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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Three-dimensional optical imaging of microvascular networks within intact lymph node <italic>in vivo</italic>
</title>
<author><name sortKey="Jung, Yeongri" sort="Jung, Yeongri" uniqKey="Jung Y" first="Yeongri" last="Jung">Yeongri Jung</name>
</author>
<author><name sortKey="Zhi, Zhongwei" sort="Zhi, Zhongwei" uniqKey="Zhi Z" first="Zhongwei" last="Zhi">Zhongwei Zhi</name>
</author>
<author><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">21054073</idno>
<idno type="pmc">2966489</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2966489</idno>
<idno type="RBID">PMC:2966489</idno>
<idno type="doi">10.1117/1.3496301</idno>
<date when="2010">2010</date>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Three-dimensional optical imaging of microvascular networks within intact lymph node <italic>in vivo</italic>
</title>
<author><name sortKey="Jung, Yeongri" sort="Jung, Yeongri" uniqKey="Jung Y" first="Yeongri" last="Jung">Yeongri Jung</name>
</author>
<author><name sortKey="Zhi, Zhongwei" sort="Zhi, Zhongwei" uniqKey="Zhi Z" first="Zhongwei" last="Zhi">Zhongwei Zhi</name>
</author>
<author><name sortKey="Wang, Ruikang K" sort="Wang, Ruikang K" uniqKey="Wang R" first="Ruikang K." last="Wang">Ruikang K. Wang</name>
</author>
</analytic>
<series><title level="j">Journal of Biomedical Optics</title>
<idno type="ISSN">1083-3668</idno>
<idno type="eISSN">1560-2281</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
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<front><div type="abstract" xml:lang="en"><p>Sentinel lymph nodes (SLNs) are the first lymph nodes to drain wastes originated from cancerous tissue. There is a need for an <italic>in vivo</italic>
imaging method that can image the intact SLN to further our understanding of its normal as well as abnormal functions. We report the use of ultrahigh sensitive optical microangiography (UHS-OMAG) to image functional microvascular and lymphatic vessel networks that innervate the intact lymph node in mice <italic>in vivo.</italic>
The promising results show a potential role of UHS-OMAG in the future understanding and diagnosis of the SLN involvement in cancer development.</p>
</div>
</front>
</TEI>
<pmc article-type="letter"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Biomed Opt</journal-id>
<journal-title-group><journal-title>Journal of Biomedical Optics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1083-3668</issn>
<issn pub-type="epub">1560-2281</issn>
<publisher><publisher-name>Society of Photo-Optical Instrumentation Engineers</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">21054073</article-id>
<article-id pub-id-type="pmc">2966489</article-id>
<article-id pub-id-type="publisher-id">041005JBO</article-id>
<article-id pub-id-type="doi">10.1117/1.3496301</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>JBO Letters</subject>
</subj-group>
</article-categories>
<title-group><article-title>Three-dimensional optical imaging of microvascular networks within intact lymph node <italic>in vivo</italic>
</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Jung</surname>
<given-names>Yeongri</given-names>
</name>
<xref ref-type="author-notes" rid="n2">b)</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Zhi</surname>
<given-names>Zhongwei</given-names>
</name>
<xref ref-type="author-notes" rid="n2">b)</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Wang</surname>
<given-names>Ruikang K.</given-names>
</name>
<xref ref-type="author-notes" rid="n1">a)</xref>
</contrib>
<aff>Oregon Health & Science University, Department of Biomedical Engineering 3303 SW Bond Avenue, Portland, Oregon 97239</aff>
</contrib-group>
<author-notes><fn id="n2"><label>b)</label>
<p>These authors contributed equally to this work.</p>
</fn>
<fn id="n1"><label>a)</label>
<p>Address all correspondence to Ruikang K. Wang. Tel: 503-418-9317; Fax: 503-418-9311; E-mail: <email>r.k.wang@bme.ogi.edu</email>
.</p>
</fn>
</author-notes>
<pub-date pub-type="ppub"><season>September-October</season>
<year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>06</day>
<month>10</month>
<year>2010</year>
</pub-date>
<volume>15</volume>
<issue>5</issue>
<elocation-id>050501</elocation-id>
<history><date date-type="received"><day>03</day>
<month>7</month>
<year>2010</year>
</date>
<date date-type="rev-recd"><day>31</day>
<month>8</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>02</day>
<month>9</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2010 Society of Photo-Optical Instrumentation Engineers</copyright-statement>
<copyright-year>2010</copyright-year>
<copyright-holder>Society of Photo-Optical Instrumentation Engineers</copyright-holder>
</permissions>
<abstract><p>Sentinel lymph nodes (SLNs) are the first lymph nodes to drain wastes originated from cancerous tissue. There is a need for an <italic>in vivo</italic>
imaging method that can image the intact SLN to further our understanding of its normal as well as abnormal functions. We report the use of ultrahigh sensitive optical microangiography (UHS-OMAG) to image functional microvascular and lymphatic vessel networks that innervate the intact lymph node in mice <italic>in vivo.</italic>
The promising results show a potential role of UHS-OMAG in the future understanding and diagnosis of the SLN involvement in cancer development.</p>
</abstract>
<kwd-group><kwd>lymph node</kwd>
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<kwd>lymphangiography</kwd>
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</kwd-group>
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