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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Microsatellite instability of gastric cancer and precancerous lesions</title><author><name sortKey="Li, Bing" sort="Li, Bing" uniqKey="Li B" first="Bing" last="Li">Bing Li</name></author><author><name sortKey="Liu, Hong Yi" sort="Liu, Hong Yi" uniqKey="Liu H" first="Hong-Yi" last="Liu">Hong-Yi Liu</name></author><author><name sortKey="Guo, Shao Hua" sort="Guo, Shao Hua" uniqKey="Guo S" first="Shao-Hua" last="Guo">Shao-Hua Guo</name></author><author><name sortKey="Sun, Peng" sort="Sun, Peng" uniqKey="Sun P" first="Peng" last="Sun">Peng Sun</name></author><author><name sortKey="Gong, Fang Ming" sort="Gong, Fang Ming" uniqKey="Gong F" first="Fang-Ming" last="Gong">Fang-Ming Gong</name></author><author><name sortKey="Jia, Bao Qing" sort="Jia, Bao Qing" uniqKey="Jia B" first="Bao-Qing" last="Jia">Bao-Qing Jia</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26885046</idno><idno type="pmc">4723891</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4723891</idno><idno type="RBID">PMC:4723891</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000657</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000657</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Microsatellite instability of gastric cancer and precancerous lesions</title><author><name sortKey="Li, Bing" sort="Li, Bing" uniqKey="Li B" first="Bing" last="Li">Bing Li</name></author><author><name sortKey="Liu, Hong Yi" sort="Liu, Hong Yi" uniqKey="Liu H" first="Hong-Yi" last="Liu">Hong-Yi Liu</name></author><author><name sortKey="Guo, Shao Hua" sort="Guo, Shao Hua" uniqKey="Guo S" first="Shao-Hua" last="Guo">Shao-Hua Guo</name></author><author><name sortKey="Sun, Peng" sort="Sun, Peng" uniqKey="Sun P" first="Peng" last="Sun">Peng Sun</name></author><author><name sortKey="Gong, Fang Ming" sort="Gong, Fang Ming" uniqKey="Gong F" first="Fang-Ming" last="Gong">Fang-Ming Gong</name></author><author><name sortKey="Jia, Bao Qing" sort="Jia, Bao Qing" uniqKey="Jia B" first="Bao-Qing" last="Jia">Bao-Qing Jia</name></author></analytic><series><title level="j">International Journal of Clinical and Experimental Medicine</title><idno type="eISSN">1940-5901</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Objective: To investigate whether microsatellite instability (MSI) of gastric cancer and precancerous lesions were existed and its effect. Methods: Laser microdissection was used. Gastric, intestinal metaplasia, dysplasia and normal mucosa were collected respectively. Five microsatellite loci were selected and MSI was detected by denaturing high-performance liquid chromatography. Results: In the five microsatellite loci REF-positive phenotype, intestinal metaplasia MSI was 20.7%. Dysplasia MSI was 22.4%. Gastric MSI was 47.9%, and there was no MSI in normal gastric mucosa. Conclusion: MSI gradually increased from precancerous lesions to gastric cancer. The early detection of MSI may be a potential early warning indicator for early diagnosis of gastric cancer.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Int J Clin Exp Med</journal-id><journal-id journal-id-type="iso-abbrev">Int J Clin Exp Med</journal-id><journal-id journal-id-type="publisher-id">ijcem</journal-id><journal-title-group><journal-title>International Journal of Clinical and Experimental Medicine</journal-title></journal-title-group><issn pub-type="epub">1940-5901</issn><publisher><publisher-name>e-Century Publishing Corporation</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26885046</article-id><article-id pub-id-type="pmc">4723891</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Article</subject></subj-group></article-categories><title-group><article-title>Microsatellite instability of gastric cancer and precancerous lesions</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Li</surname><given-names>Bing</given-names></name></contrib><contrib contrib-type="author"><name><surname>Liu</surname><given-names>Hong-Yi</given-names></name></contrib><contrib contrib-type="author"><name><surname>Guo</surname><given-names>Shao-Hua</given-names></name></contrib><contrib contrib-type="author"><name><surname>Sun</surname><given-names>Peng</given-names></name></contrib><contrib contrib-type="author"><name><surname>Gong</surname><given-names>Fang-Ming</given-names></name></contrib><contrib contrib-type="author"><name><surname>Jia</surname><given-names>Bao-Qing</given-names></name></contrib><aff><institution>Department of Surgical Oncology, General Hospital of The People’s Liberation Army</institution><addr-line>No. 28, Fuxing Road, Beijing 100853, P.R. China</addr-line></aff></contrib-group><author-notes><corresp><bold>Address correspondence to:</bold> Dr. Bao-Qing Jia, Department of Surgical Oncology, General Hospital of The People’s Liberation Army, No. 28, Fuxing Road, Beijing 100853, P.R. China. Tel: +86 010 681 82255; Fax: +86 010 668 87329; E-mail: <email>jiabaoqing1971@126.com</email></corresp></author-notes><pub-date pub-type="collection"><year>2015</year></pub-date><pub-date pub-type="epub"><day>15</day><month>11</month><year>2015</year></pub-date><volume>8</volume><issue>11</issue><fpage>21138</fpage><lpage>21144</lpage><history><date date-type="received"><day>18</day><month>3</month><year>2015</year></date><date date-type="accepted"><day>01</day><month>7</month><year>2015</year></date></history><permissions><copyright-statement>IJCEM Copyright © 2015</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><p>Objective: To investigate whether microsatellite instability (MSI) of gastric cancer and precancerous lesions were existed and its effect. Methods: Laser microdissection was used. Gastric, intestinal metaplasia, dysplasia and normal mucosa were collected respectively. Five microsatellite loci were selected and MSI was detected by denaturing high-performance liquid chromatography. Results: In the five microsatellite loci REF-positive phenotype, intestinal metaplasia MSI was 20.7%. Dysplasia MSI was 22.4%. Gastric MSI was 47.9%, and there was no MSI in normal gastric mucosa. Conclusion: MSI gradually increased from precancerous lesions to gastric cancer. The early detection of MSI may be a potential early warning indicator for early diagnosis of gastric cancer.</p></abstract><kwd-group><kwd>Gastric cancer</kwd><kwd>precancerous lesions</kwd><kwd>laser micro dissection</kwd><kwd>denaturing high performance liquid chromatography</kwd><kwd>microsatellite instability</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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