Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization
Identifieur interne : 002D53 ( Pmc/Checkpoint ); précédent : 002D52; suivant : 002D54Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization
Auteurs : Changwon Park ; Ji Yoon Lee ; Young-Sup YoonSource :
- Trends in Cardiovascular Medicine [ 1050-1738 ] ; 2011.
Abstract
The lymphatic vasculature plays a pivotal role in maintaining tissue fluid homeostasis, immune surveillance, and lipid uptake in the gastrointestinal organs. Therefore, impaired function of the lymphatic vessels caused by genetic defects, infection, trauma, or surgery leads to the abnormal accrual of lymph fluid in the tissue and culminates in the swelling of affected tissues, known as lymphedema. Although millions of people suffer from lymphedema worldwide which causes impaired wound healing, compromised immune defense and, in rare case, lymphangiosarcoma, no effective therapy is currently available. In addition, recent advances in cancer biology have disclosed an indispensable function of the lymphatic vessel in tumor growth and metastasis. Therefore, understanding the detailed mechanisms governing lymphatic vessel formation and function in pathophysiologic conditions is essential to prevent or treat these diseases. Here, we will review the developmental processes of the lymphatic vessels and postnatal lymphatic neovascularization, focusing on the role of recently identified bone-marrow (BM) derived PODOPLANIN expressing (PODOPLANIN+) cells as lymphatic endothelial progenitor cells (LEPCs).
Url:
DOI: 10.1016/j.tcm.2012.04.002
PubMed: 22732548
PubMed Central: 3384483
Affiliations:
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<front><journal-meta><journal-id journal-id-type="nlm-journal-id">9108337</journal-id><journal-id journal-id-type="pubmed-jr-id">21207</journal-id><journal-id journal-id-type="nlm-ta">Trends Cardiovasc Med</journal-id><journal-id journal-id-type="iso-abbrev">Trends Cardiovasc. Med.</journal-id><journal-title-group><journal-title>Trends in Cardiovascular Medicine</journal-title></journal-title-group><issn pub-type="ppub">1050-1738</issn><issn pub-type="epub">1873-2615</issn></journal-meta><article-meta><article-id pub-id-type="pmid">22732548</article-id><article-id pub-id-type="pmc">3384483</article-id><article-id pub-id-type="doi">10.1016/j.tcm.2012.04.002</article-id><article-id pub-id-type="manuscript">NIHMS369803</article-id><article-categories><subj-group subj-group-type="heading"><subject>Article</subject></subj-group></article-categories><title-group><article-title>Role of bone marrow-derived lymphatic endothelial progenitor cells for lymphatic neovascularization</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Park</surname><given-names>Changwon</given-names></name><aff id="A1">Department of Pharmacology, University of Illinois College of Medicine, Chicago, IL 60612, USA</aff></contrib><contrib contrib-type="author"><name><surname>Lee</surname><given-names>Ji Yoon</given-names></name><aff id="A2">Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA</aff></contrib><contrib contrib-type="author"><name><surname>Yoon</surname><given-names>Young-sup</given-names></name><aff id="A3">Department of Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA</aff></contrib></contrib-group><author-notes><corresp id="FN1">Address correspondence to: Young-sup Yoon, Department of Medicine, Division of Cardiology, Emory University School of Medicine, 101 Woodruff Circle, Woodruff Memorial Research Building, Atlanta, GA 30322, USA, Tel: 404-727-8176, <email>yyoon5@emory.edu</email></corresp></author-notes><pub-date pub-type="nihms-submitted"><day>8</day><month>5</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>7</month><year>2011</year></pub-date><pub-date pub-type="pmc-release"><day>01</day><month>7</month><year>2012</year></pub-date><volume>21</volume><issue>5</issue><fpage>135</fpage><lpage>140</lpage><permissions><copyright-statement>© 2012 Elsevier Inc. All rights reserved.</copyright-statement><copyright-year>2012</copyright-year></permissions><abstract><p id="P2">The lymphatic vasculature plays a pivotal role in maintaining tissue fluid homeostasis, immune surveillance, and lipid uptake in the gastrointestinal organs. Therefore, impaired function of the lymphatic vessels caused by genetic defects, infection, trauma, or surgery leads to the abnormal accrual of lymph fluid in the tissue and culminates in the swelling of affected tissues, known as lymphedema. Although millions of people suffer from lymphedema worldwide which causes impaired wound healing, compromised immune defense and, in rare case, lymphangiosarcoma, no effective therapy is currently available. In addition, recent advances in cancer biology have disclosed an indispensable function of the lymphatic vessel in tumor growth and metastasis. Therefore, understanding the detailed mechanisms governing lymphatic vessel formation and function in pathophysiologic conditions is essential to prevent or treat these diseases. Here, we will review the developmental processes of the lymphatic vessels and postnatal lymphatic neovascularization, focusing on the role of recently identified bone-marrow (BM) derived PODOPLANIN expressing (PODOPLANIN<sup>+</sup>) cells as lymphatic endothelial progenitor cells (LEPCs).</p></abstract><funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201000043C || HL</award-id></award-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source><award-id>HHSN268201000043C || HL</award-id></award-group></funding-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Lee, Ji Yoon" sort="Lee, Ji Yoon" uniqKey="Lee J" first="Ji Yoon" last="Lee">Ji Yoon Lee</name><name sortKey="Park, Changwon" sort="Park, Changwon" uniqKey="Park C" first="Changwon" last="Park">Changwon Park</name><name sortKey="Yoon, Young Sup" sort="Yoon, Young Sup" uniqKey="Yoon Y" first="Young-Sup" last="Yoon">Young-Sup Yoon</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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