Batroxobin protects against spinal cord injury in rats by promoting the expression of vascular endothelial growth factor to reduce apoptosis
Identifieur interne : 000266 ( Pmc/Corpus ); précédent : 000265; suivant : 000267Batroxobin protects against spinal cord injury in rats by promoting the expression of vascular endothelial growth factor to reduce apoptosis
Auteurs : Hui Yu ; Bin Lin ; Yongzhi He ; Wenbin Zhang ; Yang XuSource :
- Experimental and Therapeutic Medicine [ 1792-0981 ] ; 2015.
Abstract
The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor. We hypothesized in this study that batroxobin would exhibit protective effects following SCI by promoting the expression of VEGF to reduce the levels of apoptosis in a rat model of SCI. Ninety adult female Sprague Dawley rats were divided randomly into sham injury (group I), SCI (group II) and batroxobin treatment (group III) groups. The Basso-Bettie-Bresnahan (BBB) scores, number of apoptotic cells and expression of VEGF were assessed at 1, 3, 5, 7, 14 and 28 days post-injury. The BBB scores were significantly improved in group III compared with those in group II between days 5 and 28 post-injury (P<0.05). At each time-point subsequent to the injury, the number of apoptotic cells in group III was reduced compared with that in group II. Compared with group II, treatment with batroxobin significantly increased the expression of VEGF from day 3 until 2 weeks post-SCI (P<0.05), while no significant difference was observed at day 28. These data suggest that batroxobin has multiple beneficial effects on SCI, indicating a potential clinical application.
Url:
DOI: 10.3892/etm.2015.2368
PubMed: 26136870
PubMed Central: 4471772
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PMC:4471772Le document en format XML
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<author><name sortKey="Yu, Hui" sort="Yu, Hui" uniqKey="Yu H" first="Hui" last="Yu">Hui Yu</name>
<affiliation><nlm:aff id="af1-etm-0-0-2368">Department of Orthopedics, The 175th Hospital of the PLA, Southeast Hospital of Xiamen University, Zhangzhou, Fujian 363000, P.R. China</nlm:aff>
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<author><name sortKey="Lin, Bin" sort="Lin, Bin" uniqKey="Lin B" first="Bin" last="Lin">Bin Lin</name>
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<author><name sortKey="He, Yongzhi" sort="He, Yongzhi" uniqKey="He Y" first="Yongzhi" last="He">Yongzhi He</name>
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<author><name sortKey="Zhang, Wenbin" sort="Zhang, Wenbin" uniqKey="Zhang W" first="Wenbin" last="Zhang">Wenbin Zhang</name>
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<author><name sortKey="Xu, Yang" sort="Xu, Yang" uniqKey="Xu Y" first="Yang" last="Xu">Yang Xu</name>
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<series><title level="j">Experimental and Therapeutic Medicine</title>
<idno type="ISSN">1792-0981</idno>
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<front><div type="abstract" xml:lang="en"><p>The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor. We hypothesized in this study that batroxobin would exhibit protective effects following SCI by promoting the expression of VEGF to reduce the levels of apoptosis in a rat model of SCI. Ninety adult female Sprague Dawley rats were divided randomly into sham injury (group I), SCI (group II) and batroxobin treatment (group III) groups. The Basso-Bettie-Bresnahan (BBB) scores, number of apoptotic cells and expression of VEGF were assessed at 1, 3, 5, 7, 14 and 28 days post-injury. The BBB scores were significantly improved in group III compared with those in group II between days 5 and 28 post-injury (P<0.05). At each time-point subsequent to the injury, the number of apoptotic cells in group III was reduced compared with that in group II. Compared with group II, treatment with batroxobin significantly increased the expression of VEGF from day 3 until 2 weeks post-SCI (P<0.05), while no significant difference was observed at day 28. These data suggest that batroxobin has multiple beneficial effects on SCI, indicating a potential clinical application.</p>
</div>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Exp Ther Med</journal-id>
<journal-id journal-id-type="iso-abbrev">Exp Ther Med</journal-id>
<journal-id journal-id-type="publisher-id">ETM</journal-id>
<journal-title-group><journal-title>Experimental and Therapeutic Medicine</journal-title>
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<issn pub-type="ppub">1792-0981</issn>
<issn pub-type="epub">1792-1015</issn>
<publisher><publisher-name>D.A. Spandidos</publisher-name>
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<article-id pub-id-type="pmc">4471772</article-id>
<article-id pub-id-type="doi">10.3892/etm.2015.2368</article-id>
<article-id pub-id-type="publisher-id">ETM-0-0-2368</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Articles</subject>
</subj-group>
</article-categories>
<title-group><article-title>Batroxobin protects against spinal cord injury in rats by promoting the expression of vascular endothelial growth factor to reduce apoptosis</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>YU</surname>
<given-names>HUI</given-names>
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<xref ref-type="aff" rid="af1-etm-0-0-2368"></xref>
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<contrib contrib-type="author"><name><surname>LIN</surname>
<given-names>BIN</given-names>
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<xref ref-type="aff" rid="af1-etm-0-0-2368"></xref>
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<contrib contrib-type="author"><name><surname>ZHANG</surname>
<given-names>WENBIN</given-names>
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<contrib contrib-type="author"><name><surname>XU</surname>
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<aff id="af1-etm-0-0-2368">Department of Orthopedics, The 175th Hospital of the PLA, Southeast Hospital of Xiamen University, Zhangzhou, Fujian 363000, P.R. China</aff>
<author-notes><corresp id="c1-etm-0-0-2368"><italic>Correspondence to</italic>
: Dr Bin Lin, Department of Orthopedics, The 175th Hospital of the PLA, Southeast Hospital of Xiamen University, 269 Zhanghua Road, Zhangzhou, Fujian 363000, P.R. China, E-mail: <email>linbin813@163.com</email>
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<pub-date pub-type="ppub"><month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="epub"><day>17</day>
<month>3</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>17</day>
<month>3</month>
<year>2015</year>
</pub-date>
<pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
. </pmc-comment>
<volume>9</volume>
<issue>5</issue>
<fpage>1631</fpage>
<lpage>1638</lpage>
<history><date date-type="received"><day>05</day>
<month>7</month>
<year>2014</year>
</date>
<date date-type="accepted"><day>03</day>
<month>3</month>
<year>2015</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2015, Spandidos Publications</copyright-statement>
<copyright-year>2015</copyright-year>
</permissions>
<abstract><p>The host response to spinal cord injury (SCI) can lead to an ischemic environment that can induce cell death. Therapeutic interventions using neurotrophic factors have focused on the prevention of such reactions in order to reduce this cell death. Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor. We hypothesized in this study that batroxobin would exhibit protective effects following SCI by promoting the expression of VEGF to reduce the levels of apoptosis in a rat model of SCI. Ninety adult female Sprague Dawley rats were divided randomly into sham injury (group I), SCI (group II) and batroxobin treatment (group III) groups. The Basso-Bettie-Bresnahan (BBB) scores, number of apoptotic cells and expression of VEGF were assessed at 1, 3, 5, 7, 14 and 28 days post-injury. The BBB scores were significantly improved in group III compared with those in group II between days 5 and 28 post-injury (P<0.05). At each time-point subsequent to the injury, the number of apoptotic cells in group III was reduced compared with that in group II. Compared with group II, treatment with batroxobin significantly increased the expression of VEGF from day 3 until 2 weeks post-SCI (P<0.05), while no significant difference was observed at day 28. These data suggest that batroxobin has multiple beneficial effects on SCI, indicating a potential clinical application.</p>
</abstract>
<kwd-group><kwd>batroxobin</kwd>
<kwd>vascular endothelial growth factor</kwd>
<kwd>apoptosis</kwd>
<kwd>spinal cord injury</kwd>
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