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DIAGNOSIS AND MANAGEMENT OF SOFT-TISSUE SARCOMAS

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DIAGNOSIS AND MANAGEMENT OF SOFT-TISSUE SARCOMAS

Auteurs : G. Rajgopal

Source :

Medical Journal, Armed Forces India [ 0377-1237 ] ; 1994.

RBID : PMC:5529718

Abstract

ABSTRACT

Soft-tissue sarcomas are locally aggressive tumours with a tendency to spread haematogenously, especially to the lungs. Most patients present without obvious metastases. Their management is dependent on an adequate incisional biopsy to assess the grade of the tumour. The biopsy incision must be carefully placed so as not to compromise subsequent radical excision. Of patients so treated, 20 to 30% experience local recurrence within the first 3 years postoperatively. The use of adjuvant radiotherapy decreases the incidence of local recurrence to about 15%. Patients with retroperitoneal sarcomas have a greater tendency to suffer recurrence, with disseminated disease throughout the abdomen. The overall 5-year survival rate is about 50%. Patients may, however, have persistent disease or develop metastases beyond the 5-year period. The optimal timing of radiation and chemotherapy remains unresolved, but multimodality treatment at least allows the advocation of limb-sparing procedures for patients with soft-tissue sarcomas.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5529718

DOI: 10.1016/S0377-1237(17)31038-9
PubMed: 28769161
PubMed Central: 5529718

Affiliations:

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PMC:5529718

Le document en format XML

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<author><name sortKey="Rajgopal, G" sort="Rajgopal, G" uniqKey="Rajgopal G" first="G" last="Rajgopal">G. Rajgopal</name>
<affiliation><nlm:aff id="aff1">Classified Specialist in Surgery and Surgical Oncology, MDTC, Command Hospital (SC), PUNE – 411 040</nlm:aff>
<wicri:noCountry code="subfield">PUNE – 411 040</wicri:noCountry>
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<series><title level="j">Medical Journal, Armed Forces India</title>
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<front><div type="abstract" xml:lang="en"><title>ABSTRACT</title>
<p>Soft-tissue sarcomas are locally aggressive tumours with a tendency to spread haematogenously, especially to the lungs. Most patients present without obvious metastases. Their management is dependent on an adequate incisional biopsy to assess the grade of the tumour. The biopsy incision must be carefully placed so as not to compromise subsequent radical excision. Of patients so treated, 20 to 30% experience local recurrence within the first 3 years postoperatively. The use of adjuvant radiotherapy decreases the incidence of local recurrence to about 15%. Patients with retroperitoneal sarcomas have a greater tendency to suffer recurrence, with disseminated disease throughout the abdomen. The overall 5-year survival rate is about 50%. Patients may, however, have persistent disease or develop metastases beyond the 5-year period. The optimal timing of radiation and chemotherapy remains unresolved, but multimodality treatment at least allows the advocation of limb-sparing procedures for patients with soft-tissue sarcomas.</p>
</div>
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<pmc article-type="review-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <front><journal-meta><journal-id journal-id-type="nlm-ta">Med J Armed Forces India</journal-id>
<journal-id journal-id-type="iso-abbrev">Med J Armed Forces India</journal-id>
<journal-title-group><journal-title>Medical Journal, Armed Forces India</journal-title>
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<publisher><publisher-name>Elsevier</publisher-name>
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<article-id pub-id-type="publisher-id">S0377-1237(17)31038-9</article-id>
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<title-group><article-title>DIAGNOSIS AND MANAGEMENT OF SOFT-TISSUE SARCOMAS</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>RAJGOPAL</surname>
<given-names>G</given-names>
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<xref rid="aff1" ref-type="aff">*</xref>
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<aff id="aff1"><label>*</label>
Classified Specialist in Surgery and Surgical Oncology, MDTC, Command Hospital (SC), PUNE – 411 040</aff>
<pub-date pub-type="ppub"><month>1</month>
<year>1994</year>
</pub-date>
<pub-date pub-type="epub"><day>27</day>
<month>6</month>
<year>2017</year>
</pub-date>
<volume>50</volume>
<issue>1</issue>
<fpage>49</fpage>
<lpage>55</lpage>
<permissions><copyright-statement>.</copyright-statement>
<copyright-year>1994</copyright-year>
<copyright-holder>Elsevier B.V. on behalf of Director General, Armed Forces Medical Services</copyright-holder>
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<abstract id="ceab10"><title>ABSTRACT</title>
<p>Soft-tissue sarcomas are locally aggressive tumours with a tendency to spread haematogenously, especially to the lungs. Most patients present without obvious metastases. Their management is dependent on an adequate incisional biopsy to assess the grade of the tumour. The biopsy incision must be carefully placed so as not to compromise subsequent radical excision. Of patients so treated, 20 to 30% experience local recurrence within the first 3 years postoperatively. The use of adjuvant radiotherapy decreases the incidence of local recurrence to about 15%. Patients with retroperitoneal sarcomas have a greater tendency to suffer recurrence, with disseminated disease throughout the abdomen. The overall 5-year survival rate is about 50%. Patients may, however, have persistent disease or develop metastases beyond the 5-year period. The optimal timing of radiation and chemotherapy remains unresolved, but multimodality treatment at least allows the advocation of limb-sparing procedures for patients with soft-tissue sarcomas.</p>
</abstract>
<kwd-group id="cekeyws10"><title>KEY WORDS</title>
<kwd>Soft-tissue sarcomas-diagnosis-management</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Rajgopal, G" sort="Rajgopal, G" uniqKey="Rajgopal G" first="G" last="Rajgopal">G. Rajgopal</name>
</noCountry>
</tree>
</affiliations>
</record>

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DIAGNOSIS AND MANAGEMENT OF SOFT-TISSUE SARCOMAS

DIAGNOSIS AND MANAGEMENT OF SOFT-TISSUE SARCOMAS

Source :

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki