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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Primary tumour characteristics and axillary lymph node status in breast cancer</title><author><name sortKey="Yiangou, C" sort="Yiangou, C" uniqKey="Yiangou C" first="C" last="Yiangou">C. Yiangou</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Departments of Breast Surgery</nlm:aff></affiliation></author><author><name sortKey="Shousha, S" sort="Shousha, S" uniqKey="Shousha S" first="S" last="Shousha">S. Shousha</name><affiliation><nlm:aff id="aff1">Histopathology, Charing Cross Hospital, London, W6 8RF, UK</nlm:aff></affiliation></author><author><name sortKey="Sinnett, H D" sort="Sinnett, H D" uniqKey="Sinnett H" first="H D" last="Sinnett">H D Sinnett</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Departments of Breast Surgery</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">10471048</idno><idno type="pmc">2363157</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2363157</idno><idno type="RBID">PMC:2363157</idno><idno type="doi">10.1038/sj.bjc.6690629</idno><date when="1999">1999</date><idno type="wicri:Area/Pmc/Corpus">000111</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000111</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Primary tumour characteristics and axillary lymph node status in breast cancer</title><author><name sortKey="Yiangou, C" sort="Yiangou, C" uniqKey="Yiangou C" first="C" last="Yiangou">C. Yiangou</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Departments of Breast Surgery</nlm:aff></affiliation></author><author><name sortKey="Shousha, S" sort="Shousha, S" uniqKey="Shousha S" first="S" last="Shousha">S. Shousha</name><affiliation><nlm:aff id="aff1">Histopathology, Charing Cross Hospital, London, W6 8RF, UK</nlm:aff></affiliation></author><author><name sortKey="Sinnett, H D" sort="Sinnett, H D" uniqKey="Sinnett H" first="H D" last="Sinnett">H D Sinnett</name><affiliation><nlm:aff wicri:cut=" and" id="aff1">Departments of Breast Surgery</nlm:aff></affiliation></author></analytic><series><title level="j">British Journal of Cancer</title><idno type="ISSN">0007-0920</idno><idno type="eISSN">1532-1827</idno><imprint><date when="1999">1999</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>This paper examines the correlation between axillary lymph node status and primary tumour characteristics in breast cancer and whether this can be used to select patients for axillary lymphadenectomy. The results are based on a retrospective analysis of 909 patients who underwent axillary dissection in our unit. Axillary lymph nodes containing metastases were found in 406 patients (44.7%), all with invasive carcinomas, but in none of the 37 carcinomas-in-situ. Nodal status was negative in all T1a tumours, but lymph node metastases were present in 16.3% and 35.7% of T1b and T1c tumours respectively. When histological grade was taken into account, positivity for grade I T1b and T1c tumours fell to 13.6% and 26.7% respectively. Lymph node metastases were found in 85% of patients with lymphovascular invasion in their tumours as compared to only 15.4% of those without and in 45.5% of oestrogen and progesterone receptor-positive tumours. When one or both hormone receptors were absent this figure was much higher. It appears that for T1a breast cancers axillary dissection is not necessary, whereas for T1b, T1c and grade I T2 tumours other histopathological parameters should be taken into consideration in deciding who should undergo axillary lymphadenectomy. © 1999 Cancer Research Campaign</p></div></front></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<pmc-comment> Original-type: ra</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id><journal-title>British Journal of Cancer</journal-title><issn pub-type="ppub">0007-0920</issn><issn pub-type="epub">1532-1827</issn><publisher><publisher-name>Nature Publishing Group</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">10471048</article-id><article-id pub-id-type="pmc">2363157</article-id><article-id pub-id-type="pii">6690629</article-id><article-id pub-id-type="doi">10.1038/sj.bjc.6690629</article-id><article-categories><subj-group subj-group-type="heading"><subject>Regular Article</subject></subj-group></article-categories><title-group><article-title>Primary tumour characteristics and axillary lymph node status in breast cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Yiangou</surname><given-names>C</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Shousha</surname><given-names>S</given-names></name><xref ref-type="aff" rid="aff1">2</xref></contrib><contrib contrib-type="author"><name><surname>Sinnett</surname><given-names>H D</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><aff id="aff1"><label>1</label>Departments of Breast Surgery and<label>2</label>Histopathology, Charing Cross Hospital, London, W6 8RF, UK</aff><author-notes><corresp id="caf1"><label>*</label>Author for correspondence: </corresp></author-notes><pub-date pub-type="ppub"><month>08</month><year>1999</year></pub-date><volume>80</volume><issue>12</issue><fpage>1974</fpage><lpage>1978</lpage><history><date date-type="received"><day>14</day><month>08</month><year>1998</year></date><date date-type="rev-recd"><day>23</day><month>02</month><year>1999</year></date><date date-type="accepted"><day>24</day><month>02</month><year>1999</year></date></history><copyright-statement>Copyright 1999, Cancer Research Campaign</copyright-statement><copyright-year>1999</copyright-year><permissions><copyright-holder>Cancer Research Campaign</copyright-holder></permissions><abstract><p>This paper examines the correlation between axillary lymph node status and primary tumour characteristics in breast cancer and whether this can be used to select patients for axillary lymphadenectomy. The results are based on a retrospective analysis of 909 patients who underwent axillary dissection in our unit. Axillary lymph nodes containing metastases were found in 406 patients (44.7%), all with invasive carcinomas, but in none of the 37 carcinomas-in-situ. Nodal status was negative in all T1a tumours, but lymph node metastases were present in 16.3% and 35.7% of T1b and T1c tumours respectively. When histological grade was taken into account, positivity for grade I T1b and T1c tumours fell to 13.6% and 26.7% respectively. Lymph node metastases were found in 85% of patients with lymphovascular invasion in their tumours as compared to only 15.4% of those without and in 45.5% of oestrogen and progesterone receptor-positive tumours. When one or both hormone receptors were absent this figure was much higher. It appears that for T1a breast cancers axillary dissection is not necessary, whereas for T1b, T1c and grade I T2 tumours other histopathological parameters should be taken into consideration in deciding who should undergo axillary lymphadenectomy. © 1999 Cancer Research Campaign</p></abstract><kwd-group><kwd>axillary lymph nodes</kwd><kwd>breast cancer</kwd><kwd>primary tumour characteristics</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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