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Systematic lymphadenectomy in ovarian cancer at second-look surgery: a randomised clinical trial

Identifieur interne : 000075 ( Pmc/Corpus ); précédent : 000074; suivant : 000076

Systematic lymphadenectomy in ovarian cancer at second-look surgery: a randomised clinical trial

Auteurs : T. Dell' Anna ; M. Signorelli ; P. Benedetti-Panici ; A. Maggioni ; R. Fossati ; R. Fruscio ; R. Milani ; L. Bocciolone ; A. Buda ; C. Mangioni ; G. Scambia ; R. Angioli ; E. Campagnutta ; R. Grassi ; F. Landoni

Source :

RBID : PMC:3425968

Abstract

Background:

The role of systematic aortic and pelvic lymphadenectomy (SAPL) at second-look surgery in early stage or optimally debulked advanced ovarian cancer is unclear and never addressed by randomised studies.

Methods:

From January 1991 through May 2001, 308 patients with the International Federation of Gynaecology and Obstetrics stage IA–IV epithelial ovarian carcinoma were randomly assigned to undergo SAPL (n=158) or resection of bulky nodes only (n=150). Primary end point was overall survival (OS).

Results:

The median operating time, blood loss, percentage of patients requiring blood transfusions and hospital stay were higher in the SAPL than in the control arm (P<0.001). The median number of resected nodes and the percentage of women with nodal metastases were higher in the SAPL arm as well (44% vs 8%, P<0.001 and 24.2% vs 13.3%, P:0.02). After a median follow-up of 111 months, 171 events (i.e., recurrences or deaths) were observed, and 124 patients had died. Sites of first recurrences were similar in both arms. The adjusted risk for progression and death were not statistically different (hazard ratio (HR) for progression=1.18, 95% confidence interval (CI)=0.87–1.59; P=0.29; 5-year progression-free survival (PFS)=40.9% and 53.8% HR for death=1.04, 95% CI=0.733–1.49; P=0.81; 5-year OS=63.5% and 67.4%, in the SAPL and in the control arm, respectively).

Conclusion:

SAPL in second-look surgery for advanced ovarian cancer did not improve PFS and OS.


Url:
DOI: 10.1038/bjc.2012.336
PubMed: 22864456
PubMed Central: 3425968

Links to Exploration step

PMC:3425968

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<name sortKey="Campagnutta, E" sort="Campagnutta, E" uniqKey="Campagnutta E" first="E" last="Campagnutta">E. Campagnutta</name>
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<name sortKey="Fruscio, R" sort="Fruscio, R" uniqKey="Fruscio R" first="R" last="Fruscio">R. Fruscio</name>
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<name sortKey="Scambia, G" sort="Scambia, G" uniqKey="Scambia G" first="G" last="Scambia">G. Scambia</name>
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, Rome,
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<name sortKey="Campagnutta, E" sort="Campagnutta, E" uniqKey="Campagnutta E" first="E" last="Campagnutta">E. Campagnutta</name>
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, Aviano,
<country>Italy</country>
</nlm:aff>
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<name sortKey="Grassi, R" sort="Grassi, R" uniqKey="Grassi R" first="R" last="Grassi">R. Grassi</name>
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<institution>Treviglio Hospital</institution>
, Treviglio,
<country>Italy</country>
</nlm:aff>
</affiliation>
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<name sortKey="Landoni, F" sort="Landoni, F" uniqKey="Landoni F" first="F" last="Landoni">F. Landoni</name>
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</nlm:aff>
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<title level="j">British Journal of Cancer</title>
<idno type="ISSN">0007-0920</idno>
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<div type="abstract" xml:lang="en">
<sec>
<title>Background:</title>
<p>The role of systematic aortic and pelvic lymphadenectomy (SAPL) at second-look surgery in early stage or optimally debulked advanced ovarian cancer is unclear and never addressed by randomised studies.</p>
</sec>
<sec>
<title>Methods:</title>
<p>From January 1991 through May 2001, 308 patients with the International Federation of Gynaecology and Obstetrics stage IA–IV epithelial ovarian carcinoma were randomly assigned to undergo SAPL (
<italic>n</italic>
=158) or resection of bulky nodes only (
<italic>n</italic>
=150). Primary end point was overall survival (OS).</p>
</sec>
<sec>
<title>Results:</title>
<p>The median operating time, blood loss, percentage of patients requiring blood transfusions and hospital stay were higher in the SAPL than in the control arm (
<italic>P</italic>
<0.001). The median number of resected nodes and the percentage of women with nodal metastases were higher in the SAPL arm as well (44%
<italic>vs</italic>
8%,
<italic>P</italic>
<0.001 and 24.2%
<italic>vs</italic>
13.3%,
<italic>P</italic>
:0.02). After a median follow-up of 111 months, 171 events (i.e., recurrences or deaths) were observed, and 124 patients had died. Sites of first recurrences were similar in both arms. The adjusted risk for progression and death were not statistically different (hazard ratio (HR) for progression=1.18, 95% confidence interval (CI)=0.87–1.59;
<italic>P</italic>
=0.29; 5-year progression-free survival (PFS)=40.9% and 53.8% HR for death=1.04, 95% CI=0.733–1.49;
<italic>P</italic>
=0.81; 5-year OS=63.5% and 67.4%, in the SAPL and in the control arm, respectively).</p>
</sec>
<sec>
<title>Conclusion:</title>
<p>SAPL in second-look surgery for advanced ovarian cancer did not improve PFS and OS.</p>
</sec>
</div>
</front>
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<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff6">6</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Campagnutta</surname>
<given-names>E</given-names>
</name>
<xref ref-type="aff" rid="aff7">7</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Grassi</surname>
<given-names>R</given-names>
</name>
<xref ref-type="aff" rid="aff8">8</xref>
</contrib>
<contrib contrib-type="author">
<name>
<surname>Landoni</surname>
<given-names>F</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<aff id="aff1">
<label>1</label>
<institution>S Gerardo Hospital</institution>
, Monza,
<country>Italy</country>
</aff>
<aff id="aff2">
<label>2</label>
<institution>Department of Obtestrics and Gynecology, Università ‘ La Sapienza</institution>
, Rome,
<country>Italy</country>
</aff>
<aff id="aff3">
<label>3</label>
<institution>Istituto Europeo di Oncologia</institution>
, Milan,
<country>Italy</country>
</aff>
<aff id="aff4">
<label>4</label>
<institution>Laboratory of Clinical Cancer Research, Mario Negri Institute</institution>
, Via La Masa 19, Milan 20156,
<country>Italy</country>
</aff>
<aff id="aff5">
<label>5</label>
<institution>Department of Obtestrics and Gynecology, Università Cattolica del Sacro Cuore</institution>
, Rome,
<country>Italy</country>
</aff>
<aff id="aff6">
<label>6</label>
<institution>Department of Obtestrics and Gynecology, Università Campus Biomedico</institution>
, Rome,
<country>Italy</country>
</aff>
<aff id="aff7">
<label>7</label>
<institution>Centro di Riferimento Oncologico</institution>
, Aviano,
<country>Italy</country>
</aff>
<aff id="aff8">
<label>8</label>
<institution>Treviglio Hospital</institution>
, Treviglio,
<country>Italy</country>
</aff>
</contrib-group>
<author-notes>
<corresp id="caf1">
<label>*</label>
E-mail:
<email>roldano.fossati@marionegri.it</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub">
<day>21</day>
<month>08</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub">
<day>02</day>
<month>08</month>
<year>2012</year>
</pub-date>
<volume>107</volume>
<issue>5</issue>
<fpage>785</fpage>
<lpage>792</lpage>
<history>
<date date-type="received">
<day>13</day>
<month>04</month>
<year>2012</year>
</date>
<date date-type="rev-recd">
<day>01</day>
<month>07</month>
<year>2012</year>
</date>
<date date-type="accepted">
<day>06</day>
<month>07</month>
<year>2012</year>
</date>
</history>
<permissions>
<copyright-statement>Copyright © 2012 Cancer Research UK</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>Cancer Research UK</copyright-holder>
<license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-sa/3.0/">
<license-p>From twelve months after its original publication, this work is licensed under the Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/</license-p>
</license>
</permissions>
<abstract>
<sec>
<title>Background:</title>
<p>The role of systematic aortic and pelvic lymphadenectomy (SAPL) at second-look surgery in early stage or optimally debulked advanced ovarian cancer is unclear and never addressed by randomised studies.</p>
</sec>
<sec>
<title>Methods:</title>
<p>From January 1991 through May 2001, 308 patients with the International Federation of Gynaecology and Obstetrics stage IA–IV epithelial ovarian carcinoma were randomly assigned to undergo SAPL (
<italic>n</italic>
=158) or resection of bulky nodes only (
<italic>n</italic>
=150). Primary end point was overall survival (OS).</p>
</sec>
<sec>
<title>Results:</title>
<p>The median operating time, blood loss, percentage of patients requiring blood transfusions and hospital stay were higher in the SAPL than in the control arm (
<italic>P</italic>
<0.001). The median number of resected nodes and the percentage of women with nodal metastases were higher in the SAPL arm as well (44%
<italic>vs</italic>
8%,
<italic>P</italic>
<0.001 and 24.2%
<italic>vs</italic>
13.3%,
<italic>P</italic>
:0.02). After a median follow-up of 111 months, 171 events (i.e., recurrences or deaths) were observed, and 124 patients had died. Sites of first recurrences were similar in both arms. The adjusted risk for progression and death were not statistically different (hazard ratio (HR) for progression=1.18, 95% confidence interval (CI)=0.87–1.59;
<italic>P</italic>
=0.29; 5-year progression-free survival (PFS)=40.9% and 53.8% HR for death=1.04, 95% CI=0.733–1.49;
<italic>P</italic>
=0.81; 5-year OS=63.5% and 67.4%, in the SAPL and in the control arm, respectively).</p>
</sec>
<sec>
<title>Conclusion:</title>
<p>SAPL in second-look surgery for advanced ovarian cancer did not improve PFS and OS.</p>
</sec>
</abstract>
<kwd-group>
<kwd>lymphadenectomy</kwd>
<kwd>second-look surgery</kwd>
<kwd>ovarian cancer</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<p>Epithelial ovarian cancer represents the nineth highest in cancer incidence and the fifth highest in site-specific causes of cancer deaths in women in the Western countries (
<xref ref-type="bibr" rid="bib33">Siegel
<italic>et al</italic>
, 2012</xref>
). Only 25–30% of all cases are diagnosed with an early stage, good prognosis disease (Federation of Gynaecology and Obstetrics (FIGO) stage I–IIA; 5-year overall survival (OS)=90–95%) as most patients are still diagnosed with an advanced stage, with a 5-year OS of 30–50% (
<xref ref-type="bibr" rid="bib17">Holschneider and Berek, 2000</xref>
;
<xref ref-type="bibr" rid="bib35">Trimbos
<italic>et al</italic>
, 2010</xref>
).</p>
<p>The optimal treatment is currently based on cytoreductive surgery and adjuvant platinum-based chemotherapy. In early stage cancer the primary surgery includes hysterectomy, bilateral salpingo-oophorectomy, infracolic or infragastric omentectomy and peritoneal biopsies, whereas in case of advanced disease the goal is the complete cytoreduction of all visible tumour (
<xref ref-type="bibr" rid="bib6">Bristow
<italic>et al</italic>
, 2002</xref>
;
<xref ref-type="bibr" rid="bib34">Timmers
<italic>et al</italic>
, 2010</xref>
;
<xref ref-type="bibr" rid="bib35">Trimbos
<italic>et al</italic>
, 2010</xref>
).</p>
<p>The role of lymphadenectomy as a part of the surgical treatment of ovarian cancer has been debated over the last 30 years Retroperitoneal lymph node involvement occurs in ∼5–25% and 50–80% of women with early and advanced ovarian cancer, respectively. Retrospective studies have suggested that removal of the lymph nodes is associated with an improvement of staging and a survival benefit (
<xref ref-type="bibr" rid="bib11">Chen and Lee, 1983</xref>
;
<xref ref-type="bibr" rid="bib13">Di Re
<italic>et al</italic>
, 1989</xref>
;
<xref ref-type="bibr" rid="bib8">Burghadt
<italic>et al</italic>
, 1991</xref>
;
<xref ref-type="bibr" rid="bib4">Benedetti-Panici
<italic>et al</italic>
, 1993</xref>
;
<xref ref-type="bibr" rid="bib19">Kigawa
<italic>et al</italic>
, 1994</xref>
;
<xref ref-type="bibr" rid="bib20">Kikkawa
<italic>et al</italic>
, 1995</xref>
;
<xref ref-type="bibr" rid="bib31">Scarabelli
<italic>et al</italic>
, 1995</xref>
;
<xref ref-type="bibr" rid="bib32">Spirtos
<italic>et al</italic>
, 1995</xref>
;
<xref ref-type="bibr" rid="bib14">Di Re
<italic>et al</italic>
, 1996</xref>
).</p>
<p>In Italy, in 1990, comprehensive programs, coordinated at the Mario Negri Institute (Milan), were designed to evaluate, by randomised clinical trials (RCT), the impact of lymphadenectomy in ovarian carcinoma. Such programme aimed at evaluating staging accuracy and survival in macroscopic disease confined to the pelvis
<xref ref-type="bibr" rid="bib21">Maggioni
<italic>et al</italic>
(2006)</xref>
or in optimally debulked (previously defined as <1 cm) advanced stage (
<xref ref-type="bibr" rid="bib5">Benedetti-Panici
<italic>et al</italic>
, 2005</xref>
).</p>
<p>This trial,was launched to assess the influence of lymphadenectomy, performed at second look after primary surgery and adjuvant chemotherapy, on the survival rates of women with stage IA–IV ovarian cancer.</p>
<sec sec-type="methods">
<title>Patients and methods</title>
<sec>
<title>Patient eligibility</title>
<p>Patients with histologically proven epithelial ovarian carcinoma with FIGO stages IA-IV (
<xref ref-type="bibr" rid="bib15">FIGO Committee on Gynaecologic Oncology, 2009</xref>
), after primary surgery, with or without adjuvant chemotherapy and no evidence of disease on chest, abdominal and pelvic computed tomography scan, were eligible for participation in the study.</p>
<p>Additional eligibility criteria included age of >75 years, the Karnofsky performance status of ⩾80. Patients who underwent retroperitoneal evaluation at first surgery or had second-look surgery >12 months after first surgery were not eligible. The study protocol was revised and accepted by Local Ethics Committees, and appropriate written informed consent was obtained from all patients.</p>
</sec>
<sec>
<title>Randomisation procedures</title>
<p>Random assignment of patients, who had an equal probability of assignment to either treatment arm, was carried out by a block arrangement that balances the treatment assignment within each site. Randomisation was performed centrally by telephone at the Mario Negri Institute, Milan.</p>
<p>Patients were randomly assigned intra-operatively after open laparotomy when the surgeon was sure that the tumour was properly debulked (residual tumour <1 cm).</p>
<p>Data from all eligible patients were analysed for survival on an intention-to-treat basis.</p>
</sec>
<sec>
<title>Patient characteristics</title>
<p>Pretreatment clinical and tumour characteristics, operative details of primary surgery, front-line chemotherapy and operative details of second look surgical procedures were collected soon after surgery.</p>
<p>Chemotherapy and initial follow-up data were collected 6 months after surgery, and further follow-up data were collected annually thereafter. Data were sent to the Mario Negri Institute, Milan.</p>
</sec>
<sec>
<title>Surgical procedures</title>
<sec>
<title>Control arm</title>
<p>An attempt to achieve an optimal cytoreduction for any metastatic peritoneal implants was carried on, followed by the resection of all suspicious lymph nodes of ⩾1 cm in diameter.</p>
</sec>
<sec>
<title>Systematic lymphadenectomy arm</title>
<p>Secondary cytoreductive surgery as detailed for the control arm was followed by systematic pelvic and aortic lymphadenectomy.</p>
<p>Pelvic lymphadenectomy included external and internal iliac, superficial and deep common iliac, superficial and deep obturator and presacral nodes Unilateral lymphadenectomy was allowed in unilateral tumours. Bilateral pelvic lymph node dissection was deemed satisfactory when at least 25 nodes were removed (12 in case of unilateral lymphadenectomy).</p>
<p>Aortic lymphadenectomy dissection began at the aortic bifurcation up to the renal vessels by removing superficial and deep intercavoaortic, precaval, paracaval and retrocaval, preaortic and paraaortic nodes aortic lymphadenectomy was considered appropriate when at least 15 nodes were removed. In case of previous diagnosis of unilateral right ovarian cancer stage IA–IIA the dissection of the paraaortic nodes was optional. Similarly, in case of previous diagnosis of unilateral left ovarian cancer stage IA–IIA the dissection of the paracaval nodes was optional In these cases, the aortic lymphadenectomy was considered appropriate when at least 10 nodes were removed.</p>
</sec>
</sec>
<sec>
<title>Second-line chemotherapy</title>
<p>All patients, regardless of the trial arm, were recommended to undergo a second-line chemotherapy in case of microscopic positive histological findings (i.e., biopsies or cytology), in case of macroscopic tumour surgically converted to a complete cytoreduction or in case of any residual tumour at the second-look surgery. A ‘consolidation' chemotherapy was optional in case of negative histology.</p>
<p>Patients found to have progressive disease on follow-up were provided with further treatment at the discretion of the treating physician.</p>
</sec>
<sec>
<title>Statistical analysis</title>
<p>The primary endpoint of this study was OS, defined as the time from randomisation to death from any cause.</p>
<p>Secondary endpoints included surgical morbidity and progression-free survival (PFS), defined as the time from randomisation to the earliest occurrence of progression or death from any cause.</p>
<p>In pre-trial analysis, we calculated that when a type I error is limited to.05 (two-tailed test), a total of about 300 patients would need to be accrued to afford an 80% power to detect a 36% relative reduction in the mortality hazard rate of patients in the systematic lymphadenectomy (i.e., increasing the 5-year survival rate from 64 to 75%, which corresponds to a hazard ratio (HR) of 0.64).</p>
<p>Survival curves were estimated by the Kaplan–Meier method (
<xref ref-type="bibr" rid="bib18">Kaplan and Meier, 1958</xref>
) and compared using the log-rank test (
<xref ref-type="bibr" rid="bib25">Peto
<italic>et al</italic>
, 1977</xref>
).</p>
<p>Additional analyses were performed with the Cox proportional hazards model adjusting for multiple baseline characteristics. Proportional hazards assumptions were checked by plotting log{−log [S(
<italic>t</italic>
)]} against log
<italic>t</italic>
for each group and found to be satisfied (
<xref ref-type="bibr" rid="bib24">Parmar and Machin, 1995</xref>
).</p>
<p>Comparison of proportions between groups was performed using a two-sided
<italic>χ</italic>
<sup>2</sup>
test or, if the number of patients in a given category was less than five, a two-sided Fisher's exact test. Continuous data, including number of resected nodes, operating time, blood loss and hospital stay, were expressed as medians with interquartile ranges and were compared using a two-sided Kruskal–Wallis (nonparametric) test.</p>
</sec>
</sec>
<sec sec-type="results">
<title>Results</title>
<sec>
<title>Patient accrual</title>
<p>Between January 1991 and May 2001, 322 patients were enroled in the study at six centres. After pathological and clinical review, 14 patients were deemed ineligible.
<xref ref-type="fig" rid="fig1">Figure 1</xref>
shows the trial flow diagram and details reasons for patient ineligibility.</p>
</sec>
<sec>
<title>Patient characteristics</title>
<p>The clinical and tumour characteristics of eligible patients are listed in
<xref rid="tbl1" ref-type="table">Table 1</xref>
. Characteristics appear to be well balanced across treatment arms.</p>
<p>Approximately 50% of patients had residual disease >1 cm after primary surgery and the vast majority of patients received chemotherapy after primary cytoreductive surgery, 140 in the biopsy arm and 147 in the lymphadenectomy arm (93% in each arm). In total, 21 women did not undergo chemotherapy, of which 16 out of 70 women with early stage IA–IIA (8 in each arms) and 5 out of 238 women with advanced stage IIB–IV (2
<italic>vs</italic>
3 in the two arms).</p>
<p>No differences in chemotherapy schedules were found between the two trial arms (
<italic>P</italic>
=0.42); 98% of patients underwent platinum-based chemotherapy regimens, and only 2% of patients received non-platinum-based chemotherapy regimens. In particular, a platinum mono-chemotherapy was used in 108 women (47 assigned to lymphadenectomy
<italic>vs</italic>
61 assigned to no-lymphadenectomy) a platinum–taxanes in 31 (14
<italic>vs</italic>
17) and platinum+others in 142 (76
<italic>vs</italic>
66) patients, respectively.</p>
<p>The median number of cycles administered was 6 (range 2–10).</p>
<p>At the end of second-look surgery 18 patients (6%) had residual disease, all <1 cm.</p>
</sec>
<sec>
<title>Surgical procedures</title>
<p>The surgical procedures performed during second-look surgery before the randomisation are listed in
<xref rid="tbl2" ref-type="table">Table 2</xref>
.</p>
<p>
<xref rid="tbl3" ref-type="table">Table 3</xref>
shows the median number and inter-quartile range of resected nodes by treatment arm. In the systematic lymphadenectomy arm, the median number of removed pelvic and aortic lymph nodes was 23 (interquartile range=15–33) and 20 (interquartile range=13–28), respectively. Overall, the median number of removed nodes was 44 (interquartile range=30–63) in the lymphadenectomy arm and 8 (interquartile range=4–14.5) in the control arm. At least one positive pelvic or aortic node was detected in 58 women (18.8%), 38 in the lymphadenectomy arm and 20 in the non-lymphadenectomy arm (24.2%
<italic>vs</italic>
13.3%,
<italic>P</italic>
=0.02).</p>
<p>In particular, in the group of women with stage IA–IIA disease, nodal metastases were found in 3/30 women in the lymphadenectomy arm
<italic>vs</italic>
2/40 women in the non-lymphadenectomy arm. In the subgroup of women with stage IIB–IV disease, 35/128 women in the lymphadenectomy arm
<italic>vs</italic>
18/110 women in the non-lymphadenectomy arm had nodal metastases.</p>
<p>In the patients assigned to lymphadenectomy arm, nodal metastases were found in 8/59 (13.6%) women with no evidence of residual tumour
<italic>vs</italic>
in 30/99 (30.3%) women who had any residual tumour at the end of primary surgery (
<italic>P</italic>
=0.165).</p>
<p>Furthermore, nodal metastases were depicted in the lymphadenectomy arm, in 26/123 (21.1%) and 12/34 (35.3%), in women with no evidence of peritoneal tumour
<italic>vs</italic>
the presence of any tumour at the beginning of the second-look surgery (
<italic>P</italic>
=0.088).</p>
<p>Systematic lymphadenectomy had a statistically significant impact on surgical parameters such as median operative time, blood loss, blood transfusions and the number of hospital days (
<xref rid="tbl4" ref-type="table">Table 4</xref>
).</p>
<p>Although the number of intra-operative complications was similar between the two arms (i.e., two in the control arm and seven in lymphadenectomy arm,
<italic>P</italic>
=0.106), systematic lymphadenectomy had greater perioperative and late morbidity (14 patients
<italic>vs</italic>
3 patients in the control arm,
<italic>P</italic>
=0.008). Most of the difference in morbidity between the two trial arms was due to the formation of lymphocysts and lymphedema that occurred in six patients in the systematic lymphadenectomy group
<italic>vs</italic>
no patients in the control arm. The frequency of remaining postoperative complications were as follows: radicular damage (2
<italic>vs</italic>
0 patients), intestinal fistula (1
<italic>vs</italic>
0 patients), hemoperitoneum (1
<italic>vs</italic>
0 patients), fever (2
<italic>vs</italic>
1 patients), surgical wound diastasis (0
<italic>vs</italic>
2 patients) and adhesive small bowel obstruction (2
<italic>vs</italic>
0 patient). No surgery-related deaths occurred.</p>
</sec>
<sec>
<title>Second-line chemotherapy after second-look surgery</title>
<p>Overall, 138 (45%) out 308 patients received chemotherapy after second-look surgery (43% in the control arm and 47% in the systematic lymphadenectomy arm;
<italic>P</italic>
=0.46). In total, 79% of patients with macroscopic evidence of tumour at the beginning of second-look surgery or positive nodes underwent chemotherapy treatment whereas 28% of patients without evidence of the disease at second look and negative nodes underwent consolidation chemotherapy. No differences in chemotherapy schedules were found between the two trial arms with 70% of patients undergoing platinum or platinum-based chemotherapy regimens.</p>
</sec>
<sec>
<title>Progression-free and OS</title>
<p>At a median follow-up of 111 months (25–75th percentiles: 88–148 months) tumour has recurred in 163 patients (52.9%) and 124 patients (40.3%) have so far died. Recurrence was experienced by 74 patients (49.3%) in the control arm and by 89 patients (56.3%) who underwent systematic lymphadenectomy. The pattern of disease recurrences, stratified by stage of disease, are listed in
<xref rid="tbl5" ref-type="table">Table 5</xref>
.</p>
<p>
<xref ref-type="fig" rid="fig2">Figures 2</xref>
and
<xref ref-type="fig" rid="fig3">3</xref>
depict the overall and PFS, respectively, for all eligible patients.</p>
<p>Median PFS was 68.7 months. At 3–5–10 years, 58.8%
<italic>vs</italic>
50.5%, 53.8%
<italic>vs</italic>
40.9% and 44.4%
<italic>vs</italic>
39.4% of women in the control arm and in the lymphadenectomy arm, respectively, did not relapse. The HR for relapse in the group assigned to lymphadenectomy as compared with the group assigned to control was 1.18 (95% confidence interval (CI)=0.87–1.59;
<italic>P</italic>
=0.29).</p>
<p>Median OS was not reached at the time of analysis. At 3–5–10 years, 77.7%
<italic>vs</italic>
79.6%, 67.4%
<italic>vs</italic>
63.5% and 56.2%
<italic>vs</italic>
54.2% of women in the control arm and in the lymphadenectomy arm, respectively, were alive. The HR for death in the group assigned to lymphadenectomy as compared with the group assigned to control was 1.04 (95% CI=0.733–1.49;
<italic>P</italic>
=0.81).</p>
<p>A Cox proportional hazards analysis was performed to adjust the treatment comparison for baseline characteristics. When stage was taken into account the new HRs for death and progression remained virtually unchanged (
<xref rid="tbl6" ref-type="table">Table 6</xref>
).</p>
<p>A subgroup analysis in women with stage IA–IIA and stage IIB–IV disease was performed to evaluate the impact of lymphadenectomy in the different subsets of women. In the early stage subgroup the HR for relapse was 1.3 (95% CI=0.46–3.77;
<italic>P</italic>
=0.60) and HR for death was 1.26 (95% CI=0.41–3.91;
<italic>P</italic>
=0.69). In advanced stage the HR for relapse was 1.06 (95% CI=0.77–1.45;
<italic>P</italic>
=0.73) and for death was 0.96 (95% CI=0.66–1.40;
<italic>P</italic>
=0.83).</p>
<p>We performed also a separate survival analyses also in women with no residual tumour
<italic>vs</italic>
women with any residual disease at the end of primary surgery. Among women completely debulked the HR for relapse was 1.60 (95% CI=0.86–2.97;
<italic>P</italic>
=0.14) and for death was 1.75 (95% CI=0.86–3.57;
<italic>P</italic>
=0.12), whereas in women not completely debulked the HR for relapse was 1.60 (95% CI=0.86–2.97;
<italic>P</italic>
=0.14) and for death was 0.81 (95% CI=0.53–1.23;
<italic>P</italic>
=0.32).</p>
</sec>
</sec>
<sec sec-type="discussion">
<title>Discussion</title>
<p>Second-look surgery for ovarian cancer was introduced in the clinical practice with the main objective of accurately assessing the pathological findings in the peritoneal cavity and in pelvic and aortic nodes areas in women with apparent complete response to the front-line chemotherapy. The philosophy of second-look surgery is based on the belief that an early identification of micro- or macroscopic-resistant disease to the first-line chemotherapy, the debulking of such resistant tumour and the immediate consolidation or the second-line chemotherapy could increase the OS. A secondary objective of the second-look surgery was the restaging of women who underwent primary inadequate surgery and to complete the endo- or retro-peritoneal cytoreduction if macroscopic disease is encountered (
<xref ref-type="bibr" rid="bib27">Podratz and Cliby, 1994</xref>
).</p>
<p>The most important clinical variable influencing the presence of tumour at second-look surgery is stage. Residual tumour at second look has been described in 5–15% of women with early stage cancer, according to the adequateness of surgical staging at primary surgery. Conversely, in advanced stage, a positive histology at second look has been described in almost 25% in women with no residual disease and 50–70% in women with bulky residual tumours (
<xref ref-type="bibr" rid="bib29">Roberts
<italic>et al</italic>
, 1982</xref>
;
<xref ref-type="bibr" rid="bib3">Barnhill
<italic>et al</italic>
, 1984</xref>
;
<xref ref-type="bibr" rid="bib26">Podratz
<italic>et al</italic>
, 1985</xref>
;
<xref ref-type="bibr" rid="bib10">Cain
<italic>et al</italic>
, 1986</xref>
;
<xref ref-type="bibr" rid="bib1">Ayhan
<italic>et al</italic>
, 1991</xref>
).</p>
<p>The literature regarding second-look surgery is rife with conflicting data. Although some authors reported a survival advantage for women undergoing second-look surgery who were completed and/or optimally debulked as compared with women not optimally debulked, others authors did not confirm these results. Second-look surgery was performed particularly during the 1980s and 1990s but over the last 10 years it has been abandoned from the vast majority of the gynaecological oncology centres as clinicians progressively recognised that up to 50% of women with proved pathological complete response to chemotherapy still face recurrent disease, with a median time to recurrence ranging between 14 and 24 months (
<xref ref-type="bibr" rid="bib16">Gershenson
<italic>et al</italic>
, 1985</xref>
;
<xref ref-type="bibr" rid="bib12">Copeland
<italic>et al</italic>
, 1985</xref>
;
<xref ref-type="bibr" rid="bib30">Rubin
<italic>et al</italic>
, 1991</xref>
;
<xref ref-type="bibr" rid="bib27">Podratz and Cliby, 1994</xref>
;
<xref ref-type="bibr" rid="bib23">NIH consensus conference, 1995</xref>
).
<xref ref-type="bibr" rid="bib22">Nicoletto
<italic>et al</italic>
(1997)</xref>
showed by a small RCT that although the second-look surgery in advanced stage ovarian cancer accurately defined the complete responders it failed to demonstrated a survival benefit.</p>
<p>When we launched this RCT, the second-look surgery was widely performed in Italian gynaecological cancer centres and we decided to investigate by a RCT if lymphadenectomy would improve survival in women with apparent complete clinical response to primary surgery and front-line chemotherapy who underwent second-look surgery and to verify the possible different peritoneal
<italic>vs</italic>
nodal response to the chemotherapy.</p>
<p>Lymphadenectomy at the second look is aimed at removing small nodal metastases not otherwise detectable by clinical evaluation or palpation or by preoperative imaging. The potential benefit of this is the removal of resistant clones of tumour cells or of a poorly vascularised tumour (pharmacologic sanctuaries), which in turn, should decrease the likelihood of the early onset of drug resistance (
<xref ref-type="bibr" rid="bib13">Di Re
<italic>et al</italic>
, 1989</xref>
;
<xref ref-type="bibr" rid="bib7">Burghardt and Winter, 1989</xref>
;
<xref ref-type="bibr" rid="bib31">Scarabelli
<italic>et al</italic>
, 1995</xref>
;
<xref ref-type="bibr" rid="bib14">Di Re
<italic>et al</italic>
, 1996</xref>
). Apart from the potential survival advantage, the resection of lymph nodes at second-look surgery can avoid isolated lymph node recurrences that lead to a subsequent cytotoxic treatment or further nodal cytoreductive surgery followed by chemotherapy thus increasing morbidity and costs.</p>
<p>Only scanty data are available on the value of lymphadenectomy at second-look surgery (
<xref ref-type="bibr" rid="bib36">Wu
<italic>et al</italic>
, 1986</xref>
;
<xref ref-type="bibr" rid="bib9">Burghardt
<italic>et al</italic>
, 1986</xref>
).
<xref ref-type="bibr" rid="bib2">Baiocchi
<italic>et al</italic>
(1998)</xref>
published a small cohort of 58 women, stage I–IV, with apparent complete response to chemotherapy, undergoing systematic lymphadenectomy between 1974 and 1993. In total, 15 out of 58 women (26%) had nodal metastases. In particular, nodal metastases were found in 22% and 33% of women with early and advanced stage disease, respectively, and in 17.7% of women with no evidence of intraperitoneal disease compared with 64% of women with peritoneal residual disease at the second look. The only factors influencing the risk of relapse were the advanced stage, the grade 3 and the presence of residual disease at the primary surgery while no relation emerged between the relapse and the nodal status at the second look (relapse rate 27%
<italic>vs</italic>
25%). The rate of nodal metastases (17.7%) at the second look in this retrospective study is consistent with the data from
<xref ref-type="bibr" rid="bib28">Podratz
<italic>et al</italic>
(1988)</xref>
who reported an exclusively nodal relapse in 20% of women with a pathological proved complete response.</p>
<p>The role of systematic lymphadenectomy, in the treatment of ovarian cancer, has been evaluated in three RCTs over 10 years. Systematic pelvic and aortic lymphadenectomy improved only staging in women with cancer confined to the pelvis and PFS in the advanced stage ovarian cancer, but it failed to demonstrate a survival benefit in either group (
<xref ref-type="bibr" rid="bib5">Benedetti-Panici
<italic>et al</italic>
, 2005</xref>
;
<xref ref-type="bibr" rid="bib21">Maggioni
<italic>et al</italic>
, 2006</xref>
).</p>
<p>The current RCT found that the systematic lymphadenectomy, compared with simple nodal biopsy, enabled to detect a higher number of patients with metastatic lymph nodes (24.2%
<italic>vs</italic>
13.3%). This study also showed that systematic lymphadenectomy is a relatively safe surgical procedure, if provided by trained gynaecology oncologists. Notwithstanding, systematic lymphadenectomy is associated with an increased operating time, blood loss, blood transfusions, hospital stay and a higher incidence of postoperative complications, consisting mainly of lymphocysts or lymphedema. Such data are in keeping with the results of the other two randomised studies in early or advanced ovarian cancer.</p>
<p>This trial was designed to assess OS as primary endpoint and PFS as secondary endpoint. We found that patients who underwent systemic lymphadenectomy had neither OS nor disease-free survival benefits when compared with patients who underwent removal of bulky nodes only. Furthermore, no difference in the pattern of relapse was found and also the number of nodal relapses was the same between the two groups (
<xref rid="tbl5" ref-type="table">Table 5</xref>
).</p>
<p>The stage of the disease at the moment of the diagnosis had a strong influence on the prevalence of nodal involvement at second look. When looking at patients enroled in the lymphadenectomy arm, only 10% of women staged IA-IIA had nodal metastases (4.5% in the 22 patients who underwent adjuvant chemotherapy) but this proportion increased to 27.2% in patients with more advanced disease at first diagnosis. These findings show that chemotherapy, although active, is not able to eradicate all cancer foci in lymph nodes, especially in advanced disease. Otherwise, markers of disease aggressiveness, namely residual tumour at the end of primary surgery and the presence of peritoneal macroscopic tumour at second-look surgery were strong predictor of nodal involvement. In fact, in the lymphadenectomy arm, the prevalence of nodal metastases was statistically correlated with the residual tumour at the primary surgery (13.6% in patients with no residual tumour
<italic>vs</italic>
30.3% in patients with residual tumour,
<italic>P</italic>
=0.165), as well as with an evidence of peritoneal spread at the time of second look (21.1% absent
<italic>vs</italic>
35.3% present,
<italic>P</italic>
=0.088). Notably, both arms showed similar proportion of patients undergoing second-line chemotherapy, notwistanding wide difference in nodal involvement detection, and this allowed to explore the pure surgical debulking impact of lymphadenectomy on survival.</p>
<p>The limitations of our study must be ackwoledged. First, the trial took a long time to recruit and mature. Although many technological and scientific changes have occurred over such a long time the platinum-based chemotherapy regimens were widely used in this selected population and, above all, the randomisation procedure should have avoided the introduction of any systematic bias between arms. Another potential study limitation relates to the fact that second-look surgery, as performed in this trial, often tried to compensate first surgery inadequacy as shown in
<xref rid="tbl2" ref-type="table">Table 2</xref>
where types of second look surgical procedures were described. The inappropriateness of first surgery, according to modern standards, was due to the fact that most of the patients were randomised in specialised clinics where patients were addressed after just diagnostic explorative surgery undergone in minor general hospitals.</p>
<p>Overall, our data showed a lack of benefit in overall and PFS in patients who underwent lymphadenectomy at second look. Subgroup analyses in early and advanced disease failed to show survival benefit as well. These results should discourage the use of routine lymphadenectomy at second-look surgery after first-line chemotherapy in women with ovarian cancer. Furthermore, among the 238 women with advanced stage disease, of which 220 women with no residual tumour at the end of second-look surgery (absent or surgical converted to absent), lymphadenectomy was not associated with a survival gain (HR for relapse: 1.06; 95% CI=0.77–1.45;
<italic>P</italic>
=0.73 and HR for death: 0.96; 95% CI=0.66–1.40;
<italic>P</italic>
=0.83). Currently, the lymphadenectomy in ovarian neoplasm international RCT, sponsored by the onco-gynaecologic German group AGO, that investigates the role of systematic lymphadenectomy at primary surgery in advanced stage IIB–IV ovarian cancer, completed debulked, has enroled almost 650 women and the results are awaited.</p>
<p>In conclusion, according to this RCT a systematic lymphadenectomy at the second-look surgery after first-line chemotherapy in women with ovarian cancer offers no benefit. When a second-look surgery is required, because of an incomplete/inadequate endoperitoneal cytoreductive primary surgery, only nodal biopsies or removal of suspicious nodes should be performed, both in early and in advanced stage.</p>
</sec>
</body>
<back>
<ack>
<p>We thank Fondazione Mattioli, who provided support for Data Management.</p>
</ack>
<fn-group>
<fn>
<p>This work is published under the standard license to publish agreement. After 12 months the work will become freely available and the license terms will switch to a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License.</p>
</fn>
</fn-group>
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<colgroup>
<col align="left"></col>
<col align="center"></col>
<col align="char" char=""></col>
<col align="center"></col>
<col align="char" char=""></col>
</colgroup>
<thead valign="bottom">
<tr>
<th align="center" valign="middle" charoff="50"> </th>
<th colspan="2" align="center" valign="middle" charoff="50">
<bold>No lymphadenectomy (</bold>
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<bold>N</bold>
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<bold>=150)</bold>
<hr></hr>
</th>
<th colspan="2" align="center" valign="middle" charoff="50">
<bold>Lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=158)</bold>
<hr></hr>
</th>
</tr>
<tr>
<th align="left" valign="middle" charoff="50">
<bold>Characteristics</bold>
</th>
<th align="center" valign="middle" charoff="50">
<italic>
<bold>n</bold>
</italic>
</th>
<th align="center" valign="middle" charoff="50">
<bold>%</bold>
</th>
<th align="center" valign="middle" charoff="50">
<italic>
<bold>n</bold>
</italic>
</th>
<th align="center" valign="middle" charoff="50">
<bold>%</bold>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" valign="middle" charoff="50">Median age (25–75th percentiles)</td>
<td colspan="2" align="center" valign="middle" charoff="50">52 (45–60)</td>
<td colspan="2" align="center" valign="middle" charoff="50">50 (44–58)</td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50">
<italic>FIGO stage (primary surgery)</italic>
</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> I</td>
<td align="char" valign="middle" char="." charoff="50">36</td>
<td align="char" valign="middle" char="." charoff="50">24.0</td>
<td align="char" valign="middle" char="." charoff="50">26</td>
<td align="char" valign="middle" char="." charoff="50">16.5</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IA</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">6</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IB</td>
<td align="char" valign="middle" char="." charoff="50">5</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IC</td>
<td align="char" valign="middle" char="." charoff="50">23</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">19</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> II</td>
<td align="char" valign="middle" char="." charoff="50">17</td>
<td align="char" valign="middle" char="." charoff="50">11.5</td>
<td align="char" valign="middle" char="." charoff="50">25</td>
<td align="char" valign="middle" char="." charoff="50">15.8</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IIA</td>
<td align="char" valign="middle" char="." charoff="50">4</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">4</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IIB</td>
<td align="char" valign="middle" char="." charoff="50">7</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">14</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IIC</td>
<td align="char" valign="middle" char="." charoff="50">6</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">7</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> III</td>
<td align="char" valign="middle" char="." charoff="50">90</td>
<td align="char" valign="middle" char="." charoff="50">60.0</td>
<td align="char" valign="middle" char="." charoff="50">99</td>
<td align="char" valign="middle" char="." charoff="50">62.6</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IIIA</td>
<td align="char" valign="middle" char="." charoff="50">3</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">7</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IIIB</td>
<td align="char" valign="middle" char="." charoff="50">11</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">7</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  IIIC</td>
<td align="char" valign="middle" char="." charoff="50">76</td>
<td align="center" valign="middle" charoff="50"> </td>
<td align="char" valign="middle" char="." charoff="50">85</td>
<td align="center" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> IV</td>
<td align="char" valign="middle" char="." charoff="50">6</td>
<td align="char" valign="middle" char="." charoff="50">4.0</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.1</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1.5</td>
<td align="char" valign="middle" char="." charoff="50">0</td>
<td align="char" valign="middle" char="." charoff="50">0</td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50">
<italic>Residual tumour at first surgery</italic>
</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Absent</td>
<td align="char" valign="middle" char="." charoff="50">57</td>
<td align="char" valign="middle" char="." charoff="50">38.0</td>
<td align="char" valign="middle" char="." charoff="50">59</td>
<td align="char" valign="middle" char="." charoff="50">37.3</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  ⩽1 cm</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.3</td>
<td align="char" valign="middle" char="." charoff="50">21</td>
<td align="char" valign="middle" char="." charoff="50">13.3</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  >1 cm</td>
<td align="char" valign="middle" char="." charoff="50">73</td>
<td align="char" valign="middle" char="." charoff="50">48.7</td>
<td align="char" valign="middle" char="." charoff="50">72</td>
<td align="char" valign="middle" char="." charoff="50">45.6</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Missing data</td>
<td align="char" valign="middle" char="." charoff="50">12</td>
<td align="char" valign="middle" char="." charoff="50">8.0</td>
<td align="char" valign="middle" char="." charoff="50">6</td>
<td align="char" valign="middle" char="." charoff="50">3.8</td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50">
<italic>Tumour grade</italic>
</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  One well differentiated</td>
<td align="char" valign="middle" char="." charoff="50">17</td>
<td align="char" valign="middle" char="." charoff="50">11.3</td>
<td align="char" valign="middle" char="." charoff="50">12</td>
<td align="char" valign="middle" char="." charoff="50">7.6</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Two moderately well differentiated</td>
<td align="char" valign="middle" char="." charoff="50">36</td>
<td align="char" valign="middle" char="." charoff="50">24.0</td>
<td align="char" valign="middle" char="." charoff="50">35</td>
<td align="char" valign="middle" char="." charoff="50">22.2</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Three poorly differentiated</td>
<td align="char" valign="middle" char="." charoff="50">87</td>
<td align="char" valign="middle" char="." charoff="50">58.0</td>
<td align="char" valign="middle" char="." charoff="50">105</td>
<td align="char" valign="middle" char="." charoff="50">66.5</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Missing data</td>
<td align="char" valign="middle" char="." charoff="50">10</td>
<td align="char" valign="middle" char="." charoff="50">6.7</td>
<td align="char" valign="middle" char="." charoff="50">6</td>
<td align="char" valign="middle" char="." charoff="50">3.8</td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50">
<italic>Cell type</italic>
</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Serous</td>
<td align="char" valign="middle" char="." charoff="50">79</td>
<td align="char" valign="middle" char="." charoff="50">52.7</td>
<td align="char" valign="middle" char="." charoff="50">100</td>
<td align="char" valign="middle" char="." charoff="50">63.3</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Endometriod</td>
<td align="char" valign="middle" char="." charoff="50">31</td>
<td align="char" valign="middle" char="." charoff="50">20.7</td>
<td align="char" valign="middle" char="." charoff="50">15</td>
<td align="char" valign="middle" char="." charoff="50">9.5</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Mucinous</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.3</td>
<td align="char" valign="middle" char="." charoff="50">7</td>
<td align="char" valign="middle" char="." charoff="50">4.4</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Clear-cell</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.3</td>
<td align="char" valign="middle" char="." charoff="50">13</td>
<td align="char" valign="middle" char="." charoff="50">8.2</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Undifferentiated</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.3</td>
<td align="char" valign="middle" char="." charoff="50">15</td>
<td align="char" valign="middle" char="." charoff="50">9.5</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Other</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.3</td>
<td align="char" valign="middle" char="." charoff="50">6</td>
<td align="char" valign="middle" char="." charoff="50">3.8</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Missing data</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.3</td>
<td align="char" valign="middle" char="." charoff="50">2</td>
<td align="char" valign="middle" char="." charoff="50">1.3</td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50"> </td>
</tr>
<tr>
<td colspan="5" align="left" valign="middle" charoff="50">
<italic>Residual tumour at II look surgery</italic>
</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Absent</td>
<td align="char" valign="middle" char="." charoff="50">118</td>
<td align="char" valign="middle" char="." charoff="50">78.7</td>
<td align="char" valign="middle" char="." charoff="50">123</td>
<td align="char" valign="middle" char="." charoff="50">77.8</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Surgically converted to absent</td>
<td align="char" valign="middle" char="." charoff="50">22</td>
<td align="char" valign="middle" char="." charoff="50">14.7</td>
<td align="char" valign="middle" char="." charoff="50">26</td>
<td align="char" valign="middle" char="." charoff="50">16.4</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  ⩽1 cm</td>
<td align="char" valign="middle" char="." charoff="50">10</td>
<td align="char" valign="middle" char="." charoff="50">6.7</td>
<td align="char" valign="middle" char="." charoff="50">8</td>
<td align="char" valign="middle" char="." charoff="50">5.1</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">  Missing data</td>
<td align="char" valign="middle" char="." charoff="50">0</td>
<td align="char" valign="middle" char="." charoff="50">0</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">0.6</td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t1-fn1">
<p>Abbreviation: FIGO=Federation of Gynaecology and Obstetrics.</p>
</fn>
</table-wrap-foot>
</table-wrap>
<table-wrap id="tbl2">
<label>Table 2</label>
<caption>
<title>surgical procedures at the II look surgery</title>
</caption>
<table frame="hsides" rules="groups" border="1">
<colgroup>
<col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="char" char="("></col>
</colgroup>
<thead valign="bottom">
<tr>
<th align="left" valign="middle" charoff="50">
<bold>Surgical procedures</bold>
</th>
<th align="center" valign="middle" charoff="50">
<bold>No lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=150)</bold>
</th>
<th align="center" valign="middle" charoff="50">
<bold>Lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=158)</bold>
</th>
<th align="center" valign="middle" char="(" charoff="50">
<bold>Total (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=308) (%)</bold>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Hysterectomy</italic>
</td>
<td align="center" valign="middle" charoff="50">55 (36.9%)</td>
<td align="center" valign="middle" charoff="50">59 (37.8%)</td>
<td align="char" valign="middle" char="(" charoff="50">114 (37.4)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">2</td>
<td align="char" valign="middle" char="(" charoff="50">3 (0.9)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Unilateral or bilateral</italic>
</td>
<td align="center" valign="middle" charoff="50">42 (28%)</td>
<td align="center" valign="middle" charoff="50">38 (24%)</td>
<td align="char" valign="middle" char="(" charoff="50">80 (26)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>salpingo-oophorectomy</italic>
</td>
<td align="center" valign="middle" charoff="50">14 and 28</td>
<td align="center" valign="middle" charoff="50">13 and 25</td>
<td align="center" valign="middle" char="(" charoff="50">27 and 53</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0.6)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Omentectomy</italic>
</td>
<td align="center" valign="middle" charoff="50">107 (71.3%)</td>
<td align="center" valign="middle" charoff="50">101 (64%)</td>
<td align="char" valign="middle" char="(" charoff="50">208 (67.5)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0.6)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Appendectomy</italic>
</td>
<td align="center" valign="middle" charoff="50">36 (24.2%)</td>
<td align="center" valign="middle" charoff="50">45 (28.7%)</td>
<td align="char" valign="middle" char="(" charoff="50">81 (26.5)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0.6)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Small bowel resection</italic>
</td>
<td align="center" valign="middle" charoff="50">1 (0.7%)</td>
<td align="char" valign="middle" char="." charoff="50">0</td>
<td align="char" valign="middle" char="(" charoff="50">1 (0.3)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0.6)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Rectosigmoid or colon resection</italic>
</td>
<td align="center" valign="middle" charoff="50">6 (4%)</td>
<td align="center" valign="middle" charoff="50">1 (0.6%)</td>
<td align="char" valign="middle" char="(" charoff="50">7 (2.3)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0.6)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Pelvic peritonectomy</italic>
</td>
<td align="center" valign="middle" charoff="50">8 (5.4%)</td>
<td align="center" valign="middle" charoff="50">8 (5.1%)</td>
<td align="char" valign="middle" char="(" charoff="50">16 (5.2)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0.6)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Diaphragm stripping/resection</italic>
</td>
<td align="center" valign="middle" charoff="50">4 (2.7%)</td>
<td align="center" valign="middle" charoff="50">1 (0.6%)</td>
<td align="char" valign="middle" char="(" charoff="50">5 (1.6)</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="." charoff="50">1</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0.6)</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tbl3">
<label>Table 3</label>
<caption>
<title>Median number (25–75th percentiles) of resected nodes by treatment arm</title>
</caption>
<table frame="hsides" rules="groups" border="1">
<colgroup>
<col align="left"></col>
<col align="char" char="("></col>
<col align="char" char="("></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom">
<tr>
<th align="left" valign="middle" charoff="50">
<bold>Nodal site</bold>
</th>
<th align="center" valign="middle" char="(" charoff="50">
<bold>No lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=150)</bold>
</th>
<th align="center" valign="middle" char="(" charoff="50">
<bold>Lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=158)</bold>
</th>
<th align="center" valign="middle" char="." charoff="50">
<italic>
<bold>P</bold>
</italic>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" valign="middle" charoff="50">Pelvic</td>
<td align="char" valign="middle" char="(" charoff="50">5 (1.5–10)</td>
<td align="char" valign="middle" char="(" charoff="50">23 (15–33)</td>
<td align="char" valign="middle" char="." charoff="50"><0.001</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">Lumbo-aortic</td>
<td align="char" valign="middle" char="(" charoff="50">2 (0–4)</td>
<td align="char" valign="middle" char="(" charoff="50">20 (13–28)</td>
<td align="char" valign="middle" char="." charoff="50"><0.001</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">Pelvic and lumbo-aortic</td>
<td align="char" valign="middle" char="(" charoff="50">8 (4–14.5)</td>
<td align="char" valign="middle" char="(" charoff="50">44 (30–63)</td>
<td align="char" valign="middle" char="." charoff="50"><0.001</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">Missing data</td>
<td align="center" valign="middle" char="(" charoff="50">6</td>
<td align="center" valign="middle" char="(" charoff="50">1</td>
<td align="center" valign="middle" char="." charoff="50"> </td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tbl4">
<label>Table 4</label>
<caption>
<title>Operative details and postoperative hospital stay</title>
</caption>
<table frame="hsides" rules="groups" border="1">
<colgroup>
<col align="left"></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom">
<tr>
<th align="left" valign="middle" charoff="50">
<bold>Operative details</bold>
</th>
<th align="center" valign="middle" char="." charoff="50">
<bold>No lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=150)</bold>
</th>
<th align="center" valign="middle" char="." charoff="50">
<bold>Lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=158)</bold>
</th>
<th align="center" valign="middle" char="." charoff="50">
<italic>
<bold>P</bold>
</italic>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Median operating time (min)</italic>
</td>
<td align="char" valign="top" char="." charoff="50">135</td>
<td align="char" valign="top" char="." charoff="50">230</td>
<td align="char" valign="top" char="." charoff="50"><0.001</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> (25–75th percentiles)</td>
<td align="center" valign="top" char="." charoff="50">(100–180)</td>
<td align="center" valign="top" char="." charoff="50">(180–270)</td>
<td align="center" valign="top" char="." charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="top" char="." charoff="50">7</td>
<td align="char" valign="top" char="." charoff="50">13</td>
<td align="center" valign="top" char="." charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Median blood loss (ml)</italic>
</td>
<td align="char" valign="top" char="." charoff="50">200</td>
<td align="char" valign="top" char="." charoff="50">400</td>
<td align="char" valign="top" char="." charoff="50"><0.001</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> (25–75th percentiles)</td>
<td align="center" valign="top" char="." charoff="50">(150–350)</td>
<td align="center" valign="top" char="." charoff="50">(300–700)</td>
<td align="center" valign="top" char="." charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="top" char="." charoff="50">17</td>
<td align="char" valign="top" char="." charoff="50">21</td>
<td align="center" valign="top" char="." charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Patients transfused (%)</italic>
</td>
<td align="center" valign="top" char="." charoff="50">14 (9.3%)</td>
<td align="center" valign="top" char="." charoff="50">46 (29.1%)</td>
<td align="char" valign="top" char="." charoff="50"><0.001</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="center" valign="top" char="." charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50">
<italic>Median hospital stay (days)</italic>
</td>
<td align="char" valign="top" char="." charoff="50">6</td>
<td align="char" valign="top" char="." charoff="50">7</td>
<td align="char" valign="top" char="." charoff="50">0.0015</td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> (25–75th percentiles)</td>
<td align="center" valign="top" char="." charoff="50">(5–8)</td>
<td align="center" valign="top" char="." charoff="50">(6–8)</td>
<td align="center" valign="top" char="." charoff="50"> </td>
</tr>
<tr>
<td align="left" valign="middle" charoff="50"> Missing data</td>
<td align="char" valign="top" char="." charoff="50">11</td>
<td align="char" valign="top" char="." charoff="50">20</td>
<td align="center" valign="top" char="." charoff="50"> </td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tbl5">
<label>Table 5</label>
<caption>
<title>Site of disease recurrence by stage and treatment arm</title>
</caption>
<table frame="hsides" rules="groups" border="1">
<colgroup>
<col align="left"></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="("></col>
<col align="char" char="."></col>
<col align="char" char="."></col>
<col align="char" char="("></col>
<col align="char" char="."></col>
</colgroup>
<thead valign="bottom">
<tr>
<th align="left" valign="top" charoff="50"> </th>
<th colspan="3" align="center" valign="top" char="." charoff="50">
<bold>No lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=150)</bold>
<hr></hr>
</th>
<th colspan="3" align="center" valign="top" char="." charoff="50">
<bold>Lymphadenectomy (</bold>
<italic>
<bold>N</bold>
</italic>
<bold>=158)</bold>
<hr></hr>
</th>
<th align="center" valign="top" char="." charoff="50">
<bold>Total</bold>
</th>
</tr>
<tr>
<th align="left" valign="top" charoff="50">
<bold>Site</bold>
</th>
<th align="center" valign="top" char="." charoff="50">
<bold>Ia–IIa (</bold>
<italic>
<bold>n</bold>
</italic>
<bold>=40)</bold>
</th>
<th align="center" valign="top" char="." charoff="50">
<bold>IIb–IV (</bold>
<italic>
<bold>n</bold>
</italic>
<bold>=110)</bold>
</th>
<th align="center" valign="top" char="(" charoff="50">
<bold>Total</bold>
</th>
<th align="center" valign="top" char="." charoff="50">
<bold>Ia–IIa (</bold>
<italic>
<bold>n</bold>
</italic>
<bold>=30)</bold>
</th>
<th align="center" valign="top" char="." charoff="50">
<bold>IIb–IV (</bold>
<italic>
<bold>n</bold>
</italic>
<bold>=128)</bold>
</th>
<th align="center" valign="top" char="(" charoff="50">
<bold>Total</bold>
</th>
<th align="center" valign="top" char="." charoff="50">
<bold>308</bold>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td align="left" valign="top" charoff="50">Pelvic</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">13</td>
<td align="char" valign="top" char="(" charoff="50">15 (10%)</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">33</td>
<td align="char" valign="top" char="(" charoff="50">35 (22.2%)</td>
<td align="char" valign="top" char="." charoff="50">50</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">Intraperitoneal</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">10</td>
<td align="char" valign="top" char="(" charoff="50">10 (6.7%)</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">15</td>
<td align="char" valign="top" char="(" charoff="50">17 (10.8%)</td>
<td align="char" valign="top" char="." charoff="50">27</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">Lymphnode</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="(" charoff="50">4 (2.7%)</td>
<td align="char" valign="top" char="." charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">4</td>
<td align="char" valign="top" char="(" charoff="50">5 (3.2%)</td>
<td align="char" valign="top" char="." charoff="50">9</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">Distant site</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">9</td>
<td align="char" valign="top" char="(" charoff="50">11 (7.3%)</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">9</td>
<td align="char" valign="top" char="(" charoff="50">9 (5.7%)</td>
<td align="char" valign="top" char="." charoff="50">20</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">Multiple sites</td>
<td align="char" valign="top" char="." charoff="50">2</td>
<td align="char" valign="top" char="." charoff="50">26</td>
<td align="char" valign="top" char="(" charoff="50">28 (18.7%)</td>
<td align="char" valign="top" char="." charoff="50">0</td>
<td align="char" valign="top" char="." charoff="50">16</td>
<td align="char" valign="top" char="(" charoff="50">16 (10.1%)</td>
<td align="char" valign="top" char="." charoff="50">44</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">Missing data</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">6 (4%)</td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="." charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">7 (4.4%)</td>
<td align="char" valign="top" char="." charoff="50">13</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50">Total</td>
<td align="char" valign="top" char="." charoff="50">6</td>
<td align="char" valign="top" char="." charoff="50">62</td>
<td align="char" valign="top" char="(" charoff="50">74 (49.3%)</td>
<td align="char" valign="top" char="." charoff="50">5</td>
<td align="char" valign="top" char="." charoff="50">77</td>
<td align="char" valign="top" char="(" charoff="50">89 (56.3%)</td>
<td align="char" valign="top" char="." charoff="50">163</td>
</tr>
</tbody>
</table>
</table-wrap>
<table-wrap id="tbl6">
<label>Table 6</label>
<caption>
<title>Multivariable Cox proportional hazards analysis for PFS and OS to adjust the risk associated with therapy for various prognostic factors
<xref ref-type="fn" rid="t6-fn2">a</xref>
</title>
</caption>
<table frame="hsides" rules="groups" border="1">
<colgroup>
<col align="left"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
<col align="center"></col>
</colgroup>
<thead valign="bottom">
<tr>
<th align="left" valign="top" charoff="50"> </th>
<th colspan="2" align="center" valign="top" charoff="50">
<bold>PFS</bold>
<hr></hr>
</th>
<th colspan="2" align="center" valign="top" charoff="50">
<bold>OS</bold>
<hr></hr>
</th>
</tr>
<tr>
<th align="left" valign="top" charoff="50">
<bold>Prognostic factor</bold>
</th>
<th align="center" valign="top" charoff="50">
<bold>HR (95% CI)</bold>
</th>
<th align="center" valign="top" charoff="50">
<italic>
<bold>P</bold>
</italic>
</th>
<th align="center" valign="top" charoff="50">
<bold>HR (95% CI)</bold>
</th>
<th align="center" valign="top" charoff="50">
<italic>
<bold>P</bold>
</italic>
</th>
</tr>
</thead>
<tbody valign="top">
<tr>
<td colspan="5" align="left" valign="top" charoff="50">
<italic>Treatment arm</italic>
</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50"> No lymphadenectomy
<xref ref-type="fn" rid="t6-fn3">b</xref>
</td>
<td align="center" valign="top" charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">0.50</td>
<td align="center" valign="top" charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50">0.97</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50"> Lymphadenectomy</td>
<td align="char" valign="top" char="(" charoff="50">1.11 (0.82–1.50)</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">1.00 (0.71–1.44)</td>
<td align="center" valign="top" charoff="50"> </td>
</tr>
<tr>
<td colspan="5" align="left" valign="top" charoff="50"> </td>
</tr>
<tr>
<td colspan="5" align="left" valign="top" charoff="50">
<italic>FIGO stage at primary surgery</italic>
</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50"> 1 or 2
<xref ref-type="fn" rid="t6-fn3">b</xref>
</td>
<td align="center" valign="top" charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50"><0.001</td>
<td align="center" valign="top" charoff="50">1</td>
<td align="char" valign="top" char="." charoff="50"><0.001</td>
</tr>
<tr>
<td align="left" valign="top" charoff="50"> 3 or 4</td>
<td align="char" valign="top" char="(" charoff="50">2.90 (1.98–4.24)</td>
<td align="center" valign="top" charoff="50"> </td>
<td align="char" valign="top" char="(" charoff="50">3.26 (2.02–5.27)</td>
<td align="center" valign="top" charoff="50"> </td>
</tr>
</tbody>
</table>
<table-wrap-foot>
<fn id="t6-fn1">
<p>Abbreviations: FIGO=Federation of Gynaecology and Obstetrics; HR=hazard ratio; OS=overall survival; PFS=progression-free survival; 95% CI=confidence interval.</p>
</fn>
<fn id="t6-fn2">
<label>a</label>
<p>HR; 95% CI.</p>
</fn>
<fn id="t6-fn3">
<label>b</label>
<p>Reference category.</p>
</fn>
</table-wrap-foot>
</table-wrap>
</floats-group>
</pmc>
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