Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015
Identifieur interne : 000052 ( Pmc/Corpus ); précédent : 000051; suivant : 000053Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015
Auteurs : H. G. Schnürch ; S. Ackermann ; C. D. Alt ; J. Barinoff ; C. Böing ; C. Dannecker ; F. Gieseking ; A. Günthert ; P. Hantschmann ; L. C. Horn ; R. Kürzl ; P. Mallmann ; S. Marnitz ; G. Mehlhorn ; C. C. Hack ; M. C. Koch ; U. Torsten ; W. Weikel ; L. Wölber ; M. HamplSource :
- Geburtshilfe und Frauenheilkunde [ 0016-5751 ] ; 2016.
Abstract
Url:
DOI: 10.1055/s-0042-103728
PubMed: 27765958
PubMed Central: 5066425
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PMC:5066425Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015</title><author><name sortKey="Schnurch, H G" sort="Schnurch, H G" uniqKey="Schnurch H" first="H. G." last="Schnürch">H. G. Schnürch</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Ackermann, S" sort="Ackermann, S" uniqKey="Ackermann S" first="S." last="Ackermann">S. Ackermann</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Alt, C D" sort="Alt, C D" uniqKey="Alt C" first="C. D." last="Alt">C. D. Alt</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Barinoff, J" sort="Barinoff, J" uniqKey="Barinoff J" first="J." last="Barinoff">J. Barinoff</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Boing, C" sort="Boing, C" uniqKey="Boing C" first="C." last="Böing">C. Böing</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Dannecker, C" sort="Dannecker, C" uniqKey="Dannecker C" first="C." last="Dannecker">C. Dannecker</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Gieseking, F" sort="Gieseking, F" uniqKey="Gieseking F" first="F." last="Gieseking">F. Gieseking</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Gunthert, A" sort="Gunthert, A" uniqKey="Gunthert A" first="A." last="Günthert">A. Günthert</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Hantschmann, P" sort="Hantschmann, P" uniqKey="Hantschmann P" first="P." last="Hantschmann">P. Hantschmann</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Horn, L C" sort="Horn, L C" uniqKey="Horn L" first="L. C." last="Horn">L. C. Horn</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Kurzl, R" sort="Kurzl, R" uniqKey="Kurzl R" first="R." last="Kürzl">R. Kürzl</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Mallmann, P" sort="Mallmann, P" uniqKey="Mallmann P" first="P." last="Mallmann">P. Mallmann</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Marnitz, S" sort="Marnitz, S" uniqKey="Marnitz S" first="S." last="Marnitz">S. Marnitz</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Mehlhorn, G" sort="Mehlhorn, G" uniqKey="Mehlhorn G" first="G." last="Mehlhorn">G. Mehlhorn</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Hack, C C" sort="Hack, C C" uniqKey="Hack C" first="C. C." last="Hack">C. C. Hack</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Koch, M C" sort="Koch, M C" uniqKey="Koch M" first="M. C." last="Koch">M. C. Koch</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Torsten, U" sort="Torsten, U" uniqKey="Torsten U" first="U." last="Torsten">U. Torsten</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Weikel, W" sort="Weikel, W" uniqKey="Weikel W" first="W." last="Weikel">W. Weikel</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Wolber, L" sort="Wolber, L" uniqKey="Wolber L" first="L." last="Wölber">L. Wölber</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Hampl, M" sort="Hampl, M" uniqKey="Hampl M" first="M." last="Hampl">M. Hampl</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">27765958</idno><idno type="pmc">5066425</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5066425</idno><idno type="RBID">PMC:5066425</idno><idno type="doi">10.1055/s-0042-103728</idno><date when="2016">2016</date><idno type="wicri:Area/Pmc/Corpus">000052</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000052</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015</title><author><name sortKey="Schnurch, H G" sort="Schnurch, H G" uniqKey="Schnurch H" first="H. G." last="Schnürch">H. G. Schnürch</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Ackermann, S" sort="Ackermann, S" uniqKey="Ackermann S" first="S." last="Ackermann">S. Ackermann</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Alt, C D" sort="Alt, C D" uniqKey="Alt C" first="C. D." last="Alt">C. D. Alt</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Barinoff, J" sort="Barinoff, J" uniqKey="Barinoff J" first="J." last="Barinoff">J. Barinoff</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Boing, C" sort="Boing, C" uniqKey="Boing C" first="C." last="Böing">C. Böing</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Dannecker, C" sort="Dannecker, C" uniqKey="Dannecker C" first="C." last="Dannecker">C. Dannecker</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Gieseking, F" sort="Gieseking, F" uniqKey="Gieseking F" first="F." last="Gieseking">F. Gieseking</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Gunthert, A" sort="Gunthert, A" uniqKey="Gunthert A" first="A." last="Günthert">A. Günthert</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Hantschmann, P" sort="Hantschmann, P" uniqKey="Hantschmann P" first="P." last="Hantschmann">P. Hantschmann</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Horn, L C" sort="Horn, L C" uniqKey="Horn L" first="L. C." last="Horn">L. C. Horn</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Kurzl, R" sort="Kurzl, R" uniqKey="Kurzl R" first="R." last="Kürzl">R. Kürzl</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Mallmann, P" sort="Mallmann, P" uniqKey="Mallmann P" first="P." last="Mallmann">P. Mallmann</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Marnitz, S" sort="Marnitz, S" uniqKey="Marnitz S" first="S." last="Marnitz">S. Marnitz</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Mehlhorn, G" sort="Mehlhorn, G" uniqKey="Mehlhorn G" first="G." last="Mehlhorn">G. Mehlhorn</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Hack, C C" sort="Hack, C C" uniqKey="Hack C" first="C. C." last="Hack">C. C. Hack</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Koch, M C" sort="Koch, M C" uniqKey="Koch M" first="M. C." last="Koch">M. C. Koch</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Torsten, U" sort="Torsten, U" uniqKey="Torsten U" first="U." last="Torsten">U. Torsten</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Weikel, W" sort="Weikel, W" uniqKey="Weikel W" first="W." last="Weikel">W. Weikel</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Wolber, L" sort="Wolber, L" uniqKey="Wolber L" first="L." last="Wölber">L. Wölber</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author><author><name sortKey="Hampl, M" sort="Hampl, M" uniqKey="Hampl M" first="M." last="Hampl">M. Hampl</name><affiliation><nlm:aff>NONE</nlm:aff></affiliation></author></analytic><series><title level="j">Geburtshilfe und Frauenheilkunde</title><idno type="ISSN">0016-5751</idno><idno type="eISSN">1438-8804</idno><imprint><date when="2016">2016</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p><bold>Purpose:</bold> This is an official guideline, published and coordinated by the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO, Study Group for Gynecologic Oncology) of the Deutsche Krebsgesellschaft (DKG, German Cancer Society) and the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG, German Society for Gynecology and Obstetrics). The number of cases with vulvar cancer is on the rise, but because of the former rarity of this condition and the resulting lack of literature with a high level of evidence, in many areas knowledge of the optimal clinical management still lags behind what would be required. This updated guideline aims to disseminate the most recent recommendations, which are much clearer and more individualized, and is intended to create a basis for the assessment and improvement of quality care in hospitals. </p><p><bold>Methods:</bold> This S2k guideline was drafted by members of the AGO Committee on Vulvar and Vaginal Tumors; it was developed and formally completed in accordance with the structured consensus process of the Association of Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF). </p><p><bold>Recommendations:</bold> 1. The incidence of disease must be taken into consideration. 2. The diagnostic pathway, which is determined by the initial findings, must be followed. 3. The clinical and therapeutic management of vulvar cancer must be done on an individual basis and depends on the stage of disease. 4. The indications for sentinel lymph node biopsy must be evaluated very carefully. 5. Follow-up and treatment for recurrence must be adapted to the individual case.</p></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Geburtshilfe Frauenheilkd</journal-id><journal-id journal-id-type="iso-abbrev">Geburtshilfe Frauenheilkd</journal-id><journal-id journal-id-type="doi">10.1055/s-00000020</journal-id><journal-title-group><journal-title>Geburtshilfe und Frauenheilkunde</journal-title></journal-title-group><issn pub-type="ppub">0016-5751</issn><issn pub-type="epub">1438-8804</issn><publisher><publisher-name>Georg Thieme Verlag KG</publisher-name><publisher-loc>Stuttgart · New York</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">27765958</article-id><article-id pub-id-type="pmc">5066425</article-id><article-id pub-id-type="doi">10.1055/s-0042-103728</article-id><article-categories><subj-group><subject>Guideline</subject><subj-group><subject>GebFra Science</subject></subj-group></subj-group></article-categories><title-group><article-title>Diagnosis, Therapy and Follow-up Care of Vulvar Cancer and its Precursors. Guideline of the DGGG and DKG (S2k-Level, AWMF Registry Number 015/059, November 2015</article-title><trans-title-group xml:lang="de"><trans-title>Diagnostik, Therapie und Nachsorge des Vulvakarzinoms und seiner Vorstufen. Leitlinie der DGGG und DKG (S2k-Level, AWMF-Registernummer 015/059, November 2015)</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author"><name><surname>Schnürch</surname><given-names>H. G.</given-names></name><xref rid="AF1041-1" ref-type="aff"></xref><xref rid="CO-1" ref-type="author-notes"></xref></contrib><contrib contrib-type="author"><name><surname>Ackermann</surname><given-names>S.</given-names></name><xref rid="AF1041-2" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Alt</surname><given-names>C. D.</given-names></name><xref rid="AF1041-3" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Barinoff</surname><given-names>J.</given-names></name><xref rid="AF1041-4" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Böing</surname><given-names>C.</given-names></name><xref rid="AF1041-5" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Dannecker</surname><given-names>C.</given-names></name><xref rid="AF1041-6" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Gieseking</surname><given-names>F.</given-names></name><xref rid="AF1041-7" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Günthert</surname><given-names>A.</given-names></name><xref rid="AF1041-8" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Hantschmann</surname><given-names>P.</given-names></name><xref rid="AF1041-9" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Horn</surname><given-names>L. C.</given-names></name><xref rid="AF1041-10" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Kürzl</surname><given-names>R.</given-names></name><xref rid="AF1041-11" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Mallmann</surname><given-names>P.</given-names></name><xref rid="AF1041-12" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Marnitz</surname><given-names>S.</given-names></name><xref rid="AF1041-13" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Mehlhorn</surname><given-names>G.</given-names></name><xref rid="AF1041-14" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Hack</surname><given-names>C. C.</given-names></name><xref rid="AF1041-14" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Koch</surname><given-names>M. C.</given-names></name><xref rid="AF1041-14" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Torsten</surname><given-names>U.</given-names></name><xref rid="AF1041-15" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Weikel</surname><given-names>W.</given-names></name><xref rid="AF1041-16" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Wölber</surname><given-names>L.</given-names></name><xref rid="AF1041-17" ref-type="aff"></xref></contrib><contrib contrib-type="author"><name><surname>Hampl</surname><given-names>M.</given-names></name><xref rid="AF1041-18" ref-type="aff"></xref></contrib></contrib-group><aff id="AF1041-1"><label>1</label><institution>ehem. Frauenklinik Lukaskrankenhaus, Neuss</institution></aff><aff id="AF1041-2"><label>2</label><institution>Frauenklinik, Klinikum Darmstadt, Darmstadt</institution></aff><aff id="AF1041-3"><label>3</label><institution>Institut für Diagnostische und Interventionelle Radiologie, Universität Düsseldorf, Düsseldorf</institution></aff><aff id="AF1041-4"><label>4</label><institution>Klinik für Gynäkologie und Geburtshilfe, Markus Krankenhaus, Frankfurt am Main</institution></aff><aff id="AF1041-5"><label>5</label><institution>Katholisches Klinikum Oberhausen, Frauenklinik St. Clemens-Hospital, Oberhausen</institution></aff><aff id="AF1041-6"><label>6</label><institution>Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der Universität München, Campus Großhadern, München, Munich</institution></aff><aff id="AF1041-7"><label>7</label><institution>Dysplasiezentrum in der Frauenarztpraxis Heussweg, Hamburg</institution></aff><aff id="AF1041-8"><label>8</label><institution>Frauenklinik Luzerner Kantonsspital, Lucerne, Switzerland</institution></aff><aff id="AF1041-9"><label>9</label><institution>Abteilung Gynäkologie und Geburtshilfe, Kreiskliniken Altötting – Burghausen, Altötting</institution></aff><aff id="AF1041-10"><label>10</label><institution>Institut für Pathologie des Universitätsklinikums Leipzig, Leipzig</institution></aff><aff id="AF1041-11"><label>11</label><institution>ehem. Universitätsfrauenklinik Maistraße, Munich</institution></aff><aff id="AF1041-12"><label>12</label><institution>Klinik und Poliklinik für Frauenheilkunde und Geburtshilfe der Universität Köln, Cologne</institution></aff><aff id="AF1041-13"><label>13</label><institution>Klinik und Poliklinik für Radioonkologie und Strahlentherapie der Universität Köln, Cologne</institution></aff><aff id="AF1041-14"><label>14</label><institution>Universitätsfrauenklinik Erlangen, Erlangen</institution></aff><aff id="AF1041-15"><label>15</label><institution>Klinik für Gynäkologie und Zentrum für Beckenbodenerkrankungen, Vivantes Klinikum Neukölln, Berlin</institution></aff><aff id="AF1041-16"><label>16</label><institution>Klinik für Gynäkologie und gynäkologische Onkologie, Universitätsfrauenklinik Mainz, Mainz</institution></aff><aff id="AF1041-17"><label>17</label><institution>Klinik und Poliklinik für Gynäkologie, Universitätsklinikum Hamburg-Eppendorf, Hamburg</institution></aff><aff id="AF1041-18"><label>18</label><institution>Klinik für Frauenheilkunde und Geburtshilfe des Universitätsklinikums Düsseldorf, Düsseldorf</institution></aff><author-notes><corresp id="CO-1"><bold>Correspondence </bold>Prof. Dr. Hans-Georg Schnürch <institution>Ehemaliger Chefarzt der Frauenklinik am Lukaskrankenhaus Neuss</institution><addr-line>Im Hunengraben 9</addr-line><addr-line>41564 Kaarst</addr-line><email>hschnuerch@t-online.de</email></corresp></author-notes><pub-date pub-type="ppub"><month>10</month><year>2016</year></pub-date><volume>76</volume><issue>10</issue><fpage>1035</fpage><lpage>1049</lpage><history></history><permissions><copyright-statement>© Thieme Medical Publishers</copyright-statement></permissions><abstract><p><bold>Purpose:</bold> This is an official guideline, published and coordinated by the Arbeitsgemeinschaft Gynäkologische Onkologie (AGO, Study Group for Gynecologic Oncology) of the Deutsche Krebsgesellschaft (DKG, German Cancer Society) and the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe (DGGG, German Society for Gynecology and Obstetrics). The number of cases with vulvar cancer is on the rise, but because of the former rarity of this condition and the resulting lack of literature with a high level of evidence, in many areas knowledge of the optimal clinical management still lags behind what would be required. This updated guideline aims to disseminate the most recent recommendations, which are much clearer and more individualized, and is intended to create a basis for the assessment and improvement of quality care in hospitals. </p><p><bold>Methods:</bold> This S2k guideline was drafted by members of the AGO Committee on Vulvar and Vaginal Tumors; it was developed and formally completed in accordance with the structured consensus process of the Association of Scientific Medical Societies in Germany (Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften, AWMF). </p><p><bold>Recommendations:</bold> 1. The incidence of disease must be taken into consideration. 2. The diagnostic pathway, which is determined by the initial findings, must be followed. 3. The clinical and therapeutic management of vulvar cancer must be done on an individual basis and depends on the stage of disease. 4. The indications for sentinel lymph node biopsy must be evaluated very carefully. 5. Follow-up and treatment for recurrence must be adapted to the individual case.</p></abstract><trans-abstract xml:lang="de"><title>Zusammenfassung</title><p><bold>Ziel:</bold> Offizielle Leitlinie, publiziert und koordiniert von der Arbeitsgemeinschaft Gynäkologische Onkologie (AGO) in der Deutschen Krebsgesellschaft (DKG) und der Deutschen Gesellschaft für Gynäkologie und Geburtshilfe (DGGG). Vulvakarzinome nehmen an Anzahl stetig zu, während die Kenntnisse über das optimale klinische Management wegen der früheren Seltenheit und dem daraus resultierenden Mangel an Literatur-Evidenz dem Bedarf an vielen Stellen noch hinterherhinken. Dieses Leitlinien-Update soll die aktuell deutlich klareren und individualisierten Behandlungsempfehlungen möglichst weit verbreiten und die Grundlage für eine Qualitätsmessung und Qualitätssteigerung in Kliniken bieten. </p><p><bold>Methoden:</bold> Die vorliegende S2k-Leitlinie wurde von den Mitgliedern der Kommission Vulva- und Vaginaltumoren der AGO entworfen und in einem methodisch überwachten Konsensusverfahren der Arbeitsgemeinschaft der Wissenschaftlichen Medizinischen Fachgesellschaften (AWMF) strukturiert entwickelt und formal abgeschlossen. </p><p><bold>Empfehlungen:</bold> 1. Beachtung der Inzidenz. 2. Einhaltung der abgestuften Diagnostik in Abhängigkeit vom Ausgangsstadium. 3. Individualisiertes klinisch-therapeutisches Management der Vulvakarzinome in Abhängigkeit vom Stadium. 4. Ausgewogene Indikationsstellung zur Sentinel-Lymphknoten-Biopsie. 5. Adaptierte Nachsorge und Behandlung im Rezidivfall.</p></trans-abstract><kwd-group xml:lang="en"><title>Key words</title><kwd>vulvar cancer</kwd><kwd>diagnosis</kwd><kwd>therapy</kwd><kwd>vulvar intraepithelial neoplasia</kwd></kwd-group><kwd-group xml:lang="de"><title>Schlüsselwörter</title><kwd>Vulvakarzinom</kwd><kwd>Diagnostik</kwd><kwd>Therapie</kwd><kwd>VIN</kwd></kwd-group></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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