Rheological effects of bed rest in sickle cell disease.
Identifieur interne : 004461 ( Pmc/Checkpoint ); précédent : 004460; suivant : 004462Rheological effects of bed rest in sickle cell disease.
Auteurs : A J Keidan ; J. StuartSource :
- Journal of Clinical Pathology [ 0021-9746 ] ; 1987.
Abstract
A serial rheological study in two patients with homozygous sickle cell disease whose leg ulcers healed as a consequence of bed rest showed an improvement in erythrocyte deformability (filterability) associated with evidence of decreased haemolysis and a fall in the number of irreversibly sickled cells. This rheological improvement may aid the healing of leg ulcers by increasing blood flow in the ulcer base. The effects of bed rest on the rheology of sickle cell disease should be taken into account in future studies of vaso-occlusive crisis.
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PubMed: 3680542
PubMed Central: 1141192
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<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Pathol</journal-id><journal-title>Journal of Clinical Pathology</journal-title><issn pub-type="ppub">0021-9746</issn><issn pub-type="epub">1472-4146</issn></journal-meta><article-meta><article-id pub-id-type="pmid">3680542</article-id><article-id pub-id-type="pmc">1141192</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Rheological effects of bed rest in sickle cell disease.</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Keidan</surname><given-names>A J</given-names></name></contrib><contrib contrib-type="author"><name><surname>Stuart</surname><given-names>J</given-names></name></contrib></contrib-group><aff>Department of Haematology, Medical School, University of Birmingham.</aff><pub-date pub-type="ppub"><month>10</month><year>1987</year></pub-date><volume>40</volume><issue>10</issue><fpage>1187</fpage><lpage>1188</lpage><abstract><p>A serial rheological study in two patients with homozygous sickle cell disease whose leg ulcers healed as a consequence of bed rest showed an improvement in erythrocyte deformability (filterability) associated with evidence of decreased haemolysis and a fall in the number of irreversibly sickled cells. This rheological improvement may aid the healing of leg ulcers by increasing blood flow in the ulcer base. The effects of bed rest on the rheology of sickle cell disease should be taken into account in future studies of vaso-occlusive crisis.</p></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Keidan, A J" sort="Keidan, A J" uniqKey="Keidan A" first="A J" last="Keidan">A J Keidan</name><name sortKey="Stuart, J" sort="Stuart, J" uniqKey="Stuart J" first="J" last="Stuart">J. Stuart</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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