Update of human and mouse forkhead box (FOX) gene families
Identifieur interne : 003165 ( Pmc/Checkpoint ); précédent : 003164; suivant : 003166Update of human and mouse forkhead box (FOX) gene families
Auteurs : Brian C. Jackson [États-Unis] ; Christopher Carpenter [États-Unis] ; Daniel W. Nebert [États-Unis] ; Vasilis Vasiliou [États-Unis]Source :
- Human Genomics [ 1473-9542 ] ; 2010.
Abstract
The forkhead box (FOX) proteins are transcription factors that play complex and important roles in processes from development and organogenesis to regulation of metabolism and the immune system. There are 50
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DOI: 10.1186/1479-7364-4-5-345
PubMed: 20650821
PubMed Central: 3500164
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Update of human and mouse forkhead box (<italic>FOX</italic>
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<front><div type="abstract" xml:lang="en"><p>The forkhead box (FOX) proteins are transcription factors that play complex and important roles in processes from development and organogenesis to regulation of metabolism and the immune system. There are 50 <italic>FOX </italic>
genes in the human genome and 44 in the mouse, divided into 19 subfamilies. All human <italic>FOX </italic>
genes have close mouse orthologues, with one exception: the mouse has a single <italic>Foxd4</italic>
, whereas the human gene has undergone a recent duplication to a total of seven (<italic>FOXD4 </italic>
and <italic>FOXD4L1 </italic>
→ <italic>FOXD4L6</italic>
). Evolutionarily ancient family members can be found as far back as the fungi and metazoans. The DNA-binding domain, the forkhead domain, is an example of the winged-helix domain, and is very well conserved across the FOX family and across species, with a few notable exceptions in which divergence has created new functionality. Mutations in <italic>FOX </italic>
genes have been implicated in at least four familial human diseases, and differential expression may play a role in a number of other pathologies -- ranging from metabolic disorders to autoimmunity. Furthermore, <italic>FOX </italic>
genes are differentially expressed in a large number of cancers; their role can be either as an oncogene or tumour suppressor, depending on the family member and cell type. Although some drugs that target <italic>FOX </italic>
gene expression or activity, notably proteasome inhibitors, appear to work well, much more basic research is needed to unlock the complex interplay of upstream and downstream interactions with FOX family transcription factors.</p>
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<front><journal-meta><journal-id journal-id-type="nlm-ta">Hum Genomics</journal-id>
<journal-id journal-id-type="iso-abbrev">Hum. Genomics</journal-id>
<journal-title-group><journal-title>Human Genomics</journal-title>
</journal-title-group>
<issn pub-type="ppub">1473-9542</issn>
<issn pub-type="epub">1479-7364</issn>
<publisher><publisher-name>BioMed Central</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">20650821</article-id>
<article-id pub-id-type="pmc">3500164</article-id>
<article-id pub-id-type="publisher-id">1479-7364-4-5-345</article-id>
<article-id pub-id-type="doi">10.1186/1479-7364-4-5-345</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Genome Update</subject>
</subj-group>
</article-categories>
<title-group><article-title>Update of human and mouse forkhead box (<italic>FOX</italic>
) gene families</article-title>
</title-group>
<contrib-group><contrib contrib-type="author" id="A1"><name><surname>Jackson</surname>
<given-names>Brian C</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
</contrib>
<contrib contrib-type="author" id="A2"><name><surname>Carpenter</surname>
<given-names>Christopher</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A3"><name><surname>Nebert</surname>
<given-names>Daniel W</given-names>
</name>
<xref ref-type="aff" rid="I2">2</xref>
<email>dan.nebert@uc.edu</email>
</contrib>
<contrib contrib-type="author" corresp="yes" id="A4"><name><surname>Vasiliou</surname>
<given-names>Vasilis</given-names>
</name>
<xref ref-type="aff" rid="I1">1</xref>
<email>vasilis.vasiliou@ucdenver.edu</email>
</contrib>
</contrib-group>
<aff id="I1"><label>1</label>
Molecular Toxicology and Environmental Health Sciences Program, Department of Pharmaceutical Sciences, University of Colorado Denver, Aurora, CO 80045, USA</aff>
<aff id="I2"><label>2</label>
Department of Environmental Health and Center for Environmental Genetics (CEG), University of Cincinnati Medical Center, Cincinnati, OH 45267-0056, USA</aff>
<pub-date pub-type="collection"><year>2010</year>
</pub-date>
<pub-date pub-type="epub"><day>1</day>
<month>6</month>
<year>2010</year>
</pub-date>
<volume>4</volume>
<issue>5</issue>
<fpage>345</fpage>
<lpage>352</lpage>
<history><date date-type="received"><day>29</day>
<month>4</month>
<year>2010</year>
</date>
<date date-type="accepted"><day>29</day>
<month>4</month>
<year>2010</year>
</date>
</history>
<permissions><copyright-statement>Copyright ©2010 Henry Stewart Publications</copyright-statement>
<copyright-year>2010</copyright-year>
<copyright-holder>Henry Stewart Publications</copyright-holder>
</permissions>
<self-uri xlink:href="http://www.humgenomics.com/content/4/5/345"></self-uri>
<abstract><p>The forkhead box (FOX) proteins are transcription factors that play complex and important roles in processes from development and organogenesis to regulation of metabolism and the immune system. There are 50 <italic>FOX </italic>
genes in the human genome and 44 in the mouse, divided into 19 subfamilies. All human <italic>FOX </italic>
genes have close mouse orthologues, with one exception: the mouse has a single <italic>Foxd4</italic>
, whereas the human gene has undergone a recent duplication to a total of seven (<italic>FOXD4 </italic>
and <italic>FOXD4L1 </italic>
→ <italic>FOXD4L6</italic>
). Evolutionarily ancient family members can be found as far back as the fungi and metazoans. The DNA-binding domain, the forkhead domain, is an example of the winged-helix domain, and is very well conserved across the FOX family and across species, with a few notable exceptions in which divergence has created new functionality. Mutations in <italic>FOX </italic>
genes have been implicated in at least four familial human diseases, and differential expression may play a role in a number of other pathologies -- ranging from metabolic disorders to autoimmunity. Furthermore, <italic>FOX </italic>
genes are differentially expressed in a large number of cancers; their role can be either as an oncogene or tumour suppressor, depending on the family member and cell type. Although some drugs that target <italic>FOX </italic>
gene expression or activity, notably proteasome inhibitors, appear to work well, much more basic research is needed to unlock the complex interplay of upstream and downstream interactions with FOX family transcription factors.</p>
</abstract>
<kwd-group><kwd>FOX</kwd>
<kwd>forkhead domain</kwd>
<kwd>winged-helix domain</kwd>
<kwd>transcription factors</kwd>
<kwd>gene family</kwd>
<kwd>evolution</kwd>
<kwd>cancer</kwd>
<kwd>metabolism</kwd>
<kwd>immunity</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Jackson, Brian C" sort="Jackson, Brian C" uniqKey="Jackson B" first="Brian C" last="Jackson">Brian C. Jackson</name>
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<name sortKey="Carpenter, Christopher" sort="Carpenter, Christopher" uniqKey="Carpenter C" first="Christopher" last="Carpenter">Christopher Carpenter</name>
<name sortKey="Nebert, Daniel W" sort="Nebert, Daniel W" uniqKey="Nebert D" first="Daniel W" last="Nebert">Daniel W. Nebert</name>
<name sortKey="Vasiliou, Vasilis" sort="Vasiliou, Vasilis" uniqKey="Vasiliou V" first="Vasilis" last="Vasiliou">Vasilis Vasiliou</name>
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</record>
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