Two- to Four-Year Follow-up Results of Total Knee Arthroplasty Using a New High-Flexion Prosthesis
Identifieur interne : 000783 ( Pmc/Corpus ); précédent : 000782; suivant : 000784Two- to Four-Year Follow-up Results of Total Knee Arthroplasty Using a New High-Flexion Prosthesis
Auteurs : Man Soo Kim ; In Jun Koh ; Sung Won Jang ; Neung Han Jeon ; Yong InSource :
- Knee Surgery & Related Research [ 2234-0726 ] ; 2016.
Abstract
The purpose of this study was to evaluate minimum 2-year follow-up results of total knee arthroplasty (TKA) performed using a new high-flexion prosthesis design (LOSPA).
The 2- to 4-year results of 191 consecutive TKAs (177 patients) with the LOSPA posterior-stabilized prosthesis were evaluated. The patients were assessed clinically and radiographically using the Knee Society scoring system (KSS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).
The mean range of motion (ROM) increased significantly from 117.4° (range, 75° to 140°) preoperatively to 126.7° (range, 80° to 144°) postoperatively (p<0.001). The mean KSS and WOMAC scores improved significantly from 121.4 (range, 42 to 185) and 56.1 (range, 23 to 88) preoperatively to 174.0 (range, 130 to 200) and 16.4 (range, 0 to 85) postoperatively, respectively (both, p<0.001). One knee required revision for deep infection. No knee had aseptic loosening or osteolysis. Radiolucent lines were noted in 15 knees (7.9%).
The new high-flexion total knee prosthesis resulted in no early aseptic loosening of the component and improved postoperative ROM comparable to other high-flexion TKA prostheses at 2- to 4-year follow-ups.
Url:
DOI: 10.5792/ksrr.2016.28.1.39
PubMed: 26955612
PubMed Central: 4779804
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Two- to Four-Year Follow-up Results of Total Knee Arthroplasty Using a New High-Flexion Prosthesis</title><author><name sortKey="Kim, Man Soo" sort="Kim, Man Soo" uniqKey="Kim M" first="Man Soo" last="Kim">Man Soo Kim</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="Koh, In Jun" sort="Koh, In Jun" uniqKey="Koh I" first="In Jun" last="Koh">In Jun Koh</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="Jang, Sung Won" sort="Jang, Sung Won" uniqKey="Jang S" first="Sung Won" last="Jang">Sung Won Jang</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="Jeon, Neung Han" sort="Jeon, Neung Han" uniqKey="Jeon N" first="Neung Han" last="Jeon">Neung Han Jeon</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="In, Yong" sort="In, Yong" uniqKey="In Y" first="Yong" last="In">Yong In</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26955612</idno><idno type="pmc">4779804</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4779804</idno><idno type="RBID">PMC:4779804</idno><idno type="doi">10.5792/ksrr.2016.28.1.39</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000783</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000783</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Two- to Four-Year Follow-up Results of Total Knee Arthroplasty Using a New High-Flexion Prosthesis</title><author><name sortKey="Kim, Man Soo" sort="Kim, Man Soo" uniqKey="Kim M" first="Man Soo" last="Kim">Man Soo Kim</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="Koh, In Jun" sort="Koh, In Jun" uniqKey="Koh I" first="In Jun" last="Koh">In Jun Koh</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="Jang, Sung Won" sort="Jang, Sung Won" uniqKey="Jang S" first="Sung Won" last="Jang">Sung Won Jang</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="Jeon, Neung Han" sort="Jeon, Neung Han" uniqKey="Jeon N" first="Neung Han" last="Jeon">Neung Han Jeon</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author><author><name sortKey="In, Yong" sort="In, Yong" uniqKey="In Y" first="Yong" last="In">Yong In</name><affiliation><nlm:aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</nlm:aff></affiliation></author></analytic><series><title level="j">Knee Surgery & Related Research</title><idno type="ISSN">2234-0726</idno><idno type="eISSN">2234-2451</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>The purpose of this study was to evaluate minimum 2-year follow-up results of total knee arthroplasty (TKA) performed using a new high-flexion
prosthesis design (LOSPA).</p></sec><sec><title>Materials and Methods</title><p>The 2- to 4-year results of 191 consecutive TKAs (177 patients) with the LOSPA posterior-stabilized prosthesis were evaluated. The patients were assessed clinically and radiographically using the Knee Society scoring system (KSS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).</p></sec><sec><title>Results</title><p>The mean range of motion (ROM) increased significantly from 117.4° (range, 75° to 140°) preoperatively to 126.7° (range, 80° to 144°) postoperatively (p<0.001). The mean KSS and WOMAC scores improved significantly from 121.4 (range, 42 to 185) and 56.1 (range, 23 to 88) preoperatively to 174.0 (range, 130 to 200) and 16.4 (range, 0 to 85) postoperatively, respectively (both, p<0.001). One knee required revision for deep infection. No knee had aseptic loosening or osteolysis. Radiolucent lines were noted in 15 knees (7.9%).</p></sec><sec><title>Conclusions</title><p>The new high-flexion total knee prosthesis resulted in no early aseptic loosening of the component and improved postoperative ROM comparable to other high-flexion TKA prostheses at 2- to 4-year follow-ups.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Heiberg, K" uniqKey="Heiberg K">K Heiberg</name></author><author><name sortKey="Bruun Olsen, V" uniqKey="Bruun Olsen V">V Bruun-Olsen</name></author><author><name sortKey="Mengshoel, Am" uniqKey="Mengshoel A">AM Mengshoel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kurosaka, M" uniqKey="Kurosaka M">M Kurosaka</name></author><author><name sortKey="Yoshiya, S" uniqKey="Yoshiya S">S Yoshiya</name></author><author><name sortKey="Mizuno, K" uniqKey="Mizuno K">K Mizuno</name></author><author><name sortKey="Yamamoto, T" uniqKey="Yamamoto T">T 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Knee Surg Relat Res</journal-id><journal-id journal-id-type="iso-abbrev">Knee Surg Relat Res</journal-id><journal-id journal-id-type="publisher-id">KSRR</journal-id><journal-title-group><journal-title>Knee Surgery & Related Research</journal-title></journal-title-group><issn pub-type="ppub">2234-0726</issn><issn pub-type="epub">2234-2451</issn><publisher><publisher-name>The Korean Knee Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26955612</article-id><article-id pub-id-type="pmc">4779804</article-id><article-id pub-id-type="doi">10.5792/ksrr.2016.28.1.39</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Two- to Four-Year Follow-up Results of Total Knee Arthroplasty Using a New High-Flexion Prosthesis</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Man Soo</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name><surname>Koh</surname><given-names>In Jun</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name><surname>Jang</surname><given-names>Sung Won</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author"><name><surname>Jeon</surname><given-names>Neung Han</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>In</surname><given-names>Yong</given-names></name><degrees>MD</degrees><xref ref-type="aff" rid="A1"></xref></contrib></contrib-group><aff id="A1">Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, Seoul, Korea.</aff><author-notes><corresp>Correspondence to: Yong In, MD. Department of Orthopaedic Surgery, Seoul St. Mary's Hospital, The Catholic University of Korea College of Medicine, 222 Banpo-daero, Seocho-gu, Seoul 06591, Korea. Tel: +82-2-2258-2838, Fax: +82-2-535-9834, <email>iy1000@catholic.ac.kr</email></corresp></author-notes><pub-date pub-type="ppub"><month>3</month><year>2016</year></pub-date><pub-date pub-type="epub"><day>29</day><month>2</month><year>2016</year></pub-date><volume>28</volume><issue>1</issue><fpage>39</fpage><lpage>45</lpage><history><date date-type="received"><day>13</day><month>9</month><year>2015</year></date><date date-type="rev-recd"><day>02</day><month>12</month><year>2015</year></date><date date-type="accepted"><day>15</day><month>12</month><year>2015</year></date></history><permissions><copyright-statement>Copyright © 2016 KOREAN KNEE SOCIETY</copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an open access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><sec><title>Purpose</title><p>The purpose of this study was to evaluate minimum 2-year follow-up results of total knee arthroplasty (TKA) performed using a new high-flexion
prosthesis design (LOSPA).</p></sec><sec><title>Materials and Methods</title><p>The 2- to 4-year results of 191 consecutive TKAs (177 patients) with the LOSPA posterior-stabilized prosthesis were evaluated. The patients were assessed clinically and radiographically using the Knee Society scoring system (KSS) and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC).</p></sec><sec><title>Results</title><p>The mean range of motion (ROM) increased significantly from 117.4° (range, 75° to 140°) preoperatively to 126.7° (range, 80° to 144°) postoperatively (p<0.001). The mean KSS and WOMAC scores improved significantly from 121.4 (range, 42 to 185) and 56.1 (range, 23 to 88) preoperatively to 174.0 (range, 130 to 200) and 16.4 (range, 0 to 85) postoperatively, respectively (both, p<0.001). One knee required revision for deep infection. No knee had aseptic loosening or osteolysis. Radiolucent lines were noted in 15 knees (7.9%).</p></sec><sec><title>Conclusions</title><p>The new high-flexion total knee prosthesis resulted in no early aseptic loosening of the component and improved postoperative ROM comparable to other high-flexion TKA prostheses at 2- to 4-year follow-ups.</p></sec></abstract><kwd-group><kwd>Knee</kwd><kwd>Arthroplasty</kwd><kwd>Range of motion</kwd><kwd>Prosthesis design</kwd><kwd>Outcome assessment</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>Introduction</title><p>Total knee arthroplasty (TKA) has been widely accepted as an effective treatment for end stage osteoarthritis demonstrating satisfactory outcomes and survivorship. TKA is advantageous in relieving pain and improving knee function<xref rid="B1" ref-type="bibr">1)</xref>. Still, restoration of normal range of motion (ROM) after TKA remains as a challenge; in general, the ROM of the knee after conventional TKA (range, 110° to 120°) is less than that of a normal knee<xref rid="B2" ref-type="bibr">2)</xref>. In particular, squatting, sitting cross-legged, and kneeling with deep flexion of the knee joint that involve >125° of knee flexion are often required during daily living in Asian culture<xref rid="B3" ref-type="bibr">3)</xref>. Thus, high-flexion prostheses were developed to meet such demands<xref rid="B4" ref-type="bibr">4)</xref>.</p><p>High-flexion TKA is designed to achieve >125° of knee flexion<xref rid="B5" ref-type="bibr">5)</xref>. The femoral component of the high-flexion design has a 2–4 mm extended and thicker posterior condyle that does not necessitate additional bone cut to maintain the contact area during deep knee flexion<xref rid="B6" ref-type="bibr">6</xref><xref rid="B7" ref-type="bibr">7)</xref>. The increased contact area helps posterior femoral translation. In addition, the larger posterior condyle of the femoral component decreases the risk of impingement between the posterior cortex of the femur and the polyethylene insert<xref rid="B8" ref-type="bibr">8)</xref>. The new prosthesis has a modified cam and post mechanism with increased jump distance to avoid dislocation under deep flexion angles<xref rid="B9" ref-type="bibr">9)</xref>. It also has a longer trochlear groove for improved patellar tracking. The anterior recess in the tibial polyethylene insert reduces impingement on the patella and the patellar tendon during deep knee flexion.</p><p>The new high-flexion concept LOSPA knee system (Corentec, Seoul, Korea) has recently become available. It is designed to achieve ligament isometry from 0° to 90° using a single radial axis of the femoral component. The single radius of the femoral component contributes to stability in the mid-flexed state<xref rid="B10" ref-type="bibr">10)</xref>. Cam-post engagement occurs at 75°, which prevents unnecessary cam-post contact during level walking and has an advantage of posterior translation of the femoral condyle. The high-flexion design with more rounded femoral contour and deepened patellar groove facilitates deep flexion by reducing joint capsule overstuffing. The elongated and laterally angled patellar groove is constructed to produce good patellar tracking. This prosthesis has a 10-mm thick posterior condyle of the femoral component that replaces the 10-mm posterior femoral bone cut, which contributes to increased surface contact and bone support through a relatively larger posterior radius than the conventional design (<xref ref-type="fig" rid="F1">Fig. 1</xref>). Compared to Nexgen LPS-flex (Zimmer, Warsaw, IN, USA), another high-flexion design implant, that requires 12-mm posterior femoral bone cutting, LOSPA prosthesis is more advantageous for bone preservation.</p><p>Numerous studies have compared the high-flexion and conventional designs. Some studies demonstrated the superiority of the high-flexion prosthesis with regard to the postoperative ROM and function<xref rid="B4" ref-type="bibr">4</xref><xref rid="B11" ref-type="bibr">11)</xref> while others showed the opposite<xref rid="B7" ref-type="bibr">7</xref><xref rid="B12" ref-type="bibr">12)</xref>. A concern has been raised that high-flexion TKA accelerates early aseptic loosening compared to conventional TKA due to the increased shear force between the femoral component and the femur during high flexion of the knee<xref rid="B13" ref-type="bibr">13</xref><xref rid="B14" ref-type="bibr">14)</xref>. Cho et al.<xref rid="B13" ref-type="bibr">13)</xref> and Han et al.<xref rid="B14" ref-type="bibr">14)</xref> noted a high rate of aseptic loosening of the femoral component in their patients after high-flexion TKA. In this study, we retrospectively evaluated the clinical and radiographic results of TKA performed using the newly introduced LOSPA knee system for a minimum 2-year follow-up. We examined the following two hypotheses: 1) the ROM of the knee with the LOSPA prosthesis would be comparable to that with other high-flexion concept prostheses of the recent literatures in Korean patients and 2) the implantation of the LOSPA prosthesis would be stable without aseptic loosening at minimum 2- year follow-up.</p></sec><sec sec-type="materials|methods"><title>Materials and Methods</title><p>A total of 198 patients (215 knees) underwent TKA with the posterior-stabilized (PS) LOSPA total knee prosthesis from May 2011 to August 2013 at our institution. Of these, we retrospectively reviewed 191 knees of 177 patients (88%) who were available for a minimum 2-year follow-up. Inclusion criteria were patients with indications for primary TKA: Kellgren-Lawrence classification grade 3–4 severe osteoarthritis, osteonecrosis<xref rid="B15" ref-type="bibr">15)</xref>, and rheumatoid arthritis. Exclusion criteria were contraindications of TKA such as knee joint infection. Patient demographics are summarized in <xref ref-type="table" rid="T1">Table 1</xref>. The mean follow-up period was 2.6 years (range, 2 to 4 years).</p><p>All surgeries were performed by a senior author (In) using the PS LOSPA knee system. All procedures were performed through a subvastus approach under general anesthesia with tourniquet inflation to 300 mmHg. All components were fixated with bone cement. The drainage tube was removed 2 days after operation. Postoperatively, none of the patients did continuous passive motion exercises, but they were encouraged to perform active exercises according to our protocol of rehabilitation. Quadriceps-strengthening exercises were started immediately after surgery and patients began walking with use of a walker on the first postoperative day. On the second postoperative day, the patients started active ROM exercises under the guidance of the medical team.</p><p>Clinical and radiographic data were evaluated at postoperative 6 weeks, 3 months, 6 months, and 1 year and then yearly thereafter. Each knee was evaluated according to the Knee Society scoring system (KSS)<xref rid="B16" ref-type="bibr">16)</xref> and the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC)<xref rid="B17" ref-type="bibr">17)</xref> by one of the authors (Kim). At the time of each follow-up, active ROM of the knee was measured using a standard 60-cm goniometer with the patient placed in supine position by one of the authors (Kim) who was blinded to the implant used. All complications were recorded. Weight-bearing anteroposterior, lateral, and merchant radiographs were taken at each follow-up visit. All radiographs were reviewed to assess implant position and radiolucent lines. Radiolucent lines were examined at different zones around the femoral and tibial components using the Knee Society TKA radiographic evaluation and scoring system<xref rid="B18" ref-type="bibr">18)</xref>. All radiolucent lines were recorded and the radiographic sign of loosening was defined as the presence of a radiolucent line more than 2 mm in width at the cement-bone or cement-prosthesis interface<xref rid="B19" ref-type="bibr">19)</xref>. Implant position in relation to the limb anatomic axis and component alignment was evaluated and the presence and location of the radiolucent lines were assessed using the KSS<xref rid="B18" ref-type="bibr">18)</xref>. Preoperative and postoperative posterior femoral condylar offsets were also compared.</p><p>Preoperative and postoperative clinical outcomes (KSS and WOMAC scores) and radiographic alignment were compared using the paired <italic>t</italic>-test. A p-value of <0.05 was considered significant, and the analysis was performed using the IBM SPSS ver. 21.0 (IBM Co., Armonk, NY, USA).</p></sec><sec sec-type="results"><title>Results</title><p>The ROM at the final follow-up increased significantly compared to the preoperative ROM (<xref ref-type="table" rid="T2">Table 2</xref>). The mean KSS improved from 121.4 (range, 42 to 185) preoperatively to 174.0 (range, 130 to 200) at the last follow-up (p<0.001). The mean WOMAC score also improved from 56.1 (range, 23 to 88) preoperatively to 16.4 (range, 0 to 85) postoperatively (p<0.001) (<xref ref-type="table" rid="T3">Table 3</xref>). The mean KSS and WOMAC scores were 165.8 (range, 105 to 200) and 28.2 (range, 2 to 65), respectively, at the 6-month follow-up, 178.9 (range, 130 to 200 ) and 22.8 (range, 3 to 57), respectively, at the 1-year follow-up, 173.6 (range, 130 to 200) and 17.9 (range, 0 to 85), respectively, at the 2-year follow-up, and 174.2 (range, 130 to 200) and 14.8 (range, 0 to 85), respectively, at the 3-year follow-up.</p><p>The mean femorotibial angle was a varus of 3.7°±4.8° (range, varus of 16.8° to valgus of 12.3°) preoperatively and a valgus of 5.7°±1.8° (range, valgus of 0° to valgus of 8.4°) postoperatively (p<0.001). The coronal angle of the femoral component (α) was 96.6°±1.6° (range, 92.1° to 99.9°), the coronal angle of the tibial component (β) was 89.7°±1.7° (range, 84.2° to 95.9°), the flexion angle of the femoral component (γ) was 2.8°±1.3° (range, 0.1° to 5.5°), and the tibial slope angle (δ) was 85.8°±2.1° (range, 82.1° to 90.0°) postoperatively. The mean posterior femoral condylar offset was 29.6±2.5 mm (range, 19.8 to 36.8 mm) preoperatively and 29.9±2.8 mm (range, 20.5 to 36.9 mm) postoperatively (p=0.073). Radiolucent lines were found in 15 knees (14 patients, 7.9%): two in the medial tibial condyle (zones 1 and 2), 2 in the anterior femoral condyle (zones 1 and 2), and 11 in the posterior femoral condyle (zones 3 and 4) (<xref ref-type="fig" rid="F2">Fig. 2</xref>). No case of osteolysis was detected during the 2- to 4-year follow-up period. None of the knees developed aseptic loosening of the femoral, tibial, or patellar component. No knee had a tibiofemoral or patellofemoral joint dislocation.</p><p>Two major complications required surgery in two knees. A 70-year-old female with a history of lymphedema developed a deep infection in the extremity of the operated side 1 year postoperatively. The patient had received a radical hysterectomy with total lymph node dissection for uterine cervical cancer. Methicillin-sensitive Staphylococcus aureus was cultured from the joint fluid, and a two-stage revision operation was performed for the infected joint. A patellar fracture occurred in one patient and was treated with open reduction and internal fixation. Three minor complications occurred in three knees. One patient received brisement due to <90° ROM limitation at 4 weeks after the operation and the final flexion angle was 125°. Two patients demonstrated wound dehiscence 2 weeks postoperatively. No infection was detected, and the wound was approximated with simple sutures. Symptomatic deep vein thrombosis, pulmonary embolism, and hyperextension (recurvatum) were not observed during the follow-up.</p></sec><sec sec-type="discussion"><title>Discussion</title><p>The purpose of this study was to evaluate the ROM and early stability following TKA performed using the new high-flexion prosthesis during a short-term follow-up. The most important finding of the present study was that the newly introduced high-flexion LOSPA prosthesis resulted in no early aseptic loosening of the component and provided outcomes comparable to those used in high-flexion TKA in Korean patients (<xref ref-type="table" rid="T4">Table 4</xref>).</p><p>Postoperative ROM is an important factor for patient satisfaction after TKA, particularly among Asians<xref rid="B20" ref-type="bibr">20)</xref>. Thus, manufacturers have modified and upgraded the design of knee prostheses to allow for high flexion after TKA. Many studies have investigated the efficacy and safety of TKA using a high-flexion design prosthesis performed by Korean surgeons<xref rid="B7" ref-type="bibr">7</xref><xref rid="B11" ref-type="bibr">11</xref><xref rid="B13" ref-type="bibr">13</xref><xref rid="B14" ref-type="bibr">14</xref><xref rid="B21" ref-type="bibr">21</xref><xref rid="B22" ref-type="bibr">22</xref><xref rid="B23" ref-type="bibr">23</xref><xref rid="B24" ref-type="bibr">24</xref><xref rid="B25" ref-type="bibr">25)</xref>. However, there has been some puzzling inconsistency among studies on the efficacy of high-flexion TKA designs<xref rid="B4" ref-type="bibr">4</xref><xref rid="B7" ref-type="bibr">7</xref><xref rid="B11" ref-type="bibr">11</xref><xref rid="B12" ref-type="bibr">12)</xref>. There is still a paucity of data on the ROM of the knee following TKA using this new high-flexion implant; therefore, we investigated postoperative ROM in patients who received the newly designed high-flexion prosthesis. The LOSPA knee system demonstrated improved clinical and radiographic outcomes at 2- to 4-year follow-up. The outcomes of our study were comparable to those reported by other Korean studies on high-flexion TKA. Seo et al.<xref rid="B26" ref-type="bibr">26)</xref> compared the LOSPA PS total knee prosthesis with another high-flexion PS prosthesis. In their study, the mean postoperative flexion angle of the LOSPA group was 126.9°. The mean postoperative ROM of the patients was similar to that of the current study. Theoretically, a knee flexion angle of 140° is possible with the high-flexion LOSPA system, but it appears not to be attainable <italic>in vivo</italic>.</p><p>In the present study, the postoperative ROM of the knee was less than our expectation (up to 140°) and the superiority of the prosthesis compared with conventional TKA in terms of ROM was not observed<xref rid="B7" ref-type="bibr">7</xref><xref rid="B11" ref-type="bibr">11</xref><xref rid="B22" ref-type="bibr">22)</xref>. Several factors may contribute to the ROM after TKA including patient factors (preoperative ROM, obesity, postoperative quality of rehabilitation, patient motivation, and preoperative mental illness), intraoperative technical issues (resection of back osteophytes, ligament balancing, component positioning, altered joint line, and posterior tibial slope), and perioperative complications<xref rid="B27" ref-type="bibr">27)</xref>. It has been generally considered that the preoperative ROM is the most predictable factor for the postoperative ROM<xref rid="B28" ref-type="bibr">28)</xref>. Our study showed that the new high-flexion LOSPA prosthesis would not improve the postoperative ROM in patients with a preoperative ROM of <120°. A controversy still exists regarding the relationship between the posterior condylar offset and the ROM<xref rid="B6" ref-type="bibr">6</xref><xref rid="B29" ref-type="bibr">29)</xref>. Bellemans et al.<xref rid="B6" ref-type="bibr">6)</xref> reported that the final knee flexion angle was significantly correlated with the posterior femoral condylar offset in TKA patients. They insisted that restoring posterior condylar offset would be very important to achieve a greater flexion angle before impingement of the posterior tibial insert against the posterior femur. In contrast, Hanratty et al.<xref rid="B29" ref-type="bibr">29)</xref> found no correlation between the range of knee flexion and posterior condylar offset after TKA. In our study, postoperative posterior condylar offset was well restored compared with the preoperative value. An additional 2-mm posterior femoral bone resection was not necessary because of the 2 mm extension of the posterior condyle of the femoral component. Consequentially, there was no difference in the postoperative posterior condylar offset. Therefore, we found it difficult to determine the relationship between the posterior condylar offset and knee the flexion angle in the present study.</p><p>Concerns have been raised about aseptic loosening of the high-flexion knee systems during the early postoperative phase. Cho et al.<xref rid="B13" ref-type="bibr">13)</xref> reported that progressive radiolucent lines around the femoral component were detected in 13.8% of 218 knees that received the NexGen LPS-flex TKA at a mean follow-up of 51 months. In their study, radiolucent lines were observed around the anterior and posterior flanges of the femoral component. Han et al.<xref rid="B14" ref-type="bibr">14)</xref> noted aseptic loosening in 38% of cases at a mean follow-up of 32 months after using the same high-flexion total knee prosthesis and performed revision in 21% of cases at a mean of 23 months postoperatively. They reported radiolucent lines were most common in the anterior flange of the femoral component. In high-flexion TKA, the tibial insert only articulates with the femoral component, resulting in the absence of load sharing effect and application of greater shearing force on the femoral component. Conventional TKA requires a distinctly higher loosening force compared to high-flexion TKA. Among the high-flexion designs, those with an open geometry of the internal femoral component are more vulnerable to loosening than those with a closed geometry. Peg fixation is essential to good fixation of a component and provides stability against the loosening force<xref rid="B30" ref-type="bibr">30)</xref>. The LOSPA total knee system requires a 10-mm posterior femoral condylar bone cut, which is more conservative compared to the 12 mm required by the Nexgen LPS-flex system. In addition, peg fixation of the LOSPA prosthesis provides resistance to the loosening of component, but open femoral component geometry is not beneficial for prevention of loosening<xref rid="B30" ref-type="bibr">30)</xref>. Our results showed a 7.8% incidence of radiolucent lines around the anterior flange of the femur, the posterior femoral condyle, and the medial tibial condylar area. However, no symptoms or signs of aseptic loosening were detected in patients with radiolucent lines. Han et al.<xref rid="B14" ref-type="bibr">14)</xref> reported that the mean flexion angle was 136° in the loosening group and 125° in the well- fixed group. The proportion of patients who were able to perform high-flexion activities such as squatting and kneeling was also higher in the loosening group. The femur contacted with the posterior end of tibia at 133° of flexion angle. In our study, the mean flexion angle of the knee was 127°, which was similar with the angle of the well-fixed group and below 133°<xref rid="B14" ref-type="bibr">14)</xref>. We did not thoroughly investigate the percentage of patients who were able to perform high flexion activities, but we recommended the patients not to be involved in high-flexion activities as much as possible. It was an attempt to prevent early loosening of component following high-flexion TKA<xref rid="B13" ref-type="bibr">13)</xref>. The knees with appearance of radiolucent lines require further follow-up to assure the clinical course.</p><p>Our study has some limitations. First, this was a case series, not a comparative study. We did not have a control group to compare the knee ROM and radiographic and clinical outcomes. Second, the minimum 2-year follow-up period was relatively short, so we cannot determine the long-term clinical and radiographic outcomes.</p></sec><sec sec-type="conclusions"><title>Conclusions</title><p>The evaluation of patients who underwent TKA with the high-flexion LOSPA prosthesis revealed improved clinical and radiographic results and low complication rates after a minimum 2-year follow-up. However, a long-term follow-up is required to determine whether the new high-flexion concept design demonstrates a comparable survivorship. 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LOSPA prosthesis requires removal of additional bone from the posterior femoral condyle to add 10 mm posterior condyle at a large posterior radius of the femoral component. In addition, the femoral component has a more rounded contour and a deepened patellar groove to help deep flexion. The posterior surface of the insert is released for deep flexion favoring design.</title></caption><graphic xlink:href="ksrr-28-39-g001"></graphic></fig><fig id="F2" orientation="portrait" position="float"><label>Fig. 2</label><caption><title>The lateral radiograph of the left knee of a 68-year-old female shows radiolucent lines around the anterior cortex and posterior condylar area 3 years postoperatively. Arrow: these findings were not progressive and the patient had no symptoms or signs of aseptic loosening.</title></caption><graphic xlink:href="ksrr-28-39-g002"></graphic></fig><table-wrap id="T1" orientation="portrait" position="float"><label>Table 1</label><caption><title>Patient Demographics</title></caption><graphic xlink:href="ksrr-28-39-i001"></graphic><table-wrap-foot><fn><p>Values are presented as mean±standard deviation or number (range).</p><p>TKA: total knee arthroplasty, R: right, L: left, HKA: hip-knee-ankle.</p><p><sup>a)</sup>Data are presented as femorotibial angle.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T2" orientation="portrait" position="float"><label>Table 2</label><caption><title>Preoperative (Preop) and Postoperative (Postop) Range of Motion</title></caption><graphic xlink:href="ksrr-28-39-i002"></graphic><table-wrap-foot><fn><p>Values are presented as mean±standard deviation (range). p-value<0.001.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T3" orientation="portrait" position="float"><label>Table 3</label><caption><title>Preoperative (Preop) and Postoperative (Postop) Clinical Scores</title></caption><graphic xlink:href="ksrr-28-39-i003"></graphic><table-wrap-foot><fn><p>Values are presented as mean±standard deviation (range). p-value<0.001.</p><p>WOMAC: Western Ontario and McMaster Universities.</p></fn></table-wrap-foot></table-wrap><table-wrap id="T4" orientation="portrait" position="float"><label>Table 4</label><caption><title>Summary of Previous Studies on Flexion Angle, Radiolucent Lines, and Aseptic Loosening after Total Knee Arthroplasty Using High Flexion Design Prostheses</title></caption><graphic xlink:href="ksrr-28-39-i004"></graphic><table-wrap-foot><fn><p>F/U: follow-up, Preop: preoperative, Postop: postoperative, NR: no report.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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