Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi’s sarcoma
Identifieur interne : 003599 ( Pmc/Checkpoint ); précédent : 003598; suivant : 003600Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi’s sarcoma
Auteurs : Francesca Cainelli [Botswana] ; Alfredo Vallone [Italie]Source :
- Biologics : Targets & Therapy [ 1177-5475 ] ; 2009.
Abstract
Kaposi’s sarcoma is a vascular tumor linked to the presence of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus-8) and the incidence of which has increased considerably the world over after the onset of the human immunodeficiency virus (HIV) pandemic. Antiretroviral therapy combined with cytotoxic agents has been established as the treatment of choice in the past 10 years. Among chemotherapeutic agents, pegylated liposomal doxorubicin has become the preferred one for patients with HIV-associated Kaposi’s sarcoma in Western countries. The drug in this formulation localizes better to the tumor and has higher efficacy. Skin toxicity, mucositis, and leukopenia/neutropenia are the main side effects. Hepatotoxicity and mild cardiotoxicity are observed less frequently. Pegylated liposomal doxorubicin impacts favorably on quality of life. Although cost effective in Western countries, the drug is less so in developing countries.
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PubMed: 19774206
PubMed Central: 2747337
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi’s sarcoma</title><author><name sortKey="Cainelli, Francesca" sort="Cainelli, Francesca" uniqKey="Cainelli F" first="Francesca" last="Cainelli">Francesca Cainelli</name><affiliation wicri:level="1"><nlm:aff id="af1-btt-3-385"> Department of Internal Medicine, School of Medicine, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana</nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea> Department of Internal Medicine, School of Medicine, Faculty of Health Sciences, University of Botswana, Gaborone</wicri:regionArea><wicri:noRegion>Gaborone</wicri:noRegion></affiliation></author><author><name sortKey="Vallone, Alfredo" sort="Vallone, Alfredo" uniqKey="Vallone A" first="Alfredo" last="Vallone">Alfredo Vallone</name><affiliation wicri:level="1"><nlm:aff id="af2-btt-3-385"> Infectious Diseases Unit, Annunziata Hospital, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Infectious Diseases Unit, Annunziata Hospital, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">19774206</idno><idno type="pmc">2747337</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2747337</idno><idno type="RBID">PMC:2747337</idno><date when="2009">2009</date><idno type="wicri:Area/Pmc/Corpus">004918</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004918</idno><idno type="wicri:Area/Pmc/Curation">004917</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004917</idno><idno type="wicri:Area/Pmc/Checkpoint">003599</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003599</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi’s sarcoma</title><author><name sortKey="Cainelli, Francesca" sort="Cainelli, Francesca" uniqKey="Cainelli F" first="Francesca" last="Cainelli">Francesca Cainelli</name><affiliation wicri:level="1"><nlm:aff id="af1-btt-3-385"> Department of Internal Medicine, School of Medicine, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana</nlm:aff><country xml:lang="fr">Botswana</country><wicri:regionArea> Department of Internal Medicine, School of Medicine, Faculty of Health Sciences, University of Botswana, Gaborone</wicri:regionArea><wicri:noRegion>Gaborone</wicri:noRegion></affiliation></author><author><name sortKey="Vallone, Alfredo" sort="Vallone, Alfredo" uniqKey="Vallone A" first="Alfredo" last="Vallone">Alfredo Vallone</name><affiliation wicri:level="1"><nlm:aff id="af2-btt-3-385"> Infectious Diseases Unit, Annunziata Hospital, Cosenza, Italy</nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea> Infectious Diseases Unit, Annunziata Hospital, Cosenza</wicri:regionArea><wicri:noRegion>Cosenza</wicri:noRegion></affiliation></author></analytic><series><title level="j">Biologics : Targets & Therapy</title><idno type="ISSN">1177-5475</idno><idno type="eISSN">1177-5491</idno><imprint><date when="2009">2009</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Kaposi’s sarcoma is a vascular tumor linked to the presence of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus-8) and the incidence of which has increased considerably the world over after the onset of the human immunodeficiency virus (HIV) pandemic. Antiretroviral therapy combined with cytotoxic agents has been established as the treatment of choice in the past 10 years. Among chemotherapeutic agents, pegylated liposomal doxorubicin has become the preferred one for patients with HIV-associated Kaposi’s sarcoma in Western countries. The drug in this formulation localizes better to the tumor and has higher efficacy. Skin toxicity, mucositis, and leukopenia/neutropenia are the main side effects. Hepatotoxicity and mild cardiotoxicity are observed less frequently. Pegylated liposomal doxorubicin impacts favorably on quality of life. Although cost effective in Western countries, the drug is less so in developing countries.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name></author><author><name sortKey="Biggar, Rj" uniqKey="Biggar R">RJ Biggar</name></author><author><name sortKey="Marshall, Va" uniqKey="Marshall V">VA Marshall</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chang, Y" uniqKey="Chang Y">Y Chang</name></author><author><name sortKey="Cesarman, E" uniqKey="Cesarman E">E Cesarman</name></author><author><name sortKey="Pessin, Ms" uniqKey="Pessin M">MS Pessin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Moore, Ps" uniqKey="Moore P">PS Moore</name></author><author><name sortKey="Gao, Sj" uniqKey="Gao S">SJ Gao</name></author><author><name sortKey="Dominguez, G" uniqKey="Dominguez G">G Dominguez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cesarman, E" uniqKey="Cesarman E">E Cesarman</name></author><author><name sortKey="Chang, Y" uniqKey="Chang Y">Y Chang</name></author><author><name sortKey="Moore, Ps" uniqKey="Moore P">PS Moore</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Soulier, J" uniqKey="Soulier J">J Soulier</name></author><author><name sortKey="Grollet, L" uniqKey="Grollet L">L Grollet</name></author><author><name sortKey="Oskenhendler, E" uniqKey="Oskenhendler E">E Oskenhendler</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Biggar, Rj" uniqKey="Biggar R">RJ Biggar</name></author><author><name sortKey="Chaturvedi, Ak" uniqKey="Chaturvedi A">AK Chaturvedi</name></author><author><name sortKey="Goedert, Jj" uniqKey="Goedert J">JJ Goedert</name></author><author><name sortKey="Engels, Ea" uniqKey="Engels E">EA Engels</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goedert, Jj" uniqKey="Goedert J">JJ Goedert</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cook Mozaffari, P" uniqKey="Cook Mozaffari P">P Cook-Mozaffari</name></author><author><name sortKey="Newton, R" uniqKey="Newton R">R Newton</name></author><author><name sortKey="Beral, V" uniqKey="Beral V">V Beral</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sitas, F" uniqKey="Sitas F">F Sitas</name></author><author><name sortKey="Newton, R" uniqKey="Newton R">R Newton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cheung, Mc" uniqKey="Cheung M">MC Cheung</name></author><author><name sortKey="Pantanowitz, L" uniqKey="Pantanowitz L">L Pantanowitz</name></author><author><name sortKey="Dezube, Bj" uniqKey="Dezube B">BJ Dezube</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ioachim, Hl" uniqKey="Ioachim H">HL Ioachim</name></author><author><name sortKey="Adsay, V" uniqKey="Adsay V">V Adsay</name></author><author><name sortKey="Giancotti, Fr" uniqKey="Giancotti F">FR Giancotti</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dezube, Bj" uniqKey="Dezube B">BJ Dezube</name></author><author><name sortKey="Pantanowitz, L" uniqKey="Pantanowitz L">L Pantanowitz</name></author><author><name sortKey="Aboulafia, Dm" uniqKey="Aboulafia D">DM Aboulafia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Schiff, Nf" uniqKey="Schiff N">NF Schiff</name></author><author><name sortKey="Annino, Dj" uniqKey="Annino D">DJ Annino</name></author><author><name sortKey="Woo, P" uniqKey="Woo P">P Woo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Huang, L" uniqKey="Huang L">L Huang</name></author><author><name sortKey="Schnapp, Lm" uniqKey="Schnapp L">LM Schnapp</name></author><author><name sortKey="Gruden, Jf" uniqKey="Gruden J">JF Gruden</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Dezube, Bj" uniqKey="Dezube B">BJ Dezube</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Real, Fx" uniqKey="Real F">FX Real</name></author><author><name sortKey="Krown, Se" uniqKey="Krown S">SE Krown</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Coukell, A" uniqKey="Coukell A">A Coukell</name></author><author><name sortKey="Spencer, Cm" uniqKey="Spencer C">CM Spencer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haran, G" uniqKey="Haran G">G Haran</name></author><author><name sortKey="Cohen, R" uniqKey="Cohen R">R Cohen</name></author><author><name sortKey="Bar, Lk" uniqKey="Bar L">LK Bar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lasic, Dd" uniqKey="Lasic D">DD Lasic</name></author><author><name sortKey="Frederk, Pm" uniqKey="Frederk P">PM Frederk</name></author><author><name sortKey="Stuart, Mca" uniqKey="Stuart M">MCA Stuart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Papahadjopoulos, D" uniqKey="Papahadjopoulos D">D Papahadjopoulos</name></author><author><name sortKey="Allen, T" uniqKey="Allen T">T Allen</name></author><author><name sortKey="Gabizon, A" uniqKey="Gabizon A">A Gabizon</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Balmer, C" uniqKey="Balmer C">C Balmer</name></author><author><name sortKey="Valley, Aw" uniqKey="Valley A">AW Valley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meriwether, Wd" uniqKey="Meriwether W">WD Meriwether</name></author><author><name sortKey="Bachur, Nr" uniqKey="Bachur N">NR Bachur</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hortobagyi, Gn" uniqKey="Hortobagyi G">GN Hortobágyi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Speyer, J" uniqKey="Speyer J">J Speyer</name></author><author><name sortKey="Wasserheit, C" uniqKey="Wasserheit C">C Wasserheit</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sturzl, M" uniqKey="Sturzl M">M Stürzl</name></author><author><name sortKey="Zietz, C" uniqKey="Zietz C">C Zietz</name></author><author><name sortKey="Eisenburg, B" uniqKey="Eisenburg B">B Eisenburg</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sharpe, M" uniqKey="Sharpe M">M Sharpe</name></author><author><name sortKey="Easthope, Se" uniqKey="Easthope S">SE Easthope</name></author><author><name sortKey="Keating, Gm" uniqKey="Keating G">GM Keating</name></author><author><name sortKey="Lamb, Hm" uniqKey="Lamb H">HM Lamb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Simpson, Jk" uniqKey="Simpson J">JK Simpson</name></author><author><name sortKey="Miller, Rf" uniqKey="Miller R">RF Miller</name></author><author><name sortKey="Spittle, Mf" uniqKey="Spittle M">MF Spittle</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Harrison, M" uniqKey="Harrison M">M Harrison</name></author><author><name sortKey="Tomlinson, D" uniqKey="Tomlinson D">D Tomlinson</name></author><author><name sortKey="Stewart, S" uniqKey="Stewart S">S Stewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Northfelt, Dw" uniqKey="Northfelt D">DW Northfelt</name></author><author><name sortKey="Dezube, Bj" uniqKey="Dezube B">BJ Dezube</name></author><author><name sortKey="Thommes, Ja" uniqKey="Thommes J">JA Thommes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Stewart, S" uniqKey="Stewart S">S Stewart</name></author><author><name sortKey="Jablonowski, H" uniqKey="Jablonowski H">H Jablonowski</name></author><author><name sortKey="Goebel, Fd" uniqKey="Goebel F">FD Goebel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Northfelt, Dw" uniqKey="Northfelt D">DW Northfelt</name></author><author><name sortKey="Dezube, Bj" uniqKey="Dezube B">BJ Dezube</name></author><author><name sortKey="Thommes, Ja" uniqKey="Thommes J">JA Thommes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Carbonero, L" uniqKey="Martin Carbonero L">L Martin-Carbonero</name></author><author><name sortKey="Barrios, A" uniqKey="Barrios A">A Barrios</name></author><author><name sortKey="Saballs, P" uniqKey="Saballs P">P Saballs</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lichterfeld, M" uniqKey="Lichterfeld M">M Lichterfeld</name></author><author><name sortKey="Qurishi, N" uniqKey="Qurishi N">N Qurishi</name></author><author><name sortKey="Hoffmann, C" uniqKey="Hoffmann C">C Hoffmann</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Goebel, Fd" uniqKey="Goebel F">FD Goebel</name></author><author><name sortKey="Goldstein, D" uniqKey="Goldstein D">D Goldstein</name></author><author><name sortKey="Goos, M" uniqKey="Goos M">M Goos</name></author><author><name sortKey="Jablonowski, H" uniqKey="Jablonowski H">H Jablonowski</name></author><author><name sortKey="Stewart, Js" uniqKey="Stewart J">JS Stewart</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hengge, Ur" uniqKey="Hengge U">UR Hengge</name></author><author><name sortKey="Esser, S" uniqKey="Esser S">S Esser</name></author><author><name sortKey="Rudel, Hp" uniqKey="Rudel H">HP Rudel</name></author><author><name sortKey="Goos, M" uniqKey="Goos M">M Goos</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cooley, T" uniqKey="Cooley T">T Cooley</name></author><author><name sortKey="Henry, D" uniqKey="Henry D">D Henry</name></author><author><name sortKey="Tonda, M" uniqKey="Tonda M">M Tonda</name></author><author><name sortKey="Sun, S" uniqKey="Sun S">S Sun</name></author><author><name sortKey="O Onnell, M" uniqKey="O Onnell M">M O’Connell</name></author><author><name sortKey="Rackoff, W" uniqKey="Rackoff W">W Rackoff</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Little, Rf" uniqKey="Little R">RF Little</name></author><author><name sortKey="Aleman, K" uniqKey="Aleman K">K Aleman</name></author><author><name sortKey="Kumar, P" uniqKey="Kumar P">P Kumar</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin Carbonero, L" uniqKey="Martin Carbonero L">L Martin-Carbonero</name></author><author><name sortKey="Palacios, R" uniqKey="Palacios R">R Palacios</name></author><author><name sortKey="Valencia, E" uniqKey="Valencia E">E Valencia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nunez, M" uniqKey="Nunez M">M Nunez</name></author><author><name sortKey="Saballs, P" uniqKey="Saballs P">P Saballs</name></author><author><name sortKey="Valencia, Me" uniqKey="Valencia M">ME Valencia</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Billingham, M" uniqKey="Billingham M">M Billingham</name></author><author><name sortKey="Bristow, M" uniqKey="Bristow M">M Bristow</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Berry, G" uniqKey="Berry G">G Berry</name></author><author><name sortKey="Billingham, M" uniqKey="Billingham M">M Billingham</name></author><author><name sortKey="Alderman, E" uniqKey="Alderman E">E Alderman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Osoba, D" uniqKey="Osoba D">D Osoba</name></author><author><name sortKey="Northfelt, Dw" uniqKey="Northfelt D">DW Northfelt</name></author><author><name sortKey="Budd, Dw" uniqKey="Budd D">DW Budd</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bennett, Cl" uniqKey="Bennett C">CL Bennett</name></author><author><name sortKey="Golub, Rm" uniqKey="Golub R">RM Golub</name></author><author><name sortKey="Stinson, Tj" uniqKey="Stinson T">TJ Stinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hjortsberg, C" uniqKey="Hjortsberg C">C Hjortsberg</name></author><author><name sortKey="Person, U" uniqKey="Person U">U Person</name></author><author><name sortKey="Lidbrink, E" uniqKey="Lidbrink E">E Lidbrink</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vanni, T" uniqKey="Vanni T">T Vanni</name></author><author><name sortKey="Lopes Fonseca, Ba" uniqKey="Lopes Fonseca B">BA Lopes Fonseca</name></author><author><name sortKey="Polanczyk, Ca" uniqKey="Polanczyk C">CA Polanczyk</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Iscovich, J" uniqKey="Iscovich J">J Iscovich</name></author><author><name sortKey="Boffetta, P" uniqKey="Boffetta P">P Boffetta</name></author><author><name sortKey="Brennan, P" uniqKey="Brennan P">P Brennan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bower, M" uniqKey="Bower M">M Bower</name></author><author><name sortKey="Collins, S" uniqKey="Collins S">S Collins</name></author><author><name sortKey="Cottrill, C" uniqKey="Cottrill C">C Cottrill</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Biologics</journal-id><journal-id journal-id-type="publisher-id">Biologics: Targets & Therapy</journal-id><journal-title-group><journal-title>Biologics : Targets & Therapy</journal-title></journal-title-group><issn pub-type="ppub">1177-5475</issn><issn pub-type="epub">1177-5491</issn><publisher><publisher-name>Dove Medical Press</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">19774206</article-id><article-id pub-id-type="pmc">2747337</article-id><article-id pub-id-type="publisher-id">btt-3-385</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Safety and efficacy of pegylated liposomal doxorubicin in HIV-associated Kaposi’s sarcoma</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Cainelli</surname><given-names>Francesca</given-names></name><xref ref-type="aff" rid="af1-btt-3-385">1</xref><xref ref-type="corresp" rid="c1-btt-3-385"></xref></contrib><contrib contrib-type="author"><name><surname>Vallone</surname><given-names>Alfredo</given-names></name><xref ref-type="aff" rid="af2-btt-3-385">2</xref></contrib></contrib-group><aff id="af1-btt-3-385"><label>1</label> Department of Internal Medicine, School of Medicine, Faculty of Health Sciences, University of Botswana, Gaborone, Botswana</aff><aff id="af2-btt-3-385"><label>2</label> Infectious Diseases Unit, Annunziata Hospital, Cosenza, Italy</aff><author-notes><corresp id="c1-btt-3-385">Correspondence: Francesca Cainelli, Senior Lecturer in Internal Medicine, School of Medicine, Faculty of Health Sciences, University of Botswana, Private Bag 0022, Gaborone, Botswana, Tel +267.3554563, Email
<email>francescacainelli@yahoo.it</email></corresp></author-notes><pub-date pub-type="collection"><year>2009</year></pub-date><pmc-comment>Dove Press titles changed from ppub to collections in 2009.
Fake ppub written to satisfy Coll Date Type=ppub</pmc-comment>
<pub-date pub-type="ppub"><year>2009</year></pub-date><pub-date pub-type="epub"><day>15</day><month>9</month><year>2009</year></pub-date><volume>3</volume><fpage>385</fpage><lpage>390</lpage><permissions><copyright-statement>© 2009 Cainelli and Vallone, publisher and licensee Dove Medical Press Ltd.</copyright-statement><license><license-p>This is an Open Access article which permits unrestricted noncommercial use, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Kaposi’s sarcoma is a vascular tumor linked to the presence of Kaposi’s sarcoma-associated herpesvirus (human herpesvirus-8) and the incidence of which has increased considerably the world over after the onset of the human immunodeficiency virus (HIV) pandemic. Antiretroviral therapy combined with cytotoxic agents has been established as the treatment of choice in the past 10 years. Among chemotherapeutic agents, pegylated liposomal doxorubicin has become the preferred one for patients with HIV-associated Kaposi’s sarcoma in Western countries. The drug in this formulation localizes better to the tumor and has higher efficacy. Skin toxicity, mucositis, and leukopenia/neutropenia are the main side effects. Hepatotoxicity and mild cardiotoxicity are observed less frequently. Pegylated liposomal doxorubicin impacts favorably on quality of life. Although cost effective in Western countries, the drug is less so in developing countries.</p></abstract><kwd-group><kwd>pegylated liposomal doxorubicin</kwd><kwd>Kaposi’s sarcoma</kwd><kwd>HIV infection</kwd></kwd-group></article-meta></front><floats-group><table-wrap id="t1-btt-3-385" position="float"><label>Table 1</label><caption><p>Summary of trials of pegylated liposomal doxorubicin in patients with HIV-related Kaposi’s sarcoma. The drug was administered intravenously once during each cycle</p></caption><table frame="hsides" rules="groups"><thead><tr><th align="left" rowspan="1" colspan="1">Reference (Author, study design)</th><th align="left" rowspan="1" colspan="1">Patients no.</th><th align="left" rowspan="1" colspan="1">Dosage regimen (no. of cycles)</th><th align="left" rowspan="1" colspan="1">HAART</th><th align="left" rowspan="1" colspan="1">Response rate</th><th align="left" rowspan="1" colspan="1">Median duration of response (weeks)</th></tr></thead><tbody><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="bibr" rid="b27-btt-3-385">27</xref> (Simpson, open label)</td><td align="left" rowspan="1" colspan="1">16</td><td align="left" rowspan="1" colspan="1">20 mg/m<sup>2</sup> every 2–3 weeks (1–3)</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">68.7</td><td align="left" rowspan="1" colspan="1">14</td></tr><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="bibr" rid="b28-btt-3-385">28</xref> (Harrison, open label)</td><td align="left" rowspan="1" colspan="1">34</td><td align="left" rowspan="1" colspan="1">20 mg/m<sup>2</sup> every three weeks (2–4)</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">73.5</td><td align="left" rowspan="1" colspan="1">9</td></tr><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="bibr" rid="b29-btt-3-385">29</xref> (Northfelt, randomized, nonblind, multicenter)</td><td align="left" rowspan="1" colspan="1">133</td><td align="left" rowspan="1" colspan="1">20 mg/m<sup>2</sup> every two weeks (6)</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">45.9</td><td align="left" rowspan="1" colspan="1">13</td></tr><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="bibr" rid="b30-btt-3-385">30</xref> (Stewart, randomized, nonblind, multicenter)</td><td align="left" rowspan="1" colspan="1">121</td><td align="left" rowspan="1" colspan="1">20 mg/m<sup>2</sup> every three weeks (6)</td><td align="left" rowspan="1" colspan="1">No</td><td align="left" rowspan="1" colspan="1">58.7</td><td align="left" rowspan="1" colspan="1">20</td></tr><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="bibr" rid="b32-btt-3-385">32</xref> (Martın-Carbonero, randomized, open-label, multicenter)</td><td align="left" rowspan="1" colspan="1">13</td><td align="left" rowspan="1" colspan="1">20 mg/m<sup>2</sup> every three weeks (7–14)</td><td align="left" rowspan="1" colspan="1">Yes</td><td align="left" rowspan="1" colspan="1">76.0</td><td align="left" rowspan="1" colspan="1">Not reported</td></tr><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="bibr" rid="b33-btt-3-385">33</xref> (Lichterfeld, uncontrolled, observational)</td><td align="left" rowspan="1" colspan="1">54</td><td align="left" rowspan="1" colspan="1">20 mg/m<sup>2</sup> every two weeks (10–100)</td><td align="left" rowspan="1" colspan="1">Yes</td><td align="left" rowspan="1" colspan="1">81.5</td><td align="left" rowspan="1" colspan="1">52</td></tr><tr><td align="left" rowspan="1" colspan="1"><xref ref-type="bibr" rid="b36-btt-3-385">36</xref> (Cooley, prospective, randomized, double-blind, multicenter)</td><td align="left" rowspan="1" colspan="1">60</td><td align="left" rowspan="1" colspan="1">20 mg/m<sup>2</sup> every two weeks (6)</td><td align="left" rowspan="1" colspan="1">Yes</td><td align="left" rowspan="1" colspan="1">55.0</td><td align="left" rowspan="1" colspan="1">22</td></tr></tbody></table><table-wrap-foot><fn id="tfn1-btt-3-385"><p><bold>Abbreviation:</bold> HAART, highly active antiretroviral therapy.</p></fn></table-wrap-foot></table-wrap></floats-group></pmc><affiliations><list><country><li>Botswana</li><li>Italie</li></country></list><tree><country name="Botswana"><noRegion><name sortKey="Cainelli, Francesca" sort="Cainelli, Francesca" uniqKey="Cainelli F" first="Francesca" last="Cainelli">Francesca Cainelli</name></noRegion></country><country name="Italie"><noRegion><name sortKey="Vallone, Alfredo" sort="Vallone, Alfredo" uniqKey="Vallone A" first="Alfredo" last="Vallone">Alfredo Vallone</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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