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<fileDesc>
<titleStmt>
<title xml:lang="en">A Hybrid Effectiveness-Implementation Trial of an Evidence-Based Exercise Intervention for Breast Cancer Survivors</title>
<author>
<name sortKey="Beidas, Rinad S" sort="Beidas, Rinad S" uniqKey="Beidas R" first="Rinad S." last="Beidas">Rinad S. Beidas</name>
</author>
<author>
<name sortKey="Paciotti, Breah" sort="Paciotti, Breah" uniqKey="Paciotti B" first="Breah" last="Paciotti">Breah Paciotti</name>
</author>
<author>
<name sortKey="Barg, Fran" sort="Barg, Fran" uniqKey="Barg F" first="Fran" last="Barg">Fran Barg</name>
</author>
<author>
<name sortKey="Branas, Andrea R" sort="Branas, Andrea R" uniqKey="Branas A" first="Andrea R." last="Branas">Andrea R. Branas</name>
</author>
<author>
<name sortKey="Brown, Justin C" sort="Brown, Justin C" uniqKey="Brown J" first="Justin C." last="Brown">Justin C. Brown</name>
</author>
<author>
<name sortKey="Glanz, Karen" sort="Glanz, Karen" uniqKey="Glanz K" first="Karen" last="Glanz">Karen Glanz</name>
</author>
<author>
<name sortKey="Demichele, Angela" sort="Demichele, Angela" uniqKey="Demichele A" first="Angela" last="Demichele">Angela Demichele</name>
</author>
<author>
<name sortKey="Digiovanni, Laura" sort="Digiovanni, Laura" uniqKey="Digiovanni L" first="Laura" last="Digiovanni">Laura Digiovanni</name>
</author>
<author>
<name sortKey="Salvatore, Domenick" sort="Salvatore, Domenick" uniqKey="Salvatore D" first="Domenick" last="Salvatore">Domenick Salvatore</name>
</author>
<author>
<name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name>
</author>
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<idno type="wicri:source">PMC</idno>
<idno type="pmid">25749601</idno>
<idno type="pmc">4411538</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4411538</idno>
<idno type="RBID">PMC:4411538</idno>
<idno type="doi">10.1093/jncimonographs/lgu033</idno>
<date when="2014">2014</date>
<idno type="wicri:Area/Pmc/Corpus">000292</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000292</idno>
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<analytic>
<title xml:lang="en" level="a" type="main">A Hybrid Effectiveness-Implementation Trial of an Evidence-Based Exercise Intervention for Breast Cancer Survivors</title>
<author>
<name sortKey="Beidas, Rinad S" sort="Beidas, Rinad S" uniqKey="Beidas R" first="Rinad S." last="Beidas">Rinad S. Beidas</name>
</author>
<author>
<name sortKey="Paciotti, Breah" sort="Paciotti, Breah" uniqKey="Paciotti B" first="Breah" last="Paciotti">Breah Paciotti</name>
</author>
<author>
<name sortKey="Barg, Fran" sort="Barg, Fran" uniqKey="Barg F" first="Fran" last="Barg">Fran Barg</name>
</author>
<author>
<name sortKey="Branas, Andrea R" sort="Branas, Andrea R" uniqKey="Branas A" first="Andrea R." last="Branas">Andrea R. Branas</name>
</author>
<author>
<name sortKey="Brown, Justin C" sort="Brown, Justin C" uniqKey="Brown J" first="Justin C." last="Brown">Justin C. Brown</name>
</author>
<author>
<name sortKey="Glanz, Karen" sort="Glanz, Karen" uniqKey="Glanz K" first="Karen" last="Glanz">Karen Glanz</name>
</author>
<author>
<name sortKey="Demichele, Angela" sort="Demichele, Angela" uniqKey="Demichele A" first="Angela" last="Demichele">Angela Demichele</name>
</author>
<author>
<name sortKey="Digiovanni, Laura" sort="Digiovanni, Laura" uniqKey="Digiovanni L" first="Laura" last="Digiovanni">Laura Digiovanni</name>
</author>
<author>
<name sortKey="Salvatore, Domenick" sort="Salvatore, Domenick" uniqKey="Salvatore D" first="Domenick" last="Salvatore">Domenick Salvatore</name>
</author>
<author>
<name sortKey="Schmitz, Kathryn H" sort="Schmitz, Kathryn H" uniqKey="Schmitz K" first="Kathryn H." last="Schmitz">Kathryn H. Schmitz</name>
</author>
</analytic>
<series>
<title level="j">Journal of the National Cancer Institute. Monographs</title>
<idno type="ISSN">1052-6773</idno>
<idno type="eISSN">1745-6614</idno>
<imprint>
<date when="2014">2014</date>
</imprint>
</series>
</biblStruct>
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<front>
<div type="abstract" xml:lang="en">
<sec>
<title>Background</title>
<p>The primary aims of this hybrid Type 1 effectiveness-implementation trial were to quantitatively assess whether an evidence-based exercise intervention for breast cancer survivors, Strength After Breast Cancer, was safe and effective in a new setting and to qualitatively assess barriers to implementation.</p>
</sec>
<sec sec-type="methods">
<title>Methods</title>
<p>A cohort of 84 survivors completed measurements related to limb volume, muscle strength, and body image at baseline, 67 survivors completed measurements 12 months later. Qualitative methods were used to understand barriers to implementation experienced by referring oncology clinicians and physical therapists who delivered the program.</p>
</sec>
<sec>
<title>Results</title>
<p>Similar to the efficacy trial, the revised intervention demonstrated safety with regard to lymphedema, and led to improvements in lymphedema symptoms, muscular strength, and body image. Comparison of effects in the effectiveness trial to effects in the efficacy trial revealed larger strength increases in the efficacy trial than in the effectiveness trial (
<italic>P</italic>
< .04), but few other differences were found. Qualitative implementation data suggested significant barriers around intervention characteristics, payment, eligibility criteria, the referral process, the need for champions (ie, advocates), and the need to adapt during implementation of the intervention, which should be considered in future dissemination and implementation efforts.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>This trial successfully demonstrated that a physical therapy led strength training program for breast cancer survivors can be implemented in a community setting while retaining the effectiveness and safety of the clinical trial. However, during the translation process, strategies to reduce barriers to implementation are required. This new program can inform larger scale dissemination and implementation efforts.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article">
<pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front>
<journal-meta>
<journal-id journal-id-type="nlm-ta">J Natl Cancer Inst Monogr</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Natl. Cancer Inst. Monographs</journal-id>
<journal-id journal-id-type="hwp">jncimono</journal-id>
<journal-id journal-id-type="publisher-id">jncmon</journal-id>
<journal-title-group>
<journal-title>Journal of the National Cancer Institute. Monographs</journal-title>
</journal-title-group>
<issn pub-type="ppub">1052-6773</issn>
<issn pub-type="epub">1745-6614</issn>
<publisher>
<publisher-name>Oxford University Press</publisher-name>
<publisher-loc>US</publisher-loc>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="pmid">25749601</article-id>
<article-id pub-id-type="pmc">4411538</article-id>
<article-id pub-id-type="doi">10.1093/jncimonographs/lgu033</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Article</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>A Hybrid Effectiveness-Implementation Trial of an Evidence-Based Exercise Intervention for Breast Cancer Survivors</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author">
<name>
<surname>Beidas</surname>
<given-names>Rinad S.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Paciotti</surname>
<given-names>Breah</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Barg</surname>
<given-names>Fran</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Branas</surname>
<given-names>Andrea R.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Brown</surname>
<given-names>Justin C.</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Glanz</surname>
<given-names>Karen</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>DeMichele</surname>
<given-names>Angela</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>DiGiovanni</surname>
<given-names>Laura</given-names>
</name>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Salvatore</surname>
<given-names>Domenick</given-names>
</name>
</contrib>
<contrib contrib-type="author" corresp="yes">
<name>
<surname>Schmitz</surname>
<given-names>Kathryn H.</given-names>
</name>
</contrib>
<aff id="AF0001">
<bold>Affiliations of authors:</bold>
<institution>Department of Psychiatry</institution>
(RSB),
<institution>Department of Family Medicine and Community Health</institution>
(BP, FB, KHS),
<institution>Abramson Cancer Center</institution>
(AB, KG, AD, LD, DS, KHS), and
<institution>Center for Clinical Epidemiology</institution>
(JCB, KG, AD, LD, DS, KHS),
<institution>University of Pennsylvania Perelman School of Medicine</institution>
,
<addr-line>Philadelphia</addr-line>
,
<addr-line>PA</addr-line>
;
<institution>Good Shepherd Penn Partners</institution>
,
<addr-line>Philadelphia</addr-line>
,
<addr-line>PA</addr-line>
(AB);
<institution>Biobehavioral Health Science Department, School of Nursing, University of Pennsylvania</institution>
,
<addr-line>Philadelphia</addr-line>
,
<addr-line>PA</addr-line>
(KG).</aff>
</contrib-group>
<author-notes>
<corresp id="c1">
<bold>Correspondence to:</bold>
Kathryn H. Schmitz, PhD, MPH, University of Pennsylvania, Perelman School of Medicine, Abramson Cancer Center, Center for Clinical Epidemiology and Biostatistics, 423 Guardian Drive, 8
<sup>th</sup>
floor Blockley Hall, Philadelphia, PA 19104-6021 (e-mail:
<email>Schmitz@upenn.edu</email>
)</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>11</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="epub">
<day>4</day>
<month>11</month>
<year>2014</year>
</pub-date>
<volume>2014</volume>
<issue>50</issue>
<fpage>338</fpage>
<lpage>345</lpage>
<permissions>
<copyright-statement>© The Author 2014. Published by Oxford University Press. All rights reserved. For Permissions, please e-mail: journals.permissions@oup.com.</copyright-statement>
<copyright-year>2014</copyright-year>
</permissions>
<abstract>
<sec>
<title>Background</title>
<p>The primary aims of this hybrid Type 1 effectiveness-implementation trial were to quantitatively assess whether an evidence-based exercise intervention for breast cancer survivors, Strength After Breast Cancer, was safe and effective in a new setting and to qualitatively assess barriers to implementation.</p>
</sec>
<sec sec-type="methods">
<title>Methods</title>
<p>A cohort of 84 survivors completed measurements related to limb volume, muscle strength, and body image at baseline, 67 survivors completed measurements 12 months later. Qualitative methods were used to understand barriers to implementation experienced by referring oncology clinicians and physical therapists who delivered the program.</p>
</sec>
<sec>
<title>Results</title>
<p>Similar to the efficacy trial, the revised intervention demonstrated safety with regard to lymphedema, and led to improvements in lymphedema symptoms, muscular strength, and body image. Comparison of effects in the effectiveness trial to effects in the efficacy trial revealed larger strength increases in the efficacy trial than in the effectiveness trial (
<italic>P</italic>
< .04), but few other differences were found. Qualitative implementation data suggested significant barriers around intervention characteristics, payment, eligibility criteria, the referral process, the need for champions (ie, advocates), and the need to adapt during implementation of the intervention, which should be considered in future dissemination and implementation efforts.</p>
</sec>
<sec>
<title>Conclusions</title>
<p>This trial successfully demonstrated that a physical therapy led strength training program for breast cancer survivors can be implemented in a community setting while retaining the effectiveness and safety of the clinical trial. However, during the translation process, strategies to reduce barriers to implementation are required. This new program can inform larger scale dissemination and implementation efforts.</p>
</sec>
</abstract>
<counts>
<page-count count="8"></page-count>
</counts>
</article-meta>
</front>
</pmc>
</record>

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