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In Vivo Flow Cytometry: A Horizon of Opportunities

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In Vivo Flow Cytometry: A Horizon of Opportunities

Auteurs : Valery V. Tuchin [Russie] ; Attila Tárnok ; Vladimir P. Zharov [États-Unis]

Source :

Cytometry. Part A : the journal of the International Society for Analytical Cytology [ 1552-4922 ] ; 2011.

RBID : PMC:3663136

Abstract

Flow cytometry has been a fundamental tool of biological discovery for many years. Invasive extraction of cells from a living organism, however, may lead to changes in cell properties and prevents studying cells in their native environment. These problems can be overcome by use of in vivo flow cytometry which provides detection and imaging of circulating normal and abnormal cells directlyin blood or lymph flow. The goal of this mini-review is to provide a brief history, features and challenges of this new generation of flow cytometry methods and instruments. Spectrum of possibilities of in vivo flow cytometry in biological science (e.g., cell metabolism, immune function, or apoptosis) and medical fields (e.g., cancer, infection, cardiovascular disorder) including integrated photoacoustic-photothermal theranostics of circulating abnormal cells are discussed with focus on recent advances of this new platform.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3663136

DOI: 10.1002/cyto.a.21143
PubMed: 21915991
PubMed Central: 3663136

Affiliations:

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PMC:3663136

Le document en format XML

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<author><name sortKey="Zharov, Vladimir P" sort="Zharov, Vladimir P" uniqKey="Zharov V" first="Vladimir P." last="Zharov">Vladimir P. Zharov</name>
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<author><name sortKey="Tarnok, Attila" sort="Tarnok, Attila" uniqKey="Tarnok A" first="Attila" last="Tárnok">Attila Tárnok</name>
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<series><title level="j">Cytometry. Part A : the journal of the International Society for Analytical Cytology</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">Flow cytometry has been a fundamental tool of biological discovery for many years. Invasive extraction of cells from a living organism, however, may lead to changes in cell properties and prevents studying cells in their native environment. These problems can be overcome by use of <italic>in vivo</italic>
 flow cytometry which provides detection and imaging of circulating normal and abnormal cells directlyin blood or lymph flow. The goal of this mini-review is to provide a brief history, features and challenges of this new generation of flow cytometry methods and instruments. Spectrum of possibilities of <italic>in vivo</italic>
 flow cytometry in biological science (e.g., cell metabolism, immune function, or apoptosis) and medical fields (e.g., cancer, infection, cardiovascular disorder) including integrated photoacoustic-photothermal theranostics of circulating abnormal cells are discussed with focus on recent advances of this new platform.</p>
</div>
</front>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
  <pmc-dir>properties manuscript</pmc-dir>
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<journal-id journal-id-type="iso-abbrev">Cytometry A</journal-id>
<journal-title-group><journal-title>Cytometry. Part A : the journal of the International Society for Analytical Cytology</journal-title>
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<article-id pub-id-type="manuscript">NIHMS336722</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
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<title-group><article-title>In Vivo Flow Cytometry: A Horizon of Opportunities</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Tuchin</surname>
<given-names>Valery V.</given-names>
</name>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A2">2</xref>
<xref ref-type="aff" rid="A3">3</xref>
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<contrib contrib-type="author"><name><surname>Tárnok</surname>
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<email>tarnok@medizin.uni-leipzig.de</email>
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<contrib contrib-type="author"><name><surname>Zharov</surname>
<given-names>Vladimir P.</given-names>
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<xref ref-type="aff" rid="A5">5</xref>
<email>zharovvladimirp@uams.edu</email>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
Research-Educational Institute of Optics and Biophotonics, Saratov State University, Saratov, 410012 Russia</aff>
<aff id="A2"><label>2</label>
Institute of Precise Mechanics and Control, Russian Academy of Sciences, Saratov 410028, Russia</aff>
<aff id="A3"><label>3</label>
University of Oulu, Oulu, FI-90014 Finland</aff>
<aff id="A4"><label>4</label>
Pediatric Cardiology, Heart Center, University of Leipzig, Leipzig, G04289 Germany</aff>
<aff id="A5"><label>5</label>
Phillips Classic Laser and Nanomedicine Laboratories, University of Arkansas for Medical Sciences, Little Rock, Arkansas, 72205 USA</aff>
<author-notes><corresp id="FN1">Correspondence to: <email>tuchinvv@mail.ru</email>
</corresp>
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<pub-date pub-type="nihms-submitted"><day>16</day>
<month>4</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>13</day>
<month>9</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="ppub"><month>10</month>
<year>2011</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>24</day>
<month>5</month>
<year>2013</year>
</pub-date>
<volume>79</volume>
<issue>10</issue>
<fpage>737</fpage>
<lpage>745</lpage>
<abstract><p id="P1">Flow cytometry has been a fundamental tool of biological discovery for many years. Invasive extraction of cells from a living organism, however, may lead to changes in cell properties and prevents studying cells in their native environment. These problems can be overcome by use of <italic>in vivo</italic>
 flow cytometry which provides detection and imaging of circulating normal and abnormal cells directlyin blood or lymph flow. The goal of this mini-review is to provide a brief history, features and challenges of this new generation of flow cytometry methods and instruments. Spectrum of possibilities of <italic>in vivo</italic>
 flow cytometry in biological science (e.g., cell metabolism, immune function, or apoptosis) and medical fields (e.g., cancer, infection, cardiovascular disorder) including integrated photoacoustic-photothermal theranostics of circulating abnormal cells are discussed with focus on recent advances of this new platform.</p>
</abstract>
<kwd-group><title>Key terms</title>
<kwd>flow cytometry</kwd>
<kwd>spectral imaging</kwd>
<kwd>photoacoustic and photothermal methods</kwd>
<kwd>fluorescence</kwd>
<kwd>Raman spectroscopy</kwd>
<kwd>blood and lymph flows</kwd>
<kwd>circulating tumor cells</kwd>
<kwd>bacteria, and multicolor nanoparticles</kwd>
<kwd>theranostics</kwd>
</kwd-group>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R21 CA139373-02 || CA</award-id>
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<award-group><funding-source country="United States">National Institute of Biomedical Imaging and Bioengineering : NIBIB</funding-source>
<award-id>R01 EB009230-03 || EB</award-id>
</award-group>
<award-group><funding-source country="United States">National Institute of Biomedical Imaging and Bioengineering : NIBIB</funding-source>
<award-id>R01 EB000873-03 || EB</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA131164-03 || CA</award-id>
</award-group>
</funding-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>Russie</li>
<li>États-Unis</li>
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<region><li>Arkansas</li>
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<tree><noCountry><name sortKey="Tarnok, Attila" sort="Tarnok, Attila" uniqKey="Tarnok A" first="Attila" last="Tárnok">Attila Tárnok</name>
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<country name="Russie"><noRegion><name sortKey="Tuchin, Valery V" sort="Tuchin, Valery V" uniqKey="Tuchin V" first="Valery V." last="Tuchin">Valery V. Tuchin</name>
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<name sortKey="Tuchin, Valery V" sort="Tuchin, Valery V" uniqKey="Tuchin V" first="Valery V." last="Tuchin">Valery V. Tuchin</name>
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<country name="États-Unis"><region name="Arkansas"><name sortKey="Zharov, Vladimir P" sort="Zharov, Vladimir P" uniqKey="Zharov V" first="Vladimir P." last="Zharov">Vladimir P. Zharov</name>
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In Vivo Flow Cytometry: A Horizon of Opportunities

In Vivo Flow Cytometry: A Horizon of Opportunities

Source :

Abstract

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