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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Employment and social benefits up to 10 years after breast cancer diagnosis: a population-based study</title><author><name sortKey="Paalman, C H" sort="Paalman, C H" uniqKey="Paalman C" first="C H" last="Paalman">C H Paalman</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Leeuwen, F E" sort="Van Leeuwen, F E" uniqKey="Van Leeuwen F" first="F E" last="Van Leeuwen">F E Van Leeuwen</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Aaronson, N K" sort="Aaronson, N K" uniqKey="Aaronson N" first="N K" last="Aaronson">N K Aaronson</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="De Boer, A G E M" sort="De Boer, A G E M" uniqKey="De Boer A" first="A G E M" last="De Boer">A G E M. De Boer</name><affiliation><nlm:aff id="aff2"><institution>Coronel Institute of Occupational Health, Academic Medical Center</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van De Poll Franse, L" sort="Van De Poll Franse, L" uniqKey="Van De Poll Franse L" first="L" last="Van De Poll-Franse">L. Van De Poll-Franse</name><affiliation><nlm:aff id="aff3"><institution>Netherlands Comprehensive Cancer Organisation (IKNL)</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>CoRPS- Centre of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University</institution>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Oldenburg, H S A" sort="Oldenburg, H S A" uniqKey="Oldenburg H" first="H S A" last="Oldenburg">H S A. Oldenburg</name><affiliation><nlm:aff id="aff5"><institution>Department of Surgical Oncology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Schaapveld, M" sort="Schaapveld, M" uniqKey="Schaapveld M" first="M" last="Schaapveld">M. Schaapveld</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Netherlands Comprehensive Cancer Organisation (IKNL)</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26757424</idno><idno type="pmc">4716544</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4716544</idno><idno type="RBID">PMC:4716544</idno><idno type="doi">10.1038/bjc.2015.431</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000917</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000917</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Employment and social benefits up to 10 years after breast cancer diagnosis: a population-based study</title><author><name sortKey="Paalman, C H" sort="Paalman, C H" uniqKey="Paalman C" first="C H" last="Paalman">C H Paalman</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van Leeuwen, F E" sort="Van Leeuwen, F E" uniqKey="Van Leeuwen F" first="F E" last="Van Leeuwen">F E Van Leeuwen</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Aaronson, N K" sort="Aaronson, N K" uniqKey="Aaronson N" first="N K" last="Aaronson">N K Aaronson</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="De Boer, A G E M" sort="De Boer, A G E M" uniqKey="De Boer A" first="A G E M" last="De Boer">A G E M. De Boer</name><affiliation><nlm:aff id="aff2"><institution>Coronel Institute of Occupational Health, Academic Medical Center</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Van De Poll Franse, L" sort="Van De Poll Franse, L" uniqKey="Van De Poll Franse L" first="L" last="Van De Poll-Franse">L. Van De Poll-Franse</name><affiliation><nlm:aff id="aff3"><institution>Netherlands Comprehensive Cancer Organisation (IKNL)</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff4"><institution>CoRPS- Centre of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University</institution>,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Oldenburg, H S A" sort="Oldenburg, H S A" uniqKey="Oldenburg H" first="H S A" last="Oldenburg">H S A. Oldenburg</name><affiliation><nlm:aff id="aff5"><institution>Department of Surgical Oncology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation></author><author><name sortKey="Schaapveld, M" sort="Schaapveld, M" uniqKey="Schaapveld M" first="M" last="Schaapveld">M. Schaapveld</name><affiliation><nlm:aff id="aff1"><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></nlm:aff></affiliation><affiliation><nlm:aff id="aff3"><institution>Netherlands Comprehensive Cancer Organisation (IKNL)</institution>, Utrecht,<country>The Netherlands</country></nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background:</title><p>Little is known about employment outcomes after breast cancer (BC) beyond the first years after treatment.</p></sec><sec><title>Methods:</title><p>Employment outcomes were compared with a general population comparison group (<italic>N</italic>=91 593) up to 10 years after BC for 26 120 patients, diagnosed before age 55 between 2000–2005, with income and social benefits data from Statistics Netherlands. Treatment effects were studied in 14 916 patients, with information on BC recurrences and new cancer events.</p></sec><sec><title>Results:</title><p>BC survivors experienced higher risk of losing paid employment (Hazard Ratio (HR): 1.6, 95% Confidence Interval (95% CI) 1.4–1.8) or any work-related event up to 5–7 years (HR 1.5, 95% CI 1.3–1.6) and of receiving disability benefits up to 10 years after diagnosis (HR 2.0, 95% CI 1.6–2.5), with higher risks for younger patients. Axillary lymph node dissection increased risk of disability benefits (HR 1.5, 95% CI 1.4–1.7) or losing paid employment (HR 1.3, 95% CI 1.2–1.5) during the first 5 years of follow-up. Risk of disability benefits was increased among patients receiving mastectomy and radiotherapy (HR 1.2; 95% CI 1.1–1.3) and after chemotherapy (HR 1.7; 95% CI 1.5–1.9) during the first 5 years after diagnosis.</p></sec><sec><title>Conclusions:</title><p>BC treatment at least partly explains the increased risk of adverse employment outcomes up to 10 years after BC.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-id journal-id-type="iso-abbrev">Br. J. Cancer</journal-id><journal-title-group><journal-title>British Journal of Cancer</journal-title></journal-title-group><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26757424</article-id><article-id pub-id-type="pmc">4716544</article-id><article-id pub-id-type="pii">bjc2015431</article-id><article-id pub-id-type="doi">10.1038/bjc.2015.431</article-id><article-categories><subj-group subj-group-type="heading"><subject>Epidemiology</subject></subj-group></article-categories><title-group><article-title>Employment and social benefits up to 10 years after breast cancer diagnosis: a population-based study</article-title><alt-title alt-title-type="running">Employment 10 years after breast cancer diagnosis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Paalman</surname><given-names>C H</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>van Leeuwen</surname><given-names>F E</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Aaronson</surname><given-names>N K</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>de Boer</surname><given-names>A G E M</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>van de Poll-Franse</surname><given-names>L</given-names></name><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Oldenburg</surname><given-names>H S A</given-names></name><xref ref-type="aff" rid="aff5">5</xref></contrib><contrib contrib-type="author"><name><surname>Schaapveld</surname><given-names>M</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="aff" rid="aff3">3</xref><xref ref-type="corresp" rid="caf1">*</xref></contrib><aff id="aff1"><label>1</label><institution>Division of Psychosocial Research and Epidemiology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></aff><aff id="aff2"><label>2</label><institution>Coronel Institute of Occupational Health, Academic Medical Center</institution>, Amsterdam,<country>The Netherlands</country></aff><aff id="aff3"><label>3</label><institution>Netherlands Comprehensive Cancer Organisation (IKNL)</institution>, Utrecht,<country>The Netherlands</country></aff><aff id="aff4"><label>4</label><institution>CoRPS- Centre of Research on Psychology in Somatic Diseases, Department of Medical and Clinical Psychology, Tilburg University</institution>,<country>The Netherlands</country></aff><aff id="aff5"><label>5</label><institution>Department of Surgical Oncology, The Netherlands Cancer Institute</institution>, Amsterdam,<country>The Netherlands</country></aff></contrib-group><author-notes><corresp id="caf1"><label>*</label>E-mail: <email>m.schaapveld@nki.nl</email></corresp></author-notes><pub-date pub-type="ppub"><day>12</day><month>01</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>12</day><month>01</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>12</day><month>1</month><year>2016</year></pub-date><volume>114</volume><issue>1</issue><fpage>81</fpage><lpage>87</lpage><history><date date-type="received"><day>29</day><month>06</month><year>2015</year></date><date date-type="rev-recd"><day>30</day><month>10</month><year>2015</year></date><date date-type="accepted"><day>05</day><month>11</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2016 Cancer Research UK</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Cancer Research UK</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0/"><pmc-comment>author-paid</pmc-comment>
<license-p>This work is licensed under the Creative Commons Attribution-Non-Commercial-Share Alike 4.0 International License. To view a copy of this license, visit <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc-sa/4.0/">http://creativecommons.org/licenses/by-nc-sa/4.0/</ext-link></license-p></license></permissions><abstract><sec><title>Background:</title><p>Little is known about employment outcomes after breast cancer (BC) beyond the first years after treatment.</p></sec><sec><title>Methods:</title><p>Employment outcomes were compared with a general population comparison group (<italic>N</italic>=91 593) up to 10 years after BC for 26 120 patients, diagnosed before age 55 between 2000–2005, with income and social benefits data from Statistics Netherlands. Treatment effects were studied in 14 916 patients, with information on BC recurrences and new cancer events.</p></sec><sec><title>Results:</title><p>BC survivors experienced higher risk of losing paid employment (Hazard Ratio (HR): 1.6, 95% Confidence Interval (95% CI) 1.4–1.8) or any work-related event up to 5–7 years (HR 1.5, 95% CI 1.3–1.6) and of receiving disability benefits up to 10 years after diagnosis (HR 2.0, 95% CI 1.6–2.5), with higher risks for younger patients. Axillary lymph node dissection increased risk of disability benefits (HR 1.5, 95% CI 1.4–1.7) or losing paid employment (HR 1.3, 95% CI 1.2–1.5) during the first 5 years of follow-up. Risk of disability benefits was increased among patients receiving mastectomy and radiotherapy (HR 1.2; 95% CI 1.1–1.3) and after chemotherapy (HR 1.7; 95% CI 1.5–1.9) during the first 5 years after diagnosis.</p></sec><sec><title>Conclusions:</title><p>BC treatment at least partly explains the increased risk of adverse employment outcomes up to 10 years after BC.</p></sec></abstract><kwd-group><kwd>breast cancer</kwd><kwd>work</kwd><kwd>employment</kwd><kwd>disability benefits</kwd><kwd>long term effects</kwd></kwd-group></article-meta></front><body><p>Breast cancer (BC) is the most common malignancy among women in the Western world. About a third of all women diagnosed with BC is under the age of 55. Prognosis of BC has improved markedly over the last two decades due to earlier diagnosis and better treatment, with current 10-year BC survival approaching 80% for patients diagnosed before age 55 (<xref ref-type="bibr" rid="bib39">Verdecchia <italic>et al</italic>, 2007</xref>).</p><p>With employment rates above 60% for women in the Netherlands, a large proportion of women diagnosed with BC before age 55 is working. For those confronted with cancer, work offers a sense of control in insecure times (<xref ref-type="bibr" rid="bib28">Lilliehorn <italic>et al</italic>, 2013</xref>; <xref ref-type="bibr" rid="bib22">Islam <italic>et al</italic>, 2014</xref>). Moreover, work gives meaning to life, may provide distraction from the disease and is positively associated with quality of life (<xref ref-type="bibr" rid="bib37">Spelten <italic>et al</italic>, 2002</xref>; <xref ref-type="bibr" rid="bib26">Kennedy <italic>et al</italic>, 2007</xref>). Previous studies have shown that 60%–93% of the BC survivors will successfully return to work within the first two years after diagnosis (<xref ref-type="bibr" rid="bib7">Bushunow <italic>et al</italic>, 1995</xref>; <xref ref-type="bibr" rid="bib35">Satariano and DeLorenze, 1996</xref>; <xref ref-type="bibr" rid="bib37">Spelten <italic>et al</italic>, 2002</xref>; <xref ref-type="bibr" rid="bib30">Maunsell <italic>et al</italic>, 2004</xref>; <xref ref-type="bibr" rid="bib6">Bradley <italic>et al</italic>, 2005</xref>; <xref ref-type="bibr" rid="bib32">Nieuwenhuijsen <italic>et al</italic>, 2006</xref>). Nonetheless, a meta-analysis showed that BC survivors have a 1.3-fold (95% CI 1.1–1.5) higher risk of becoming unemployed compared to the general population (<xref ref-type="bibr" rid="bib10">de Boer <italic>et al</italic>, 2009</xref>). A considerable group of BC survivors will face long term disabilities which may greatly impact on their financial position and social well-being (<xref ref-type="bibr" rid="bib9">de Boer and Frings-Dresen, 2009</xref>; <xref ref-type="bibr" rid="bib20">Hauglann <italic>et al</italic>, 2012</xref>). Even in early stage BC, the ability to work was negatively influenced at least up to 5 years after diagnosis (<xref ref-type="bibr" rid="bib15">Eaker <italic>et al</italic>, 2011</xref>).</p><p>Studies have shown that BC treatment is an important risk factor for impaired work-ability (<xref ref-type="bibr" rid="bib5">Bouknight <italic>et al</italic>, 2006</xref>; <xref ref-type="bibr" rid="bib2">Balak <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib11">de Boer <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib27">Lavigne <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib40">Yoon <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib1">Ahn <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib16">Fantoni <italic>et al</italic>, 2010</xref>; <xref ref-type="bibr" rid="bib21">Hedayati <italic>et al</italic>, 2012</xref>). Chemo- or hormonal therapy and mastectomy have been associated with higher risks of unemployment and lower ability to work within the first years after diagnosis, whereas no such effects were found for radiotherapy (<xref ref-type="bibr" rid="bib13">Drolet <italic>et al</italic>, 2005a</xref>; <xref ref-type="bibr" rid="bib2">Balak <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib15">Eaker <italic>et al</italic>, 2011</xref>; <xref ref-type="bibr" rid="bib29">Lindbohm <italic>et al</italic>, 2011</xref>).</p><p>Because in most studies on return to work patients were followed for only a short time-period, generally less than five years after treatment, it remains largely unknown what happens after these first years. With the increasing number of young BC survivors, it is important to understand the effects of BC and its treatment on employment beyond the first years after diagnosis. The objective of this study was to assess the effects of BC and its treatment on employment and social benefits in a large, unselected sample of women diagnosed with BC before age 55 up to ten years after BC diagnosis.</p><sec><title>MATERIALS AND Methods</title><sec><title>Study population and data</title><p>We composed a cohort comprising all 26 120 women diagnosed with primary invasive BC as their first malignancy before the age of 55 years of age in the Netherlands in the period 2000–2005. Patients were identified through the Netherlands Cancer Registry (NCR). The cohort contained information on tumor characteristics and treatment for the primary BC as well as all subsequent cancers. Details on the prevailing treatment guidelines in the study period are provided in <xref ref-type="supplementary-material" rid="sup1">Supplementary Appendix 1</xref> (<xref ref-type="bibr" rid="bib34">Rutgers <italic>et al</italic>, 2002</xref>). We linked the NCR cohort with individual social security data, which included data on individual income, receipt of disability benefits, unemployment benefits and welfare at Statistics Netherlands, using date of birth, sex, the date of BC diagnosis and the numerical part of the patient's postal code at BC diagnosis. Of all women in the cohort, 23 760 (91%) could be uniquely identified based on these variables. Statistics Netherlands anonymized the linked cohort and made the data available to the researchers by secured remote access. The study protocol was reviewed by the NCR internal review board and Statistics Netherlands and requirement for individual informed consent was waived.</p></sec><sec><title>General population control sample</title><p>We randomly selected women, frequency-matched on age at diagnosis, from the national population registry for each of the years 2000 to 2005 as comparison group. For each BC patient four women were selected. This general population control sample and the cohort of breast cancer patients were mutually exclusive. This comparison group was also linked with social security data at Statistics Netherlands (<italic>N</italic>=91 593).</p></sec><sec><title>Work-related outcomes</title><sec><title>Loss of paid employment</title><p>Individual, personal yearly income for each women was available for 1999–2010 and was based on income tax data. We defined loss of paid employment as no income from employment for at least two consecutive years since BC diagnosis, and only considered women who had had income from employment before BC.</p></sec><sec><title>Disability Benefits</title><p>In the Netherlands, during the first two years of sick leave, the employer continues paying at least 70% of the employee's last salary (<xref ref-type="supplementary-material" rid="sup1">Supplementary Appendix 2</xref>). In principle, the employee cannot be fired during this period. There is no national registry that tracks sick days of employees during these first two years. That means that women on sick leave are considered to have an income from employment in these first two years. If a patient is considered unable to work after two years, she is entitled to a disability pension to compensate for salary-loss if the salary loss is >35%. However, when recovery from an illness is considered unlikely, a disability pension can be obtained from 3 weeks after the first sick-day.</p></sec><sec><title>Unemployment Benefits and Social Welfare</title><p>In the Netherlands, everyone with paid employment is eligible to receive unemployment benefits, the duration of which depends on the individual's working history. After the maximum duration of unemployment benefits (3 years and 3 months), local governments are responsible for the last resort of the Dutch Social Security System: social welfare. Information received from Statistics Netherlands included starting date and stop date of unemployment benefits or welfare.</p></sec><sec><title>Combined measure of work-related events</title><p>Because social security policies differ between countries, we composed the measure ‘any work-related event', reflecting an overall change in employment status based on either loss of paid employment, receipt of disability pension, unemployment benefits or welfare.</p></sec></sec><sec><title>BC-subsample</title><p>Data on subsequent breast cancer events (local, regional or distal recurrence), collected by the NCR, were available up to 7 years after BC diagnosis for 14 916 women without distant metastases at initial BC diagnosis. We studied clinical factors associated with employment outcomes in this subsample.</p></sec><sec><title>Statistical analysis</title><p>BC stage was based on clinical and pathological information. We classified primary treatment as receipt of chemotherapy (yes/no), hormonal therapy (yes/no), axillary lymph node dissection (yes/no), and receipt of either lumpectomy with radiotherapy, mastectomy with radiotherapy, mastectomy without radiotherapy, or other local therapy. Information on subsequent cancer events in the subsample was categorized (yes/no) as non-invasive BC; invasive BC localized; invasive BC metastasized or non-breast second primary malignancy, other than non-melanoma skin cancer.</p><p>We compared the prevalence of work-related events from one year prior to diagnosis up to ten years after diagnosis between patients in the BC cohort and the general population sample, and estimated cumulative incidence of work-related events, accounting for death as competing event.</p><p>Cox regression was used to compare the risk of work-related events <italic>after</italic> BC diagnosis between BC patients and population controls, accounting for age, individual income before diagnosis (lowest tertile, middle tertle, highest tertile) and self-employment. Analysis were adjusted for self-employment as protection through insurance against loss of income due to unemployment, sickness and disability is fairly expensive in the Netherlands for self-employed as this is not organized by the government but largely left to the private sector. We used the first date of the event in the analyses. Because of non-proportional hazards over time, analyses were performed for four separate time intervals: up to 2 years, 2 to 5 years, 5 to 7 years and 7 to 10 years after diagnosis.</p><p>We investigated the impact of breast cancer treatment on work-related outcomes in the BC-subsample using multivariable Cox regression models with age as timescale, and adjusted for income before diagnosis, self-employment and new cancer events. New cancer events were included as time-dependent covariates. All analyses were performed using STATA statistical software (Stata 13, StataCorp LP, College Station, TX, USA).</p></sec></sec><sec><title>Results</title><sec><title>Comparisons with the population control group</title><p>Prior to diagnosis, 69.2% of the BC survivors and 66.6% of the population controls had paid employment (<xref ref-type="fig" rid="fig1">Figure 1</xref>). The cumulative incidence of paid employment decreased over time more strongly among BC survivors than among population controls (<italic>P</italic><0.001, <xref ref-type="fig" rid="fig2">Figure 2</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 1</xref>). The cumulative incidence of <italic>loss of paid employment</italic> was 51.1% among BC survivors compared to 46.3% among population controls after 10 years of follow-up.</p><p>Among BC survivors, the prevalence of receiving <italic>disability benefits</italic> increased strongly in the first two years after diagnosis from 9.2% prior to BC diagnosis to 25.3% two years later, whereas among population controls the prevalence of disability benefits remained fairly stable (7.7% at inclusion and 9.9% at two years; <xref ref-type="fig" rid="fig1">Figure 1</xref>). During follow-up, BC survivors maintained a higher cumulative incidence of disability benefits (<italic>P</italic><0.001, <xref ref-type="fig" rid="fig2">Figure 2</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 1</xref>). At 10 years of follow-up, the cumulative incidence of obtaining disability benefits was 32.7% among BC survivors and 14.1% among population controls.</p><p>Before diagnosis, around 3% of both the BC patients and population controls received <italic>unemployment benefits</italic> (<xref ref-type="fig" rid="fig1">Figure 1</xref>). The cumulative incidence of unemployment benefits did not differ between BC survivors and population controls (<xref ref-type="fig" rid="fig2">Figure 2</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 1</xref>).</p><p>Prior to diagnosis 4.6% of the BC patients and 4.3% of population controls received social <italic>welfare.</italic> During follow-up BC patients were at slightly increased risk of receiving welfare (<italic>P</italic><0.001; <xref ref-type="fig" rid="fig2">Figure 2</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 1</xref>), so that after 10 years of follow-up cumulative incidence of women receiving welfare was 7.9% among BC survivors and 7.4% among the population controls.</p><p>After 10 years of follow-up, 65.5% of the BC patients and 50.6% of the population controls had experienced at least one of these work-related events (<italic>P</italic><0.001, <xref ref-type="fig" rid="fig2">Figure 2</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 1</xref>).</p><p><xref rid="tbl1" ref-type="table">Table 1</xref> compares risks for work-related events among BC survivors to risk among population controls. The risk of <italic>loss of personal income</italic> was increased in BC survivors up to 5–7 years after BC diagnosis (HR 0–2 years: 1.3, 95% CI 1.2–1.3; HR 2–5 years: 2.0, 95% CI 1.9–2.1; HR 5–7 years 1.6, 95% CI 1.4–1.8), but did not differ from that in population controls 7–10 years after BC diagnosis. Risk was increased to a lesser extent among BC survivors aged 50–55 years compared to BC patients <50 years at diagnosis (<italic>P</italic><sub>interaction</sub><0.001). Except for the period 7–10 years after BC diagnosis, risk of loss of personal income increased with stage (<xref ref-type="supplementary-material" rid="sup1">Supplementary Table 2</xref>). The effect of income before diagnosis on risk of loss of personal income differed between BC patients and general population controls during the first 5 years of follow-up (<italic>P</italic><sub>interaction</sub> <0.001, <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 2</xref>). Whereas 0–2 years after diagnosis risk more strongly decreased with income among BC patients than controls, at 2–5 years risk was higher for BC patients in the second or third tertile of income. Self-employed BC patients had a lower risk of loss of personal income.</p><p>BC survivors had a strongly increased risk of obtaining <italic>disability benefits</italic>, irrespective of follow-up interval. Whereas among controls risks increased with age, BC patients had considerably higher risks at younger ages (<italic>P</italic><sub>interaction</sub><0.001, <xref rid="tbl1" ref-type="table">Table 1</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 3</xref>). In the first two years post-diagnosis, the risk of obtaining disability benefits was 13.3-fold increased (95% CI 9.7–18.1) among women <35 years and 7.1-fold increased among women aged 50–55 years with stage I BC. The risk of obtaining disability benefits was still 3.3-fold increased among women <35 years and 1.9-fold increased among women aged 45–50 with stage I BC at 7–10 years of follow-up. Risk of disability benefits increased with higher BC stage in all intervals. Self-employed BC patients less often received disability benefits.</p><p>BC survivors had a slightly higher risk of obtaining <italic>unemployment</italic> benefits in the interval 2–5 years after diagnosis (HR 1.2, 95% CI 1.1–1.3). Risk did not differ by stage and appeared to be limited to BC patients in the lower or middle tertile of income (HR 1.3, 95% CI 1.1–1.5 and HR 1.4, 95% CI 1.2–1.7, respectively; <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 4</xref>). BC survivors had a higher risk of obtaining <italic>welfare</italic> 0–2 years after diagnosis (HR 0–2 years 1.2, 95% CI 1.0–1.5, <xref rid="tbl1" ref-type="table">Table 1</xref> and <xref ref-type="supplementary-material" rid="sup1">Supplementary Table 5</xref>). Beyond 2 years of follow-up, uptake of welfare benefits did not differ between BC survivors and population controls.</p><p>Overall, BC survivors experienced markedly increased risks of <italic>any work-related event</italic> up to 7 years after diagnosis compared to population controls (HR at 5–7 years: 1.5, 95% CI 1.3–1.6, <xref rid="tbl1" ref-type="table">Table 1</xref>). At 7–10 years of follow-up, risk of a work-related event was only increased for BC survivors, aged 45–50 at diagnosis (HR 1.4, 95% CI 1.2–1.8), whereas BC survivors aged 50–55 at diagnosis even had a somewhat lower risk of experiencing a work-related event (HR 0.8, 95% CI 0.7–1.0). Risk of <italic>any work-related event</italic> increased with stage and with tertile of personal income before BC diagnosis for the first 5 years after BC diagnosis (<xref ref-type="supplementary-material" rid="sup1">Supplementary Table 6</xref>).</p></sec><sec><title>Effects of treatment: Within cohort comparisons</title><p>The sub-cohort (<italic>N</italic>=14 916), in which effects of treatment were investigated did not differ from other BC survivors other than by initial stage (<xref ref-type="supplementary-material" rid="sup1">Supplementary Table 7</xref>). Treatment differed by age with BC patients <35 years women more often receiving mastectomy followed by radiotherapy, axillary dissection and chemotherapy than BC patients aged 50–55 years (<xref ref-type="supplementary-material" rid="sup1">Supplementary Table 8</xref>). Compared to women treated with lumpectomy followed by radiotherapy and adjusted for age, time since diagnosis, individual income before diagnosis, self-employment and subsequent cancer events, women treated with mastectomy followed by radiotherapy had a higher risk of obtaining disability benefits (HR 1.2, 95% CI 1.1–1.3) or any work-related event (HR 1.1, 95% CI 1.0–1.2) (<xref rid="tbl2" ref-type="table">Table 2</xref>). Axillary lymph node dissection was associated with increased risk of loss of personal income up to 5 years after diagnosis (HR 1.3, 95% CI 1.2–1.5) but not thereafter, as well as with obtaining disability benefits (HR 1.5, 95% CI 1.4–1.7) and any work-related event (HR 1.4, 95% CI 1.3–1.5).</p><p>Chemotherapy was associated with increased risk of obtaining disability benefits (HR 1.7, 95% CI 1.5–1.9) and any work-related event (HR 1.4, 95% CI 1.2–1.5) during the first 5 years after diagnosis. Women treated with mastectomy followed by radiotherapy had, on the other hand, a lower risk of obtaining unemployment benefits compared to women treated with lumpectomy followed by radiotherapy (HR 0.8, 95% CI 0.6–1.0). Women treated with hormonal therapy had lower risk of any work-related event than women not treated with hormonal therapy (HR 0.9, 95% CI 0.8–1.0).</p></sec></sec><sec><title>Discussion</title><p>This nationwide population-based study showed that BC survivors experienced increased risk of obtaining disability benefits up to ten years after diagnosis, increased risk of loss of paid employment up to 7 years after diagnosis and increased risk of obtaining unemployment benefits up to five years after diagnosis. The magnitude of risk of adverse work-related outcomes differed by age, with women diagnosed before 35 years of age having the highest risk of obtaining disability benefits and women aged 35–45 having the highest risk of obtaining unemployment benefits. BC survivors treated with mastectomy followed by radiotherapy, chemotherapy or axillary lymph node dissection experienced higher risk of adverse employment outcomes, other than unemployment.</p><p>Previously <xref ref-type="bibr" rid="bib10">de Boer <italic>et al</italic> (2009)</xref> found a 1.3-fold increased risk of unemployment among BC survivors. We found a smaller, 1.2-fold increased risk of obtaining unemployment benefits, limited to the period 2–5 years after diagnosis. This may be explained by differences in the definition of unemployment in both studies and the fact that the meta-analysis by de Boer and colleagues included studies from various countries with a diversity of social security systems. While in the meta-analysis various work-related outcomes such as sick leave and disability benefits were combined into one measure ‘not being employed', in contrast our study only considered women who actually received unemployment benefits. Our results for any work-related event, which probably better resembles the outcome used in the meta-analyses, however showed much higher risks.</p><p>In the first two years after BC diagnosis we found no increased risks of receiving unemployment benefits, which may reflect Dutch regulations (<xref ref-type="bibr" rid="bib36">Sharp and Timmons, 2011</xref>; <xref ref-type="bibr" rid="bib18">Gimeno <italic>et al</italic>, 2014</xref>). However, beyond 2 years after diagnosis BC survivors, and particularly those aged 35–45 at diagnosis, do appear to experience increased risk of losing their job. Life course specific factors, such as having young children at the time of BC diagnosis, may at least partly explain these differences in risk with age.</p><p>Although several previous studies observed higher risks of adverse employment outcomes with older age at diagnosis (<xref ref-type="bibr" rid="bib13">Drolet <italic>et al</italic>, 2005a</xref>; <xref ref-type="bibr" rid="bib8">Carlsen <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib19">Hassett <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib22">Islam <italic>et al</italic>, 2014</xref>) we found, in general, higher risks among women younger than 45 years at diagnosis. Although it may be expected that a serious illness such as breast cancer is associated with adverse employment outcomes, even 7–10 years after diagnosis the risk of obtaining disability benefits remains increased, particularly among younger BC patients. BC and its treatment is often more aggressive at younger ages and young BC survivors may therefore also face more severe long-term adverse effects, including those which are work-related (<xref ref-type="bibr" rid="bib4">Bloom <italic>et al</italic>, 2013</xref>). In addition, age-differences regarding survivorship issues have been reported. For instance, Ganz and colleagues found that younger BC survivors reported more impact of cancer on a range of life plans and activities, including working life, 5–10 years after diagnosis, compared to older women (<xref ref-type="bibr" rid="bib17">Ganz <italic>et al</italic>, 2002</xref>). It is therefore important to further investigate the needs of women in specific age groups to enhance sustainable return to work and to prevent these women from dropping out of the labor market long after their treatment has ended.</p><p>In line with previous studies (<xref ref-type="bibr" rid="bib14">Drolet <italic>et al</italic>, 2005b</xref>; <xref ref-type="bibr" rid="bib2">Balak <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib1">Ahn <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib25">Johnsson <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib19">Hassett <italic>et al</italic>, 2009</xref>; <xref ref-type="bibr" rid="bib16">Fantoni <italic>et al</italic>, 2010</xref>; <xref ref-type="bibr" rid="bib24">Johnsson <italic>et al</italic>, 2010</xref>; <xref ref-type="bibr" rid="bib3">Blinder <italic>et al</italic>, 2012</xref>; <xref ref-type="bibr" rid="bib21">Hedayati <italic>et al</italic>, 2012</xref>; <xref ref-type="bibr" rid="bib23">Jagsi <italic>et al</italic>, 2014</xref>), we found that patients treated with mastectomy followed by radiotherapy, axillary lymph node dissection or chemotherapy had higher risk of various work-related events, even after accounting for new cancer events. Mastectomy followed by radiotherapy and axillary lymph node dissection may influence working life long after treatment due to increased risk of chronic pain and lymphedema (<xref ref-type="bibr" rid="bib31">Nesvold <italic>et al</italic>, 2010</xref>; <xref ref-type="bibr" rid="bib15">Eaker <italic>et al</italic>, 2011</xref>). Although many side effects of chemotherapy are temporary (<xref ref-type="bibr" rid="bib15">Eaker <italic>et al</italic>, 2011</xref>), studies have found that chemotherapy may impact on cognitive functioning (<xref ref-type="bibr" rid="bib12">de Ruiter <italic>et al</italic>, 2011</xref>) and fatigue (<xref ref-type="bibr" rid="bib33">Reinertsen <italic>et al</italic>, 2010</xref>) up to 10 years after diagnosis. Both cognitive functioning and fatigue have been associated with impaired work functioning (<xref ref-type="bibr" rid="bib22">Islam <italic>et al</italic>, 2014</xref>). Further research is needed on underlying mechanisms causing long-term treatment side effects and their impact on employment.</p><p>In contrast to previous studies (<xref ref-type="bibr" rid="bib15">Eaker <italic>et al</italic>, 2011</xref>; <xref ref-type="bibr" rid="bib22">Islam <italic>et al</italic>, 2014</xref>), we found no increased risk of adverse work-related events after hormonal therapy. Most of these studies only assessed the effects on (short-term) sickness absence whereas in our study women were followed up to ten years after BC diagnosis. Women with hormone sensitive tumors have better overall prognoses and may less often need to obtain disability benefits.</p><p>As we accounted for new (breast) cancer events and the treatment effects appeared independent of subsequent (breast) cancer events, the effects of treatment we found do not merely reflect the underlying differences in stage.</p><sec><title>Strengths and limitations</title><p>Some limitations need to be considered when interpreting the results. First of all, we acknowledge that we present many significance tests and therefore caution against over-interpretation of our findings, especially when based on <italic>P</italic>-values >0.001. Furthermore, our study does reflect the Dutch social benefits and welfare system and therefore our results may not be fully generalizable to other countries in the European Union, let alone farther afield. In general, the structure of social security legislation in the Netherlands does provide reasonable protection to Dutch employees which may be less so elsewhere. The vulnerable position of young women has, however, been found in other countries as well, which may indicate that BC survivors share risk factors transcending mere effects of social security systems. Furthermore, our results need to be interpreted within the context of a continuously changing landscape, due to changes in both BC treatment and work-related legislation. Further research could focus on the impact of legislation on adverse work-related outcomes in order to improve the employment position of BC survivors.</p><p>Data on subsequent cancer events were only available for a part of our BC cohort. However, again our data did not provide any indication that the sub-cohort differed from other BC survivors other than by initial stage (women with tumor stage IV were not followed-up by the NCR). Furthermore, our study lacked information on reasons for losing paid employment and we have no information on, for instance, perceived work ability of the women in our study. In order to enhance sustainable work among BC survivors, more detailed information from BC survivors and other stakeholders, such as their employer and their colleagues is needed. Therefore the present study was followed-up by a survey study in order to gain more insight in factors hampering or facilitating employment after BC.</p><p>Nonetheless, this is one among few studies to evaluate adverse work-related events in a large, population-based cohort of fairly recently treated BC survivors beyond the first 5 years after initial BC treatment, with good quality data on initial treatment (<xref ref-type="bibr" rid="bib8">Carlsen <italic>et al</italic>, 2008</xref>; <xref ref-type="bibr" rid="bib20">Hauglann <italic>et al</italic>, 2012</xref>). We used highly reliable, high quality social security data from Dutch government institutions to identify identified work-related events using, instead of relying on self-reported outcomes, resulting in unbiased information. Furthermore, this study took new BC events into account when evaluating the effect of BC and its treatment on work-related outcomes.</p><p>Since many BC survivors will experience work-related problems and considering the fact that work is an important aspect of rehabilitation, work and return to work should be a standard topic to discuss after completion of treatment. Oncologists should timely refer patients, whenever patients may need support with work reintegration. In the Netherlands, several innovative rehabilitation programs are being initiated to improve the occupational rehabilitation of breast cancer patients, including support of occupational physicians with a specialised training in oncological issues (<xref ref-type="bibr" rid="bib41">Zaman <italic>et al</italic>, 2015</xref>) and hospital-based work support interventions (<xref ref-type="bibr" rid="bib38">Tamminga <italic>et al</italic>, 2013</xref>).</p></sec></sec></body><back><ack><p>Funding: This work was supported by Pink Ribbon [2011.WO17.C102]. The funding party had no role in study design, in the collection, analysis, and interpretation of data, in the writing of the report, nor in the decision to submit the article for publication.</p><p><bold>Authors Contributors</bold></p><p>Contributorship statement: FEvL, NKA, and MS were responsible for the study concept and design and obtained funding. CHP and MS acquired and analyzed the data. CHP, MS, FEvL and NKA interpreted the data. CHP and MS drafted the manuscript, which was critically revised for important intellectual content by all authors. All authors commented on and approved the final draft. MS is guarantor of the study. 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(<bold>B</bold>) % women with disability benefits. (<bold>C</bold>) % women with unemployment benefits. (<bold>D</bold>) % women on welfare. *<italic>P</italic><0.05; **<italic>P</italic><0.01; ***<italic>P</italic><0.001.</p></caption><graphic xlink:href="bjc2015431f1"></graphic></fig><fig id="fig2"><label>Figure 2</label><caption><p><bold>Cumulative incidence of losing paid employment and the uptake of social benefits during follow-up in BC patients and general population controls.</bold> (<bold>A</bold>) Loss of personal income. (<bold>B</bold>) Disability benefits. (<bold>C</bold>) Unemployment benefits. (<bold>D</bold>) Welfare. (<bold>E</bold>) Any work-related event.</p></caption><graphic xlink:href="bjc2015431f2"></graphic></fig><table-wrap id="tbl1"><label>Table 1</label><caption><title>Risk (HR) of work-related outcomes after diagnosis: BC survivors compared to general population controls by time since breast cancer diagnosis and age</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th><th colspan="2" align="center" valign="top" charoff="50">0–2 years after diagnosis HR 95%CI</th><th colspan="2" align="center" valign="top" charoff="50">2–5 years after diagnosis HR 95%CI</th><th colspan="2" align="center" valign="top" charoff="50">5–7 years after diagnosis HR 95%CI</th><th colspan="2" align="center" valign="top" charoff="50">7–10 years after diagnosis HR 95%CI</th></tr></thead><tbody valign="top"><tr><td align="left" valign="top" charoff="50"><bold>Loss of personal income</bold><xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="center" valign="top" charoff="50">1.3</td><td align="center" valign="top" charoff="50">1.2–1.3</td><td align="center" valign="top" charoff="50">2.0</td><td align="center" valign="top" charoff="50">1.9–2.1</td><td align="center" valign="top" charoff="50">1.6</td><td align="center" valign="top" charoff="50">1.4–1.8</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.9–1.1</td></tr><tr><td align="left" valign="top" charoff="50">Age differences (<italic>P</italic><sub>interaction</sub>)<xref ref-type="fn" rid="t1-fn4">b</xref></td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.020</td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> <35 at diagnosis</td><td align="center" valign="top" charoff="50">1.3</td><td align="center" valign="top" charoff="50">1.1–1.6</td><td align="center" valign="top" charoff="50">2.2</td><td align="center" valign="top" charoff="50">1.7–2.9</td><td align="center" valign="top" charoff="50">2.5</td><td align="center" valign="top" charoff="50">1.4–4.4</td><td align="center" valign="top" charoff="50">2.0<sup>#5</sup></td><td align="center" valign="top" charoff="50">1.0–4.3</td></tr><tr><td align="left" valign="top" charoff="50"> 35–45 at diagnosis</td><td align="center" valign="top" charoff="50">1.5</td><td align="center" valign="top" charoff="50">1.4–1.7</td><td align="center" valign="top" charoff="50">2.3</td><td align="center" valign="top" charoff="50">2.0–2.6</td><td align="center" valign="top" charoff="50">2.9</td><td align="center" valign="top" charoff="50">2.2–3.7</td><td align="center" valign="top" charoff="50">1.2</td><td align="center" valign="top" charoff="50">0.8–1.7</td></tr><tr><td align="left" valign="top" charoff="50"> 45–50 at diagnosis</td><td align="center" valign="top" charoff="50">1.4</td><td align="center" valign="top" charoff="50">1.2–4.6</td><td align="center" valign="top" charoff="50">2.1</td><td align="center" valign="top" charoff="50">1.9–2.3</td><td align="center" valign="top" charoff="50">2.0</td><td align="center" valign="top" charoff="50">1.7–2.5</td><td align="center" valign="top" charoff="50">1.3</td><td align="center" valign="top" charoff="50">0.9–1.7</td></tr><tr><td align="left" valign="top" charoff="50"> 50–55 at diagnosis</td><td align="center" valign="top" charoff="50">1.1<sup>#1</sup></td><td align="center" valign="top" charoff="50">1.0–1.2</td><td align="center" valign="top" charoff="50">1.7</td><td align="center" valign="top" charoff="50">1.6–1.9</td><td align="center" valign="top" charoff="50">1.2<sup>#3</sup></td><td align="center" valign="top" charoff="50">1.0–1.3</td><td align="center" valign="top" charoff="50">0.9<sup>#6</sup></td><td align="center" valign="top" charoff="50">0.7–1.0</td></tr><tr><td align="left" valign="top" charoff="50"><bold>Disability benefits</bold><xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="center" valign="top" charoff="50">14.7</td><td align="center" valign="top" charoff="50">13.8–15.8</td><td align="center" valign="top" charoff="50">5.1</td><td align="center" valign="top" charoff="50">4.7–5.6</td><td align="center" valign="top" charoff="50">2.8</td><td align="center" valign="top" charoff="50">2.4–3.4</td><td align="center" valign="top" charoff="50">2.0</td><td align="center" valign="top" charoff="50">1.6–2.5</td></tr><tr><td align="left" valign="top" charoff="50">Age differences (<italic>P</italic><sub>interaction</sub>)<xref ref-type="fn" rid="t1-fn4">b</xref></td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.023</td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> <35 at diagnosis</td><td align="center" valign="top" charoff="50">22.3</td><td align="center" valign="top" charoff="50">16.5–30.2</td><td align="center" valign="top" charoff="50">12.3</td><td align="center" valign="top" charoff="50">8.1–18.6</td><td align="center" valign="top" charoff="50">5.8</td><td align="center" valign="top" charoff="50">2.6–12.8</td><td align="center" valign="top" charoff="50">4.0</td><td align="center" valign="top" charoff="50">1.7–9.7</td></tr><tr><td align="left" valign="top" charoff="50"> 35–45 at diagnosis</td><td align="center" valign="top" charoff="50">18.5</td><td align="center" valign="top" charoff="50">16.2–21.0</td><td align="center" valign="top" charoff="50">7.0</td><td align="center" valign="top" charoff="50">5.9–8.3</td><td align="center" valign="top" charoff="50">4.6</td><td align="center" valign="top" charoff="50">3.5–6.1</td><td align="center" valign="top" charoff="50">2.6</td><td align="center" valign="top" charoff="50">1.8–3.8</td></tr><tr><td align="left" valign="top" charoff="50"> 45–50 at diagnosis</td><td align="center" valign="top" charoff="50">16.0</td><td align="center" valign="top" charoff="50">14.2–18.1</td><td align="center" valign="top" charoff="50">4.6</td><td align="center" valign="top" charoff="50">3.4–5.4</td><td align="center" valign="top" charoff="50">2.9</td><td align="center" valign="top" charoff="50">2.1–3.8</td><td align="center" valign="top" charoff="50">2.1</td><td align="center" valign="top" charoff="50">1.4–2.9</td></tr><tr><td align="left" valign="top" charoff="50"> 50–55 at diagnosis</td><td align="center" valign="top" charoff="50">11.1</td><td align="center" valign="top" charoff="50">10.0–12.4</td><td align="center" valign="top" charoff="50">3.8</td><td align="center" valign="top" charoff="50">3.2–4.4</td><td align="center" valign="top" charoff="50">1.4<sup>#4</sup></td><td align="center" valign="top" charoff="50">1.0–2.0</td><td align="center" valign="top" charoff="50">1.2</td><td align="center" valign="top" charoff="50">0.8–1.9</td></tr><tr><td align="left" valign="top" charoff="50"><bold>Unemployment benefits</bold><xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.9–1.1</td><td align="center" valign="top" charoff="50">1.2</td><td align="center" valign="top" charoff="50">1.1–1.3</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.8–1.1</td><td align="center" valign="top" charoff="50">0.8<sup>#7</sup></td><td align="center" valign="top" charoff="50">0.7–1.0</td></tr><tr><td align="left" valign="top" charoff="50">Age differences (<italic>P</italic><sub>interaction</sub>)<xref ref-type="fn" rid="t1-fn4">b</xref></td><td align="center" valign="top" charoff="50">0.28</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.88</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.06</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.32</td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"><bold>Welfare pension</bold><xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="center" valign="top" charoff="50">1.2<sup>#2</sup></td><td align="center" valign="top" charoff="50">1.0–1.5</td><td align="center" valign="top" charoff="50">1.1</td><td align="center" valign="top" charoff="50">0.9–1.4</td><td align="center" valign="top" charoff="50">0.8</td><td align="center" valign="top" charoff="50">0.6–1.2</td><td align="center" valign="top" charoff="50">0.9</td><td align="center" valign="top" charoff="50">0.7–1.3</td></tr><tr><td align="left" valign="top" charoff="50">Age differences (<italic>P</italic><sub>interaction</sub>)<xref ref-type="fn" rid="t1-fn4">b</xref></td><td align="center" valign="top" charoff="50">0.31</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.45</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.83</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.64</td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"><bold>Any work-related event</bold><xref ref-type="fn" rid="t1-fn3">a</xref></td><td align="center" valign="top" charoff="50">3.8</td><td align="center" valign="top" charoff="50">3.7–4.0</td><td align="center" valign="top" charoff="50">1.6</td><td align="center" valign="top" charoff="50">1.5–1.7</td><td align="center" valign="top" charoff="50">1.5</td><td align="center" valign="top" charoff="50">1.3–1.6</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.9–1.2</td></tr><tr><td align="left" valign="top" charoff="50">Age differences (<italic>P</italic><sub>interaction</sub>)<xref ref-type="fn" rid="t1-fn4">b</xref></td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"><0.001</td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> <35 at diagnosis</td><td align="center" valign="top" charoff="50">3.6</td><td align="center" valign="top" charoff="50">3.0–4.2</td><td align="center" valign="top" charoff="50">1.7</td><td align="center" valign="top" charoff="50">1.3–2.2</td><td align="center" valign="top" charoff="50">2.4</td><td align="center" valign="top" charoff="50">1.5–3.8</td><td align="center" valign="top" charoff="50">1.1</td><td align="center" valign="top" charoff="50">0.5–2.2</td></tr><tr><td align="left" valign="top" charoff="50"> 35–45 at diagnosis</td><td align="center" valign="top" charoff="50">4.3</td><td align="center" valign="top" charoff="50">4.0–4.7</td><td align="center" valign="top" charoff="50">2.1</td><td align="center" valign="top" charoff="50">1.8–2.3</td><td align="center" valign="top" charoff="50">2.3</td><td align="center" valign="top" charoff="50">1.9–2.7</td><td align="center" valign="top" charoff="50">1.2</td><td align="center" valign="top" charoff="50">0.9–1.6</td></tr><tr><td align="left" valign="top" charoff="50"> 45–50 at diagnosis</td><td align="center" valign="top" charoff="50">4.4</td><td align="center" valign="top" charoff="50">4.1–4.8</td><td align="center" valign="top" charoff="50">1.7</td><td align="center" valign="top" charoff="50">1.5–1.9</td><td align="center" valign="top" charoff="50">1.6</td><td align="center" valign="top" charoff="50">1.3–1.9</td><td align="center" valign="top" charoff="50">1.4</td><td align="center" valign="top" charoff="50">1.2–1.8</td></tr><tr><td align="left" valign="top" charoff="50"> 50–55 at diagnosis</td><td align="center" valign="top" charoff="50">3.1</td><td align="center" valign="top" charoff="50">2.9–3.4</td><td align="center" valign="top" charoff="50">1.4</td><td align="center" valign="top" charoff="50">1.2–1.5</td><td align="center" valign="top" charoff="50">1.1</td><td align="center" valign="top" charoff="50">0.9–1.2</td><td align="center" valign="top" charoff="50">0.8<sup>#8</sup></td><td align="center" valign="top" charoff="50">0.7–1.0</td></tr></tbody></table><table-wrap-foot><fn id="t1-fn1"><p>Abbreviations: HR=Hazard ratio; 95% CI=95% confidence interval. Differences in HRs of the outcome measures between follow-up intervals were all significant (<italic>P</italic><0.001 loss of personal income, disability benefits, unemployment benefits, any work-related event and <italic>P</italic><0.005 for welfare pension).</p></fn><fn id="t1-fn2"><p><sup>#1</sup><italic>P</italic>=0.34; <sup>#2</sup><italic>P</italic>=0.034; <sup>#3</sup><italic>P</italic>=0.018; <sup>#4</sup><italic>P</italic>=0.057; <sup>#5</sup><italic>P</italic>=0.063; <sup>#6</sup><italic>P</italic>=0.064; <sup>#7</sup><italic>P</italic>=0.035; <sup>#8</sup><italic>P</italic>=0.044.</p></fn><fn id="t1-fn3"><label>a</label><p>adjusted for age, income before diagnosis and being self-employed (no interactions).</p></fn><fn id="t1-fn4"><label>b</label><p>adjusted for age, income before diagnosis and being self-employed (evaluation of interaction for age, averaged effect over stage).</p></fn></table-wrap-foot></table-wrap><table-wrap id="tbl2"><label>Table 2</label><caption><title>Associations of treatment for primary BC with work-related outcomes <italic>after</italic> BC in the BC subsample</title></caption><table frame="hsides" rules="groups" border="1"><colgroup><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="left"></col><col align="center"></col><col align="center"></col><col align="center"></col><col align="center"></col></colgroup><thead valign="bottom"><tr><th align="left" valign="top" charoff="50"> </th><th colspan="3" align="center" valign="top" charoff="50">Loss of personal income<hr></hr></th><th colspan="3" align="center" valign="top" charoff="50">Disability benefits<hr></hr></th><th colspan="3" align="center" valign="top" charoff="50">Unemployment benefits<hr></hr></th><th colspan="3" align="center" valign="top" charoff="50">Any work-related event<hr></hr></th></tr><tr><th align="left" valign="top" charoff="50"> </th><th align="center" valign="top" charoff="50">Tot/event*</th><th align="center" valign="top" charoff="50">HR**</th><th align="center" valign="top" charoff="50">95%CI</th><th align="center" valign="top" charoff="50">Tot/event</th><th align="center" valign="top" charoff="50">HR</th><th align="center" valign="top" charoff="50">95%CI</th><th align="center" valign="top" charoff="50">Tot/event</th><th align="left" valign="top" charoff="50">HR</th><th align="center" valign="top" charoff="50">95%CI</th><th align="center" valign="top" charoff="50">Tot/event</th><th align="center" valign="top" charoff="50">HR</th><th align="center" valign="top" charoff="50">95%CI</th></tr></thead><tbody valign="top"><tr><td colspan="13" align="left" valign="top" charoff="50"><bold>Surgery</bold><hr></hr></td></tr><tr><td align="left" valign="top" charoff="50">Lumpectomy & RT***</td><td align="center" valign="top" charoff="50">5920/1275</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">Ref</td><td align="center" valign="top" charoff="50">6997/1278</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">Ref</td><td align="center" valign="top" charoff="50">7216/553</td><td align="char" valign="top" char="." charoff="50">1.0</td><td align="center" valign="top" charoff="50">Ref</td><td align="center" valign="top" charoff="50">4841/1794</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">Ref</td></tr><tr><td align="left" valign="top" charoff="50">Mastectomy</td><td align="center" valign="top" charoff="50">2965/652</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.9–1.1</td><td align="center" valign="top" charoff="50">3653/717</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.9–1.1</td><td align="center" valign="top" charoff="50">3814/267</td><td align="char" valign="top" char="." charoff="50">0.9</td><td align="center" valign="top" charoff="50">0.8–1.1</td><td align="center" valign="top" charoff="50">2425/971</td><td align="center" valign="top" charoff="50">1.0<sup>#6</sup></td><td align="center" valign="top" charoff="50">1.0–1.1</td></tr><tr><td align="left" valign="top" charoff="50">Mastectomy & RT</td><td align="center" valign="top" charoff="50">1940/474</td><td align="center" valign="top" charoff="50">1.1<sup>#1</sup></td><td align="center" valign="top" charoff="50">1.0–1.3</td><td align="center" valign="top" charoff="50">2384/701</td><td align="center" valign="top" charoff="50">1.2</td><td align="center" valign="top" charoff="50">1.1–1.3</td><td align="center" valign="top" charoff="50">2488/130</td><td align="char" valign="top" char="." charoff="50">0.8<sup>#4</sup></td><td align="center" valign="top" charoff="50">0.6–1.0</td><td align="center" valign="top" charoff="50">1582/754</td><td align="center" valign="top" charoff="50">1.1<sup>#7</sup></td><td align="center" valign="top" charoff="50">1.0–1.2</td></tr><tr><td align="left" valign="top" charoff="50">Axillary lymph node dissection</td><td align="center" valign="top" charoff="50">6463/1535</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">7930/1975</td><td align="center" valign="top" charoff="50">1.5</td><td align="center" valign="top" charoff="50">1.4–1.7</td><td align="center" valign="top" charoff="50">8242/557</td><td align="char" valign="top" char="." charoff="50">1.1<sup>#5</sup></td><td align="center" valign="top" charoff="50">1.0–1.3</td><td align="center" valign="top" charoff="50">5315/2364</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> <5 years after diagnosis</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">1.3</td><td align="center" valign="top" charoff="50">1.2–1.5</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">1.4</td><td align="center" valign="top" charoff="50">1.3–1.5</td></tr><tr><td align="left" valign="top" charoff="50"> >5 years after diagnosis</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">0.8<sup>#2</sup></td><td align="center" valign="top" charoff="50">0.6–1.0</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.8–1.3</td></tr><tr><td align="left" valign="top" charoff="50">Chemotherapy</td><td align="center" valign="top" charoff="50">7019/1560</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.9–1.2</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">8601/582</td><td align="char" valign="top" char="." charoff="50">0.9</td><td align="center" valign="top" charoff="50">0.8–1.1</td><td align="center" valign="top" charoff="50">5745/2466</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td></tr><tr><td align="left" valign="top" charoff="50"> <5 years after diagnosis</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">1.7</td><td align="center" valign="top" charoff="50">1.5–1.9</td><td align="center" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">1.4</td><td align="center" valign="top" charoff="50">1.2–1.5</td></tr><tr><td align="left" valign="top" charoff="50"> >5 years after diagnosis</td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.7–1.3</td><td align="center" valign="top" charoff="50"> </td><td align="left" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50"> </td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.8–1.2</td></tr><tr><td align="left" valign="top" charoff="50">Hormone therapy</td><td align="center" valign="top" charoff="50">4899/1132</td><td align="center" valign="top" charoff="50">1.0</td><td align="center" valign="top" charoff="50">0.9–1.1</td><td align="center" valign="top" charoff="50">5839/1362</td><td align="center" valign="top" charoff="50">0.9<sup>#3</sup></td><td align="center" valign="top" charoff="50">0.9–1.0</td><td align="center" valign="top" charoff="50">6067/403</td><td align="char" valign="top" char="." charoff="50">0.9</td><td align="center" valign="top" charoff="50">0.8–1.1</td><td align="center" valign="top" charoff="50">4019/1663</td><td align="center" valign="top" charoff="50">0.9<sup>#8</sup></td><td align="center" valign="top" charoff="50">0.8–1.0</td></tr></tbody></table><table-wrap-foot><fn id="t2-fn1"><p>Abbreviations: *Tot= total; **HR= hazard ratio; 95% CI =95% confidence interval; ***RT= radiotherapy.</p></fn><fn id="t2-fn2"><p>Note1: Model adjusted for age (time scale, continuous), time since diagnosis (0–2, 2–5, 5–7 and ⩾7 years), self-employment, individual income before diagnosis (tertiles) and new (breast) cancer events (time-varying). Data for subsequent breast events (loco-regional recurrence and/or distant metastases) were available up to 6 years after diagnosis, data for new cancer events (including newly diagnosed ipsilateral or contralateral breast cancer) up to 10 year after diagnosis.</p></fn><fn id="t2-fn3"><p><sup>#1</sup><italic>P</italic>=0.051; <sup>#2</sup><italic>P</italic>=0.10; <sup>#3</sup><italic>P</italic>=0.12; <sup>#4</sup><italic>P</italic>=0.011; <sup>#5</sup><italic>P</italic>=0.15; <sup>#6</sup><italic>P</italic>=0.47; <sup>#7</sup><italic>P</italic>=0.018.; <sup>#8</sup><italic>P</italic>=0.021.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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