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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Characterization of internodal collecting lymphatic vessel function after surgical removal of an axillary lymph node in mice</title><author><name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name><affiliation><nlm:aff id="aff1">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine The University of Texas Health Science Center, Houston, TX 77030,<country country="USA">USA</country></nlm:aff></affiliation></author><author><name sortKey="Price, Roger E" sort="Price, Roger E" uniqKey="Price R" first="Roger E." last="Price">Roger E. Price</name><affiliation><nlm:aff id="aff2">Comparative Pathology Laboratory, Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas 77030,<country country="USA">USA</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27446639</idno><idno type="pmc">4929625</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4929625</idno><idno type="RBID">PMC:4929625</idno><idno type="doi">10.1364/BOE.7.001100</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000638</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000638</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Characterization of internodal collecting lymphatic vessel function after surgical removal of an axillary lymph node in mice</title><author><name sortKey="Kwon, Sunkuk" sort="Kwon, Sunkuk" uniqKey="Kwon S" first="Sunkuk" last="Kwon">Sunkuk Kwon</name><affiliation><nlm:aff id="aff1">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine The University of Texas Health Science Center, Houston, TX 77030,<country country="USA">USA</country></nlm:aff></affiliation></author><author><name sortKey="Price, Roger E" sort="Price, Roger E" uniqKey="Price R" first="Roger E." last="Price">Roger E. Price</name><affiliation><nlm:aff id="aff2">Comparative Pathology Laboratory, Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas 77030,<country country="USA">USA</country></nlm:aff></affiliation></author></analytic><series><title level="j">Biomedical Optics Express</title><idno type="eISSN">2156-7085</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Secondary lymphedema is an acquired lymphatic disorder, which occurs because of damage to the lymphatic system from surgery and/or radiation therapy for cancer treatment. However, it remains unknown how post-nodal collecting lymphatic vessels (CLVs) draining to the surgical wound area change in response to lymphadenectomy. We investigated functional and architectural changes of inguinal-to-axillary internodal CLVs (ICLVs) in mice after a single axillary LN (ALN) dissection using near-infrared fluorescence imaging. Our data showed no lymph flow in the ICLVs draining from the inguinal LN (ILN) at 2 days post-surgery. External compression enabled visualization of a small segment of contractile fluorescent ICLVs, but not all the way to the axillary region. At day 6, abnormal lymphatic drainage patterns, including lateral and retrograde lymph flow via vessels branching off the ICLVs were observed, which started to disappear beginning 9 days after surgery. The administration of vascular endothelial growth factor (VEGF)-C into the wound increased resolution of altered lymphatic drainage. Lymphatic drainage from the base of the tail to the ILN did not significantly change over time. These results demonstrate that lymph flow in the CLVs is dramatically affected by a LN dissection and long-term interruption of lymph flow might cause CLV dysfunction and thus contribute to chronic lymphatic disorders.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Opt Express</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Opt Express</journal-id><journal-id journal-id-type="publisher-id">BOE</journal-id><journal-title-group><journal-title>Biomedical Optics Express</journal-title></journal-title-group><issn pub-type="epub">2156-7085</issn><publisher><publisher-name>Optical Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27446639</article-id><article-id pub-id-type="pmc">4929625</article-id><article-id pub-id-type="publisher-id">255572</article-id><article-id pub-id-type="doi">10.1364/BOE.7.001100</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Characterization of internodal collecting lymphatic vessel function after surgical removal of an axillary lymph node in mice</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kwon</surname><given-names>Sunkuk</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><contrib contrib-type="author"><name><surname>Price</surname><given-names>Roger E.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><aff id="aff1"><label>1</label>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine The University of Texas Health Science Center, Houston, TX 77030,<country country="USA">USA</country></aff><aff id="aff2"><label>2</label>Comparative Pathology Laboratory, Center for Comparative Medicine, Baylor College of Medicine, Houston, Texas 77030,<country country="USA">USA</country></aff></contrib-group><author-notes><corresp id="cor1"><label>*</label><email xlink:href="sunkuk.kwon@uth.tmc.edu">sunkuk.kwon@uth.tmc.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>03</day><month>3</month><year>2016</year></pub-date><pub-date pub-type="collection"><day>01</day><month>4</month><year>2016</year></pub-date><pub-date pub-type="pmc-release"><day>03</day><month>3</month><year>2016</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>7</volume><issue>4</issue><fpage>1100</fpage><lpage>1115</lpage><history><date date-type="received"><day>14</day><month>12</month><year>2015</year></date><date date-type="rev-recd"><day>08</day><month>2</month><year>2016</year></date><date date-type="accepted"><day>26</day><month>2</month><year>2016</year></date></history><permissions><copyright-statement>© 2016 Optical Society of America</copyright-statement><copyright-year>2016</copyright-year><copyright-holder>Optical Society of America</copyright-holder></permissions><abstract><p>Secondary lymphedema is an acquired lymphatic disorder, which occurs because of damage to the lymphatic system from surgery and/or radiation therapy for cancer treatment. However, it remains unknown how post-nodal collecting lymphatic vessels (CLVs) draining to the surgical wound area change in response to lymphadenectomy. We investigated functional and architectural changes of inguinal-to-axillary internodal CLVs (ICLVs) in mice after a single axillary LN (ALN) dissection using near-infrared fluorescence imaging. Our data showed no lymph flow in the ICLVs draining from the inguinal LN (ILN) at 2 days post-surgery. External compression enabled visualization of a small segment of contractile fluorescent ICLVs, but not all the way to the axillary region. At day 6, abnormal lymphatic drainage patterns, including lateral and retrograde lymph flow via vessels branching off the ICLVs were observed, which started to disappear beginning 9 days after surgery. The administration of vascular endothelial growth factor (VEGF)-C into the wound increased resolution of altered lymphatic drainage. Lymphatic drainage from the base of the tail to the ILN did not significantly change over time. These results demonstrate that lymph flow in the CLVs is dramatically affected by a LN dissection and long-term interruption of lymph flow might cause CLV dysfunction and thus contribute to chronic lymphatic disorders.</p></abstract><kwd-group kwd-group-type="OCIS"><title>OCIS codes: </title><kwd>(170.0170) Medical optics and biotechnology</kwd><kwd>(170.0110) Imaging systems</kwd><kwd>(170.2655) Functional monitoring and imaging</kwd><kwd>(170.3880) Medical and biological imaging</kwd><kwd>(170.4580) Optical diagnostics for medicine</kwd></kwd-group><funding-group><award-group id="sp1"><funding-source>National Cancer Institute (NCI)<named-content content-type="doi">10.13039/100000054</named-content></funding-source><award-id>R21CA159193</award-id></award-group><award-group id="sp2"><funding-source>National Institutes of Health (NIH)<named-content content-type="doi">10.13039/100000002</named-content></funding-source></award-group></funding-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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