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Three-dimensional optical imaging of microvascular networks within intact lymph node in vivo

Identifieur interne : 003175 ( Pmc/Checkpoint ); précédent : 003174; suivant : 003176

Three-dimensional optical imaging of microvascular networks within intact lymph node in vivo

Auteurs : Yeongri Jung ; Zhongwei Zhi ; Ruikang K. Wang

Source :

RBID : PMC:2966489

Abstract

Sentinel lymph nodes (SLNs) are the first lymph nodes to drain wastes originated from cancerous tissue. There is a need for an in vivo imaging method that can image the intact SLN to further our understanding of its normal as well as abnormal functions. We report the use of ultrahigh sensitive optical microangiography (UHS-OMAG) to image functional microvascular and lymphatic vessel networks that innervate the intact lymph node in mice in vivo. The promising results show a potential role of UHS-OMAG in the future understanding and diagnosis of the SLN involvement in cancer development.


Url:
DOI: 10.1117/1.3496301
PubMed: 21054073
PubMed Central: 2966489


Affiliations:


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PMC:2966489

Le document en format XML

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<p>Sentinel lymph nodes (SLNs) are the first lymph nodes to drain wastes originated from cancerous tissue. There is a need for an
<italic>in vivo</italic>
imaging method that can image the intact SLN to further our understanding of its normal as well as abnormal functions. We report the use of ultrahigh sensitive optical microangiography (UHS-OMAG) to image functional microvascular and lymphatic vessel networks that innervate the intact lymph node in mice
<italic>in vivo.</italic>
The promising results show a potential role of UHS-OMAG in the future understanding and diagnosis of the SLN involvement in cancer development.</p>
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<p>Address all correspondence to Ruikang K. Wang. Tel: 503-418-9317; Fax: 503-418-9311; E-mail:
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<year>2010</year>
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<p>Sentinel lymph nodes (SLNs) are the first lymph nodes to drain wastes originated from cancerous tissue. There is a need for an
<italic>in vivo</italic>
imaging method that can image the intact SLN to further our understanding of its normal as well as abnormal functions. We report the use of ultrahigh sensitive optical microangiography (UHS-OMAG) to image functional microvascular and lymphatic vessel networks that innervate the intact lymph node in mice
<italic>in vivo.</italic>
The promising results show a potential role of UHS-OMAG in the future understanding and diagnosis of the SLN involvement in cancer development.</p>
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