Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
Identifieur interne : 000654 ( Pmc/Corpus ); précédent : 000653; suivant : 000655Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves
Auteurs : Boksik Cha ; Xin Geng ; Md. Riaj Mahamud ; Jianxin Fu ; Anish Mukherjee ; Yeunhee Kim ; Eek-Hoon Jho ; Tae Hoon Kim ; Mark L. Kahn ; Lijun Xia ; J. Brandon Dixon ; Hong Chen ; R. Sathish SrinivasanSource :
- Genes & Development [ 0890-9369 ] ; 2016.
Abstract
In this study, Cha et al. show that the Wnt/β-catenin signaling pathway is the link between fluid flow and lymphatic vascular morphogenesis. They provide a molecular and structural framework to study mammalian lymphatic vasculature by demonstrating that mechanical stimulation is a critical regulator of lymphatic vascular development via activation of Wnt/β-catenin signaling.
Url:
DOI: 10.1101/gad.282400.116
PubMed: 27313318
PubMed Central: 4926867
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Riaj Mahamud</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Mukherjee, Anish" sort="Mukherjee, Anish" uniqKey="Mukherjee A" first="Anish" last="Mukherjee">Anish Mukherjee</name><affiliation><nlm:aff id="af3">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;</nlm:aff></affiliation></author><author><name sortKey="Kim, Yeunhee" sort="Kim, Yeunhee" uniqKey="Kim Y" first="Yeunhee" last="Kim">Yeunhee Kim</name><affiliation><nlm:aff id="af4">Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080, USA;</nlm:aff></affiliation></author><author><name sortKey="Jho, Eek Hoon" sort="Jho, Eek Hoon" uniqKey="Jho E" first="Eek-Hoon" last="Jho">Eek-Hoon Jho</name><affiliation><nlm:aff id="af5">Department of Life Science, University of Seoul, Seoul 130-743, Korea;</nlm:aff></affiliation></author><author><name sortKey="Kim, Tae Hoon" sort="Kim, Tae Hoon" uniqKey="Kim T" first="Tae Hoon" last="Kim">Tae Hoon Kim</name><affiliation><nlm:aff id="af4">Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080, USA;</nlm:aff></affiliation></author><author><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L." last="Kahn">Mark L. Kahn</name><affiliation><nlm:aff id="af6">Department of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;</nlm:aff></affiliation></author><author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af7">Department of Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><affiliation><nlm:aff id="af3">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;</nlm:aff></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation><nlm:aff id="af8">Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27313318</idno><idno type="pmc">4926867</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4926867</idno><idno type="RBID">PMC:4926867</idno><idno type="doi">10.1101/gad.282400.116</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000654</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000654</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves</title><author><name sortKey="Cha, Boksik" sort="Cha, Boksik" uniqKey="Cha B" first="Boksik" last="Cha">Boksik Cha</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Geng, Xin" sort="Geng, Xin" uniqKey="Geng X" first="Xin" last="Geng">Xin Geng</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Mahamud, Md Riaj" sort="Mahamud, Md Riaj" uniqKey="Mahamud M" first="Md. Riaj" last="Mahamud">Md. Riaj Mahamud</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Fu, Jianxin" sort="Fu, Jianxin" uniqKey="Fu J" first="Jianxin" last="Fu">Jianxin Fu</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Mukherjee, Anish" sort="Mukherjee, Anish" uniqKey="Mukherjee A" first="Anish" last="Mukherjee">Anish Mukherjee</name><affiliation><nlm:aff id="af3">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;</nlm:aff></affiliation></author><author><name sortKey="Kim, Yeunhee" sort="Kim, Yeunhee" uniqKey="Kim Y" first="Yeunhee" last="Kim">Yeunhee Kim</name><affiliation><nlm:aff id="af4">Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080, USA;</nlm:aff></affiliation></author><author><name sortKey="Jho, Eek Hoon" sort="Jho, Eek Hoon" uniqKey="Jho E" first="Eek-Hoon" last="Jho">Eek-Hoon Jho</name><affiliation><nlm:aff id="af5">Department of Life Science, University of Seoul, Seoul 130-743, Korea;</nlm:aff></affiliation></author><author><name sortKey="Kim, Tae Hoon" sort="Kim, Tae Hoon" uniqKey="Kim T" first="Tae Hoon" last="Kim">Tae Hoon Kim</name><affiliation><nlm:aff id="af4">Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080, USA;</nlm:aff></affiliation></author><author><name sortKey="Kahn, Mark L" sort="Kahn, Mark L" uniqKey="Kahn M" first="Mark L." last="Kahn">Mark L. Kahn</name><affiliation><nlm:aff id="af6">Department of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;</nlm:aff></affiliation></author><author><name sortKey="Xia, Lijun" sort="Xia, Lijun" uniqKey="Xia L" first="Lijun" last="Xia">Lijun Xia</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af7">Department of Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author><author><name sortKey="Dixon, J Brandon" sort="Dixon, J Brandon" uniqKey="Dixon J" first="J. Brandon" last="Dixon">J. Brandon Dixon</name><affiliation><nlm:aff id="af3">Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;</nlm:aff></affiliation></author><author><name sortKey="Chen, Hong" sort="Chen, Hong" uniqKey="Chen H" first="Hong" last="Chen">Hong Chen</name><affiliation><nlm:aff id="af8">Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA</nlm:aff></affiliation></author><author><name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name><affiliation><nlm:aff id="af1">Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation><affiliation><nlm:aff id="af2">Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</nlm:aff></affiliation></author></analytic><series><title level="j">Genes & Development</title><idno type="ISSN">0890-9369</idno><idno type="eISSN">1549-5477</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In this study, Cha et al. show that the Wnt/β-catenin signaling pathway is the link between fluid flow and lymphatic vascular morphogenesis. They provide a molecular and structural framework to study mammalian lymphatic vasculature by demonstrating that mechanical stimulation is a critical regulator of lymphatic vascular development via activation of Wnt/β-catenin signaling.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Genes Dev</journal-id><journal-id journal-id-type="iso-abbrev">Genes Dev</journal-id><journal-id journal-id-type="hwp">genesdev</journal-id><journal-id journal-id-type="pmc">genesdev</journal-id><journal-id journal-id-type="publisher-id">GAD</journal-id><journal-title-group><journal-title>Genes & Development</journal-title></journal-title-group><issn pub-type="ppub">0890-9369</issn><issn pub-type="epub">1549-5477</issn><publisher><publisher-name>Cold Spring Harbor Laboratory Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27313318</article-id><article-id pub-id-type="pmc">4926867</article-id><article-id pub-id-type="medline">8711660</article-id><article-id pub-id-type="doi">10.1101/gad.282400.116</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Paper</subject></subj-group></article-categories><title-group><article-title>Mechanotransduction activates canonical Wnt/β-catenin signaling to promote lymphatic vascular patterning and the development of lymphatic and lymphovenous valves</article-title><alt-title alt-title-type="left-running">Cha et al.</alt-title><alt-title alt-title-type="right-running">Wnt signaling in lymphatic vascular development</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cha</surname><given-names>Boksik</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Geng</surname><given-names>Xin</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mahamud</surname><given-names>Md. Riaj</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib><contrib contrib-type="author"><name><surname>Fu</surname><given-names>Jianxin</given-names></name><xref ref-type="aff" rid="af1">1</xref></contrib><contrib contrib-type="author"><name><surname>Mukherjee</surname><given-names>Anish</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Yeunhee</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Jho</surname><given-names>Eek-hoon</given-names></name><xref ref-type="aff" rid="af5">5</xref></contrib><contrib contrib-type="author"><name><surname>Kim</surname><given-names>Tae Hoon</given-names></name><xref ref-type="aff" rid="af4">4</xref></contrib><contrib contrib-type="author"><name><surname>Kahn</surname><given-names>Mark L.</given-names></name><xref ref-type="aff" rid="af6">6</xref></contrib><contrib contrib-type="author"><name><surname>Xia</surname><given-names>Lijun</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af7">7</xref></contrib><contrib contrib-type="author"><name><surname>Dixon</surname><given-names>J. Brandon</given-names></name><xref ref-type="aff" rid="af3">3</xref></contrib><contrib contrib-type="author"><name><surname>Chen</surname><given-names>Hong</given-names></name><xref ref-type="aff" rid="af8">8</xref></contrib><contrib contrib-type="author"><name><surname>Srinivasan</surname><given-names>R. Sathish</given-names></name><xref ref-type="aff" rid="af1">1</xref><xref ref-type="aff" rid="af2">2</xref></contrib></contrib-group><aff id="af1"><label>1</label>Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, Oklahoma 73104, USA;</aff><aff id="af2"><label>2</label>Department of Cell Biology, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</aff><aff id="af3"><label>3</label>Parker H. Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, Georgia 30332, USA;</aff><aff id="af4"><label>4</label>Department of Biological Sciences, Center for Systems Biology, The University of Texas at Dallas, Richardson, Texas 75080, USA;</aff><aff id="af5"><label>5</label>Department of Life Science, University of Seoul, Seoul 130-743, Korea;</aff><aff id="af6"><label>6</label>Department of Medicine, Division of Cardiology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA;</aff><aff id="af7"><label>7</label>Department of Biochemistry, University of Oklahoma Health Sciences Center, Oklahoma City, Oklahoma 73104, USA;</aff><aff id="af8"><label>8</label>Vascular Biology Program, Boston Children's Hospital, Boston, Massachusetts 02115, USA</aff><author-notes><corresp>Corresponding author: <email>sathish-srinivasan@omrf.org</email></corresp></author-notes><pub-date pub-type="ppub"><day>15</day><month>6</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>15</day><month>6</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>30</volume><issue>12</issue><fpage>1454</fpage><lpage>1469</lpage><history><date date-type="received"><day>7</day><month>4</month><year>2016</year></date><date date-type="accepted"><day>23</day><month>5</month><year>2016</year></date></history><permissions><copyright-statement><ext-link ext-link-type="uri" xlink:href="http://genesdev.cshlp.org/site/misc/terms.xhtml">© 2016 Cha et al.; Published by Cold Spring Harbor Laboratory Press</ext-link></copyright-statement><copyright-year>2016</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This article, published in <italic>Genes & Development</italic>, is available under a Creative Commons License (Attribution 4.0 International), as described at <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">http://creativecommons.org/licenses/by/4.0/</ext-link>.</license-p></license></permissions><self-uri content-type="pdf" xlink:href="1454.pdf"></self-uri><abstract abstract-type="precis"><p>In this study, Cha et al. show that the Wnt/β-catenin signaling pathway is the link between fluid flow and lymphatic vascular morphogenesis. They provide a molecular and structural framework to study mammalian lymphatic vasculature by demonstrating that mechanical stimulation is a critical regulator of lymphatic vascular development via activation of Wnt/β-catenin signaling.</p></abstract><abstract><p>Lymphatic vasculature regulates fluid homeostasis by returning interstitial fluid to blood circulation. Lymphatic endothelial cells (LECs) are the building blocks of the entire lymphatic vasculature. LECs originate as a homogeneous population of cells predominantly from the embryonic veins and undergo stepwise morphogenesis to become the lymphatic capillaries, collecting vessels or valves. The molecular mechanisms underlying the morphogenesis of the lymphatic vasculature remain to be fully understood. Here we show that canonical Wnt/β-catenin signaling is necessary for lymphatic vascular morphogenesis. Lymphatic vascular-specific ablation of β-catenin in mice prevents the formation of lymphatic and lymphovenous valves. Additionally, lymphatic vessel patterning is defective in these mice, with abnormal recruitment of mural cells. We found that oscillatory shear stress (OSS), which promotes lymphatic vessel maturation, triggers Wnt/β-catenin signaling in LECs. In turn, Wnt/β-catenin signaling controls the expression of several molecules, including the lymphedema-associated transcription factor FOXC2. Importantly, FOXC2 completely rescues the lymphatic vessel patterning defects in mice lacking β-catenin. Thus, our work reveals that mechanical stimulation is a critical regulator of lymphatic vascular development via activation of Wnt/β-catenin signaling and, in turn, FOXC2.</p></abstract><kwd-group><kwd>FOXC2</kwd><kwd>lymphatic valves</kwd><kwd>lymphatic vascular development</kwd><kwd>lymphovenous valves</kwd><kwd>PROX1</kwd><kwd>Wnt/β-catenin signaling</kwd></kwd-group><funding-group><award-group id="funding-1"><funding-source>National Institutes of Health <named-content content-type="funder-id">http://dx.doi.org/10.13039/100000002</named-content></funding-source><award-id>R01HL131652</award-id></award-group><award-group id="funding-2"><funding-source>Oklahoma Medical Research Foundation <named-content content-type="funder-id">http://dx.doi.org/10.13039/100008907</named-content></funding-source></award-group><award-group id="funding-3"><funding-source>Oklahoma Center for Adult Stem Cell Research</funding-source><award-id>4340</award-id></award-group><award-group id="funding-4"><funding-source>American Heart Association <named-content content-type="funder-id">http://dx.doi.org/10.13039/100000968</named-content></funding-source><award-id>15BGIA25710032</award-id></award-group><award-group id="funding-5"><funding-source>American Heart Association <named-content content-type="funder-id">http://dx.doi.org/10.13039/100000968</named-content></funding-source><award-id>15POST25080182</award-id></award-group><award-group id="funding-6"><funding-source>National Research Foundation <named-content content-type="funder-id">http://dx.doi.org/10.13039/501100001321</named-content></funding-source><award-id>2012M3A9C6050109</award-id></award-group><award-group id="funding-7"><funding-source>National Institute of Allergy and Infectious Diseases <named-content content-type="funder-id">http://dx.doi.org/10.13039/100000060</named-content></funding-source><award-id>R21AI107067</award-id><award-id>R01CA140485</award-id></award-group></funding-group><counts><page-count count="16"></page-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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