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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Effect of Lump Size and Nodal Status on Prognosis in Invasive Breast Cancer: Experience from Rural India</title>
<author><name sortKey="Garg, Monique" sort="Garg, Monique" uniqKey="Garg M" first="Monique" last="Garg">Monique Garg</name>
<affiliation><nlm:aff id="aff1"> Senior Resident, Department of Surgery,<institution>Maharishi Markendeshwar Medical College</institution>
,<addr-line>Kumarhatti, Solan, Himachal Pradesh, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nagpal, Nitin" sort="Nagpal, Nitin" uniqKey="Nagpal N" first="Nitin" last="Nagpal">Nitin Nagpal</name>
<affiliation><nlm:aff id="aff2"> Associate Professor, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sidhu, Darshan Singh" sort="Sidhu, Darshan Singh" uniqKey="Sidhu D" first="Darshan Singh" last="Sidhu">Darshan Singh Sidhu</name>
<affiliation><nlm:aff id="aff3"> Professor and Head, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Singh, Amandeep" sort="Singh, Amandeep" uniqKey="Singh A" first="Amandeep" last="Singh">Amandeep Singh</name>
<affiliation><nlm:aff id="aff4"> Assistant Professor, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">27504343</idno>
<idno type="pmc">4963703</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4963703</idno>
<idno type="RBID">PMC:4963703</idno>
<idno type="doi">10.7860/JCDR/2016/20470.8039</idno>
<date when="2016">2016</date>
<idno type="wicri:Area/Pmc/Corpus">000670</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000670</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Effect of Lump Size and Nodal Status on Prognosis in Invasive Breast Cancer: Experience from Rural India</title>
<author><name sortKey="Garg, Monique" sort="Garg, Monique" uniqKey="Garg M" first="Monique" last="Garg">Monique Garg</name>
<affiliation><nlm:aff id="aff1"> Senior Resident, Department of Surgery,<institution>Maharishi Markendeshwar Medical College</institution>
,<addr-line>Kumarhatti, Solan, Himachal Pradesh, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Nagpal, Nitin" sort="Nagpal, Nitin" uniqKey="Nagpal N" first="Nitin" last="Nagpal">Nitin Nagpal</name>
<affiliation><nlm:aff id="aff2"> Associate Professor, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sidhu, Darshan Singh" sort="Sidhu, Darshan Singh" uniqKey="Sidhu D" first="Darshan Singh" last="Sidhu">Darshan Singh Sidhu</name>
<affiliation><nlm:aff id="aff3"> Professor and Head, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Singh, Amandeep" sort="Singh, Amandeep" uniqKey="Singh A" first="Amandeep" last="Singh">Amandeep Singh</name>
<affiliation><nlm:aff id="aff4"> Assistant Professor, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</nlm:aff>
</affiliation>
</author>
</analytic>
<series><title level="j">Journal of Clinical and Diagnostic Research : JCDR</title>
<idno type="ISSN">2249-782X</idno>
<idno type="eISSN">0973-709X</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Introduction</title>
<p>Breast cancer is now the leading cause of cancer among Indian women. Usually large tumour size and axillary lymph node involvement are linked with adverse outcome and this notion forms the basis of screening programs i.e. early detection.</p>
</sec>
<sec><title>Aim</title>
<p>The present study was carried out to analyse relationship between tumour size, lymph node status and there relation with outcome after treatment.</p>
</sec>
<sec><title>Materials and Methods</title>
<p>Fifty patients with cytology-proven invasive breast tumours were evaluated for size, clinical and pathologic characteristics of tumour, axillary lymph node status and outcome data recorded on sequential follow-up.</p>
</sec>
<sec><title>Results</title>
<p>Mean age of all participated patients was 52.24±10 years. Most common tumour location was in the upper outer quadrant with mean size of primary tumour being 3.31±1.80cm. On pathology number of lymph nodes examined ranged from 10 to 24 and 72% of patients recorded presence of disease in axilla. Significant positive correlation (p<0.013; r<sup>2</sup>
=0.026) between tumour size and axillary lymph node involvement on linear regression. Also an indicative correlation between size and grade of tumour and axillary lymph node status was found with survival from the disease.</p>
</sec>
<sec><title>Conclusion</title>
<p>The present study highlights that the size of the primary tumour and the number of positive lymph nodes have an inverse linear relationship with prognosis. Despite advances in diagnostic modalities, evolution of newer markers and genetic typing both size of tumour as T and axillary lymphadenopathy as N form an integral part of TNM staging and are of paramount importance for their role in treatment decisions and illustrate prognosis in patients with invasive breast cancer.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Diagn Res</journal-id>
<journal-id journal-id-type="iso-abbrev">J Clin Diagn Res</journal-id>
<journal-id journal-id-type="hwp">Journal of Clinical and Diagnostic Research</journal-id>
<journal-id journal-id-type="publisher-id">JCDR</journal-id>
<journal-title-group><journal-title>Journal of Clinical and Diagnostic Research : JCDR</journal-title>
</journal-title-group>
<issn pub-type="ppub">2249-782X</issn>
<issn pub-type="epub">0973-709X</issn>
<publisher><publisher-name>JCDR Research and Publications (P) Limited</publisher-name>
<publisher-loc>Delhi, India</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">27504343</article-id>
<article-id pub-id-type="pmc">4963703</article-id>
<article-id pub-id-type="doi">10.7860/JCDR/2016/20470.8039</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Surgery Section</subject>
<subj-group subj-group-type="heading"><subject>Original Article</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Effect of Lump Size and Nodal Status on Prognosis in Invasive Breast Cancer: Experience from Rural India</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Garg</surname>
<given-names>Monique</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Nagpal</surname>
<given-names>Nitin</given-names>
</name>
<xref ref-type="aff" rid="aff2">2</xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Sidhu</surname>
<given-names>Darshan Singh</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Singh</surname>
<given-names>Amandeep</given-names>
</name>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
Senior Resident, Department of Surgery,<institution>Maharishi Markendeshwar Medical College</institution>
,<addr-line>Kumarhatti, Solan, Himachal Pradesh, India</addr-line>
.</aff>
<aff id="aff2"><label>2</label>
Associate Professor, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</aff>
<aff id="aff3"><label>3</label>
Professor and Head, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</aff>
<aff id="aff4"><label>4</label>
Assistant Professor, Department of Surgery,<institution>GGS Medical College</institution>
,<addr-line>Faridkot, Punjab, India</addr-line>
.</aff>
<author-notes><corresp id="cor1">NAME, ADDRESS, E-MAIL ID OF THE CORRESPONDING AUTHOR: Dr. Nitin Nagpal, 79, Medical Campus, Sadiq Road, Faridkot, Punjab, India. E-mail: <email>drnitinnagpal@gmail.com</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2016</year>
</pub-date>
<pub-date pub-type="epub"><day>01</day>
<month>6</month>
<year>2016</year>
</pub-date>
<volume>10</volume>
<issue>6</issue>
<fpage>PC08</fpage>
<lpage>PC11</lpage>
<history><date date-type="received"><day>02</day>
<month>4</month>
<year>2016</year>
</date>
<date date-type="rev-request"><day>25</day>
<month>4</month>
<year>2016</year>
</date>
<date date-type="accepted"><day>02</day>
<month>5</month>
<year>2016</year>
</date>
</history>
<permissions><copyright-statement>© 2016 Journal of Clinical and Diagnostic Research</copyright-statement>
<copyright-year>2016</copyright-year>
</permissions>
<abstract><sec><title>Introduction</title>
<p>Breast cancer is now the leading cause of cancer among Indian women. Usually large tumour size and axillary lymph node involvement are linked with adverse outcome and this notion forms the basis of screening programs i.e. early detection.</p>
</sec>
<sec><title>Aim</title>
<p>The present study was carried out to analyse relationship between tumour size, lymph node status and there relation with outcome after treatment.</p>
</sec>
<sec><title>Materials and Methods</title>
<p>Fifty patients with cytology-proven invasive breast tumours were evaluated for size, clinical and pathologic characteristics of tumour, axillary lymph node status and outcome data recorded on sequential follow-up.</p>
</sec>
<sec><title>Results</title>
<p>Mean age of all participated patients was 52.24±10 years. Most common tumour location was in the upper outer quadrant with mean size of primary tumour being 3.31±1.80cm. On pathology number of lymph nodes examined ranged from 10 to 24 and 72% of patients recorded presence of disease in axilla. Significant positive correlation (p<0.013; r<sup>2</sup>
=0.026) between tumour size and axillary lymph node involvement on linear regression. Also an indicative correlation between size and grade of tumour and axillary lymph node status was found with survival from the disease.</p>
</sec>
<sec><title>Conclusion</title>
<p>The present study highlights that the size of the primary tumour and the number of positive lymph nodes have an inverse linear relationship with prognosis. Despite advances in diagnostic modalities, evolution of newer markers and genetic typing both size of tumour as T and axillary lymphadenopathy as N form an integral part of TNM staging and are of paramount importance for their role in treatment decisions and illustrate prognosis in patients with invasive breast cancer.</p>
</sec>
</abstract>
<kwd-group><kwd>Carcinoma breast</kwd>
<kwd>Tumour size</kwd>
<kwd>Axillary lymph node involvement</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
</record>
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