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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Yellow Nail Syndrome: Report of a Case Successfully Treated with Octreotide</title><author><name sortKey="Lotfollahi, Legha" sort="Lotfollahi, Legha" uniqKey="Lotfollahi L" first="Legha" last="Lotfollahi">Legha Lotfollahi</name><affiliation><nlm:aff id="AFF1"> Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Abedini, Atefeh" sort="Abedini, Atefeh" uniqKey="Abedini A" first="Atefeh" last="Abedini">Atefeh Abedini</name><affiliation><nlm:aff id="AFF2"> Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Alavi Darazam, Ilad" sort="Alavi Darazam, Ilad" uniqKey="Alavi Darazam I" first="Ilad" last="Alavi Darazam">Ilad Alavi Darazam</name><affiliation><nlm:aff id="AFF1"> Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Kiani, Arda" sort="Kiani, Arda" uniqKey="Kiani A" first="Arda" last="Kiani">Arda Kiani</name><affiliation><nlm:aff id="AFF2"> Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Fadaii, Abbas" sort="Fadaii, Abbas" uniqKey="Fadaii A" first="Abbas" last="Fadaii">Abbas Fadaii</name><affiliation><nlm:aff id="AFF3"> Pulmonology Department, Labbafi Nejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">26221155</idno><idno type="pmc">4515333</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4515333</idno><idno type="RBID">PMC:4515333</idno><date when="2015">2015</date><idno type="wicri:Area/Pmc/Corpus">000210</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000210</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Yellow Nail Syndrome: Report of a Case Successfully Treated with Octreotide</title><author><name sortKey="Lotfollahi, Legha" sort="Lotfollahi, Legha" uniqKey="Lotfollahi L" first="Legha" last="Lotfollahi">Legha Lotfollahi</name><affiliation><nlm:aff id="AFF1"> Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Abedini, Atefeh" sort="Abedini, Atefeh" uniqKey="Abedini A" first="Atefeh" last="Abedini">Atefeh Abedini</name><affiliation><nlm:aff id="AFF2"> Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Alavi Darazam, Ilad" sort="Alavi Darazam, Ilad" uniqKey="Alavi Darazam I" first="Ilad" last="Alavi Darazam">Ilad Alavi Darazam</name><affiliation><nlm:aff id="AFF1"> Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Kiani, Arda" sort="Kiani, Arda" uniqKey="Kiani A" first="Arda" last="Kiani">Arda Kiani</name><affiliation><nlm:aff id="AFF2"> Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran</nlm:aff></affiliation></author><author><name sortKey="Fadaii, Abbas" sort="Fadaii, Abbas" uniqKey="Fadaii A" first="Abbas" last="Fadaii">Abbas Fadaii</name><affiliation><nlm:aff id="AFF3"> Pulmonology Department, Labbafi Nejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</nlm:aff></affiliation></author></analytic><series><title level="j">Tanaffos</title><idno type="ISSN">1735-0344</idno><idno type="eISSN">2345-3729</idno><imprint><date when="2015">2015</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Yellow nail syndrome (YNS) is an uncommon condition characterized by a triad of yellow nail coloration, lymphedema and respiratory tract involvement. This syndrome typically affects middle-aged persons. Although several etiologies have been described, to date; the exact etiology remains unclear. Different treatment plans have been suggested, but all data available emphasize the fact that treatment is mainly symptomatic and the underlying disease is not targeted. The most reported treatment protocol is chemical pleurodesis combined with alpha-tocopherol (vitamin E). Hereby, we describe a case of YNS in a 34 year-old woman with the onset of symptoms in childhood. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Tanaffos</journal-id><journal-id journal-id-type="iso-abbrev">Tanaffos</journal-id><journal-id journal-id-type="publisher-id">Tanaffos</journal-id><journal-id journal-id-type="pmc">Tanaffos</journal-id><journal-title-group><journal-title>Tanaffos</journal-title></journal-title-group><issn pub-type="ppub">1735-0344</issn><issn pub-type="epub">2345-3729</issn><publisher><publisher-name>National Research Institute of Tuberculosis and Lung Disease</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">26221155</article-id><article-id pub-id-type="pmc">4515333</article-id><article-id pub-id-type="publisher-id">tanaffos-14-67</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Yellow Nail Syndrome: Report of a Case Successfully Treated with Octreotide</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Lotfollahi</surname><given-names>Legha</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Abedini</surname><given-names>Atefeh</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Alavi Darazam</surname><given-names>Ilad</given-names></name><xref ref-type="aff" rid="AFF1"><sup>1</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Kiani</surname><given-names>Arda</given-names></name><xref ref-type="aff" rid="AFF2"><sup>2</sup></xref><xref ref-type="corresp" rid="C1"></xref></contrib><contrib contrib-type="author"><name><surname>Fadaii</surname><given-names>Abbas</given-names></name><xref ref-type="aff" rid="AFF3"><sup>3</sup></xref></contrib><aff id="AFF1"><label>1</label> Chronic Respiratory Diseases Research Center, National Research Institute of Tuberculosis and Lung Diseases (NRITLD), Shahid Beheshti University of Medical Sciences, Tehran, Iran</aff><aff id="AFF2"><label>2</label> Tracheal Diseases Research Center, NRITLD, Shahid Beheshti University of Medical Sciences, Tehran, Iran</aff><aff id="AFF3"><label>3</label> Pulmonology Department, Labbafi Nejad Hospital, Shahid Beheshti University of Medical Sciences, Tehran, Iran.</aff></contrib-group><author-notes><corresp id="C1">Correspondence to: Kiani A, Address: NRITLD, Masih Daneshvari Hospital, Shahid Bahonar Ave, Darabad, Tehran 19569, P.O:19575/154, IRAN, Email address: <email>ilad13@yahoo.com</email></corresp></author-notes><pub-date pub-type="ppub"><year>2015</year></pub-date><volume>14</volume><issue>1</issue><fpage>67</fpage><lpage>71</lpage><history><date date-type="received"><day>13</day><month>9</month><year>2014</year></date><date date-type="accepted"><day>29</day><month>11</month><year>2014</year></date></history><permissions><copyright-statement>Copyright© 2015 National Research Institute of Tuberculosis and Lung Disease</copyright-statement><copyright-year>2015</copyright-year><license><license-p>This work is licensed under a Creative Commons Attribution-NonCommercial 3.0 Unported License which allows users to read, copy, distribute and make derivative works for non-commercial purposes from the material, as long as the author of the original work is cited properly.</license-p></license></permissions><abstract><p>Yellow nail syndrome (YNS) is an uncommon condition characterized by a triad of yellow nail coloration, lymphedema and respiratory tract involvement. This syndrome typically affects middle-aged persons. Although several etiologies have been described, to date; the exact etiology remains unclear. Different treatment plans have been suggested, but all data available emphasize the fact that treatment is mainly symptomatic and the underlying disease is not targeted. The most reported treatment protocol is chemical pleurodesis combined with alpha-tocopherol (vitamin E). Hereby, we describe a case of YNS in a 34 year-old woman with the onset of symptoms in childhood. The symptoms improved dramatically after treatment with octreotide.</p></abstract><kwd-group><kwd>Yellow nail syndrome</kwd><kwd>Octreotide</kwd><kwd>Respiratory tract</kwd></kwd-group></article-meta></front><body><sec sec-type="intro"><title>INTRODUCTION</title><p>Yellow nail syndrome (YNS) is an uncommon entity first described by Samman and White in 1964 (<xref rid="B1" ref-type="bibr">1</xref>–<xref rid="B5" ref-type="bibr">5</xref>). Classically, it is described as a triad of yellow nail coloration, lymphedema and respiratory tract involvement. Two of the three classical symptoms are required to confirm the diagnosis of YNS (<xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B3" ref-type="bibr">3</xref>). Almost always, YNS appears in middle-aged persons (<xref rid="B7" ref-type="bibr">7</xref>) and has rarely been reported in children (<xref rid="B8" ref-type="bibr">8</xref>). It is a very rare clinical condition and only about 100 cases have been reported since 1995. The exact etiology is unknown, yet several hypotheses have been proposed. The most common hypothesis emphasizes on a lymphatic anatomical or functional abnormality and a previously published report considered the capillary involvement as a possible cause (<xref rid="B9" ref-type="bibr">9</xref>), suggesting the pathology to be rather acquired than congenital (<xref rid="B3" ref-type="bibr">3</xref>). Coincidence with several autoimmune diseases and malignancies has been reported (<xref rid="B2" ref-type="bibr">2</xref>), which emphasizes on the importance of diagnostic workup for an underlying disease before starting symptomatic treatment, an approach emphasized by multiple experts. The treatment, although controversial, includes the treatment of the underlying disease (if diagnosed) or it is only symptomatic. The YNS can regress in 7–30% of the cases, spontaneously (<xref rid="B2" ref-type="bibr">2</xref>). Different approaches have been suggested for treatment, most of which with a satisfactory success rate. This case report reviews the literature and describes YNS in a 34 year-old woman, with the onset of symptoms in childhood, which was successfully treated with intravenous (IV) octreotide (<xref rid="B10" ref-type="bibr">10</xref>).</p></sec><sec><title>CASE SUMMARIES</title><p>A 34 year-old woman presented with dyspnea, which had begun progressively in the past two months. She also complained of right leg swelling from childhood, and a tendency of koilonychia was noted when she was 18. She did not complain of weight loss, anorexia, night sweat or malaise. She had no medical or surgical history, and the family history was negative for any disease. She was a non-smoker, denied alcohol consumption and did not use illicit drugs. On physical examination, she was a thin woman (weigh: 45 Kg, BMI: 23) with no malaise. Vital signs included blood pressure of 110/60 mmHg, pulse rate of 80 beats/minute, respiratory rate 16 breaths/minute and body temperature of 36.8°C. There was no lymphadenopathy, ascites or upper extremity edema. Heart sounds were normal. Lung auscultation revealed decreased left side respiratory sounds, accompanied by diminished tactile fremitus and a slight deadened tone in the same region. Yellowish concave nails and right leg edema were noted. Based on these findings, YNS was our first diagnosis, since the patient presented the complete triad of this syndrome. Chest X-ray revealed massive right-sided pleural effusion and mild shift to the left. Consequently, we continued our diagnostic workup with a computed tomography. There was massive right sided pleural effusion, with extension to the azygoesophageal recess and a major fissure leading to passive collapse of the underlying lung, and consequent contralateral shift of the heart and the mediastinum (<xref ref-type="fig" rid="F1">Figure 1</xref>). The aerated lungs were hyper perfused in the context of a probable degree of pulmonary hypertension. Based on these imaging findings, we decided to perform thoracocentesis, with the following results of pleural fluid analysis: protein=8 g/dL, WBC=850/μL, lymphocytes=85%, glucose=124 mg/dL, lactate dehydrogenase (LDH)=162 IU/L, cholesterol=91 mg/dL, triglycerides (TG)=821 mg/dL and albumin=3.8 g/dL. Simultaneous blood analysis showed the following results: erythrocyte sedimentation rate (ESR)=120 mm/h, serum albumin=4.8 g/dL, LDH=253 IU/L, cholesterol=170 mg/dL and TG=65 mg/dL. The cytology of pleural fluid revealed only lymphocytosis and the cultures for bacteria, mycobacterium and fungi were negative. Pleural biopsy was the next step, justified by the dominant exudative lymph pleural fluid aspect, which revealed chronic inflammation. The pathology report ruled out alternative diagnoses like malignant processes – absence of cells with nuclear anomalies, aspergillosis – no visible branching structures, hyphae, absence of caseating or non-caseating granuloma, and the diagnosis of YNS was confirmed. At this stage, we initiated the treatment with pleurodesis with talk powder. However, during the follow up visits, no improvement was seen and repeated thoracocentesis was performed because of refractory fluid buildup in the pleural space. Furthermore, we tried to treat the patient with orally administered medium chain fatty acids and intravenous (IV) octreotide. The administration protocol for octreotide was as follows: IV Octreotide 100 mcg 3 times/day (TID) for 3 days, followed by 50 mcg TID for one week, then 50 mcg daily for 3 weeks (<xref ref-type="fig" rid="F2">Figure 2</xref>), with a 3-month follow-up. After the 3 months, the patient’s symptoms improved and there was no visible fluid accumulation on chest roentgenogram.</p><fig id="F1" position="float"><label>Figure 1.</label><caption><p>Right-sided massive pleural effusion associated with passive collapse of the underlying lung, and consequent contralateral shift of the heart and the mediastinum.</p></caption><graphic xlink:href="Tanaffos-14-67-g001"></graphic></fig><fig id="F2" position="float"><label>Figure 2.</label><caption><p>Chest X-ray after treatment with octreotide during hospital admission.</p></caption><graphic xlink:href="Tanaffos-14-67-g002"></graphic></fig></sec><sec sec-type="discussion"><title>DISCUSSION</title><p>The YNS is a rare syndrome characterized by a triad of respiratory involvement, discoloration of nails and lymphedema. Although it often occurs sporadically, several cases may be inherited (<xref rid="B11" ref-type="bibr">11</xref>). Diagnosis of YNS is made based on clinical findings, in which two of the three components of the classical triad are adequate for diagnosis. Associations of YNS with the following malignant or autoimmune conditions have been described: autoimmune hypothyroidism (<xref rid="B1" ref-type="bibr">1</xref>), membranous glomerulonephritis (<xref rid="B2" ref-type="bibr">2</xref>), xanthogranulomatous pyelonephritis (<xref rid="B4" ref-type="bibr">4</xref>), minimal change disease (<xref rid="B12" ref-type="bibr">12</xref>), carcinoma of the larynx (<xref rid="B13" ref-type="bibr">13</xref>), common variable immunodeficiency (CVID) (<xref rid="B14" ref-type="bibr">14</xref>), breast cancer (<xref rid="B15" ref-type="bibr">15</xref>), arteriovenous fistula in a patient with end stage renal disease (<xref rid="B16" ref-type="bibr">16</xref>). Drug induced YNS have been reported as a consequence of treatment with penicillamine (<xref rid="B5" ref-type="bibr">5</xref>) and bucillamine in a patient with rheumatoid arthritis (<xref rid="B17" ref-type="bibr">17</xref>). Since YNS disappeared after treatment of the underlying disease (<xref rid="B12" ref-type="bibr">12</xref>, <xref rid="B18" ref-type="bibr">18</xref>) in many cases, the emphasis should be placed on the diagnosis and treatment of the underlying pathology, before starting symptomatic treatment. Respiratory involvement is one of the three manifestations of YNS, with the most frequent presentation being pleural effusion. It is usually bilateral, (<xref rid="B1" ref-type="bibr">1</xref>) yet there were previous cases with unilateral involvement (<xref rid="B3" ref-type="bibr">3</xref>, <xref rid="B4" ref-type="bibr">4</xref>, <xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B19" ref-type="bibr">19</xref>). Although it is usually an exudative pleural effusion, there are rare cases in which it has the appearance of a frank chylothorax, with lymphocyte predominance. The gross appearance of the fluid is milky (<xref rid="B1" ref-type="bibr">1</xref>) or cloudy (<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B3" ref-type="bibr">3</xref>). The LDH levels of the fluid are often high (<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B4" ref-type="bibr">4</xref>) and the protein levels are 4–5 g/dL (<xref rid="B1" ref-type="bibr">1</xref>, <xref rid="B3" ref-type="bibr">3</xref>, <xref rid="B4" ref-type="bibr">4</xref>). The concentrations of cholesterol and triglycerides of the fluid are consistent with chylous ascites (<xref rid="B5" ref-type="bibr">5</xref>). Histopathology of pleura is nonspecific, with fibrotic changes (<xref rid="B1" ref-type="bibr">1</xref>, <xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B3" ref-type="bibr">3</xref>, <xref rid="B6" ref-type="bibr">6</xref>, <xref rid="B7" ref-type="bibr">7</xref>). Other respiratory manifestations include chronic paranasal sinusitis, recurrent respiratory tract infections and bronchiectasis (<xref rid="B2" ref-type="bibr">2</xref>). The underlying reasons for development of bronchiectasis are not completely understood (<xref rid="B3" ref-type="bibr">3</xref>). Nail discoloration is another manifestation of YNS occurring in one third of patients (yellow-greenish discoloration of nails). Other nail abnormalities include overcurvature, thickening, shrinking, onycholysis, slow growth and loss of lanulae and cuticles, and their mechanisms have yet to be understood (<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B3" ref-type="bibr">3</xref>). Lymphedema, as an important manifestation of YNS, is a part of the classic triad and is usually confirmed by lymphangiography (<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B3" ref-type="bibr">3</xref>). Edema is observed mostly in the legs and treatment has been based on exercise and use of elastic bandage in the majority of the former cases (<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B3" ref-type="bibr">3</xref>). Diuretics have not shown any benefit (<xref rid="B2" ref-type="bibr">2</xref>).</p><p>Our patient was a 34 year-old woman, with the onset of one symptom in childhood. The patient showed the triad at the time of diagnosis. This is beyond the usual age at which this syndrome presents. Pleural effusion, in this case, was right sided. Other characteristics of the fluid, such as TG level, were similar with the cases previously described in the literature. Lymphedema was right sided and as likely as the pleural effusion. The most common treatment, used for successful treatment of almost all the former cases, is chemical pleurodesis with materials such as picibanil, (<xref rid="B20" ref-type="bibr">20</xref>, <xref rid="B19" ref-type="bibr">19</xref>) tetracycline (<xref rid="B21" ref-type="bibr">21</xref>) and talk powder (<xref rid="B22" ref-type="bibr">22</xref>). Other treatment modalities for treatment of YNS available in the literature in order of frequency include: oral and topical alpha-tocopherol (vitamin E) (<xref rid="B3" ref-type="bibr">3</xref>, <xref rid="B11" ref-type="bibr">11</xref>, <xref rid="B23" ref-type="bibr">23</xref>–<xref rid="B27" ref-type="bibr">27</xref>), enteral azoles (<xref rid="B23" ref-type="bibr">23</xref>, <xref rid="B26" ref-type="bibr">26</xref>, <xref rid="B28" ref-type="bibr">28</xref>), systemically administered corticosteroids (most often in cases associated with underlying autoimmunity, such as rheumatoid arthritis or glomerulonephritis) and topical corticosteroids (<xref rid="B2" ref-type="bibr">2</xref>, <xref rid="B27" ref-type="bibr">27</xref>). Rarely, fluorouracil (<xref rid="B29" ref-type="bibr">29</xref>), vitamin A (<xref rid="B26" ref-type="bibr">26</xref>), oral zinc (<xref rid="B30" ref-type="bibr">30</xref>), diuretics (<xref rid="B23" ref-type="bibr">23</xref>) and dimethyl sulfoxide have been used with different results. However, further trials are necessary to confirm their efficacy. Given the probable etiologies of YNS, it is necessary to find out which treatment approach would be most suitable for the given etiology of YNS in each particular case. However, this task will be very difficult because of the low frequency of YNS. 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<lpage>6</lpage>.<pub-id pub-id-type="pmid">1031360</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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