Histopathologic Analysis of Palpebral Conjunctiva in Thyroid-Related Orbitopathy (An American Ophthalmological Society Thesis)
Identifieur interne : 003396 ( Pmc/Checkpoint ); précédent : 003395; suivant : 003397Histopathologic Analysis of Palpebral Conjunctiva in Thyroid-Related Orbitopathy (An American Ophthalmological Society Thesis)
Auteurs : Don O. KikkawaSource :
- Transactions of the American Ophthalmological Society [ 0065-9533 ] ; 2010.
Abstract
To examine the histopathology of palpebral conjunctiva in patients with thyroid-related orbitopathy. Based on previously published anecdotes, the hypothesis is that conjunctiva shows increased inflammation and fibrosis.
This was a comparative case series. Superior palpebral conjunctiva was examined from two groups. The study group consisted of 20 patients undergoing thyroid-related upper eyelid retraction surgery. The control group consisted of 18 patients undergoing ptosis repair. Specimens were processed and stained using hematoxylin and eosin and trichrome. Histopathologic grading was performed using light microscopy. Main outcome measures were degree of inflammation and fibrosis, mast cell infiltration, and fibroblast count.
The two groups did not differ with regard to age or gender. Mean degree of inflammation was 1.4 (95% CI: 0.9, 1.9) for the control group and 1.7 (95% CI: 1.3, 2.1) for the study group. Relative intensity of blue from trichrome staining mean was 134.3 (95% CI: 130.3, 138.3) for the control group and 138.6 (95% CI: 133.7, 143.6) for the study group. The Mann-Whitney test showed no difference between groups in inflammation (
While there is a trend toward higher inflammation in the study group, the superior palpebral conjunctiva of patients with thyroid-related orbitopathy is largely spared from autoimmune changes. This has implications in surgical approaches to eyelid retraction repair.
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PubMed: 21212848
PubMed Central: 3016081
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Histopathologic Analysis of Palpebral Conjunctiva in Thyroid-Related Orbitopathy (An American Ophthalmological Society Thesis)</title><author><name sortKey="Kikkawa, Don O" sort="Kikkawa, Don O" uniqKey="Kikkawa D" first="Don O." last="Kikkawa">Don O. Kikkawa</name></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21212848</idno><idno type="pmc">3016081</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3016081</idno><idno type="RBID">PMC:3016081</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">003210</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003210</idno><idno type="wicri:Area/Pmc/Curation">003209</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003209</idno><idno type="wicri:Area/Pmc/Checkpoint">003396</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003396</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Histopathologic Analysis of Palpebral Conjunctiva in Thyroid-Related Orbitopathy (An American Ophthalmological Society Thesis)</title><author><name sortKey="Kikkawa, Don O" sort="Kikkawa, Don O" uniqKey="Kikkawa D" first="Don O." last="Kikkawa">Don O. Kikkawa</name></author></analytic><series><title level="j">Transactions of the American Ophthalmological Society</title><idno type="ISSN">0065-9533</idno><idno type="eISSN">1545-6110</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose:</title><p>To examine the histopathology of palpebral conjunctiva in patients with thyroid-related orbitopathy. Based on previously published anecdotes, the hypothesis is that conjunctiva shows increased inflammation and fibrosis.</p></sec><sec><title>Methods:</title><p>This was a comparative case series. Superior palpebral conjunctiva was examined from two groups. The study group consisted of 20 patients undergoing thyroid-related upper eyelid retraction surgery. The control group consisted of 18 patients undergoing ptosis repair. Specimens were processed and stained using hematoxylin and eosin and trichrome. Histopathologic grading was performed using light microscopy. Main outcome measures were degree of inflammation and fibrosis, mast cell infiltration, and fibroblast count.</p></sec><sec><title>Results:</title><p>The two groups did not differ with regard to age or gender. Mean degree of inflammation was 1.4 (95% CI: 0.9, 1.9) for the control group and 1.7 (95% CI: 1.3, 2.1) for the study group. Relative intensity of blue from trichrome staining mean was 134.3 (95% CI: 130.3, 138.3) for the control group and 138.6 (95% CI: 133.7, 143.6) for the study group. The Mann-Whitney test showed no difference between groups in inflammation (<italic>P</italic>=.17), relative blue intensity (<italic>P</italic>=.11), degree of mast cell infiltration (<italic>P</italic>=.61), and fibroblast count (<italic>P</italic>=.45). Point estimates show a trend toward greater inflammation in the study group.</p></sec><sec><title>Conclusions:</title><p>While there is a trend toward higher inflammation in the study group, the superior palpebral conjunctiva of patients with thyroid-related orbitopathy is largely spared from autoimmune changes. This has implications in surgical approaches to eyelid retraction repair.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Trans Am Ophthalmol Soc</journal-id><journal-id journal-id-type="publisher-id">7506106</journal-id><journal-title-group><journal-title>Transactions of the American Ophthalmological Society</journal-title></journal-title-group><issn pub-type="ppub">0065-9533</issn><issn pub-type="epub">1545-6110</issn><publisher><publisher-name>The American Ophthalmological Society</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21212848</article-id><article-id pub-id-type="pmc">3016081</article-id><article-id pub-id-type="publisher-id">1545-6110_v108_p046</article-id><article-categories><subj-group subj-group-type="heading"><subject>Theses</subject></subj-group></article-categories><title-group><article-title>Histopathologic Analysis of Palpebral Conjunctiva in Thyroid-Related Orbitopathy (An American Ophthalmological Society Thesis)</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kikkawa</surname><given-names>Don O.</given-names></name><degrees>MD</degrees></contrib><aff id="af1-1545-6110_v108_p046">From the Division of Ophthalmic Plastic and Reconstructive Surgery, Department of Ophthalmology, University of California San Diego, La Jolla, California</aff></contrib-group><pub-date pub-type="ppub"><month>12</month><year>2010</year></pub-date><volume>108</volume><fpage>46</fpage><lpage>61</lpage><permissions><copyright-statement>©American Ophthalmological Society 2010</copyright-statement></permissions><abstract><sec><title>Purpose:</title><p>To examine the histopathology of palpebral conjunctiva in patients with thyroid-related orbitopathy. Based on previously published anecdotes, the hypothesis is that conjunctiva shows increased inflammation and fibrosis.</p></sec><sec><title>Methods:</title><p>This was a comparative case series. Superior palpebral conjunctiva was examined from two groups. The study group consisted of 20 patients undergoing thyroid-related upper eyelid retraction surgery. The control group consisted of 18 patients undergoing ptosis repair. Specimens were processed and stained using hematoxylin and eosin and trichrome. Histopathologic grading was performed using light microscopy. Main outcome measures were degree of inflammation and fibrosis, mast cell infiltration, and fibroblast count.</p></sec><sec><title>Results:</title><p>The two groups did not differ with regard to age or gender. Mean degree of inflammation was 1.4 (95% CI: 0.9, 1.9) for the control group and 1.7 (95% CI: 1.3, 2.1) for the study group. Relative intensity of blue from trichrome staining mean was 134.3 (95% CI: 130.3, 138.3) for the control group and 138.6 (95% CI: 133.7, 143.6) for the study group. The Mann-Whitney test showed no difference between groups in inflammation (<italic>P</italic>=.17), relative blue intensity (<italic>P</italic>=.11), degree of mast cell infiltration (<italic>P</italic>=.61), and fibroblast count (<italic>P</italic>=.45). Point estimates show a trend toward greater inflammation in the study group.</p></sec><sec><title>Conclusions:</title><p>While there is a trend toward higher inflammation in the study group, the superior palpebral conjunctiva of patients with thyroid-related orbitopathy is largely spared from autoimmune changes. This has implications in surgical approaches to eyelid retraction repair.</p></sec></abstract></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Kikkawa, Don O" sort="Kikkawa, Don O" uniqKey="Kikkawa D" first="Don O." last="Kikkawa">Don O. Kikkawa</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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