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Lymphatic vessels in the uterine wall

Identifieur interne : 003B32 ( Pmc/Checkpoint ); précédent : 003B31; suivant : 003B33

Lymphatic vessels in the uterine wall

Auteurs : Kristy Red-Horse

Source :

RBID : PMC:2435487

Abstract

During pregnancy, maternal uterine blood vessels undergo dramatic vascular remodeling. However, until now, little was known about whether the lymphatic circulation undergoes similar changes and whether these vessels interact with placental cells that invade maternal tissue. Recent studies demonstrate that normally lymphatic vessels in the uterine wall are highly compartmentalized where their presence is mostly detected in deeper layers. In humans, this arrangement changes during pregnancy when extensive lymphangiogenesis occurs at the maternal-fetal interface. Placental cytotrophoblasts stimulate lymphatic growth in vivo and in vitro suggesting that they play a role in triggering pregnancy-induced decidual lymphangiogenesis. These data indicate that lymphatic vessels may have important functions at the implantation site during pregnancy.


Url:
DOI: 10.1016/j.placenta.2007.11.011
PubMed: 18155143
PubMed Central: 2435487


Affiliations:


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PMC:2435487

Le document en format XML

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<p id="P1">During pregnancy, maternal uterine blood vessels undergo dramatic vascular remodeling. However, until now, little was known about whether the lymphatic circulation undergoes similar changes and whether these vessels interact with placental cells that invade maternal tissue. Recent studies demonstrate that normally lymphatic vessels in the uterine wall are highly compartmentalized where their presence is mostly detected in deeper layers. In humans, this arrangement changes during pregnancy when extensive lymphangiogenesis occurs at the maternal-fetal interface. Placental cytotrophoblasts stimulate lymphatic growth
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suggesting that they play a role in triggering pregnancy-induced decidual lymphangiogenesis. These data indicate that lymphatic vessels may have important functions at the implantation site during pregnancy.</p>
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<abstract>
<p id="P1">During pregnancy, maternal uterine blood vessels undergo dramatic vascular remodeling. However, until now, little was known about whether the lymphatic circulation undergoes similar changes and whether these vessels interact with placental cells that invade maternal tissue. Recent studies demonstrate that normally lymphatic vessels in the uterine wall are highly compartmentalized where their presence is mostly detected in deeper layers. In humans, this arrangement changes during pregnancy when extensive lymphangiogenesis occurs at the maternal-fetal interface. Placental cytotrophoblasts stimulate lymphatic growth
<italic>in vivo</italic>
and
<italic>in vitro</italic>
suggesting that they play a role in triggering pregnancy-induced decidual lymphangiogenesis. These data indicate that lymphatic vessels may have important functions at the implantation site during pregnancy.</p>
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