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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">A review of performance of near-infrared fluorescence imaging devices used in clinical studies</title>
<author><name sortKey="Zhu, B" sort="Zhu, B" uniqKey="Zhu B" first="B" last="Zhu">B. Zhu</name>
</author>
<author><name sortKey="Sevick Muraca, E M" sort="Sevick Muraca, E M" uniqKey="Sevick Muraca E" first="E M" last="Sevick-Muraca">E M Sevick-Muraca</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">25410320</idno>
<idno type="pmc">4277384</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4277384</idno>
<idno type="RBID">PMC:4277384</idno>
<idno type="doi">10.1259/bjr.20140547</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000484</idno>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A review of performance of near-infrared fluorescence imaging devices used in clinical studies</title>
<author><name sortKey="Zhu, B" sort="Zhu, B" uniqKey="Zhu B" first="B" last="Zhu">B. Zhu</name>
</author>
<author><name sortKey="Sevick Muraca, E M" sort="Sevick Muraca, E M" uniqKey="Sevick Muraca E" first="E M" last="Sevick-Muraca">E M Sevick-Muraca</name>
</author>
</analytic>
<series><title level="j">The British Journal of Radiology</title>
<idno type="ISSN">0007-1285</idno>
<idno type="eISSN">1748-880X</idno>
<imprint><date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
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<front><div type="abstract" xml:lang="en"><p>Near-infrared fluorescence (NIRF) molecular imaging holds great promise as a new “point-of-care” medical imaging modality that can potentially provide the sensitivity of nuclear medicine techniques, but without the radioactivity that can otherwise place limitations of usage. Recently, NIRF imaging devices of a variety of designs have emerged in the market and in investigational clinical studies using indocyanine green (ICG) as a non-targeting NIRF contrast agent to demark the blood and lymphatic vasculatures both non-invasively and intraoperatively. Approved in the USA since 1956 for intravenous administration, ICG has been more recently used off label in intradermal or subcutaneous administrations for fluorescence imaging of the lymphatic vasculature and lymph nodes. Herein, we summarize the devices of a variety of designs, summarize their performance in lymphatic imaging in a tabular format and comment on necessary efforts to develop standards for device performance to compare and use these emerging devices in future, NIRF molecular imaging studies.</p>
</div>
</front>
</TEI>
<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Radiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Br J Radiol</journal-id>
<journal-id journal-id-type="publisher-id">bjr</journal-id>
<journal-title-group><journal-title>The British Journal of Radiology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0007-1285</issn>
<issn pub-type="epub">1748-880X</issn>
<publisher><publisher-name>The British Institute of Radiology.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">25410320</article-id>
<article-id pub-id-type="pmc">4277384</article-id>
<article-id pub-id-type="publisher-manuscript">14547</article-id>
<article-id pub-id-type="doi">10.1259/bjr.20140547</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Review Article</subject>
</subj-group>
<subj-group subj-group-type="collection"><subject>Technical/Instrumental</subject>
<subject>Molecular Imaging</subject>
<subject>Breast</subject>
</subj-group>
</article-categories>
<title-group><article-title>A review of performance of near-infrared fluorescence imaging devices used in clinical studies</article-title>
<alt-title alt-title-type="left-running-head">B Zhu and EM Sevick-Muraca</alt-title>
<alt-title alt-title-type="right-running-head">A review of performance of near-infrared fluorescence imaging devices used in clinical studies</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Zhu</surname>
<given-names>B</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<contrib contrib-type="author" corresp="yes"><name><surname>Sevick-Muraca</surname>
<given-names>E M</given-names>
</name>
<degrees>PhD</degrees>
</contrib>
<aff><addr-line>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX, USA</addr-line>
</aff>
</contrib-group>
<author-notes><corresp id="cor1">Address correspondence to: Professor Eva M Sevick-Muraca. E-mail: <email xlink:href="Eva.Sevick@uth.tmc.edu">Eva.Sevick@uth.tmc.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>1</month>
<year>2015</year>
<string-date>January 2015</string-date>
</pub-date>
<pub-date pub-type="epub"><day>18</day>
<month>12</month>
<year>2014</year>
</pub-date>
<volume>88</volume>
<issue>1045</issue>
<elocation-id>20140547</elocation-id>
<history><date date-type="received"><day>14</day>
<month>8</month>
<year>2014</year>
<string-date>Received on August 14, 2014</string-date>
</date>
<date date-type="rev-recd"><day>4</day>
<month>11</month>
<year>2014</year>
<string-date>Revised on November 4, 2014</string-date>
</date>
<date date-type="accepted"><day>18</day>
<month>11</month>
<year>2014</year>
<string-date>Accepted on November 18, 2014</string-date>
</date>
</history>
<permissions><copyright-statement>© 2015 The Authors. Published by the British Institute of Radiology</copyright-statement>
<copyright-year>2015</copyright-year>
<copyright-holder>The British Institute of Radiology</copyright-holder>
</permissions>
<self-uri content-type="pdf" xlink:href="bjr.20140547.pdf"></self-uri>
<abstract><p>Near-infrared fluorescence (NIRF) molecular imaging holds great promise as a new “point-of-care” medical imaging modality that can potentially provide the sensitivity of nuclear medicine techniques, but without the radioactivity that can otherwise place limitations of usage. Recently, NIRF imaging devices of a variety of designs have emerged in the market and in investigational clinical studies using indocyanine green (ICG) as a non-targeting NIRF contrast agent to demark the blood and lymphatic vasculatures both non-invasively and intraoperatively. Approved in the USA since 1956 for intravenous administration, ICG has been more recently used off label in intradermal or subcutaneous administrations for fluorescence imaging of the lymphatic vasculature and lymph nodes. Herein, we summarize the devices of a variety of designs, summarize their performance in lymphatic imaging in a tabular format and comment on necessary efforts to develop standards for device performance to compare and use these emerging devices in future, NIRF molecular imaging studies.</p>
</abstract>
<counts><fig-count count="4"></fig-count>
<table-count count="6"></table-count>
<ref-count count="129"></ref-count>
<page-count count="26"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>
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