup><xref ref-type="bibr" rid="bib25">25</xref></sup> (65–66% of patients). Horie <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib9">9</xref></sup> developed a new equation specifically to estimate REE in 120 severely obese subjects (BMI=46.9±6.2); however, this equation did not improve the prediction accuracy in our sample (data not shown). In addition, although Dobratz <italic>et al.</italic><sup><xref ref-type="bibr" rid="bib37">37</xref></sup> reported that the Mifflin equation was accurate in 14 severely obese women (BMI 49.8±6.2 kg m<sup>−</sup><sup>2</sup>), their estimates of REE showed many limitations, as reported by the authors, including the small sample size, inconsistent menstrual status and impaired glucose control.</p><p>There are several factors that may contribute to errors when estimating REE, especially in severely obese patients. The extreme excess of adipose tissue, being less metabolically active than FFM, can reduce efficacy of estimating REE.<sup><xref ref-type="bibr" rid="bib38">38</xref></sup> There is also a lack of consensus concerning the correct weight to use in REE estimations in these individuals (current, ideal or adjusted body weight). Genders should be separated in statistical analyses to avoid any confounding factors when comparing IC data,<sup><xref ref-type="bibr" rid="bib8">8</xref></sup> as was done in this study. The variability in REE measurements due to inaccuracy of IC measurements should also be considered.<sup><xref ref-type="bibr" rid="bib39">39</xref></sup> Finally, although BIA has some problems when used in severely obese cases because of FM distribution and hydration status, dual-energy X-ray absorptiometry, the gold standard method for body composition evaluation, cannot be performed for body weights above 120 kg.</p><p>In conclusion, this study showed a wide variation for predicting REE that was higher for body composition-based equations than weight-based equations; however, accuracy was very low for all the predictive equations analyzed. This finding highlights the importance of measuring REE by IC, as we found that REE was underestimated in roughly 50% of subjects, indicating that PREE was much lower than MREE. A reduced REE estimate provides inadequate energy intake values and thus impairs diet compliance, which can affect weight loss and management. On the basis of our results, it would be useful to validate REE predictive equations specifically for patients with a BMI higher than 40 kg m<sup>−</sup><sup>2</sup> to improve their effectiveness in clinical practice.</p></sec></body><back><fn-group><fn><p><xref ref-type="supplementary-material" rid="sup1">Supplementary Information</xref> accompanies this paper on International Journal of Obesity website (http://www.nature.com/ijo)</p></fn><fn fn-type="COI-statement"><p>The authors declare no conflict of interest.</p></fn></fn-group><ref-list><ref id="bib1"><mixed-citation publication-type="journal">Pinheiro Volp AC, Esteves de Oliveira FC, Duarte Moreira Alves R, Esteves EA, Bressan J. <article-title>Energy expenditure: components and evaluation methods</article-title>. <source>Nutr Hosp</source><year>2011</year>; <volume>26</volume>: <fpage>430</fpage>–440.<pub-id pub-id-type="pmid">21892558</pub-id></mixed-citation></ref><ref id="bib2"><mixed-citation publication-type="journal">Marra M, Scalfi L, Covino A, Esposito-Del Puente A, Contaldo F. <article-title>Fasting respiratory quotient as a predictor of weight changes in non-obese women</article-title>. <source>Int J Obes Relat Metab Disord</source><year>1998</year>; <volume>22</volume>: <fpage>601</fpage>.<pub-id pub-id-type="pmid">9665683</pub-id></mixed-citation></ref><ref id="bib3"><mixed-citation publication-type="journal">Harris JA, Benedict FG. <article-title>A biometric study of human basal metabolism</article-title>. <source>Proc Natl Acad Sci USA</source><year>1918</year>; <volume>4</volume>: <fpage>370</fpage>–373.<pub-id pub-id-type="pmid">16576330</pub-id></mixed-citation></ref><ref id="bib4"><mixed-citation publication-type="journal">Schofield WN. <article-title>Predicting basal metabolic rate, new standards and review of previous work</article-title>. <source>Hum Nutr Clin Nutr</source><year>1985</year>; <volume>39</volume>: <fpage>5</fpage>–41.<pub-id pub-id-type="pmid">4044297</pub-id></mixed-citation></ref><ref id="bib5"><mixed-citation publication-type="journal">FAO/WHO/UNU.. <article-title>Energy and protein requirements. 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<volume>94</volume>: <fpage>843</fpage>–849.<pub-id pub-id-type="pmid">16277790</pub-id></mixed-citation></ref></ref-list><sec sec-type="supplementary-material" id="sup1"><title>Supplementary Material</title><supplementary-material content-type="local-data" id="xob1"><label>Supplementary Appendix</label><media xlink:href="ijo201734x1.doc"><caption><p>Click here for additional data file.</p></caption></media></supplementary-material></sec></back><floats-group><fig id="fig1"><label>Figure 1</label><caption><p>Bland–Altman plot of differences in REE measured by IC and calculated using predictive equations in 670 male (<bold>a</bold>) and 1181 female (<bold>b</bold>) obese adults. The dotted lines represent 2 s.d.'s from the mean (limits of agreement).</p></caption><graphic xlink:href="ijo201734f1"></graphic></fig><fig id="fig2"><label>Figure 2</label><caption><p>Accuracy of prediction equations for measurements of REE within ±10% using each equation in 670 male and 1181 female obese subjects (<bold>a</bold>, <bold>b</bold>), respectively.</p></caption><graphic xlink:href="ijo201734f2"></graphic></fig><fig id="fig3"><label>Figure 3</label><caption><p>Accuracy of prediction equations for measurements of REE within ±10% using each equation according to BMI subgroups in 670 male and 1181 female obese subjects (<bold>a</bold>, <bold>b</bold>), respectively.</p></caption><graphic xlink:href="ijo201734f3"></graphic></fig><table-wrap id="tbl1"><label>Table 1</label><caption><title>Patient characteristics according to sex and BMI</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char" char="±"></col><col align="char" char="±"></col><col align="char" char="±"></col><col align="char" char="±"></col><col align="char" char="±"></col><col align="char" char="±"></col><col align="char" char="±"></col><col align="char" char="±"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th><th colspan="2" align="center" valign="top" char="±" charoff="50"><italic>Group 1</italic><hr></hr></th><th colspan="2" align="center" valign="top" char="±" charoff="50"><italic>Group 2</italic><hr></hr></th><th colspan="2" align="center" valign="top" char="±" charoff="50"><italic>Group 3</italic><hr></hr></th><th colspan="2" align="center" valign="top" char="±" charoff="50"><italic>All</italic><hr></hr></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" char="±" charoff="50"><italic>M</italic></th><th align="center" valign="top" char="±" charoff="50"><italic>F</italic></th><th align="center" valign="top" char="±" charoff="50"><italic>M</italic></th><th align="center" valign="top" char="±" charoff="50"><italic>F</italic></th><th align="center" valign="top" char="±" charoff="50"><italic>M</italic></th><th align="center" valign="top" char="±" charoff="50"><italic>F</italic></th><th align="center" valign="top" char="±" charoff="50"><italic>M</italic></th><th align="center" valign="top" char="±" charoff="50"><italic>F</italic></th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50"><italic>N</italic></td><td align="center" valign="top" char="±" charoff="50">249</td><td align="center" valign="top" char="±" charoff="50">494</td><td align="center" valign="top" char="±" charoff="50">282</td><td align="char" valign="top" char="±" charoff="50">498</td><td align="center" valign="top" char="±" charoff="50">139</td><td align="center" valign="top" char="±" charoff="50">189</td><td align="center" valign="top" char="±" charoff="50">670</td><td align="center" valign="top" char="±" charoff="50">1181</td></tr><tr><td align="left" valign="top" charoff="50">Age (y)</td><td align="char" valign="top" char="±" charoff="50">36.5±11.2</td><td align="char" valign="top" char="±" charoff="50">34.9±12.5</td><td align="char" valign="top" char="±" charoff="50">34.1±10.7</td><td align="char" valign="top" char="±" charoff="50">34.9±11.7</td><td align="char" valign="top" char="±" charoff="50">33.8±10.0<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">36.9±10.2</td><td align="char" valign="top" char="±" charoff="50">34.9±10.8</td><td align="char" valign="top" char="±" charoff="50">35.2±11.8</td></tr><tr><td align="left" valign="top" charoff="50">Weight (kg)</td><td align="char" valign="top" char="±" charoff="50">111±12<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">92.0±10.5</td><td align="char" valign="top" char="±" charoff="50">137±13<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">116±12</td><td align="char" valign="top" char="±" charoff="50">166±18<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">144±16</td><td align="char" valign="top" char="±" charoff="50">133±25<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">111±22</td></tr><tr><td align="left" valign="top" charoff="50">Height (cm)</td><td align="char" valign="top" char="±" charoff="50">176±7<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">162±6</td><td align="char" valign="top" char="±" charoff="50">175±7<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">162±6</td><td align="char" valign="top" char="±" charoff="50">173±7<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">160±6</td><td align="char" valign="top" char="±" charoff="50">175±7<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">161±6</td></tr><tr><td align="left" valign="top" charoff="50">BMI (kg m<sup>−</sup><sup>2</sup>)</td><td align="char" valign="top" char="±" charoff="50">35.7±2.9<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">35.2±2.90</td><td align="char" valign="top" char="±" charoff="50">44.8±2.9</td><td align="char" valign="top" char="±" charoff="50">44.5±2.8</td><td align="char" valign="top" char="±" charoff="50">55.5±4.5</td><td align="char" valign="top" char="±" charoff="50">55.8±5.4</td><td align="char" valign="top" char="±" charoff="50">43.6±8.0<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">42.4±8.0</td></tr><tr><td align="left" valign="top" charoff="50">MREE (kcal d<sup>−1</sup>)</td><td align="char" valign="top" char="±" charoff="50">2291±334<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">1757±247</td><td align="char" valign="top" char="±" charoff="50">2651±401<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">2125±302</td><td align="char" valign="top" char="±" charoff="50">2998±356</td><td align="char" valign="top" char="±" charoff="50">2484±343</td><td align="char" valign="top" char="±" charoff="50">2589±452<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">2028±388</td></tr><tr><td align="left" valign="top" charoff="50">RQ</td><td align="char" valign="top" char="±" charoff="50">0.860±0.068</td><td align="char" valign="top" char="±" charoff="50">0.855±0.063</td><td align="char" valign="top" char="±" charoff="50">0.848±0.066</td><td align="char" valign="top" char="±" charoff="50">0.844±0.074</td><td align="char" valign="top" char="±" charoff="50">0.850±0.06</td><td align="char" valign="top" char="±" charoff="50">0.837±0.078</td><td align="char" valign="top" char="±" charoff="50">0.852±0.067</td><td align="char" valign="top" char="±" charoff="50">0.847±0.070</td></tr><tr><td align="left" valign="top" charoff="50">FFM (kg)</td><td align="char" valign="top" char="±" charoff="50">69.5±8.40<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">50.6±6.5</td><td align="char" valign="top" char="±" charoff="50">77.6±10.3<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">57.5±6.7</td><td align="char" valign="top" char="±" charoff="50">86.2±12.4<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">65.9±8.3</td><td align="char" valign="top" char="±" charoff="50">76.6±12.1<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">55.9±8.7</td></tr><tr><td align="left" valign="top" charoff="50">FM (kg)</td><td align="char" valign="top" char="±" charoff="50">41.0±9.7</td><td align="char" valign="top" char="±" charoff="50">41.5±7.6</td><td align="char" valign="top" char="±" charoff="50">59.2±10.0</td><td align="char" valign="top" char="±" charoff="50">58.8±8.6</td><td align="char" valign="top" char="±" charoff="50">77.8±14.2</td><td align="char" valign="top" char="±" charoff="50">78.0±12.1</td><td align="char" valign="top" char="±" charoff="50">56.6±18.0<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">54.6±15.7</td></tr><tr><td align="left" valign="top" charoff="50">FM (%)</td><td align="char" valign="top" char="±" charoff="50">36.8±6.7<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">44.9±5.4</td><td align="char" valign="top" char="±" charoff="50">43.2±5.7<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">50.5±4.3</td><td align="char" valign="top" char="±" charoff="50">47.3±6.27<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">54.1±4.3</td><td align="char" valign="top" char="±" charoff="50">41.7±7.4<xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="char" valign="top" char="±" charoff="50">48.7±5.9</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: BMI, body mass index; F, female; FFM, fat-free mass; FM, fat mass; M, male; MREE, measured resting energy expenditure; RQ, respiratory quotient.</p></fn><fn id="t1-fn2"><p>Data are expressed as mean±s.d. Group 1=BMI 30–39.9 kg m<sup>−</sup><sup>2</sup>; Group 2= BMI 40–49.9 kg m<sup>−</sup><sup>2</sup>; Group 3=BMI >50.</p></fn><fn id="t1-fn3"><label>a</label><p><italic>P</italic><0.05 between sexes.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2a"><label>Table 2a</label><caption><title>Evaluation of REE with different predictive equations in 670 males based on differences predicted–measured, bias and RMSE</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>REE predictive equations</italic></th><th colspan="2" align="center" valign="top" char="." charoff="50"><italic>Diff predicted–measured kcal per day</italic><hr></hr></th><th colspan="4" align="center" valign="top" char="." charoff="50"><italic>Mean</italic><hr></hr></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" char="." charoff="50"><italic>Mean</italic></th><th align="center" valign="top" char="." charoff="50"><italic>s.d.</italic></th><th align="center" valign="top" char="." charoff="50">Bias<xref ref-type="fn" rid="tbl2a-fn3">a</xref> %</th><th align="center" valign="top" char="." charoff="50"><italic>Max negative error %</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Max positive error %</italic></th><th align="center" valign="top" char="." charoff="50"><italic>RMSE kcal per day</italic></th></tr></thead><tbody valign="top"><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>Equation for normal-weight subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> HB</td><td align="center" valign="top" char="." charoff="50">−76</td><td align="center" valign="top" char="." charoff="50">317</td><td align="center" valign="top" char="." charoff="50">−1.7</td><td align="center" valign="top" char="." charoff="50">−31.1</td><td align="center" valign="top" char="." charoff="50">32.4</td><td align="center" valign="top" char="." charoff="50">257</td></tr><tr><td align="left" valign="top" charoff="50"> Henry</td><td align="center" valign="top" char="." charoff="50">−38</td><td align="center" valign="top" char="." charoff="50">331</td><td align="center" valign="top" char="." charoff="50">−0.3</td><td align="center" valign="top" char="." charoff="50">−30.8</td><td align="center" valign="top" char="." charoff="50">36.7</td><td align="center" valign="top" char="." charoff="50">263</td></tr><tr><td align="left" valign="top" charoff="50"> Muller1</td><td align="center" valign="top" char="." charoff="50">−394</td><td align="center" valign="top" char="." charoff="50">373</td><td align="center" valign="top" char="." charoff="50">−13.2</td><td align="center" valign="top" char="." charoff="50">−40.8</td><td align="center" valign="top" char="." charoff="50">27.1</td><td align="center" valign="top" char="." charoff="50">434</td></tr><tr><td align="left" valign="top" charoff="50"> Muller1 (BC)</td><td align="center" valign="top" char="." charoff="50">−195</td><td align="center" valign="top" char="." charoff="50">349</td><td align="center" valign="top" char="." charoff="50">−5.6</td><td align="center" valign="top" char="." charoff="50">−36</td><td align="center" valign="top" char="." charoff="50">35.1</td><td align="center" valign="top" char="." charoff="50">311</td></tr><tr><td align="left" valign="top" charoff="50"> Schofield</td><td align="center" valign="top" char="." charoff="50">−75</td><td align="center" valign="top" char="." charoff="50">344</td><td align="center" valign="top" char="." charoff="50">−1.6</td><td align="center" valign="top" char="." charoff="50">−32</td><td align="center" valign="top" char="." charoff="50">37.8</td><td align="center" valign="top" char="." charoff="50">276</td></tr><tr><td align="left" valign="top" charoff="50"> FAO</td><td align="center" valign="top" char="." charoff="50">−52</td><td align="center" valign="top" char="." charoff="50">343</td><td align="center" valign="top" char="." charoff="50">−0.7</td><td align="center" valign="top" char="." charoff="50">−31.4</td><td align="center" valign="top" char="." charoff="50">38.8</td><td align="center" valign="top" char="." charoff="50">273</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>Equation for both normal weight and obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Muller2</td><td align="center" valign="top" char="." charoff="50">28.5</td><td align="center" valign="top" char="." charoff="50">331</td><td align="center" valign="top" char="." charoff="50">3</td><td align="center" valign="top" char="." charoff="50">−292</td><td align="center" valign="top" char="." charoff="50">45.9</td><td align="center" valign="top" char="." charoff="50">271</td></tr><tr><td align="left" valign="top" charoff="50"> Muller2 (BC)</td><td align="center" valign="top" char="." charoff="50">−231</td><td align="center" valign="top" char="." charoff="50">349</td><td align="center" valign="top" char="." charoff="50">−7</td><td align="center" valign="top" char="." charoff="50">−36.4</td><td align="center" valign="top" char="." charoff="50">33.1</td><td align="center" valign="top" char="." charoff="50">326</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin</td><td align="center" valign="top" char="." charoff="50">−342</td><td align="center" valign="top" char="." charoff="50">321</td><td align="center" valign="top" char="." charoff="50">−11.9</td><td align="center" valign="top" char="." charoff="50">−38.9</td><td align="center" valign="top" char="." charoff="50">20.6</td><td align="center" valign="top" char="." charoff="50">377</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin (BC)</td><td align="center" valign="top" char="." charoff="50">−668</td><td align="center" valign="top" char="." charoff="50">383</td><td align="center" valign="top" char="." charoff="50">−24.4</td><td align="center" valign="top" char="." charoff="50">−50.4</td><td align="center" valign="top" char="." charoff="50">10.5</td><td align="center" valign="top" char="." charoff="50">672</td></tr><tr><td align="left" valign="top" charoff="50"> De Lorenzo</td><td align="center" valign="top" char="." charoff="50">−102</td><td align="center" valign="top" char="." charoff="50">316</td><td align="center" valign="top" char="." charoff="50">−2.7</td><td align="center" valign="top" char="." charoff="50">−32</td><td align="center" valign="top" char="." charoff="50">31.0</td><td align="center" valign="top" char="." charoff="50">261</td></tr><tr><td align="left" valign="top" charoff="50"> Owen</td><td align="center" valign="top" char="." charoff="50">−352</td><td align="center" valign="top" char="." charoff="50">324</td><td align="center" valign="top" char="." charoff="50">−12.1</td><td align="center" valign="top" char="." charoff="50">−38.1</td><td align="center" valign="top" char="." charoff="50">19.8</td><td align="center" valign="top" char="." charoff="50">383</td></tr><tr><td align="left" valign="top" charoff="50"> Owen (BC)</td><td align="center" valign="top" char="." charoff="50">−592</td><td align="center" valign="top" char="." charoff="50">385</td><td align="center" valign="top" char="." charoff="50">−21.5</td><td align="center" valign="top" char="." charoff="50">−48.7</td><td align="center" valign="top" char="." charoff="50">15.5</td><td align="center" valign="top" char="." charoff="50">604</td></tr><tr><td align="left" valign="top" charoff="50"> Korth</td><td align="center" valign="top" char="." charoff="50">−116</td><td align="center" valign="top" char="." charoff="50">323</td><td align="center" valign="top" char="." charoff="50">−2.9</td><td align="center" valign="top" char="." charoff="50">−32.8</td><td align="center" valign="top" char="." charoff="50">35.0</td><td align="center" valign="top" char="." charoff="50">268</td></tr><tr><td align="left" valign="top" charoff="50"> Korth (BC)</td><td align="center" valign="top" char="." charoff="50">−318</td><td align="center" valign="top" char="." charoff="50">390</td><td align="center" valign="top" char="." charoff="50">−10.7</td><td align="center" valign="top" char="." charoff="50">−41.7</td><td align="center" valign="top" char="." charoff="50">31.4</td><td align="center" valign="top" char="." charoff="50">400</td></tr><tr><td align="left" valign="top" charoff="50"> Johnstone (BC)</td><td align="center" valign="top" char="." charoff="50">−228</td><td align="center" valign="top" char="." charoff="50">331</td><td align="center" valign="top" char="." charoff="50">−7.6</td><td align="center" valign="top" char="." charoff="50">−35.8</td><td align="center" valign="top" char="." charoff="50">25.8</td><td align="center" valign="top" char="." charoff="50">316</td></tr><tr><td align="left" valign="top" charoff="50"> Livingstone</td><td align="center" valign="top" char="." charoff="50">−370</td><td align="center" valign="top" char="." charoff="50">335</td><td align="center" valign="top" char="." charoff="50">−12.7</td><td align="center" valign="top" char="." charoff="50">−39.3</td><td align="center" valign="top" char="." charoff="50">22.9</td><td align="center" valign="top" char="." charoff="50">402</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>Equation for obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer</td><td align="center" valign="top" char="." charoff="50">−169</td><td align="center" valign="top" char="." charoff="50">317</td><td align="center" valign="top" char="." charoff="50">−5.0</td><td align="center" valign="top" char="." charoff="50">−32.5</td><td align="center" valign="top" char="." charoff="50">28.9</td><td align="center" valign="top" char="." charoff="50">280</td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer (BC)</td><td align="center" valign="top" char="." charoff="50">−343</td><td align="center" valign="top" char="." charoff="50">377</td><td align="center" valign="top" char="." charoff="50">−11.5</td><td align="center" valign="top" char="." charoff="50">−40.4</td><td align="center" valign="top" char="." charoff="50">27.6</td><td align="center" valign="top" char="." charoff="50">402</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3</td><td align="center" valign="top" char="." charoff="50">96</td><td align="center" valign="top" char="." charoff="50">327</td><td align="center" valign="top" char="." charoff="50">5.5</td><td align="center" valign="top" char="." charoff="50">−27.3</td><td align="center" valign="top" char="." charoff="50">48.9</td><td align="center" valign="top" char="." charoff="50">282</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3 (BC)</td><td align="center" valign="top" char="." charoff="50">−22</td><td align="center" valign="top" char="." charoff="50">331</td><td align="center" valign="top" char="." charoff="50">0.9</td><td align="center" valign="top" char="." charoff="50">−31.1</td><td align="center" valign="top" char="." charoff="50">42.9</td><td align="center" valign="top" char="." charoff="50">269</td></tr><tr><td align="left" valign="top" charoff="50"> Huang</td><td align="center" valign="top" char="." charoff="50">−265</td><td align="center" valign="top" char="." charoff="50">322</td><td align="center" valign="top" char="." charoff="50">−8.8</td><td align="center" valign="top" char="." charoff="50">−35.1</td><td align="center" valign="top" char="." charoff="50">25.5</td><td align="center" valign="top" char="." charoff="50">326</td></tr><tr><td align="left" valign="top" charoff="50"> Huang (BC)</td><td align="center" valign="top" char="." charoff="50">−288</td><td align="center" valign="top" char="." charoff="50">320</td><td align="center" valign="top" char="." charoff="50">−9.8</td><td align="center" valign="top" char="." charoff="50">−36.4</td><td align="center" valign="top" char="." charoff="50">22.5</td><td align="center" valign="top" char="." charoff="50">338</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein</td><td align="center" valign="top" char="." charoff="50">−568</td><td align="center" valign="top" char="." charoff="50">322</td><td align="center" valign="top" char="." charoff="50">−21.1</td><td align="center" valign="top" char="." charoff="50">−46.3</td><td align="center" valign="top" char="." charoff="50">7.3</td><td align="center" valign="top" char="." charoff="50">572</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein (BC)</td><td align="center" valign="top" char="." charoff="50">−740</td><td align="center" valign="top" char="." charoff="50">349</td><td align="center" valign="top" char="." charoff="50">−27.5</td><td align="center" valign="top" char="." charoff="50">−50.8</td><td align="center" valign="top" char="." charoff="50">0.2</td><td align="center" valign="top" char="." charoff="50">740</td></tr></tbody></table><table-wrap-foot><fn id="tbl2a-fn1"><p>Abbreviations: BC, body composition; Max, maximum; REE, resting energy expenditure; RMSE, root mean square error.</p></fn><fn id="tbl2a-fn2"><p>Average REE measured with indirect calorimetry=2589±452 kcal per day.</p></fn><fn id="tbl2a-fn3"><label>a</label><p>Mean percentage error between predictive equations and measured value.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2b"><label>Table 2b</label><caption><title>Evaluation of REE with different predictive equations in 1181 females based on differences predicted–measured, bias and RMSE</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="char" char="."></col><col align="center"></col><col align="char" char="."></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>REE predictive equations</italic></th><th colspan="2" align="center" valign="top" charoff="50"><italic>Diff predicted–measured kcal per day</italic><hr></hr></th><th colspan="4" align="center" valign="top" charoff="50"><italic>Mean</italic><hr></hr></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"><italic>Mean</italic></th><th align="center" valign="top" char="." charoff="50"><italic>s.d.</italic></th><th align="center" valign="top" charoff="50"><italic>BIAS</italic><xref ref-type="fn" rid="t1-fn3">a</xref><italic>%</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Max negative error %</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Max positive error %</italic></th><th align="center" valign="top" char="." charoff="50"><italic>RMSE kcal per day</italic></th></tr></thead><tbody valign="top"><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>Equation for normal-weight subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> HB</td><td align="center" valign="top" charoff="50">−181</td><td align="char" valign="top" char="." charoff="50">258</td><td align="center" valign="top" charoff="50">−7.2</td><td align="char" valign="top" char="." charoff="50">−32.9</td><td align="char" valign="top" char="." charoff="50">40.5</td><td align="char" valign="top" char="." charoff="50">243</td></tr><tr><td align="left" valign="top" charoff="50"> Henry</td><td align="center" valign="top" charoff="50">−169</td><td align="char" valign="top" char="." charoff="50">265</td><td align="center" valign="top" charoff="50">−6.8</td><td align="char" valign="top" char="." charoff="50">−34.9</td><td align="char" valign="top" char="." charoff="50">42.5</td><td align="char" valign="top" char="." charoff="50">243</td></tr><tr><td align="left" valign="top" charoff="50"> Muller<xref ref-type="fn" rid="tbl2b-fn3">a</xref></td><td align="center" valign="top" charoff="50">−230</td><td align="char" valign="top" char="." charoff="50">307</td><td align="center" valign="top" charoff="50">−9.0</td><td align="char" valign="top" char="." charoff="50">−37.8</td><td align="char" valign="top" char="." charoff="50">38.1</td><td align="char" valign="top" char="." charoff="50">299</td></tr><tr><td align="left" valign="top" charoff="50"> Muller<xref ref-type="fn" rid="tbl2b-fn3">a</xref> (BC)</td><td align="center" valign="top" charoff="50">−81</td><td align="char" valign="top" char="." charoff="50">281</td><td align="center" valign="top" charoff="50">−1.7</td><td align="char" valign="top" char="." charoff="50">−30.8</td><td align="char" valign="top" char="." charoff="50">47.0</td><td align="char" valign="top" char="." charoff="50">228</td></tr><tr><td align="left" valign="top" charoff="50"> Schofield</td><td align="center" valign="top" charoff="50">−134</td><td align="char" valign="top" char="." charoff="50">306</td><td align="center" valign="top" charoff="50">−5.0</td><td align="char" valign="top" char="." charoff="50">−36.2</td><td align="char" valign="top" char="." charoff="50">50.4</td><td align="char" valign="top" char="." charoff="50">258</td></tr><tr><td align="left" valign="top" charoff="50"> FAO</td><td align="center" valign="top" charoff="50">−106</td><td align="char" valign="top" char="." charoff="50">290</td><td align="center" valign="top" charoff="50">−3.6</td><td align="char" valign="top" char="." charoff="50">−34.7</td><td align="char" valign="top" char="." charoff="50">50.3</td><td align="char" valign="top" char="." charoff="50">239</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>Equation for both normal weight and obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Muller2</td><td align="center" valign="top" charoff="50">107</td><td align="char" valign="top" char="." charoff="50">260</td><td align="center" valign="top" charoff="50">7.4</td><td align="char" valign="top" char="." charoff="50">−23.3</td><td align="char" valign="top" char="." charoff="50">57.3</td><td align="char" valign="top" char="." charoff="50">232</td></tr><tr><td align="left" valign="top" charoff="50"> Muller2 (BC)</td><td align="center" valign="top" charoff="50">−91</td><td align="char" valign="top" char="." charoff="50">282</td><td align="center" valign="top" charoff="50">−2.3</td><td align="char" valign="top" char="." charoff="50">−30.6</td><td align="char" valign="top" char="." charoff="50">44.3</td><td align="char" valign="top" char="." charoff="50">231</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin</td><td align="center" valign="top" charoff="50">−257</td><td align="char" valign="top" char="." charoff="50">254</td><td align="center" valign="top" charoff="50">−11.3</td><td align="char" valign="top" char="." charoff="50">−37.7</td><td align="char" valign="top" char="." charoff="50">35.1</td><td align="char" valign="top" char="." charoff="50">289</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin (BC)</td><td align="center" valign="top" charoff="50">−513</td><td align="char" valign="top" char="." charoff="50">304</td><td align="center" valign="top" charoff="50">−23.7</td><td align="char" valign="top" char="." charoff="50">−50.9</td><td align="char" valign="top" char="." charoff="50">29.1</td><td align="char" valign="top" char="." charoff="50">517</td></tr><tr><td align="left" valign="top" charoff="50"> De Lorenzo</td><td align="center" valign="top" charoff="50">−112</td><td align="char" valign="top" char="." charoff="50">246</td><td align="center" valign="top" charoff="50">−4.0</td><td align="char" valign="top" char="." charoff="50">−30.1</td><td align="char" valign="top" char="." charoff="50">43.6</td><td align="char" valign="top" char="." charoff="50">211</td></tr><tr><td align="left" valign="top" charoff="50"> Owen</td><td align="center" valign="top" charoff="50">−439</td><td align="char" valign="top" char="." charoff="50">282</td><td align="center" valign="top" charoff="50">−20</td><td align="char" valign="top" char="." charoff="50">−42.7</td><td align="char" valign="top" char="." charoff="50">17.9</td><td align="char" valign="top" char="." charoff="50">445</td></tr><tr><td align="left" valign="top" charoff="50"> Owen (BC)</td><td align="center" valign="top" charoff="50">−592</td><td align="char" valign="top" char="." charoff="50">304</td><td align="center" valign="top" charoff="50">−27.7</td><td align="char" valign="top" char="." charoff="50">−53.6</td><td align="char" valign="top" char="." charoff="50">23.0</td><td align="char" valign="top" char="." charoff="50">594</td></tr><tr><td align="left" valign="top" charoff="50"> Korth</td><td align="center" valign="top" charoff="50">−157</td><td align="char" valign="top" char="." charoff="50">256</td><td align="center" valign="top" charoff="50">−6.2</td><td align="char" valign="top" char="." charoff="50">−34.2</td><td align="char" valign="top" char="." charoff="50">43.4</td><td align="char" valign="top" char="." charoff="50">234</td></tr><tr><td align="left" valign="top" charoff="50"> Korth (BC)</td><td align="center" valign="top" charoff="50">−289</td><td align="char" valign="top" char="." charoff="50">294</td><td align="center" valign="top" charoff="50">−18.6</td><td align="char" valign="top" char="." charoff="50">−44.2</td><td align="char" valign="top" char="." charoff="50">50.1</td><td align="char" valign="top" char="." charoff="50">330</td></tr><tr><td align="left" valign="top" charoff="50"> Johnstone (BC)</td><td align="center" valign="top" charoff="50">−128</td><td align="char" valign="top" char="." charoff="50">247</td><td align="center" valign="top" charoff="50">−5.0</td><td align="char" valign="top" char="." charoff="50">−33.3</td><td align="char" valign="top" char="." charoff="50">49.4</td><td align="char" valign="top" char="." charoff="50">217</td></tr><tr><td align="left" valign="top" charoff="50"> Livingstone</td><td align="center" valign="top" charoff="50">−291</td><td align="char" valign="top" char="." charoff="50">277</td><td align="center" valign="top" charoff="50">−12.5</td><td align="char" valign="top" char="." charoff="50">−39.1</td><td align="char" valign="top" char="." charoff="50">34.1</td><td align="char" valign="top" char="." charoff="50">319</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="7" align="left" valign="top" charoff="50"><italic>Equation for obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer</td><td align="center" valign="top" charoff="50">−154</td><td align="char" valign="top" char="." charoff="50">246</td><td align="center" valign="top" charoff="50">−6.0</td><td align="char" valign="top" char="." charoff="50">−30.4</td><td align="char" valign="top" char="." charoff="50">38.7</td><td align="char" valign="top" char="." charoff="50">225</td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer (BC)</td><td align="center" valign="top" charoff="50">−176</td><td align="char" valign="top" char="." charoff="50">301</td><td align="center" valign="top" charoff="50">−6.5</td><td align="char" valign="top" char="." charoff="50">−38.9</td><td align="char" valign="top" char="." charoff="50">55.6</td><td align="char" valign="top" char="." charoff="50">267</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3</td><td align="center" valign="top" charoff="50">124</td><td align="char" valign="top" char="." charoff="50">255</td><td align="center" valign="top" charoff="50">8.1</td><td align="char" valign="top" char="." charoff="50">−22.6</td><td align="char" valign="top" char="." charoff="50">57.8</td><td align="char" valign="top" char="." charoff="50">234</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3 (BC)</td><td align="center" valign="top" charoff="50">47</td><td align="char" valign="top" char="." charoff="50">259</td><td align="center" valign="top" charoff="50">4.4</td><td align="char" valign="top" char="." charoff="50">−25.7</td><td align="char" valign="top" char="." charoff="50">54.1</td><td align="char" valign="top" char="." charoff="50">213</td></tr><tr><td align="left" valign="top" charoff="50"> Huang</td><td align="center" valign="top" charoff="50">−260</td><td align="char" valign="top" char="." charoff="50">251</td><td align="center" valign="top" charoff="50">−11.4</td><td align="char" valign="top" char="." charoff="50">−35.8</td><td align="char" valign="top" char="." charoff="50">31.1</td><td align="char" valign="top" char="." charoff="50">290</td></tr><tr><td align="left" valign="top" charoff="50"> Huang (BC)</td><td align="center" valign="top" charoff="50">−258</td><td align="char" valign="top" char="." charoff="50">247</td><td align="center" valign="top" charoff="50">−11.3</td><td align="char" valign="top" char="." charoff="50">−35.6</td><td align="char" valign="top" char="." charoff="50">31.9</td><td align="char" valign="top" char="." charoff="50">286</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein</td><td align="center" valign="top" charoff="50">−531</td><td align="char" valign="top" char="." charoff="50">277</td><td align="center" valign="top" charoff="50">−24.7</td><td align="char" valign="top" char="." charoff="50">−45.7</td><td align="char" valign="top" char="." charoff="50">12.6</td><td align="char" valign="top" char="." charoff="50">532</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein (BC)</td><td align="center" valign="top" charoff="50">−579</td><td align="char" valign="top" char="." charoff="50">271</td><td align="center" valign="top" charoff="50">−27.4</td><td align="char" valign="top" char="." charoff="50">−50.8</td><td align="char" valign="top" char="." charoff="50">18.3</td><td align="char" valign="top" char="." charoff="50">580</td></tr></tbody></table><table-wrap-foot><fn id="tbl2b-fn1"><p>Abbreviations: BC, body composition; Max, maximum; REE, resting energy expenditure; RMSE, root mean square error.</p></fn><fn id="tbl2b-fn2"><p>Average REE measured with indirect calorimetry=2028±388 kcal per day.</p></fn><fn id="tbl2b-fn3"><label>a</label><p>Mean percentage error between predictive equations and measured value.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl3a"><label>Table 3a</label><caption><title>Evaluation of REE with different predictive equations in 670 males based on differences P–M, bias and RMSE according to BMI groups</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="char" char="."></col><col align="center"></col><col align="center"></col><col align="char" char="."></col><col align="center"></col><col align="center"></col><col align="char" char="."></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>REE predictive equations</italic></th><th colspan="3" align="center" valign="top" charoff="50"><italic>Group 1;</italic> N<italic>=249</italic><hr></hr></th><th colspan="3" align="center" valign="top" charoff="50"><italic>Group 2</italic>; N<italic>=282</italic><hr></hr></th><th colspan="3" align="center" valign="top" charoff="50"><italic>Group 3</italic>; N<italic>=139</italic><hr></hr></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"><italic>Diff P–M kcal per day</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Bias</italic><xref ref-type="fn" rid="tbl3a-fn3">a</xref><italic>%</italic></th><th align="center" valign="top" charoff="50"><italic>RMSE kcal per day</italic></th><th align="center" valign="top" charoff="50"><italic>Diff P–M kcal per day</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Bias</italic><xref ref-type="fn" rid="tbl3a-fn3">a</xref><italic>%</italic></th><th align="center" valign="top" charoff="50"><italic>RMSE kcal per day</italic></th><th align="center" valign="top" charoff="50"><italic>Diff P–M kcal per day</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Bias</italic><xref ref-type="fn" rid="tbl3a-fn3">a</xref><italic>%</italic></th><th align="center" valign="top" char="." charoff="50"><italic>RMSE kcal per day</italic></th></tr></thead><tbody valign="top"><tr><td colspan="10" align="left" valign="top" charoff="50"><italic>Equation for normal-weight subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> HB</td><td align="center" valign="top" charoff="50">−86</td><td align="char" valign="top" char="." charoff="50">− 2.5</td><td align="center" valign="top" charoff="50">226</td><td align="center" valign="top" charoff="50">−85</td><td align="char" valign="top" char="." charoff="50">−1.7</td><td align="center" valign="top" charoff="50">273</td><td align="center" valign="top" charoff="50">−42</td><td align="char" valign="top" char="." charoff="50">−0.5</td><td align="char" valign="top" char="." charoff="50">279</td></tr><tr><td align="left" valign="top" charoff="50"> Henry</td><td align="center" valign="top" charoff="50">−86</td><td align="char" valign="top" char="." charoff="50">−2.4</td><td align="center" valign="top" charoff="50">231</td><td align="center" valign="top" charoff="50">−44</td><td align="char" valign="top" char="." charoff="50">−0.1</td><td align="center" valign="top" charoff="50">273</td><td align="center" valign="top" charoff="50">58</td><td align="char" valign="top" char="." charoff="50">2.9</td><td align="char" valign="top" char="." charoff="50">303</td></tr><tr><td align="left" valign="top" charoff="50"> Muller1</td><td align="center" valign="top" charoff="50">−206</td><td align="char" valign="top" char="." charoff="50">−7.3</td><td align="center" valign="top" charoff="50">287</td><td align="center" valign="top" charoff="50">−439</td><td align="char" valign="top" char="." charoff="50">−14.9</td><td align="center" valign="top" charoff="50">462</td><td align="center" valign="top" charoff="50">−638</td><td align="char" valign="top" char="." charoff="50">−20.4</td><td align="char" valign="top" char="." charoff="50">640</td></tr><tr><td align="left" valign="top" charoff="50"> Muller1 (BC)</td><td align="center" valign="top" charoff="50">−73</td><td align="char" valign="top" char="." charoff="50">−1.5</td><td align="center" valign="top" charoff="50">249</td><td align="center" valign="top" charoff="50">−231</td><td align="char" valign="top" char="." charoff="50">−7.0</td><td align="center" valign="top" charoff="50">334</td><td align="center" valign="top" charoff="50">−342</td><td align="char" valign="top" char="." charoff="50">−10.4</td><td align="char" valign="top" char="." charoff="50">375</td></tr><tr><td align="left" valign="top" charoff="50"> Schofield</td><td align="center" valign="top" charoff="50">−81</td><td align="char" valign="top" char="." charoff="50">−2.1</td><td align="center" valign="top" charoff="50">235</td><td align="center" valign="top" charoff="50">−87</td><td align="char" valign="top" char="." charoff="50">−1.7</td><td align="center" valign="top" charoff="50">289</td><td align="center" valign="top" charoff="50">−39</td><td align="char" valign="top" char="." charoff="50">−0.3</td><td align="char" valign="top" char="." charoff="50">324</td></tr><tr><td align="left" valign="top" charoff="50"> FAO</td><td align="center" valign="top" charoff="50">−61</td><td align="char" valign="top" char="." charoff="50">−1.3</td><td align="center" valign="top" charoff="50">232</td><td align="center" valign="top" charoff="50">−63</td><td align="char" valign="top" char="." charoff="50">−0.9</td><td align="center" valign="top" charoff="50">285</td><td align="center" valign="top" charoff="50">−11</td><td align="char" valign="top" char="." charoff="50">0.7</td><td align="char" valign="top" char="." charoff="50">322</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="10" align="left" valign="top" charoff="50"><italic>Equation for normal-weight and obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Muller2</td><td align="center" valign="top" charoff="50">88</td><td align="char" valign="top" char="." charoff="50">5.7</td><td align="center" valign="top" charoff="50">257</td><td align="center" valign="top" charoff="50">2.9</td><td align="char" valign="top" char="." charoff="50">2.0</td><td align="center" valign="top" charoff="50">284</td><td align="center" valign="top" charoff="50">−27</td><td align="char" valign="top" char="." charoff="50">−0.2</td><td align="char" valign="top" char="." charoff="50">269</td></tr><tr><td align="left" valign="top" charoff="50"> Muller2 (BC)</td><td align="center" valign="top" charoff="50">−104</td><td align="char" valign="top" char="." charoff="50">−2.8</td><td align="center" valign="top" charoff="50">254</td><td align="center" valign="top" charoff="50">−267</td><td align="char" valign="top" char="." charoff="50">−8.3</td><td align="center" valign="top" charoff="50">349</td><td align="center" valign="top" charoff="50">−384</td><td align="char" valign="top" char="." charoff="50">−11.8</td><td align="char" valign="top" char="." charoff="50">409</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin</td><td align="center" valign="top" charoff="50">−272</td><td align="char" valign="top" char="." charoff="50">−10.6</td><td align="center" valign="top" charoff="50">310</td><td align="center" valign="top" charoff="50">−364</td><td align="char" valign="top" char="." charoff="50">−12.3</td><td align="center" valign="top" charoff="50">404</td><td align="center" valign="top" charoff="50">−424</td><td align="char" valign="top" char="." charoff="50">−13.3</td><td align="char" valign="top" char="." charoff="50">440</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin (BC)</td><td align="center" valign="top" charoff="50">−509</td><td align="char" valign="top" char="." charoff="50">−21.0</td><td align="center" valign="top" charoff="50">514</td><td align="center" valign="top" charoff="50">−709</td><td align="char" valign="top" char="." charoff="50">−25.5</td><td align="center" valign="top" charoff="50">714</td><td align="center" valign="top" charoff="50">−868</td><td align="char" valign="top" char="." charoff="50">−28.2</td><td align="char" valign="top" char="." charoff="50">868</td></tr><tr><td align="left" valign="top" charoff="50"> De Lorenzo</td><td align="center" valign="top" charoff="50">−96</td><td align="char" valign="top" char="." charoff="50">−2.9</td><td align="center" valign="top" charoff="50">228</td><td align="center" valign="top" charoff="50">−113</td><td align="char" valign="top" char="." charoff="50">−2.8</td><td align="center" valign="top" charoff="50">279</td><td align="center" valign="top" charoff="50">−90</td><td align="char" valign="top" char="." charoff="50">−2.1</td><td align="char" valign="top" char="." charoff="50">280</td></tr><tr><td align="left" valign="top" charoff="50"> Owen</td><td align="center" valign="top" charoff="50">−285</td><td align="char" valign="top" char="." charoff="50">−11.0</td><td align="center" valign="top" charoff="50">321</td><td align="center" valign="top" charoff="50">−376</td><td align="char" valign="top" char="." charoff="50">−12.7</td><td align="center" valign="top" charoff="50">411</td><td align="center" valign="top" charoff="50">−422</td><td align="char" valign="top" char="." charoff="50">−13.2</td><td align="char" valign="top" char="." charoff="50">438</td></tr><tr><td align="left" valign="top" charoff="50"> Owen (BC)</td><td align="center" valign="top" charoff="50">−41</td><td align="char" valign="top" char="." charoff="50">−18.5</td><td align="center" valign="top" charoff="50">224</td><td align="center" valign="top" charoff="50">−630</td><td align="char" valign="top" char="." charoff="50">−25.5</td><td align="center" valign="top" charoff="50">644</td><td align="center" valign="top" charoff="50">−764</td><td align="char" valign="top" char="." charoff="50">−24.8</td><td align="char" valign="top" char="." charoff="50">768</td></tr><tr><td align="left" valign="top" charoff="50"> Korth</td><td align="center" valign="top" charoff="50">−203</td><td align="char" valign="top" char="." charoff="50">−0.4</td><td align="center" valign="top" charoff="50">301</td><td align="center" valign="top" charoff="50">−139</td><td align="char" valign="top" char="." charoff="50">−3.7</td><td align="center" valign="top" charoff="50">289</td><td align="center" valign="top" charoff="50">−204</td><td align="char" valign="top" char="." charoff="50">−5.9</td><td align="char" valign="top" char="." charoff="50">306</td></tr><tr><td align="left" valign="top" charoff="50"> Korth (BC)</td><td align="center" valign="top" charoff="50">−205</td><td align="char" valign="top" char="." charoff="50">−7.4</td><td align="center" valign="top" charoff="50">277</td><td align="center" valign="top" charoff="50">−353</td><td align="char" valign="top" char="." charoff="50">−11.9</td><td align="center" valign="top" charoff="50">431</td><td align="center" valign="top" charoff="50">−453</td><td align="char" valign="top" char="." charoff="50">−14.3</td><td align="char" valign="top" char="." charoff="50">515</td></tr><tr><td align="left" valign="top" charoff="50"> Johnstone (BC)</td><td align="center" valign="top" charoff="50">−263</td><td align="char" valign="top" char="." charoff="50">−7.7</td><td align="center" valign="top" charoff="50">306</td><td align="center" valign="top" charoff="50">−246</td><td align="char" valign="top" char="." charoff="50">−7.9</td><td align="center" valign="top" charoff="50">340</td><td align="center" valign="top" charoff="50">−235</td><td align="char" valign="top" char="." charoff="50">−7.0</td><td align="char" valign="top" char="." charoff="50">338</td></tr><tr><td align="left" valign="top" charoff="50">Livingstone</td><td align="center" valign="top" charoff="50">−41</td><td align="char" valign="top" char="." charoff="50">−10.1</td><td align="center" valign="top" charoff="50">224</td><td align="center" valign="top" charoff="50">−391</td><td align="char" valign="top" char="." charoff="50">−13.2</td><td align="center" valign="top" charoff="50">425</td><td align="center" valign="top" charoff="50">−519</td><td align="char" valign="top" char="." charoff="50">16.4</td><td align="char" valign="top" char="." charoff="50">527</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="10" align="left" valign="top" charoff="50"><italic>Equation for obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer</td><td align="center" valign="top" charoff="50">−125</td><td align="char" valign="top" char="." charoff="50">−4.0</td><td align="center" valign="top" charoff="50">240</td><td align="center" valign="top" charoff="50">−189</td><td align="char" valign="top" char="." charoff="50">−5.5</td><td align="center" valign="top" charoff="50">304</td><td align="center" valign="top" charoff="50">−209</td><td align="char" valign="top" char="." charoff="50">−6.0</td><td align="char" valign="top" char="." charoff="50">303</td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer (BC)</td><td align="center" valign="top" charoff="50">−187</td><td align="char" valign="top" char="." charoff="50">−6.7</td><td align="center" valign="top" charoff="50">280</td><td align="center" valign="top" charoff="50">−383</td><td align="char" valign="top" char="." charoff="50">−12.9</td><td align="center" valign="top" charoff="50">432</td><td align="center" valign="top" charoff="50">−541</td><td align="char" valign="top" char="." charoff="50">−17.2</td><td align="char" valign="top" char="." charoff="50">560</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3</td><td align="center" valign="top" charoff="50">129</td><td align="char" valign="top" char="." charoff="50">7.4</td><td align="center" valign="top" charoff="50">269</td><td align="center" valign="top" charoff="50">74</td><td align="char" valign="top" char="." charoff="50">4.7</td><td align="center" valign="top" charoff="50">289</td><td align="center" valign="top" charoff="50">79</td><td align="char" valign="top" char="." charoff="50">3.7</td><td align="char" valign="top" char="." charoff="50">288</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3 (BC)</td><td align="center" valign="top" charoff="50">35</td><td align="char" valign="top" char="." charoff="50">3.3</td><td align="center" valign="top" charoff="50">246</td><td align="center" valign="top" charoff="50">−48</td><td align="char" valign="top" char="." charoff="50">0.1</td><td align="center" valign="top" charoff="50">287</td><td align="center" valign="top" charoff="50">−73.8</td><td align="char" valign="top" char="." charoff="50">−1.4</td><td align="char" valign="top" char="." charoff="50">274</td></tr><tr><td align="left" valign="top" charoff="50"> Huang</td><td align="center" valign="top" charoff="50">−195</td><td align="char" valign="top" char="." charoff="50">−7.1</td><td align="center" valign="top" charoff="50">267</td><td align="center" valign="top" charoff="50">−289</td><td align="char" valign="top" char="." charoff="50">−9.4</td><td align="center" valign="top" charoff="50">353</td><td align="center" valign="top" charoff="50">−341</td><td align="char" valign="top" char="." charoff="50">−10.5</td><td align="char" valign="top" char="." charoff="50">377</td></tr><tr><td align="left" valign="top" charoff="50"> Huang (BC)</td><td align="center" valign="top" charoff="50">−283</td><td align="char" valign="top" char="." charoff="50">−9.1</td><td align="center" valign="top" charoff="50">288</td><td align="center" valign="top" charoff="50">−310</td><td align="char" valign="top" char="." charoff="50">−10.2</td><td align="center" valign="top" charoff="50">364</td><td align="center" valign="top" charoff="50">−334</td><td align="char" valign="top" char="." charoff="50">−10.2</td><td align="char" valign="top" char="." charoff="50">373</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein</td><td align="center" valign="top" charoff="50">−518</td><td align="char" valign="top" char="." charoff="50">−21.7</td><td align="center" valign="top" charoff="50">521</td><td align="center" valign="top" charoff="50">−586</td><td align="center" valign="top" char="." charoff="50">−21</td><td align="center" valign="top" charoff="50">592</td><td align="center" valign="top" charoff="50">−622</td><td align="char" valign="top" char="." charoff="50">−20.1</td><td align="char" valign="top" char="." charoff="50">623</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein (BC)</td><td align="center" valign="top" charoff="50">−637</td><td align="char" valign="top" char="." charoff="50">−26.8</td><td align="center" valign="top" charoff="50">637</td><td align="center" valign="top" charoff="50">−771</td><td align="center" valign="top" char="." charoff="50">−28</td><td align="center" valign="top" charoff="50">771</td><td align="center" valign="top" charoff="50">−861</td><td align="char" valign="top" char="." charoff="50">−28.1</td><td align="char" valign="top" char="." charoff="50">861</td></tr></tbody></table><table-wrap-foot><fn id="tbl3a-fn1"><p>Abbreviations: BC, body composition; BMI, body mass index; Diff, difference; REE, resting energy expenditure; RMSE, root mean square error; P–M, predicted–measured.</p></fn><fn id="tbl3a-fn2"><p>Group 1 (BMI=30–39.9 kg m<sup>−</sup><sup>2</sup>); Group 2 (BMI=40–49.9 kg m<sup>−</sup><sup>2</sup>); Group 3 (BMI>50 kg m<sup>−</sup><sup>2</sup>).</p></fn><fn id="tbl3a-fn3"><label>a</label><p>Mean percentage error between predictive equation and measured value.</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl3b"><label>Table 3b</label><caption><title>Evaluation of REE with different predictive equations in 1181 females based on differences P–M, bias and RMSE according to BMI groups</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="char" char="."></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="char" char="."></col><col align="center"></col><col align="center"></col><col align="char" char="."></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"><italic>REE predictive equations</italic></th><th colspan="3" align="center" valign="top" charoff="50"><italic>Group 1;</italic> N<italic>=494</italic><hr></hr></th><th colspan="3" align="center" valign="top" charoff="50"><italic>Group 2;</italic> N<italic>=498</italic><hr></hr></th><th colspan="3" align="center" valign="top" charoff="50"><italic>Group 3;</italic> N<italic>=189</italic><hr></hr></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50"><italic>Diff P–M kcal per day</italic></th><th align="center" valign="top" char="." charoff="50"><italic>Bias</italic><xref ref-type="fn" rid="tbl3b-fn3">a</xref></th><th align="center" valign="top" charoff="50"><italic>RMSE kcal per day</italic></th><th align="center" valign="top" charoff="50"><italic>Diff P–M kcal per day</italic></th><th align="center" valign="top" charoff="50"><italic>Bias</italic><xref ref-type="fn" rid="tbl3b-fn3">a</xref><italic>%</italic></th><th align="center" valign="top" char="." charoff="50"><italic>RMSE kcal per day</italic></th><th align="center" valign="top" charoff="50"><italic>Diff P–M kcal per day</italic></th><th align="center" valign="top" charoff="50"><italic>Bias</italic><xref ref-type="fn" rid="tbl3b-fn3">a</xref><italic>%</italic></th><th align="center" valign="top" char="." charoff="50"><italic>RMSE kcal per day</italic></th></tr></thead><tbody valign="top"><tr><td colspan="10" align="left" valign="top" charoff="50"><italic>Equation for normal-weight subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> HB</td><td align="center" valign="top" charoff="50">−79</td><td align="char" valign="top" char="." charoff="50">−3.2</td><td align="center" valign="top" charoff="50">172</td><td align="center" valign="top" charoff="50">−222</td><td align="center" valign="top" charoff="50">−9.2</td><td align="char" valign="top" char="." charoff="50">267</td><td align="center" valign="top" charoff="50">−338</td><td align="center" valign="top" charoff="50">−12.5</td><td align="char" valign="top" char="." charoff="50">366</td></tr><tr><td align="left" valign="top" charoff="50"> Henry</td><td align="center" valign="top" charoff="50">−96</td><td align="char" valign="top" char="." charoff="50">−4.3</td><td align="center" valign="top" charoff="50">181</td><td align="center" valign="top" charoff="50">−197</td><td align="center" valign="top" charoff="50">−8.0</td><td align="char" valign="top" char="." charoff="50">263</td><td align="center" valign="top" charoff="50">−284</td><td align="center" valign="top" charoff="50">−10.3</td><td align="char" valign="top" char="." charoff="50">355</td></tr><tr><td align="left" valign="top" charoff="50"> Muller</td><td align="center" valign="top" charoff="50">−57</td><td align="char" valign="top" char="." charoff="50">−1.6</td><td align="center" valign="top" charoff="50">186</td><td align="center" valign="top" charoff="50">−296</td><td align="center" valign="top" charoff="50">−12.5</td><td align="char" valign="top" char="." charoff="50">330</td><td align="center" valign="top" charoff="50">−509</td><td align="center" valign="top" charoff="50">−19.3</td><td align="char" valign="top" char="." charoff="50">515</td></tr><tr><td align="left" valign="top" charoff="50"> Muller1 (BC)</td><td align="center" valign="top" charoff="50">44</td><td align="char" valign="top" char="." charoff="50">4.2</td><td align="center" valign="top" charoff="50">182</td><td align="center" valign="top" charoff="50">−333</td><td align="center" valign="top" charoff="50">−4.7</td><td align="char" valign="top" char="." charoff="50">240</td><td align="center" valign="top" charoff="50">−268</td><td align="center" valign="top" charoff="50">−9.5</td><td align="char" valign="top" char="." charoff="50">318</td></tr><tr><td align="left" valign="top" charoff="50"> Schofield</td><td align="center" valign="top" charoff="50">−53</td><td align="char" valign="top" char="." charoff="50">−1.7</td><td align="center" valign="top" charoff="50">185</td><td align="center" valign="top" charoff="50">−159</td><td align="center" valign="top" charoff="50">−6.4</td><td align="char" valign="top" char="." charoff="50">272</td><td align="center" valign="top" charoff="50">−278</td><td align="center" valign="top" charoff="50">−10</td><td align="char" valign="top" char="." charoff="50">410</td></tr><tr><td align="left" valign="top" charoff="50"> FAO</td><td align="center" valign="top" charoff="50">−32</td><td align="char" valign="top" char="." charoff="50">−0.5</td><td align="center" valign="top" charoff="50">177</td><td align="center" valign="top" charoff="50">−131</td><td align="center" valign="top" charoff="50">−5.0</td><td align="char" valign="top" char="." charoff="50">250</td><td align="center" valign="top" charoff="50">−235</td><td align="center" valign="top" charoff="50">−8.2</td><td align="char" valign="top" char="." charoff="50">368</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="10" align="left" valign="top" charoff="50"><italic>Equation for normal-weight and obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Muller2</td><td align="center" valign="top" charoff="50">178</td><td align="char" valign="top" char="." charoff="50">11.9</td><td align="center" valign="top" charoff="50">235</td><td align="center" valign="top" charoff="50">70.8</td><td align="center" valign="top" charoff="50">5.1</td><td align="char" valign="top" char="." charoff="50">230</td><td align="center" valign="top" charoff="50">16</td><td align="center" valign="top" charoff="50">2.0</td><td align="char" valign="top" char="." charoff="50">229</td></tr><tr><td align="left" valign="top" charoff="50"> Muller2 (BC)</td><td align="center" valign="top" charoff="50">36</td><td align="char" valign="top" char="." charoff="50">3.7</td><td align="center" valign="top" charoff="50">181</td><td align="center" valign="top" charoff="50">−145</td><td align="center" valign="top" charoff="50">−5.2</td><td align="char" valign="top" char="." charoff="50">243</td><td align="center" valign="top" charoff="50">−284</td><td align="center" valign="top" charoff="50">−10.1</td><td align="char" valign="top" char="." charoff="50">328</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin</td><td align="center" valign="top" charoff="50">−168</td><td align="char" valign="top" char="." charoff="50">−8.5</td><td align="center" valign="top" charoff="50">213</td><td align="center" valign="top" charoff="50">−294</td><td align="center" valign="top" charoff="50">−12.7</td><td align="char" valign="top" char="." charoff="50">319</td><td align="center" valign="top" charoff="50">−394</td><td align="center" valign="top" charoff="50">−14.9</td><td align="char" valign="top" char="." charoff="50">411</td></tr><tr><td align="left" valign="top" charoff="50"> Mifflin (BC)</td><td align="center" valign="top" charoff="50">−348</td><td align="char" valign="top" char="." charoff="50">−18.7</td><td align="center" valign="top" charoff="50">356</td><td align="center" valign="top" charoff="50">−579</td><td align="center" valign="top" charoff="50">−26.1</td><td align="char" valign="top" char="." charoff="50">580</td><td align="center" valign="top" charoff="50">−773</td><td align="center" valign="top" charoff="50">−30.2</td><td align="char" valign="top" char="." charoff="50">772</td></tr><tr><td align="left" valign="top" charoff="50"> De Lorenzo</td><td align="center" valign="top" charoff="50">−44</td><td align="char" valign="top" char="." charoff="50">−1.3</td><td align="center" valign="top" charoff="50">168</td><td align="center" valign="top" charoff="50">−144</td><td align="center" valign="top" charoff="50">−6.5</td><td align="char" valign="top" char="." charoff="50">228</td><td align="center" valign="top" charoff="50">−210</td><td align="center" valign="top" charoff="50">−7.3</td><td align="char" valign="top" char="." charoff="50">280</td></tr><tr><td align="left" valign="top" charoff="50"> Owen</td><td align="center" valign="top" charoff="50">−301</td><td align="char" valign="top" char="." charoff="50">−15.8</td><td align="center" valign="top" charoff="50">309</td><td align="center" valign="top" charoff="50">−495</td><td align="center" valign="top" charoff="50">−22</td><td align="char" valign="top" char="." charoff="50">498</td><td align="center" valign="top" charoff="50">−656</td><td align="center" valign="top" charoff="50">−25.4</td><td align="char" valign="top" char="." charoff="50">656</td></tr><tr><td align="left" valign="top" charoff="50"> Owen (BC)</td><td align="center" valign="top" charoff="50">−427</td><td align="char" valign="top" char="." charoff="50">−23.3</td><td align="center" valign="top" charoff="50">430</td><td align="center" valign="top" charoff="50">−658</td><td align="center" valign="top" charoff="50">−30</td><td align="char" valign="top" char="." charoff="50">658</td><td align="center" valign="top" charoff="50">−852</td><td align="center" valign="top" charoff="50">−33.5</td><td align="char" valign="top" char="." charoff="50">852</td></tr><tr><td align="left" valign="top" charoff="50"> Korth</td><td align="center" valign="top" charoff="50">−66</td><td align="char" valign="top" char="." charoff="50">−2.6</td><td align="center" valign="top" charoff="50">176</td><td align="center" valign="top" charoff="50">−194</td><td align="center" valign="top" charoff="50">−8</td><td align="char" valign="top" char="." charoff="50">253</td><td align="center" valign="top" charoff="50">−298</td><td align="center" valign="top" charoff="50">−10.9</td><td align="char" valign="top" char="." charoff="50">335</td></tr><tr><td align="left" valign="top" charoff="50">Korth (BC)</td><td align="center" valign="top" charoff="50">−157</td><td align="char" valign="top" char="." charoff="50">−7.7</td><td align="center" valign="top" charoff="50">221</td><td align="center" valign="top" charoff="50">−346</td><td align="center" valign="top" charoff="50">−15</td><td align="char" valign="top" char="." charoff="50">372</td><td align="center" valign="top" charoff="50">−488</td><td align="center" valign="top" charoff="50">−18.6</td><td align="char" valign="top" char="." charoff="50">502</td></tr><tr><td align="left" valign="top" charoff="50">Johnstone (BC)</td><td align="center" valign="top" charoff="50">−70</td><td align="char" valign="top" char="." charoff="50">−2.9</td><td align="center" valign="top" charoff="50">173</td><td align="center" valign="top" charoff="50">−158</td><td align="center" valign="top" charoff="50">−6.2</td><td align="char" valign="top" char="." charoff="50">238</td><td align="center" valign="top" charoff="50">−198</td><td align="center" valign="top" charoff="50">−6.9</td><td align="char" valign="top" char="." charoff="50">274</td></tr><tr><td align="left" valign="top" charoff="50">Livingstone</td><td align="center" valign="top" charoff="50">−159</td><td align="char" valign="top" char="." charoff="50">−7.8</td><td align="center" valign="top" charoff="50">206</td><td align="center" valign="top" charoff="50">−336</td><td align="center" valign="top" charoff="50">−14.5</td><td align="char" valign="top" char="." charoff="50">353</td><td align="center" valign="top" charoff="50">−515</td><td align="center" valign="top" charoff="50">−19.6</td><td align="char" valign="top" char="." charoff="50">521</td></tr><tr><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" char="." charoff="50"> </td></tr><tr><td colspan="10" align="left" valign="top" charoff="50"><italic>Equation for obese subjects</italic></td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer</td><td align="center" valign="top" charoff="50">−85</td><td align="char" valign="top" char="." charoff="50">−3.6</td><td align="center" valign="top" charoff="50">173</td><td align="center" valign="top" charoff="50">−187</td><td align="center" valign="top" charoff="50">−7.5</td><td align="char" valign="top" char="." charoff="50">248</td><td align="center" valign="top" charoff="50">−249</td><td align="center" valign="top" charoff="50">−8.9</td><td align="char" valign="top" char="." charoff="50">302</td></tr><tr><td align="left" valign="top" charoff="50"> Lazzer (BC)</td><td align="center" valign="top" charoff="50">−9</td><td align="char" valign="top" char="." charoff="50">0.9</td><td align="center" valign="top" charoff="50">173</td><td align="center" valign="top" charoff="50">−241</td><td align="center" valign="top" charoff="50">−10</td><td align="char" valign="top" char="." charoff="50">288</td><td align="center" valign="top" charoff="50">−441</td><td align="center" valign="top" charoff="50">−16.6</td><td align="char" valign="top" char="." charoff="50">459</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3</td><td align="center" valign="top" charoff="50">173</td><td align="char" valign="top" char="." charoff="50">11.6</td><td align="center" valign="top" charoff="50">232</td><td align="center" valign="top" charoff="50">95</td><td align="center" valign="top" charoff="50">6.2</td><td align="char" valign="top" char="." charoff="50">234</td><td align="center" valign="top" charoff="50">73</td><td align="center" valign="top" charoff="50">4.3</td><td align="char" valign="top" char="." charoff="50">238</td></tr><tr><td align="left" valign="top" charoff="50"> Muller3 (BC)</td><td align="center" valign="top" charoff="50">119</td><td align="char" valign="top" char="." charoff="50">8.4</td><td align="center" valign="top" charoff="50">203</td><td align="center" valign="top" charoff="50">11</td><td align="center" valign="top" charoff="50">2.2</td><td align="char" valign="top" char="." charoff="50">219</td><td align="center" valign="top" charoff="50">−43</td><td align="center" valign="top" charoff="50">−0.4</td><td align="char" valign="top" char="." charoff="50">228</td></tr><tr><td align="left" valign="top" charoff="50"> Huang</td><td align="center" valign="top" charoff="50">−176</td><td align="char" valign="top" char="." charoff="50">−8.8</td><td align="center" valign="top" charoff="50">215</td><td align="center" valign="top" charoff="50">−298</td><td align="center" valign="top" charoff="50">−12.8</td><td align="char" valign="top" char="." charoff="50">322</td><td align="center" valign="top" charoff="50">−384</td><td align="center" valign="top" charoff="50">−14.4</td><td align="char" valign="top" char="." charoff="50">401</td></tr><tr><td align="left" valign="top" charoff="50"> Huang (BC)</td><td align="center" valign="top" charoff="50">−185</td><td align="char" valign="top" char="." charoff="50">−9.4</td><td align="center" valign="top" charoff="50">218</td><td align="center" valign="top" charoff="50">−293</td><td align="center" valign="top" charoff="50">−12.6</td><td align="char" valign="top" char="." charoff="50">319</td><td align="center" valign="top" charoff="50">−357</td><td align="center" valign="top" charoff="50">−13.3</td><td align="char" valign="top" char="." charoff="50">378</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein</td><td align="center" valign="top" charoff="50">−397</td><td align="char" valign="top" char="." charoff="50">−21.5</td><td align="center" valign="top" charoff="50">400</td><td align="center" valign="top" charoff="50">−584</td><td align="center" valign="top" charoff="50">−26.4</td><td align="char" valign="top" char="." charoff="50">584</td><td align="center" valign="top" charoff="50">−742</td><td align="center" valign="top" charoff="50">−28.9</td><td align="char" valign="top" char="." charoff="50">742</td></tr><tr><td align="left" valign="top" charoff="50"> Bernstein (BC)</td><td align="center" valign="top" charoff="50">−458</td><td align="char" valign="top" char="." charoff="50">25.2</td><td align="center" valign="top" charoff="50">460</td><td align="center" valign="top" charoff="50">−630</td><td align="center" valign="top" charoff="50">−28.7</td><td align="char" valign="top" char="." charoff="50">630</td><td align="center" valign="top" charoff="50">−761</td><td align="center" valign="top" charoff="50">−29.8</td><td align="char" valign="top" char="." charoff="50">761</td></tr></tbody></table><table-wrap-foot><fn id="tbl3b-fn1"><p>Abbreviations: BC, body composition; BMI, body mass index; Diff, difference; REE, resting energy expenditure; RMSE, root mean square error; P–M, predicted–measured.</p></fn><fn id="tbl3b-fn2"><p>Group 1 (BMI=30–40 kg m<sup>−</sup><sup>2</sup>); Group 2 (BMI=40–50 kg m<sup>−</sup><sup>2</sup>); Group 3 (BMI>50 kg m<sup>−</sup><sup>2</sup>).</p></fn><fn id="tbl3b-fn3"><label>a</label><p>Mean percentage error between predictive equation and measured value.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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