A transplant patient with a swollen leg
Identifieur interne : 000328 ( Pmc/Corpus ); précédent : 000327; suivant : 000329A transplant patient with a swollen leg
Auteurs : Vijay Thanaraj ; Alex Woywodt ; John AndertonSource :
- Clinical Kidney Journal [ 2048-8505 ] ; 2012.
Url:
DOI: 10.1093/ckj/sfs109
PubMed: 26019829
PubMed Central: 4432419
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uniqKey="Paghdal K">KV Paghdal</name></author><author><name sortKey="Schwartz, Ra" uniqKey="Schwartz R">RA Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Leblanc, Kg" uniqKey="Leblanc K">KG Leblanc</name></author><author><name sortKey="Hughes, Mp" uniqKey="Hughes M">MP Hughes</name></author><author><name sortKey="Sheehan, Dj" uniqKey="Sheehan D">DJ Sheehan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Benjamin, D" uniqKey="Benjamin D">D Benjamin</name></author><author><name sortKey="Colombi, M" uniqKey="Colombi M">M Colombi</name></author><author><name sortKey="Moroni, C" uniqKey="Moroni C">C Moroni</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dowling, Rj" uniqKey="Dowling R">RJ Dowling</name></author><author><name sortKey="Topisirovic, I" uniqKey="Topisirovic I">I Topisirovic</name></author><author><name sortKey="Fonseca, Bd" uniqKey="Fonseca B">BD 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uniqKey="Kreuger J">J Kreuger</name></author><author><name sortKey="Nilsson, I" uniqKey="Nilsson I">I Nilsson</name></author><author><name sortKey="Kerjaschki, D" uniqKey="Kerjaschki D">D Kerjaschki</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Karkkainen, Mj" uniqKey="Karkkainen M">MJ Karkkainen</name></author><author><name sortKey="Ferrell, Re" uniqKey="Ferrell R">RE Ferrell</name></author><author><name sortKey="Lawrence, Ec" uniqKey="Lawrence E">EC Lawrence</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huber, S" uniqKey="Huber S">S Huber</name></author><author><name sortKey="Bruns, Cj" uniqKey="Bruns C">CJ Bruns</name></author><author><name sortKey="Schmid, G" uniqKey="Schmid G">G Schmid</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kobayashi, S" uniqKey="Kobayashi S">S Kobayashi</name></author><author><name sortKey="Kishimoto, T" uniqKey="Kishimoto T">T Kishimoto</name></author><author><name sortKey="Kamata, S" uniqKey="Kamata S">S Kamata</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Clin Kidney J</journal-id><journal-id journal-id-type="iso-abbrev">Clin Kidney J</journal-id><journal-id journal-id-type="publisher-id">ckj</journal-id><journal-id journal-id-type="hwp">ndtplus</journal-id><journal-title-group><journal-title>Clinical Kidney Journal</journal-title></journal-title-group><issn pub-type="ppub">2048-8505</issn><issn pub-type="epub">2048-8513</issn><publisher><publisher-name>Oxford University Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26019829</article-id><article-id pub-id-type="pmc">4432419</article-id><article-id pub-id-type="doi">10.1093/ckj/sfs109</article-id><article-id pub-id-type="publisher-id">sfs109</article-id><article-categories><subj-group subj-group-type="heading"><subject>Educational Papers</subject><subj-group subj-group-type="heading"><subject>Teaching Points</subject></subj-group></subj-group></article-categories><title-group><article-title>A transplant patient with a swollen leg</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Thanaraj</surname><given-names>Vijay</given-names></name></contrib><contrib contrib-type="author"><name><surname>Woywodt</surname><given-names>Alex</given-names></name></contrib><contrib contrib-type="author"><name><surname>Anderton</surname><given-names>John</given-names></name><xref ref-type="corresp" rid="cor1"></xref></contrib><aff><addr-line>Department of Renal Medicine</addr-line>,<institution>Lancashire Teaching Hospitals NHS Foundation Trust</institution>,<addr-line>Preston, Lancashire</addr-line>,<country>UK</country></aff><aff id="af2"><label>2</label><addr-line>Renal Unit</addr-line>,<institution>Lancashire Teaching Hospitals NHS Trust, Royal Preston Hospital</institution>,<addr-line>Preston</addr-line>,<country>UK</country></aff></contrib-group><author-notes><corresp id="cor1"><italic>Correspondence and offprint requests to:</italic> John Anderton; E-mail: <email>John.Anderton@lthtr.nhs.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><month>10</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>5</volume><issue>5</issue><fpage>467</fpage><lpage>470</lpage><history><date date-type="received"><day>17</day><month>7</month><year>2012</year></date><date date-type="accepted"><day>18</day><month>7</month><year>2012</year></date></history><permissions><copyright-statement>© The Author 2012. Published by Oxford University Press on behalf of ERA-EDTA. All rights reserved. For permissions, please email: journals.permissions@oup.com</copyright-statement><copyright-year>2012</copyright-year><license license-type="creative-commons" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (<uri xlink:type="simple" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</uri>), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com</license-p></license></permissions><self-uri content-type="pdf" xlink:type="simple" xlink:href="sfs109.pdf"></self-uri><kwd-group><kwd>lymphoedema</kwd><kwd>renal transplant</kwd><kwd>sirolimus</kwd></kwd-group></article-meta></front><body><sec sec-type="intro" id="s1"><title>Introduction</title><p>Some degree of peripheral oedema is not uncommon following renal transplantation. Bilateral peripheral oedema is seen in the context of congestive heart failure, delayed graft function with extracellular volume expansion or nephrotic syndrome due to glomerular disease. Mild unilateral peripheral oedema is also often seen, typically early after surgery and on the transplanted side. In these cases, it is usually assumed that some form of damage to the lymphatic ducts has occurred during transplant surgery. The swelling is usually mild and often settles over time. However, severe peripheral oedema on the contralateral side is uncommon, especially if deep venous thrombosis has already been excluded. We report such a case, which led to an unusual diagnosis. We also provide a brief review of the relevant literature and discuss recent insight into possible mechanisms and pathways.</p></sec><sec id="s2"><title>Case</title><p>A 52-year-old woman with adult polycystic kidney disease received a first deceased renal transplant into the right iliac fossa in December 2008. Her medical history included bilateral native nephrectomy of her large polycystic kidneys as well as excision of a malignant melanoma <italic>in situ</italic> from the anterior chest in 2006. She had remained free of recurrence since then and remained under regular surveillance with a dermatologist. Following transplantation in 2008, her initial immunosuppression had been with tacrolimus, mycophenolate mofetil and prednisolone. There was a period of delayed graft function and renal biopsy showed acute tubular necrosis. Eventually, she was converted to sirolimus. Transplant function improved greatly, and serum creatinine when discharged was 150 μmol/L.</p><p>In March 2010, the patient presented to the outpatient clinic with a very swollen left leg. On examination, the patient was essentially well and afebrile. There were no signs of infection and no palpable lymph nodes in either groin. There were no clinical signs of deep venous thrombosis or of phlebitis. The remainder of the clinical examination was essentially unremarkable. There was no history of surgery, trauma or infection in the left leg, nor had she ever had a femoral dialysis access. The general practitioner had started compression bandages but the affected leg remained grossly oedematous (<xref ref-type="fig" rid="SFS109F1">Figure 1</xref>). Doppler studies revealed no deep vein thrombosis and left leg venogram confirmed patent veins up to the inferior vena cava. Diuretics were administered, but without any clinical benefit. The patient was seen at the regional referral centre for lymphoedema and a complex regime of bandaging and lymphatic drainage exercises was begun. Computed tomogram of the chest, abdomen and pelvis showed minor lymphadenopathy in the left groin. Around spring, 2010, the cause of her leg swelling was still essentially unclear. Cytomegalovirus and the Epstein–Barr virus polymerase chain reaction were negative, and serum lactate dehydrogenase was normal. Given her previous history of melanoma, we proceeded to a left inguinal lymph node biopsy, which showed no significant abnormality and no tumour cells. Eventually, the possibility of sirolimus-associated lymphoedema was considered. Sirolimus levels throughout this period of follow-up were within the target range (6.3–10.5 μg/L). Lymphoscintigraphy demonstrated the complete absence of tracer drainage from the left lower limb (<xref ref-type="fig" rid="SFS109F2">Figure 2</xref>). A tentative diagnosis of unilateral lymphoedema due to a mammalian target of rapamycin (mTOR) inhibitor was made and sirolimus was withdrawn. Within 2 weeks, the swelling improved dramatically. When last seen in May 2012, she was very well with no discernible leg swelling (<xref ref-type="fig" rid="SFS109F3">Figure 3</xref>) and good transplant function (creatinine 156 μmol/L).
<fig id="SFS109F1" position="float"><label>Fig. 1.</label><caption><p>Swollen left leg when the patient first presented.</p></caption><graphic xlink:href="sfs10901"></graphic></fig><fig id="SFS109F2" position="float"><label>Fig. 2.</label><caption><p>Lymphoscintigraphy of the patient. Note the almost complete absence of lymphatic transport in the left leg.</p></caption><graphic xlink:href="sfs10902"></graphic></fig><fig id="SFS109F3" position="float"><label>Fig. 3.</label><caption><p>Resolution of left swelling following withdrawal of sirolimus.</p></caption><graphic xlink:href="sfs10903"></graphic></fig></p></sec><sec sec-type="discussion" id="s3"><title>Discussion</title><p>Sirolimus is an inhibitor of the mTOR with immunosuppressant and anti-proliferative properties [<xref rid="SFS109C1" ref-type="bibr">1</xref>]. A macrolide, sirolimus was first discovered in a soil sample from Easter Island—an island also known as Rapa Nui, hence the name rapamycin. Inhibitors of the mTOR, such as sirolimus and everolimus, have a unique role in immunosuppression after solid-organ transplantation. This is mainly due to their anti-proliferative properties [<xref rid="SFS109C2" ref-type="bibr">2</xref>] and also because they lack the tubular and vascular toxicity associated with calcineurin inhibitors. The use of mTOR inhibitors for routine maintenance immunosuppression, however, remains controversial and some recent studies did not demonstrate a survival benefit for mTOR-based regimes when compared with those relying on calcineurin inhibitors.</p><p>More recently, two more mTOR inhibitors have become available clinically, everolimus and temsirolimus. mTOR inhibitors are currently also being evaluated for treating, among others, lymphangioleiomyomatosis, polycystic kidney disease, renal cell carcinoma and tuberous sclerosis [<xref rid="SFS109C3" ref-type="bibr">3</xref>]. More and more mTOR inhibitors are emerging and the term ‘rapalogues’ has now been coined [<xref rid="SFS109C3" ref-type="bibr">3</xref>]. Some of these new drugs are more specific than traditional mTOR inhibitors, in that they target the active site of mTOR systems to exert more prominent effects on mTOR functional outputs than rapamycin itself [<xref rid="SFS109C4" ref-type="bibr">4</xref>].</p><p>Our understanding of mTOR pathways has also improved substantially in recent years. These mechanisms are obviously beyond the scope of our little teaching point and are reviewed in great details elsewhere [<xref rid="SFS109C4" ref-type="bibr">4</xref>]. Briefly, mTOR itself is a system of serine/threonine kinases. We now know that mTOR is present in two distinct protein complexes commonly referred to as mTOR complex 1 (mTORC1) and mTOR complex 2 (mTORC2). mTORC1 features a companion protein with the interesting name of Raptor (regulatory-associated protein of mTOR). The corresponding protein in mTORC2 has been dubbed Rictor (rapamycin-insensitive companion of mTOR). mTORC1 and mTORC2 phosphorylate different substrates to regulate distinct cellular functions. For instance, mTORC2 phosphorylates proteins associated with cell survival and cytoskeletal organization, whereas mTORC1 stimulates cell growth and proliferation [<xref rid="SFS109C4" ref-type="bibr">4</xref>].</p><p>The spectrum of side effects reported with mTOR inhibitors is as unique as their mode of action [<xref rid="SFS109C1" ref-type="bibr">1</xref>, <xref rid="SFS109C5" ref-type="bibr">5</xref>] and there is a reason to believe that most of these effects are associated with the entire drug class and not with individual substances. Most nephrologists will be familiar with aphthous ulcers, diarrhoea, hyperlipidaemia and bone marrow suppression as common side effects of these drugs and perhaps recall the fact that these drugs impair wound healing. However, the spectrum of side effects is much wider (Table <xref ref-type="table" rid="SFS109TB1">1</xref>).
<table-wrap id="SFS109TB1" position="float"><label>Table 1.</label><caption><p>Side effects of mTOR inhibitors [<xref rid="SFS109C1" ref-type="bibr">1</xref>, <xref rid="SFS109C5" ref-type="bibr">5</xref>]</p></caption><table frame="hsides" rules="groups"><colgroup span="1"><col align="left" span="1"></col></colgroup><tbody><tr><td colspan="1" rowspan="1">Angioedema (usually when administered with ACE-inhibitors)</td></tr><tr><td colspan="1" rowspan="1">Arthralgia</td></tr><tr><td colspan="1" rowspan="1">Bone marrow depression</td></tr><tr><td colspan="1" rowspan="1">Diarrhoea and other gastrointestinal symptoms</td></tr><tr><td colspan="1" rowspan="1">Hyperlipidaemia</td></tr><tr><td colspan="1" rowspan="1">Oral ulcers (typically dose-related)</td></tr><tr><td colspan="1" rowspan="1">Hypokalaemia</td></tr><tr><td colspan="1" rowspan="1">Hypophosphataemia</td></tr><tr><td colspan="1" rowspan="1">Lymphocele</td></tr><tr><td colspan="1" rowspan="1">Interstitial pneumonitis (resembling bronchiolitis obliterans-organizing pneumonia with lymphocytic alveolitis on bronchio-alveolar lavage)</td></tr><tr><td colspan="1" rowspan="1">Oedema (peripheral oedema incl. anasarca, pericardial and pleural effusion, ascites, unusual locations such as eyelid)</td></tr><tr><td colspan="1" rowspan="1">Proteinuria (usually focal and segmental glomerulosclerosis)</td></tr><tr><td colspan="1" rowspan="1">Skin disorders (acneiform, folliculitis, hidradenitis suppurativa)</td></tr><tr><td colspan="1" rowspan="1">Thrombotic microangiopathy (usually when administered in combination with cyclosporine)</td></tr><tr><td colspan="1" rowspan="1">Disturbed wound healing</td></tr></tbody></table></table-wrap></p><p>Cases of lymphoedema attributed to mTOR inhibitors have been reported time and again in the transplant [<xref rid="SFS109C6" ref-type="bibr">6</xref>–<xref rid="SFS109C9" ref-type="bibr">9</xref>] and dermatology [<xref rid="SFS109C10" ref-type="bibr">10</xref>] literature. Desai <italic>et al</italic>. reported a series of eight cases from a single institution and reviewed eleven cases described elsewhere in the literature [<xref rid="SFS109C5" ref-type="bibr">5</xref>]. We report a case of unilateral lower limb lymphoedema associated with sirolimus. The fact that the oedema occurred unilaterally and not on the transplanted side is remarkable, but similar cases have been reported before [<xref rid="SFS109C10" ref-type="bibr">10</xref>]. Comprehensive evaluation, including imaging and lymph node biopsy, did not reveal any other cause of the swelling. Lymphoscintigraphy confirmed the complete absence of tracer drainage from the left lower limb. Others have reported very similar imaging findings in lymphoedema associated with mTOR inhibitors [<xref rid="SFS109C10" ref-type="bibr">10</xref>]. The fact that the oedema resolved to a large degree after discontinuation of the drug gives us further confidence in the interpretation. Lymphoedema associated with mTOR inhibitors can affect the lower limbs only but may also involve atypical locations, such as the eyelid [<xref rid="SFS109C11" ref-type="bibr">11</xref>]. Pericardial and pleural effusion and ascites are also seen.</p><p>Lymph drainage involves several steps: first, interstitial fluid is absorbed into initial lymphatics and then transported to the main collecting lymphatics. Transport is via contraction of smooth muscle cells in the vessel wall and also due to contraction of the adjacent skeletal muscle and arterial pulsation. Lymphatic vessels also feature valves, which prevent backflow of lymphatic fluid. Lymphatic survival, proliferation and migration are mediated by the vascular endothelial growth factor (VEGF) system [<xref rid="SFS109C12" ref-type="bibr">12</xref>]. Mutations in VEGF receptor 3 cause lymphoedema [<xref rid="SFS109C13" ref-type="bibr">13</xref>]. Recent studies have demonstrated that mTOR is a downstream signal in the VEGF C/D pathway and that mTOR inhibitors such as sirolimus are capable of inhibiting lymphangiogenesis <italic>in vitro</italic> [<xref rid="SFS109C14" ref-type="bibr">14</xref>, <xref rid="SFS109C15" ref-type="bibr">15</xref>]. Those findings provide a possible mechanism for lymphoedema associated with mTOR inhibitors. The fact that these drugs are also associated with increased incidence of lymphocele underscores their unique propensity to affect the lymphatic system. However, it remains unclear as to why some patients develop this complication whereas many others, who are similarly exposed to these drugs, do not [<xref rid="SFS109C10" ref-type="bibr">10</xref>]. Predisposing factors such as previous trauma, surgery or inflammation have been invoked but our patient had none of these. In particular, the lymphoedema occurred on the non-transplanted side. The time frame seen in our case is in keeping with that reported in the literature whereby lymphoedema occurred between 11 weeks to 36 months from the commencement of sirolimus. Most of the patients responded to either conversion of sirolimus to alternative immunosuppressive regime or to dose reduction in sirolimus along with supportive management.</p></sec><sec sec-type="conclusions" id="s4"><title>Conclusion</title><p>Lymphoedema is a recognized adverse effect of mTOR inhibitors, which is surprisingly well described in the dermatology [<xref rid="SFS109C2" ref-type="bibr">2</xref>] and transplant [<xref rid="SFS109C1" ref-type="bibr">1</xref>] literature. In hindsight, we feel that the diagnosis could have been made earlier, which would have avoided unnecessary investigations and delay. We take some consolation from the fact that a number of highly experienced colleagues, including the regional lymphoedema referral centre, were equally unaware of this rare cause of lymphoedema. Our encounter with a mysteriously swollen leg eventually provided an interesting detour into the mechanisms of mTOR inhibition and into rare side effects of mTOR inhibitors. We also took the opportunity to revise our knowledge of the somewhat neglected lymphatic system.</p></sec><sec id="s5"><title>Teaching points</title><p><list list-type="roman-lower"><list-item><p>Inhibitors of the mTOR have a unique mode of action in preventing rejection in recipients of solid-organ transplants. Their use is also under investigation for a variety of other disorders.</p></list-item><list-item><p>mTOR inhibitors also feature a unique profile of side effects.</p></list-item><list-item><p>Lymphoedema is a well-described side effect of mTOR inhibitors that is reversible on discontinuation of these drugs.</p></list-item><list-item><p>Awareness and early recognition of this side effect may avoid unnecessary investigations.</p></list-item></list></p></sec><sec id="s6"><title>Conflict of interest statement</title><p>None declared.</p></sec></body><back><ack><title>Acknowledgements</title><p>We are indebted to the regional lymphoedema service for clinical advice. We are also grateful to the patient for allowing us to publish her case.</p></ack><ref-list><title>References</title><ref id="SFS109C1"><label>1</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Paghdal</surname><given-names>KV</given-names></name><name><surname>Schwartz</surname><given-names>RA</given-names></name></person-group><article-title>Sirolimus (rapamycin): from the soil of Easter Island to a bright future</article-title><source>J Am Acad Dermatol</source><year>2007</year><volume>57</volume><fpage>1046</fpage><lpage>1050</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.jaad.2007.05.021">doi:10.1016/j.jaad.2007.05.021</ext-link></comment><pub-id pub-id-type="pmid">17583372</pub-id></element-citation></ref><ref id="SFS109C2"><label>2</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Leblanc</surname><given-names>KG</given-names><suffix>Jr</suffix></name><name><surname>Hughes</surname><given-names>MP</given-names></name><name><surname>Sheehan</surname><given-names>DJ</given-names></name></person-group><article-title>The role of sirolimus in the prevention of cutaneous squamous cell carcinoma in organ transplant recipients</article-title><source>Dermatol Surg</source><year>2011</year><volume>37</volume><fpage>744</fpage><lpage>749</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1111/j.1524-4725.2011.01973.x">doi:10.1111/j.1524-4725.2011.01973.x</ext-link></comment><pub-id pub-id-type="pmid">21605234</pub-id></element-citation></ref><ref id="SFS109C3"><label>3</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Benjamin</surname><given-names>D</given-names></name><name><surname>Colombi</surname><given-names>M</given-names></name><name><surname>Moroni</surname><given-names>C</given-names></name><etal></etal></person-group><article-title>Rapamycin passes the torch: a new generation of mTOR inhibitors</article-title><source>Nat Rev Drug Discov</source><year>2011</year><volume>10</volume><fpage>868</fpage><lpage>880</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1038/nrd3531">doi:10.1038/nrd3531</ext-link></comment><pub-id pub-id-type="pmid">22037041</pub-id></element-citation></ref><ref id="SFS109C4"><label>4</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Dowling</surname><given-names>RJ</given-names></name><name><surname>Topisirovic</surname><given-names>I</given-names></name><name><surname>Fonseca</surname><given-names>BD</given-names></name><etal></etal></person-group><article-title>Dissecting the role of mTOR: lessons from mTOR inhibitors</article-title><source>Biochim Biophys Acta</source><year>2010</year><volume>1804</volume><fpage>433</fpage><lpage>439</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.bbapap.2009.12.001">doi:10.1016/j.bbapap.2009.12.001</ext-link></comment><pub-id pub-id-type="pmid">20005306</pub-id></element-citation></ref><ref id="SFS109C5"><label>5</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Watson</surname><given-names>CJE</given-names></name></person-group><article-title>Sirolimus (rapamycin) in clinical transplantation</article-title><source>Transplant Rev</source><year>2001</year><volume>15</volume><fpage>165</fpage><lpage>177</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/S0955-470X(01)80016-1">doi:10.1016/S0955-470X(01)80016-1</ext-link></comment></element-citation></ref><ref id="SFS109C6"><label>6</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>De Bartolomeis</surname><given-names>C</given-names></name><name><surname>Collini</surname><given-names>A</given-names></name><name><surname>Rumberger</surname><given-names>B</given-names></name><etal></etal></person-group><article-title>Generalized lymphedema in a sirolimus-treated renal transplant patient</article-title><source>Clin Transplant</source><year>2008</year><volume>22</volume><fpage>254</fpage><lpage>257</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1111/j.1399-0012.2007.00766.x">doi:10.1111/j.1399-0012.2007.00766.x</ext-link></comment><pub-id pub-id-type="pmid">18339149</pub-id></element-citation></ref><ref id="SFS109C7"><label>7</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Al-Otaibi</surname><given-names>T</given-names></name><name><surname>Ahamed</surname><given-names>N</given-names></name><name><surname>Nampoory</surname><given-names>MR</given-names></name><etal></etal></person-group><article-title>Lymphedema: an unusual complication of sirolimus therapy</article-title><source>Transplant Proc</source><year>2007</year><volume>39</volume><fpage>1207</fpage><lpage>1210</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.transproceed.2007.03.058">doi:10.1016/j.transproceed.2007.03.058</ext-link></comment><pub-id pub-id-type="pmid">17524934</pub-id></element-citation></ref><ref id="SFS109C8"><label>8</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aboujaoude</surname><given-names>W</given-names></name><name><surname>Milgrom</surname><given-names>ML</given-names></name><name><surname>Govani</surname><given-names>MV</given-names></name></person-group><article-title>Lymphedema associated with sirolimus in renal transplant recipients</article-title><source>Transplantation</source><year>2004</year><volume>77</volume><fpage>1094</fpage><lpage>1096</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1097/01.TP.0000118406.01509.75">doi:10.1097/01.TP.0000118406.01509.75</ext-link></comment><pub-id pub-id-type="pmid">15087777</pub-id></element-citation></ref><ref id="SFS109C9"><label>9</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Romagnoli</surname><given-names>J</given-names></name><name><surname>Citterio</surname><given-names>F</given-names></name><name><surname>Nanni</surname><given-names>G</given-names></name><etal></etal></person-group><article-title>Severe limb lymphedema in sirolimus-treated patients</article-title><source>Transplant Proc</source><year>2005</year><volume>37</volume><fpage>834</fpage><lpage>836</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1016/j.transproceed.2004.12.180">doi:10.1016/j.transproceed.2004.12.180</ext-link></comment><pub-id pub-id-type="pmid">15848548</pub-id></element-citation></ref><ref id="SFS109C10"><label>10</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Desai</surname><given-names>N</given-names></name><name><surname>Heenan</surname><given-names>S</given-names></name><name><surname>Mortimer</surname><given-names>PS</given-names></name></person-group><article-title>Sirolimus-associated lymphoedema: eight new cases and a proposed mechanism</article-title><source>Br J Dermatol</source><year>2009</year><volume>160</volume><fpage>1322</fpage><lpage>1326</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1111/j.1365-2133.2009.09098.x">doi:10.1111/j.1365-2133.2009.09098.x</ext-link></comment><pub-id pub-id-type="pmid">19302070</pub-id></element-citation></ref><ref id="SFS109C11"><label>11</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mohaupt</surname><given-names>MG</given-names></name><name><surname>Vogt</surname><given-names>B</given-names></name><name><surname>Frey</surname><given-names>FJ</given-names></name></person-group><article-title>Sirolimus-associated eyelid edema in kidney transplant recipients</article-title><source>Transplantation</source><year>2001</year><volume>72</volume><fpage>162</fpage><lpage>164</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1097/00007890-200107150-00031">doi:10.1097/00007890-200107150-00031</ext-link></comment><pub-id pub-id-type="pmid">11468553</pub-id></element-citation></ref><ref id="SFS109C12"><label>12</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kreuger</surname><given-names>J</given-names></name><name><surname>Nilsson</surname><given-names>I</given-names></name><name><surname>Kerjaschki</surname><given-names>D</given-names></name><etal></etal></person-group><article-title>Early lymph vessel development from embryonic stem cells</article-title><source>Arterioscler Thromb Vasc Biol</source><year>2006</year><volume>26</volume><fpage>1073</fpage><lpage>1078</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1161/01.ATV.0000217610.58032.b7">doi:10.1161/01.ATV.0000217610.58032.b7</ext-link></comment><pub-id pub-id-type="pmid">16543496</pub-id></element-citation></ref><ref id="SFS109C13"><label>13</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Karkkainen</surname><given-names>MJ</given-names></name><name><surname>Ferrell</surname><given-names>RE</given-names></name><name><surname>Lawrence</surname><given-names>EC</given-names></name><etal></etal></person-group><article-title>Missense mutations interfere with VEGFR-3 signalling in primary lymphoedema</article-title><source>Nat Genet</source><year>2000</year><volume>25</volume><fpage>153</fpage><lpage>159</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1038/75997">doi:10.1038/75997</ext-link></comment><pub-id pub-id-type="pmid">10835628</pub-id></element-citation></ref><ref id="SFS109C14"><label>14</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Huber</surname><given-names>S</given-names></name><name><surname>Bruns</surname><given-names>CJ</given-names></name><name><surname>Schmid</surname><given-names>G</given-names></name><etal></etal></person-group><article-title>Inhibition of the mammalian target of rapamycin impedes lymphangiogenesis</article-title><source>Kidney Int</source><year>2007</year><volume>71</volume><fpage>771</fpage><lpage>777</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1038/sj.ki.5002112">doi:10.1038/sj.ki.5002112</ext-link></comment><pub-id pub-id-type="pmid">17299523</pub-id></element-citation></ref><ref id="SFS109C15"><label>15</label><element-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kobayashi</surname><given-names>S</given-names></name><name><surname>Kishimoto</surname><given-names>T</given-names></name><name><surname>Kamata</surname><given-names>S</given-names></name><etal></etal></person-group><article-title>Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis</article-title><source>Cancer Sci</source><year>2007</year><volume>98</volume><fpage>726</fpage><lpage>733</lpage><comment><ext-link ext-link-type="uri" xlink:href="http://dx.doi.org/10.1111/j.1349-7006.2007.00439.x">doi:10.1111/j.1349-7006.2007.00439.x</ext-link></comment><pub-id pub-id-type="pmid">17425689</pub-id></element-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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