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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Use of the Sentinel Lymph Node Technique Compared to Complete
Inguino-femoral Lymph Node Removal in Patients with Invasive Vulvar Cancer in
Germany</title><author><name sortKey="Kramer, F" sort="Kramer, F" uniqKey="Kramer F" first="F." last="Kramer">F. Kramer</name><affiliation><nlm:aff id="AF581-1"><institution>Gynecology and Obstetrics, Medical School Hanover, Hanover</institution></nlm:aff></affiliation></author><author><name sortKey="Hertel, H" sort="Hertel, H" uniqKey="Hertel H" first="H." last="Hertel">H. Hertel</name><affiliation><nlm:aff id="AF581-1"><institution>Gynecology and Obstetrics, Medical School Hanover, Hanover</institution></nlm:aff></affiliation></author><author><name sortKey="Hillemanns, P" sort="Hillemanns, P" uniqKey="Hillemanns P" first="P." last="Hillemanns">P. Hillemanns</name><affiliation><nlm:aff id="AF581-1"><institution>Gynecology and Obstetrics, Medical School Hanover, Hanover</institution></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">24771911</idno><idno type="pmc">3859150</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3859150</idno><idno type="RBID">PMC:3859150</idno><idno type="doi">10.1055/s-0032-1328133</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000055</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000055</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Use of the Sentinel Lymph Node Technique Compared to Complete
Inguino-femoral Lymph Node Removal in Patients with Invasive Vulvar Cancer in
Germany</title><author><name sortKey="Kramer, F" sort="Kramer, F" uniqKey="Kramer F" first="F." last="Kramer">F. Kramer</name><affiliation><nlm:aff id="AF581-1"><institution>Gynecology and Obstetrics, Medical School Hanover, Hanover</institution></nlm:aff></affiliation></author><author><name sortKey="Hertel, H" sort="Hertel, H" uniqKey="Hertel H" first="H." last="Hertel">H. Hertel</name><affiliation><nlm:aff id="AF581-1"><institution>Gynecology and Obstetrics, Medical School Hanover, Hanover</institution></nlm:aff></affiliation></author><author><name sortKey="Hillemanns, P" sort="Hillemanns, P" uniqKey="Hillemanns P" first="P." last="Hillemanns">P. Hillemanns</name><affiliation><nlm:aff id="AF581-1"><institution>Gynecology and Obstetrics, Medical School Hanover, Hanover</institution></nlm:aff></affiliation></author></analytic><series><title level="j">Geburtshilfe und Frauenheilkunde</title><idno type="ISSN">0016-5751</idno><idno type="eISSN">1438-8804</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>In the current S2 guidelines, the standard surgical therapy for patients with
vulvar cancer also includes inguino-femoral lymphadenectomy. However, in
view of the severe side-effects associated with this approach such as
problems with wound healing, lymphoceles and lymphoedema, the search is on
for alternative treatments that could decrease treatment-associated
morbidity and improve patientsʼ quality of life, particularly for
node-negative patients. The sentinel lymph node technique is currently the
gold standard in the treatment of unifocal breast cancer (clinically
negative axilla), and studies on the use of this technique in the treatment
of vulvar cancer are promising. To date, the diagnostic accuracy of this
method in vulvar cancer has only been evaluated in a single, one-arm,
non-randomised, multicentre study. In preparation for a multicentre study,
in 2010 we surveyed 41 German hospitals to investigate how often they used
the sentinel lymph node technique compared to inguino-femoral
lymphadenectomy. The hospitals were grouped according to hospital size and
number of patients treated for vulvar cancer. The decision criteria to
determine the type of procedure performed were also investigated. Finally,
the hospitals were asked whether they would be willing to participate in a
prospective clinical study to evaluate the sentinel lymph node technique in
patients with vulvar cancer. The majority of surgeons questioned (73 %)
already had some experience with this technique in patients with vulvar
cancer. In our survey, 27 % of hospitals carried out inguino-femoral
lymphadenectomy, 10 % used the sentinel lymph node technique, and 63 % used
both methods. In 24 % of hospitals, the standard procedure consisted of the
sentinel lymph node technique supplemented by inguino-femoral
lymphadenectomy. Only 20 % of the institutions surveyed in our study carried
out sentinel lymph node biopsy alone in accordance with the criteria of the
consensus recommendations. The majority of the investigated institutions
were willing to participate in a randomised prospective clinical study to
evaluate the effectiveness of sentinel lymph node sampling in patients with
vulvar cancer.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Geburtshilfe Frauenheilkd</journal-id><journal-id journal-id-type="iso-abbrev">Geburtshilfe Frauenheilkd</journal-id><journal-id journal-id-type="publisher-id">Geburtshilfe und Frauenheilkunde</journal-id><journal-title-group><journal-title>Geburtshilfe und Frauenheilkunde</journal-title></journal-title-group><issn pub-type="ppub">0016-5751</issn><issn pub-type="epub">1438-8804</issn><publisher><publisher-name>Georg Thieme Verlag KG</publisher-name><publisher-loc>Stuttgart · New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24771911</article-id><article-id pub-id-type="pmc">3859150</article-id><article-id pub-id-type="doi">10.1055/s-0032-1328133</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Use of the Sentinel Lymph Node Technique Compared to Complete
Inguino-femoral Lymph Node Removal in Patients with Invasive Vulvar Cancer in
Germany</article-title><trans-title-group xml:lang="de"><trans-title>Verbreitung der Sentinellymphknotentechnik im Vergleich zur
kompletten inguinofemoralen Lymphknotenentfernung beim invasiven Vulvakarzinom
in Deutschland</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kramer</surname><given-names>F.</given-names></name><xref rid="AF581-1" ref-type="aff">1</xref><xref rid="CO-1" ref-type="author-notes"></xref></contrib><contrib contrib-type="author"><name><surname>Hertel</surname><given-names>H.</given-names></name><xref rid="AF581-1" ref-type="aff">1</xref></contrib><contrib contrib-type="author"><name><surname>Hillemanns</surname><given-names>P.</given-names></name><xref rid="AF581-1" ref-type="aff">1</xref></contrib></contrib-group><aff id="AF581-1"><label>1</label><institution>Gynecology and Obstetrics, Medical School Hanover, Hanover</institution></aff><author-notes><corresp id="CO-1"><bold>Correspondence </bold>Dr. Frauke Kramer, Medical Doctor <institution>Medical
School Hanover, Gynecology and Obstetrics</institution><addr-line>Hanover</addr-line><email>kramer.frauke@mh-hannover.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>2</month><year>2013</year></pub-date><volume>73</volume><issue>2</issue><fpage>142</fpage><lpage>147</lpage><history><date date-type="received"><day>26</day><month>6</month><year>2012</year></date><date date-type="rev-recd"><day>31</day><month>10</month><year>2012</year></date><date date-type="accepted"><day>13</day><month>12</month><year>2012</year></date></history><permissions><copyright-statement>© Thieme Medical Publishers</copyright-statement></permissions><abstract><p>In the current S2 guidelines, the standard surgical therapy for patients with
vulvar cancer also includes inguino-femoral lymphadenectomy. However, in
view of the severe side-effects associated with this approach such as
problems with wound healing, lymphoceles and lymphoedema, the search is on
for alternative treatments that could decrease treatment-associated
morbidity and improve patientsʼ quality of life, particularly for
node-negative patients. The sentinel lymph node technique is currently the
gold standard in the treatment of unifocal breast cancer (clinically
negative axilla), and studies on the use of this technique in the treatment
of vulvar cancer are promising. To date, the diagnostic accuracy of this
method in vulvar cancer has only been evaluated in a single, one-arm,
non-randomised, multicentre study. In preparation for a multicentre study,
in 2010 we surveyed 41 German hospitals to investigate how often they used
the sentinel lymph node technique compared to inguino-femoral
lymphadenectomy. The hospitals were grouped according to hospital size and
number of patients treated for vulvar cancer. The decision criteria to
determine the type of procedure performed were also investigated. Finally,
the hospitals were asked whether they would be willing to participate in a
prospective clinical study to evaluate the sentinel lymph node technique in
patients with vulvar cancer. The majority of surgeons questioned (73 %)
already had some experience with this technique in patients with vulvar
cancer. In our survey, 27 % of hospitals carried out inguino-femoral
lymphadenectomy, 10 % used the sentinel lymph node technique, and 63 % used
both methods. In 24 % of hospitals, the standard procedure consisted of the
sentinel lymph node technique supplemented by inguino-femoral
lymphadenectomy. Only 20 % of the institutions surveyed in our study carried
out sentinel lymph node biopsy alone in accordance with the criteria of the
consensus recommendations. The majority of the investigated institutions
were willing to participate in a randomised prospective clinical study to
evaluate the effectiveness of sentinel lymph node sampling in patients with
vulvar cancer.</p></abstract><trans-abstract xml:lang="de"><sec><title>Zusammenfassung</title><p>Die inguinofemorale Lymphonodektomie stellt nach aktuellen Leitlinien das
Standardverfahren beim Vulvakarzinom dar. Aufgrund erhöhter Raten an
Wundheilungsstörungen, Lymphozelen und Lymphödemen könnten alternative
Behandlungsmethoden insbesondere für nodalnegative Patientinnen zu einer
Senkung der krankheitsassoziierten Morbidität und zu einer Steigerung der
Lebensqualität führen. Die Sentinellymphonodektomie stellt beim unifokalen
Mammakarzinom (klinisch unauffällige Axilla) den Goldstandard dar, und
Studien zum Einsatz beim Vulvakarzinom weisen vielversprechende Ergebnisse
auf. Bisher wurde in lediglich einer einarmigen, nicht randomisierten Studie
die Wertigkeit dieser Methode überprüft. In einer Umfrage unter 41
deutschsprachigen Kliniken wurde 2010 die Verbreitung der
Sentinellymphknotentechnik im Vergleich zur inguinofemoralen
Lymphonodektomie erfasst. Die Kliniken wurden nach Größe und nach Anzahl der
Vulvakarzinom-Patientinnen unterteilt. Erfasst wurde, welche Art der
Lymphonodektomie nach welchen Entscheidungskriterien angewandt wird.
Abschließend wurde die Bereitschaft zur Teilnahme an einer
klinisch-prospektiven Studie zur Evaluation der Sentinellymphonodektomie
beim Vulvakarzinom ermittelt. Die Mehrheit der Befragten (73 %) hatte
Erfahrung mit dieser Technik beim Vulvakarzinom. In 27 % der Kliniken wurde
die inguinofemorale, in 10 % die Sentinellymphonodektomie und in 63 % wurden
beide Methoden angewandt. Eine Komplettierung der Sentinellymphknotentechnik
wurde in 24 % der Kliniken grundsätzlich durchgeführt. Bei der
Sentinellymphonodektomie gaben 20 % der Befragten an, gemäß Kriterien zu
verfahren, die in den Konsensusempfehlungen empfohlen wurden. Die Mehrheit
der befragten Kliniken würde an einer randomisierten klinisch-prospektiven
Studie zur Evaluation der Wertigkeit der Sentinellymphonodektomie beim
Vulvakarzinom teilnehmen.</p></sec></trans-abstract><kwd-group xml:lang="en"><title>Key words</title><kwd>Vulvar cancer</kwd><kwd>sentinel lymph node dissection</kwd><kwd>complete inguino-femoral lymphadenectomy</kwd></kwd-group><kwd-group xml:lang="de"><title>Schlüsselwörter</title><kwd>Vulvamalignom</kwd><kwd>Sentinellymphonodektomie</kwd><kwd>komplette inguinofemorale Lymphonodektomie</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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