Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity
Identifieur interne : 003256 ( Pmc/Checkpoint ); précédent : 003255; suivant : 003257Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity
Auteurs : Kenji Yoshida ; Ryohei Sasaki ; Hideki Nishimura ; Daisuke Miyawaki ; Tetsuya Kawabe [Japon] ; Yoshiaki Okamoto [Japon] ; Koji Nakabayashi ; Shigeki Yoshida ; Kazuro SugimuraSource :
- Archives of Gynecology and Obstetrics [ 0932-0067 ] ; 2010.
Abstract
To examine the preliminary survival outcomes and treatment-related toxicity for elderly patients with cervical cancer treated with radiotherapy (RT).
Forty patients ≥75 years old with cervical cancer who were treated with RT were evaluated. Of these 40 patients, 25 were classified as FIGO stage I or II and 15 as stage III or IVA. Thirty-five patients were treated with radical RT (RRT), and five were treated with surgery plus adjuvant RT (S + ART). External beam radiotherapy combined with high-dose-rate intracavitary brachytherapy was performed on 31 patients who were treated with RRT and on 2 patients who were treated with S + ART because of positive vaginal surgical margins. The patients’ median age was 78 years (range 75–89 years). Concurrent chemotherapy (CCT) was performed on five patients (RRT: 3, S + ART: 2).
The median follow-up period was 20 months (range 1–85 months). Only one patient could not complete RT. The 3-year overall and disease-specific survival (OS and DSS) rates for all patients were 58 and 80%, respectively. Five patients experienced Grade 3 acute toxicity; two were treated with RRT (2/35), and three were treated with S + ART (3/5, 2 of them with CCT). Two patients experienced Grade 3 late toxicity; one was treated with RRT (1/35, with CCT) and the other was treated with S + ART (1/5). No Grade 4 or higher toxicity was experienced.
RRT for elderly patients with cervical cancer is generally effective and safe, but severe toxicity may occur with more aggressive treatment modalities.
Url:
DOI: 10.1007/s00404-010-1777-6
PubMed: 21116639
PubMed Central: 3171672
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity</title><author><name sortKey="Yoshida, Kenji" sort="Yoshida, Kenji" uniqKey="Yoshida K" first="Kenji" last="Yoshida">Kenji Yoshida</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Sasaki, Ryohei" sort="Sasaki, Ryohei" uniqKey="Sasaki R" first="Ryohei" last="Sasaki">Ryohei Sasaki</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Nishimura, Hideki" sort="Nishimura, Hideki" uniqKey="Nishimura H" first="Hideki" last="Nishimura">Hideki Nishimura</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Miyawaki, Daisuke" sort="Miyawaki, Daisuke" uniqKey="Miyawaki D" first="Daisuke" last="Miyawaki">Daisuke Miyawaki</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Kawabe, Tetsuya" sort="Kawabe, Tetsuya" uniqKey="Kawabe T" first="Tetsuya" last="Kawabe">Tetsuya Kawabe</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Radiology, Dokkyou Medical University, Tochigi, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Dokkyou Medical University, Tochigi</wicri:regionArea><wicri:noRegion>Tochigi</wicri:noRegion></affiliation></author><author><name sortKey="Okamoto, Yoshiaki" sort="Okamoto, Yoshiaki" uniqKey="Okamoto Y" first="Yoshiaki" last="Okamoto">Yoshiaki Okamoto</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Radiology, Osaka Police Hospital, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Osaka Police Hospital, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Nakabayashi, Koji" sort="Nakabayashi, Koji" uniqKey="Nakabayashi K" first="Koji" last="Nakabayashi">Koji Nakabayashi</name><affiliation><nlm:aff id="Aff4">Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo Japan</wicri:noCountry></affiliation></author><author><name sortKey="Yoshida, Shigeki" sort="Yoshida, Shigeki" uniqKey="Yoshida S" first="Shigeki" last="Yoshida">Shigeki Yoshida</name><affiliation><nlm:aff id="Aff4">Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo Japan</wicri:noCountry></affiliation></author><author><name sortKey="Sugimura, Kazuro" sort="Sugimura, Kazuro" uniqKey="Sugimura K" first="Kazuro" last="Sugimura">Kazuro Sugimura</name><affiliation><nlm:aff id="Aff5">Department of Radiology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo Japan</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">21116639</idno><idno type="pmc">3171672</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3171672</idno><idno type="RBID">PMC:3171672</idno><idno type="doi">10.1007/s00404-010-1777-6</idno><date when="2010">2010</date><idno type="wicri:Area/Pmc/Corpus">000C14</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000C14</idno><idno type="wicri:Area/Pmc/Curation">000C13</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000C13</idno><idno type="wicri:Area/Pmc/Checkpoint">003256</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">003256</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity</title><author><name sortKey="Yoshida, Kenji" sort="Yoshida, Kenji" uniqKey="Yoshida K" first="Kenji" last="Yoshida">Kenji Yoshida</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Sasaki, Ryohei" sort="Sasaki, Ryohei" uniqKey="Sasaki R" first="Ryohei" last="Sasaki">Ryohei Sasaki</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Nishimura, Hideki" sort="Nishimura, Hideki" uniqKey="Nishimura H" first="Hideki" last="Nishimura">Hideki Nishimura</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Miyawaki, Daisuke" sort="Miyawaki, Daisuke" uniqKey="Miyawaki D" first="Daisuke" last="Miyawaki">Daisuke Miyawaki</name><affiliation><nlm:aff id="Aff1">Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo 650-0017 Japan</wicri:noCountry></affiliation></author><author><name sortKey="Kawabe, Tetsuya" sort="Kawabe, Tetsuya" uniqKey="Kawabe T" first="Tetsuya" last="Kawabe">Tetsuya Kawabe</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Radiology, Dokkyou Medical University, Tochigi, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Dokkyou Medical University, Tochigi</wicri:regionArea><wicri:noRegion>Tochigi</wicri:noRegion></affiliation></author><author><name sortKey="Okamoto, Yoshiaki" sort="Okamoto, Yoshiaki" uniqKey="Okamoto Y" first="Yoshiaki" last="Okamoto">Yoshiaki Okamoto</name><affiliation wicri:level="1"><nlm:aff id="Aff3">Department of Radiology, Osaka Police Hospital, Osaka, Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Radiology, Osaka Police Hospital, Osaka</wicri:regionArea><wicri:noRegion>Osaka</wicri:noRegion></affiliation></author><author><name sortKey="Nakabayashi, Koji" sort="Nakabayashi, Koji" uniqKey="Nakabayashi K" first="Koji" last="Nakabayashi">Koji Nakabayashi</name><affiliation><nlm:aff id="Aff4">Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo Japan</wicri:noCountry></affiliation></author><author><name sortKey="Yoshida, Shigeki" sort="Yoshida, Shigeki" uniqKey="Yoshida S" first="Shigeki" last="Yoshida">Shigeki Yoshida</name><affiliation><nlm:aff id="Aff4">Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo Japan</wicri:noCountry></affiliation></author><author><name sortKey="Sugimura, Kazuro" sort="Sugimura, Kazuro" uniqKey="Sugimura K" first="Kazuro" last="Sugimura">Kazuro Sugimura</name><affiliation><nlm:aff id="Aff5">Department of Radiology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</nlm:aff><wicri:noCountry code="subfield">Hyogo Japan</wicri:noCountry></affiliation></author></analytic><series><title level="j">Archives of Gynecology and Obstetrics</title><idno type="ISSN">0932-0067</idno><idno type="eISSN">1432-0711</idno><imprint><date when="2010">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Purpose</title><p>To examine the preliminary survival outcomes and treatment-related toxicity for elderly patients with cervical cancer treated with radiotherapy (RT).</p></sec><sec><title>Methods</title><p>Forty patients ≥75 years old with cervical cancer who were treated with RT were evaluated. Of these 40 patients, 25 were classified as FIGO stage I or II and 15 as stage III or IVA. Thirty-five patients were treated with radical RT (RRT), and five were treated with surgery plus adjuvant RT (S + ART). External beam radiotherapy combined with high-dose-rate intracavitary brachytherapy was performed on 31 patients who were treated with RRT and on 2 patients who were treated with S + ART because of positive vaginal surgical margins. The patients’ median age was 78 years (range 75–89 years). Concurrent chemotherapy (CCT) was performed on five patients (RRT: 3, S + ART: 2).</p></sec><sec><title>Results</title><p>The median follow-up period was 20 months (range 1–85 months). Only one patient could not complete RT. The 3-year overall and disease-specific survival (OS and DSS) rates for all patients were 58 and 80%, respectively. Five patients experienced Grade 3 acute toxicity; two were treated with RRT (2/35), and three were treated with S + ART (3/5, 2 of them with CCT). Two patients experienced Grade 3 late toxicity; one was treated with RRT (1/35, with CCT) and the other was treated with S + ART (1/5). No Grade 4 or higher toxicity was experienced.</p></sec><sec><title>Conclusions</title><p>RRT for elderly patients with cervical cancer is generally effective and safe, but severe toxicity may occur with more aggressive treatment modalities.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Schwartz, S" uniqKey="Schwartz S">S Schwartz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Yang, L" uniqKey="Yang L">L Yang</name></author><author><name sortKey="Fujimoto, J" uniqKey="Fujimoto J">J Fujimoto</name></author><author><name sortKey="Qiu, D" uniqKey="Qiu D">D Qiu</name></author><author><name sortKey="Sakamoto, N" uniqKey="Sakamoto N">N Sakamoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kokawa, K" uniqKey="Kokawa K">K Kokawa</name></author><author><name sortKey="Takekida, S" uniqKey="Takekida S">S 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Arch Gynecol Obstet</journal-id><journal-title-group><journal-title>Archives of Gynecology and Obstetrics</journal-title></journal-title-group><issn pub-type="ppub">0932-0067</issn><issn pub-type="epub">1432-0711</issn><publisher><publisher-name>Springer-Verlag</publisher-name><publisher-loc>Berlin/Heidelberg</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">21116639</article-id><article-id pub-id-type="pmc">3171672</article-id><article-id pub-id-type="publisher-id">1777</article-id><article-id pub-id-type="doi">10.1007/s00404-010-1777-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Gynecologic Oncology</subject></subj-group></article-categories><title-group><article-title>Radiotherapy for Japanese elderly patients with cervical cancer: preliminary survival outcomes and evaluation of treatment-related toxicity</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Yoshida</surname><given-names>Kenji</given-names></name><address><phone>+81-78-3826104</phone><fax>+81-78-3826129</fax><email>kyoshi@med.kobe-u.ac.jp</email></address><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Sasaki</surname><given-names>Ryohei</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Nishimura</surname><given-names>Hideki</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Miyawaki</surname><given-names>Daisuke</given-names></name><xref ref-type="aff" rid="Aff1">1</xref></contrib><contrib contrib-type="author"><name><surname>Kawabe</surname><given-names>Tetsuya</given-names></name><xref ref-type="aff" rid="Aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>Okamoto</surname><given-names>Yoshiaki</given-names></name><xref ref-type="aff" rid="Aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>Nakabayashi</surname><given-names>Koji</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Yoshida</surname><given-names>Shigeki</given-names></name><xref ref-type="aff" rid="Aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>Sugimura</surname><given-names>Kazuro</given-names></name><xref ref-type="aff" rid="Aff5">5</xref></contrib><aff id="Aff1"><label>1</label>Department of Radiation Oncology, Kobe University Graduate School of Medicine, 7-5-2 Kusunokicho, Chuouku, Kobe City, Hyogo 650-0017 Japan</aff><aff id="Aff2"><label>2</label>Department of Radiology, Dokkyou Medical University, Tochigi, Japan</aff><aff id="Aff3"><label>3</label>Department of Radiology, Osaka Police Hospital, Osaka, Japan</aff><aff id="Aff4"><label>4</label>Department of Gynecology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</aff><aff id="Aff5"><label>5</label>Department of Radiology, Kobe University Graduate School of Medicine, Kobe City, Hyogo Japan</aff></contrib-group><pub-date pub-type="epub"><day>30</day><month>11</month><year>2010</year></pub-date><pub-date pub-type="pmc-release"><day>30</day><month>11</month><year>2010</year></pub-date><pub-date pub-type="ppub"><month>10</month><year>2011</year></pub-date><volume>284</volume><issue>4</issue><fpage>1007</fpage><lpage>1014</lpage><history><date date-type="received"><day>5</day><month>8</month><year>2010</year></date><date date-type="accepted"><day>11</day><month>11</month><year>2010</year></date></history><permissions><copyright-statement>© The Author(s) 2010</copyright-statement></permissions><abstract id="Abs1"><sec><title>Purpose</title><p>To examine the preliminary survival outcomes and treatment-related toxicity for elderly patients with cervical cancer treated with radiotherapy (RT).</p></sec><sec><title>Methods</title><p>Forty patients ≥75 years old with cervical cancer who were treated with RT were evaluated. Of these 40 patients, 25 were classified as FIGO stage I or II and 15 as stage III or IVA. Thirty-five patients were treated with radical RT (RRT), and five were treated with surgery plus adjuvant RT (S + ART). External beam radiotherapy combined with high-dose-rate intracavitary brachytherapy was performed on 31 patients who were treated with RRT and on 2 patients who were treated with S + ART because of positive vaginal surgical margins. The patients’ median age was 78 years (range 75–89 years). Concurrent chemotherapy (CCT) was performed on five patients (RRT: 3, S + ART: 2).</p></sec><sec><title>Results</title><p>The median follow-up period was 20 months (range 1–85 months). Only one patient could not complete RT. The 3-year overall and disease-specific survival (OS and DSS) rates for all patients were 58 and 80%, respectively. Five patients experienced Grade 3 acute toxicity; two were treated with RRT (2/35), and three were treated with S + ART (3/5, 2 of them with CCT). Two patients experienced Grade 3 late toxicity; one was treated with RRT (1/35, with CCT) and the other was treated with S + ART (1/5). No Grade 4 or higher toxicity was experienced.</p></sec><sec><title>Conclusions</title><p>RRT for elderly patients with cervical cancer is generally effective and safe, but severe toxicity may occur with more aggressive treatment modalities.</p></sec></abstract><kwd-group><title>Keywords</title><kwd>Cervical cancer</kwd><kwd>Radiotherapy</kwd><kwd>Elderly patients</kwd><kwd>Treatment-related toxicity</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer-Verlag 2011</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Japon</li></country></list><tree><noCountry><name sortKey="Miyawaki, Daisuke" sort="Miyawaki, Daisuke" uniqKey="Miyawaki D" first="Daisuke" last="Miyawaki">Daisuke Miyawaki</name><name sortKey="Nakabayashi, Koji" sort="Nakabayashi, Koji" uniqKey="Nakabayashi K" first="Koji" last="Nakabayashi">Koji Nakabayashi</name><name sortKey="Nishimura, Hideki" sort="Nishimura, Hideki" uniqKey="Nishimura H" first="Hideki" last="Nishimura">Hideki Nishimura</name><name sortKey="Sasaki, Ryohei" sort="Sasaki, Ryohei" uniqKey="Sasaki R" first="Ryohei" last="Sasaki">Ryohei Sasaki</name><name sortKey="Sugimura, Kazuro" sort="Sugimura, Kazuro" uniqKey="Sugimura K" first="Kazuro" last="Sugimura">Kazuro Sugimura</name><name sortKey="Yoshida, Kenji" sort="Yoshida, Kenji" uniqKey="Yoshida K" first="Kenji" last="Yoshida">Kenji Yoshida</name><name sortKey="Yoshida, Shigeki" sort="Yoshida, Shigeki" uniqKey="Yoshida S" first="Shigeki" last="Yoshida">Shigeki Yoshida</name></noCountry><country name="Japon"><noRegion><name sortKey="Kawabe, Tetsuya" sort="Kawabe, Tetsuya" uniqKey="Kawabe T" first="Tetsuya" last="Kawabe">Tetsuya Kawabe</name></noRegion><name sortKey="Okamoto, Yoshiaki" sort="Okamoto, Yoshiaki" uniqKey="Okamoto Y" first="Yoshiaki" last="Okamoto">Yoshiaki Okamoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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