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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Penile cancer: Perspective from a Canadian tertiary care centre</title><author><name sortKey="Beech, Benjamin" sort="Beech, Benjamin" uniqKey="Beech B" first="Benjamin" last="Beech">Benjamin Beech</name><affiliation><nlm:aff id="af1-cuaj-9-10-315">Schulich School of Medicine and Dentistry, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Izawa, Jonathan" sort="Izawa, Jonathan" uniqKey="Izawa J" first="Jonathan" last="Izawa">Jonathan Izawa</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Pautler, Stephen" sort="Pautler, Stephen" uniqKey="Pautler S" first="Stephen" last="Pautler">Stephen Pautler</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Chin, Joseph" sort="Chin, Joseph" uniqKey="Chin J" first="Joseph" last="Chin">Joseph Chin</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Power, Nicholas" sort="Power, Nicholas" uniqKey="Power N" first="Nicholas" last="Power">Nicholas Power</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26644802</idno><idno type="pmc">4662391</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4662391</idno><idno type="RBID">PMC:4662391</idno><idno type="doi">10.5489/cuaj.3230</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000261</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000261</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Penile cancer: Perspective from a Canadian tertiary care centre</title><author><name sortKey="Beech, Benjamin" sort="Beech, Benjamin" uniqKey="Beech B" first="Benjamin" last="Beech">Benjamin Beech</name><affiliation><nlm:aff id="af1-cuaj-9-10-315">Schulich School of Medicine and Dentistry, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Izawa, Jonathan" sort="Izawa, Jonathan" uniqKey="Izawa J" first="Jonathan" last="Izawa">Jonathan Izawa</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Pautler, Stephen" sort="Pautler, Stephen" uniqKey="Pautler S" first="Stephen" last="Pautler">Stephen Pautler</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Chin, Joseph" sort="Chin, Joseph" uniqKey="Chin J" first="Joseph" last="Chin">Joseph Chin</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author><author><name sortKey="Power, Nicholas" sort="Power, Nicholas" uniqKey="Power N" first="Nicholas" last="Power">Nicholas Power</name><affiliation><nlm:aff id="af2-cuaj-9-10-315">Division of Urology, Department of Surgery, Western University, London, ON;</nlm:aff></affiliation></author></analytic><series><title level="j">Canadian Urological Association Journal</title><idno type="ISSN">1911-6470</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Introduction:</title><p>Penile squamous cell carcinoma (SCC) is rare in North America; however, the morbidity can be devastating. This analysis represents the first reported penile cancer experience at a tertiary care centre in Canada.</p></sec><sec><title>Methods:</title><p>We carried out a retrospective review of all patients who received care at our centre for penile SCC from 2005 until the present time. Epidemiological and clinical data were collected for all patients. Survival analysis was performed using Kaplan-Meier methods with log-rank test and Cox regression for univariate and multivariate analysis, respectively.</p></sec><sec><title>Results:</title><p>We identified 42 patients who were treated at our centre for penile SCC. Of these, 29% underwent excisional biopsy, 38% had partial penectomy, and 33% had total penectomy. Five patients with high-risk tumours underwent modified inguinal lymph node dissection (ILND), while 7 patients had radical ILND for clinically palpable disease. Overall, the median cancer specific survival (CSS) was undefined, with a 60% survival at 102 months. However CSS was significantly correlated to pT stage, pN stage, and tumour grade. The median follow-up was 25 months (interquartile range: 11–48).</p></sec><sec><title>Conclusion:</title><p>These findings confirm the poor CSS of patients with positive lymph nodes in penile SCC. Patients with pN0 after ILND had a durable CSS. Risk factors for penile SCC were confirmed as elevated body mass index, positive smoking history, and lack of circumcision. This first epidemiologic report on penile SCC from a Canadian tertiary care centre should be expanded to other national centres.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Can Urol Assoc J</journal-id><journal-id journal-id-type="iso-abbrev">Can Urol Assoc J</journal-id><journal-id journal-id-type="publisher-id">CUAJ</journal-id><journal-title-group><journal-title>Canadian Urological Association Journal</journal-title></journal-title-group><issn pub-type="ppub">1911-6470</issn><publisher><publisher-name>Canadian Medical Association</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26644802</article-id><article-id pub-id-type="pmc">4662391</article-id><article-id pub-id-type="doi">10.5489/cuaj.3230</article-id><article-id pub-id-type="publisher-id">cuaj-9-10-315</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Research</subject></subj-group></article-categories><title-group><article-title>Penile cancer: Perspective from a Canadian tertiary care centre</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Beech</surname><given-names>Benjamin</given-names></name><degrees>BSc</degrees><xref ref-type="aff" rid="af1-cuaj-9-10-315"><sup>*</sup></xref><xref rid="c1-cuaj-9-10-315" ref-type="corresp"></xref></contrib><contrib contrib-type="author"><name><surname>Izawa</surname><given-names>Jonathan</given-names></name><degrees>MD, FRCSC</degrees><xref ref-type="aff" rid="af2-cuaj-9-10-315"><sup>†</sup></xref></contrib><contrib contrib-type="author"><name><surname>Pautler</surname><given-names>Stephen</given-names></name><degrees>MD, FRCSC</degrees><xref ref-type="aff" rid="af2-cuaj-9-10-315"><sup>†</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chin</surname><given-names>Joseph</given-names></name><degrees>MD, FRCSC</degrees><xref ref-type="aff" rid="af2-cuaj-9-10-315"><sup>†</sup></xref></contrib><contrib contrib-type="author"><name><surname>Power</surname><given-names>Nicholas</given-names></name><degrees>MD, FRCSC</degrees><xref ref-type="aff" rid="af2-cuaj-9-10-315"><sup>†</sup></xref></contrib><aff id="af1-cuaj-9-10-315"><label>*</label>Schulich School of Medicine and Dentistry, Western University, London, ON;</aff><aff id="af2-cuaj-9-10-315"><label>†</label>Division of Urology, Department of Surgery, Western University, London, ON;</aff></contrib-group><author-notes><corresp id="c1-cuaj-9-10-315">Correspondence: Dr. Benjamin Beech, Schulich School of Medicine and Dentistry, Western University, London, ON; <email>bbeech2016@meds.uwo.ca</email></corresp></author-notes><pub-date pub-type="ppub"><season>Sep-Oct</season><year>2015</year></pub-date><volume>9</volume><issue>9-10</issue><fpage>315</fpage><lpage>319</lpage><permissions><copyright-statement>Copyright: © 2015 Canadian Urological Association or its licensors</copyright-statement><copyright-year>2015</copyright-year></permissions><abstract><sec><title>Introduction:</title><p>Penile squamous cell carcinoma (SCC) is rare in North America; however, the morbidity can be devastating. This analysis represents the first reported penile cancer experience at a tertiary care centre in Canada.</p></sec><sec><title>Methods:</title><p>We carried out a retrospective review of all patients who received care at our centre for penile SCC from 2005 until the present time. Epidemiological and clinical data were collected for all patients. Survival analysis was performed using Kaplan-Meier methods with log-rank test and Cox regression for univariate and multivariate analysis, respectively.</p></sec><sec><title>Results:</title><p>We identified 42 patients who were treated at our centre for penile SCC. Of these, 29% underwent excisional biopsy, 38% had partial penectomy, and 33% had total penectomy. Five patients with high-risk tumours underwent modified inguinal lymph node dissection (ILND), while 7 patients had radical ILND for clinically palpable disease. Overall, the median cancer specific survival (CSS) was undefined, with a 60% survival at 102 months. However CSS was significantly correlated to pT stage, pN stage, and tumour grade. The median follow-up was 25 months (interquartile range: 11–48).</p></sec><sec><title>Conclusion:</title><p>These findings confirm the poor CSS of patients with positive lymph nodes in penile SCC. Patients with pN0 after ILND had a durable CSS. Risk factors for penile SCC were confirmed as elevated body mass index, positive smoking history, and lack of circumcision. This first epidemiologic report on penile SCC from a Canadian tertiary care centre should be expanded to other national centres.</p></sec></abstract></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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