Autoinflammation: translating mechanism to therapy
Identifieur interne : 003086 ( Pmc/Checkpoint ); précédent : 003085; suivant : 003087Autoinflammation: translating mechanism to therapy
Auteurs : Taylor A. Doherty ; Susannah D. Brydges [États-Unis] ; Hal M. Hoffman [États-Unis]Source :
- Journal of Leukocyte Biology [ 0741-5400 ] ; 2011.
Abstract
Review discusses autoinflammatory diseases as a new classification of immune disorders due to dysregulated innate immunity yet sensitive to targeted cytokine therapy.
Url:
DOI: 10.1189/jlb.1110616
PubMed: 21330349
PubMed Central: 3219035
Affiliations:
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PMC:3219035Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Review discusses autoinflammatory diseases as a new classification of immune disorders due to dysregulated innate immunity yet sensitive to targeted cytokine therapy.</p>
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<xref ref-type="aff" rid="aff2"><sup>†</sup>
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Medicine and</aff>
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Pediatrics, Division of Allergy, Immunology, and Rheumatology, University of California at San Diego and Rady Children's Hospital, La Jolla, CA, USA</aff>
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<author-notes><corresp id="cor1"><label>1.</label>
Correspondence: <addr-line>Departments of Medicine and Pediatrics, Division of Allergy, Immunology, and Rheumatology, University of California at San Diego, School of Medicine, 9500 Gilman Dr., La Jolla, CA 92093-0635, USA.</addr-line>
E-mail: <email>hahoffman@ucsd.edu</email>
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<history><date date-type="received"><day>15</day>
<month>11</month>
<year>2010</year>
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<permissions><copyright-statement>© 2011 Society for Leukocyte Biology</copyright-statement>
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<abstract abstract-type="precis"><p>Review discusses autoinflammatory diseases as a new classification of immune disorders due to dysregulated innate immunity yet sensitive to targeted cytokine therapy.</p>
</abstract>
<abstract><p>Autoinflammatory syndromes are a clinically heterogeneous collection of diseases characterized by dysregulation of the innate immune system. The hereditary recurrent fever disorders were the first to be defined as autoinflammatory. Several of the responsible genes are now known to encode proteins forming multimeric complexes called inflammasomes, which are intracellular “danger sensors” that respond to a variety of different signals by activating caspase-1, responsible for cleavage and subsequent release of bioactive IL-1β. This discovery of the causative link between autoinflammation and IL-1β maturation has led to a significantly improved understanding of the mechanisms of innate immunity, as well as life-altering treatments for patients. Targeting IL-1β for the treatment of autoinflammatory syndromes is an excellent example of the power of translational research. Given the central role of inflammation in many complex multigenic diseases, these treatments may benefit larger numbers of patients in the future. Here, we review current treatment strategies of autoinflammatory diseases with a focus on IL-1 antagonism.</p>
</abstract>
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