Primary tumour characteristics and axillary lymph node status in breast cancer
Identifieur interne : 000111 ( Pmc/Corpus ); précédent : 000110; suivant : 000112Primary tumour characteristics and axillary lymph node status in breast cancer
Auteurs : C. Yiangou ; S. Shousha ; H D SinnettSource :
- British Journal of Cancer [ 0007-0920 ] ; 1999.
Abstract
This paper examines the correlation between axillary lymph node status and primary tumour characteristics in breast cancer and whether this can be used to select patients for axillary lymphadenectomy. The results are based on a retrospective analysis of 909 patients who underwent axillary dissection in our unit. Axillary lymph nodes containing metastases were found in 406 patients (44.7%), all with invasive carcinomas, but in none of the 37 carcinomas-in-situ. Nodal status was negative in all T1a tumours, but lymph node metastases were present in 16.3% and 35.7% of T1b and T1c tumours respectively. When histological grade was taken into account, positivity for grade I T1b and T1c tumours fell to 13.6% and 26.7% respectively. Lymph node metastases were found in 85% of patients with lymphovascular invasion in their tumours as compared to only 15.4% of those without and in 45.5% of oestrogen and progesterone receptor-positive tumours. When one or both hormone receptors were absent this figure was much higher. It appears that for T1a breast cancers axillary dissection is not necessary, whereas for T1b, T1c and grade I T2 tumours other histopathological parameters should be taken into consideration in deciding who should undergo axillary lymphadenectomy. © 1999 Cancer Research Campaign
Url:
DOI: 10.1038/sj.bjc.6690629
PubMed: 10471048
PubMed Central: 2363157
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PMC:2363157Le document en format XML
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<author><name sortKey="Shousha, S" sort="Shousha, S" uniqKey="Shousha S" first="S" last="Shousha">S. Shousha</name>
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<author><name sortKey="Sinnett, H D" sort="Sinnett, H D" uniqKey="Sinnett H" first="H D" last="Sinnett">H D Sinnett</name>
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<front><div type="abstract" xml:lang="en"><p>This paper examines the correlation between axillary lymph node status and primary tumour characteristics in breast cancer and whether this can be used to select patients for axillary lymphadenectomy. The results are based on a retrospective analysis of 909 patients who underwent axillary dissection in our unit. Axillary lymph nodes containing metastases were found in 406 patients (44.7%), all with invasive carcinomas, but in none of the 37 carcinomas-in-situ. Nodal status was negative in all T1a tumours, but lymph node metastases were present in 16.3% and 35.7% of T1b and T1c tumours respectively. When histological grade was taken into account, positivity for grade I T1b and T1c tumours fell to 13.6% and 26.7% respectively. Lymph node metastases were found in 85% of patients with lymphovascular invasion in their tumours as compared to only 15.4% of those without and in 45.5% of oestrogen and progesterone receptor-positive tumours. When one or both hormone receptors were absent this figure was much higher. It appears that for T1a breast cancers axillary dissection is not necessary, whereas for T1b, T1c and grade I T2 tumours other histopathological parameters should be taken into consideration in deciding who should undergo axillary lymphadenectomy. © 1999 Cancer Research Campaign</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Br J Cancer</journal-id>
<journal-title>British Journal of Cancer</journal-title>
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<article-id pub-id-type="doi">10.1038/sj.bjc.6690629</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Regular Article</subject>
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<title-group><article-title>Primary tumour characteristics and axillary lymph node status in breast cancer</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Yiangou</surname>
<given-names>C</given-names>
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<contrib contrib-type="author"><name><surname>Shousha</surname>
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<contrib contrib-type="author"><name><surname>Sinnett</surname>
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Departments of Breast Surgery and<label>2</label>
Histopathology, Charing Cross Hospital, London, W6 8RF, UK</aff>
<author-notes><corresp id="caf1"><label>*</label>
Author for correspondence: </corresp>
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<pub-date pub-type="ppub"><month>08</month>
<year>1999</year>
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<volume>80</volume>
<issue>12</issue>
<fpage>1974</fpage>
<lpage>1978</lpage>
<history><date date-type="received"><day>14</day>
<month>08</month>
<year>1998</year>
</date>
<date date-type="rev-recd"><day>23</day>
<month>02</month>
<year>1999</year>
</date>
<date date-type="accepted"><day>24</day>
<month>02</month>
<year>1999</year>
</date>
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<copyright-statement>Copyright 1999, Cancer Research Campaign</copyright-statement>
<copyright-year>1999</copyright-year>
<permissions><copyright-holder>Cancer Research Campaign</copyright-holder>
</permissions>
<abstract><p>This paper examines the correlation between axillary lymph node status and primary tumour characteristics in breast cancer and whether this can be used to select patients for axillary lymphadenectomy. The results are based on a retrospective analysis of 909 patients who underwent axillary dissection in our unit. Axillary lymph nodes containing metastases were found in 406 patients (44.7%), all with invasive carcinomas, but in none of the 37 carcinomas-in-situ. Nodal status was negative in all T1a tumours, but lymph node metastases were present in 16.3% and 35.7% of T1b and T1c tumours respectively. When histological grade was taken into account, positivity for grade I T1b and T1c tumours fell to 13.6% and 26.7% respectively. Lymph node metastases were found in 85% of patients with lymphovascular invasion in their tumours as compared to only 15.4% of those without and in 45.5% of oestrogen and progesterone receptor-positive tumours. When one or both hormone receptors were absent this figure was much higher. It appears that for T1a breast cancers axillary dissection is not necessary, whereas for T1b, T1c and grade I T2 tumours other histopathological parameters should be taken into consideration in deciding who should undergo axillary lymphadenectomy. © 1999 Cancer Research Campaign</p>
</abstract>
<kwd-group><kwd>axillary lymph nodes</kwd>
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<kwd>primary tumour characteristics</kwd>
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