Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
Identifieur interne : 002B53 ( Pmc/Checkpoint ); précédent : 002B52; suivant : 002B54Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans
Auteurs : Jingdan Zhang [États-Unis] ; Shaohua Kevin Zhou [États-Unis] ; Xiaoyan Xiang [États-Unis] ; Merrick L. Bautista [États-Unis] ; Blake A. Niccum [États-Unis] ; Gabriel S. Dickinson [États-Unis] ; I-Chih Tan [États-Unis] ; Wenyaw Chan [États-Unis] ; Eva M. Sevick-Muraca [États-Unis] ; John C. Rasmussen [États-Unis]Source :
- Biomedical Optics Express [ 2156-7085 ] ; 2012.
Abstract
ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans.
Url:
DOI: 10.1364/BOE.3.001713
PubMed: 22808440
PubMed Central: 3395493
Affiliations:
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Bautista</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Niccum, Blake A" sort="Niccum, Blake A" uniqKey="Niccum B" first="Blake A." last="Niccum">Blake A. Niccum</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dickinson, Gabriel S" sort="Dickinson, Gabriel S" uniqKey="Dickinson G" first="Gabriel S." last="Dickinson">Gabriel S. Dickinson</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Tan, I Chih" sort="Tan, I Chih" uniqKey="Tan I" first="I-Chih" last="Tan">I-Chih Tan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Chan, Wenyaw" sort="Chan, Wenyaw" uniqKey="Chan W" first="Wenyaw" last="Chan">Wenyaw Chan</name><affiliation wicri:level="1"><nlm:aff id="aff3">Division of Biostatistics, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Herman Pressler St., Houston, Texas, 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M." last="Sevick-Muraca">Eva M. Sevick-Muraca</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Rasmussen, John C" sort="Rasmussen, John C" uniqKey="Rasmussen J" first="John C." last="Rasmussen">John C. Rasmussen</name><affiliation wicri:level="1"><nlm:aff id="aff2">Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Biomedical Optics Express</title><idno type="eISSN">2156-7085</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Shpilfoygel, S D" uniqKey="Shpilfoygel S">S. D. Shpilfoygel</name></author><author><name sortKey="Close, R A" uniqKey="Close R">R. A. Close</name></author><author><name sortKey="Valentino, D J" uniqKey="Valentino D">D. J. Valentino</name></author><author><name sortKey="Duckwiler, G R" uniqKey="Duckwiler G">G. R. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Biomed Opt Express</journal-id><journal-id journal-id-type="iso-abbrev">Biomed Opt Express</journal-id><journal-id journal-id-type="publisher-id">BOE</journal-id><journal-title-group><journal-title>Biomedical Optics Express</journal-title></journal-title-group><issn pub-type="epub">2156-7085</issn><publisher><publisher-name>Optical Society of America</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22808440</article-id><article-id pub-id-type="pmc">3395493</article-id><article-id pub-id-type="publisher-id">169247</article-id><article-id pub-id-type="doi">10.1364/BOE.3.001713</article-id><article-categories><subj-group subj-group-type="heading"><subject>Image Processing</subject></subj-group></article-categories><title-group><article-title>Automated analysis of investigational near-infrared fluorescence lymphatic imaging in humans</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Zhang</surname><given-names>Jingdan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Zhou</surname><given-names>Shaohua Kevin</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Xiang</surname><given-names>Xiaoyan</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bautista</surname><given-names>Merrick L.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Niccum</surname><given-names>Blake A.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dickinson</surname><given-names>Gabriel S.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Tan</surname><given-names>I-Chih</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Chan</surname><given-names>Wenyaw</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Sevick-Muraca</surname><given-names>Eva M.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Rasmussen</surname><given-names>John C.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib><aff id="aff1"><label>1</label>Whole Body and Oncology Image Analytics Program, Siemens Corporate Research, 755 College Road East, Princeton, New Jersey, 08540,<country>USA</country></aff><aff id="aff2"><label>2</label>Center for Molecular Imaging, The Brown Foundation Institute of Molecular Medicine, The University of Texas Health Science Center at Houston, 1825 Pressler Street, Houston, Texas, 77030,<country>USA</country></aff><aff id="aff3"><label>3</label>Division of Biostatistics, School of Public Health, The University of Texas Health Science Center at Houston, 1200 Herman Pressler St., Houston, Texas, 77030,<country>USA</country></aff><aff id="aff4"><label>4</label><email xlink:href="Shaohua.Zhou@siemens.com">Shaohua.Zhou@siemens.com</email> (algorithm)</aff></contrib-group><author-notes><corresp id="cor1"><label>*</label><email xlink:href="John.Rasmussen@uth.tmc.edu">John.Rasmussen@uth.tmc.edu</email></corresp></author-notes><pub-date pub-type="epub"><day>22</day><month>6</month><year>2012</year></pub-date><pub-date pub-type="collection"><day>01</day><month>7</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>22</day><month>6</month><year>2012</year></pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>3</volume><issue>7</issue><fpage>1713</fpage><lpage>1723</lpage><history><date date-type="received"><day>24</day><month>5</month><year>2012</year></date><date date-type="accepted"><day>10</day><month>6</month><year>2012</year></date></history><permissions><copyright-statement>©2012 Optical Society of America</copyright-statement><copyright-year>2012</copyright-year><copyright-holder>OSA</copyright-holder><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-No Derivative Works 3.0 Unported License, which permits download and redistribution, provided that the original work is properly cited. This license restricts the article from being modified or used commercially.</license-p></license></permissions><abstract><p>ALFIA (Automated Lymphatic Function Imaging Analysis), an algorithm providing quantitative analysis of investigational near-infrared fluorescence lymphatic images, is described. Images from nine human subjects were analyzed for apparent lymphatic propagation velocities and propulsion periods using manual analysis and ALFIA. While lymphatic propulsion was more easily detected using ALFIA than with manual analysis, statistical analyses indicate no significant difference in the apparent lymphatic velocities although ALFIA tended to calculate longer propulsion periods. With the base ALFIA algorithms validated, further automation can now proceed to provide a clinically relevant analytic tool for quantitatively assessing lymphatic function in humans.</p></abstract><kwd-group kwd-group-type="OCIS"><title>OCIS codes: </title><kwd>(110.2960) Image analysis</kwd><kwd>(170.0110) Imaging systems</kwd><kwd>(170.2655) Functional monitoring and imaging</kwd><kwd>(170.3880) Medical and biological imaging</kwd></kwd-group><funding-group><award-group><funding-source id="sp1">Tactile Systems Technology, Inc.</funding-source></award-group></funding-group><funding-group><award-group><funding-source id="sp2">National Institutes of Health</funding-source><award-id rid="sp2">R01 HL092923</award-id><award-id rid="sp2">U54 CA136404</award-id></award-group></funding-group><custom-meta-group><custom-meta><meta-name>OpenAccess</meta-name><meta-value>True</meta-value></custom-meta><custom-meta><meta-name>OpenAccessEmbargo</meta-name><meta-value>0</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>États-Unis</li></country></list><tree><country name="États-Unis"><noRegion><name sortKey="Zhang, Jingdan" sort="Zhang, Jingdan" uniqKey="Zhang J" first="Jingdan" last="Zhang">Jingdan Zhang</name></noRegion><name sortKey="Bautista, Merrick L" sort="Bautista, Merrick L" uniqKey="Bautista M" first="Merrick L." last="Bautista">Merrick L. Bautista</name><name sortKey="Chan, Wenyaw" sort="Chan, Wenyaw" uniqKey="Chan W" first="Wenyaw" last="Chan">Wenyaw Chan</name><name sortKey="Dickinson, Gabriel S" sort="Dickinson, Gabriel S" uniqKey="Dickinson G" first="Gabriel S." last="Dickinson">Gabriel S. Dickinson</name><name sortKey="Niccum, Blake A" sort="Niccum, Blake A" uniqKey="Niccum B" first="Blake A." last="Niccum">Blake A. Niccum</name><name sortKey="Rasmussen, John C" sort="Rasmussen, John C" uniqKey="Rasmussen J" first="John C." last="Rasmussen">John C. Rasmussen</name><name sortKey="Sevick Muraca, Eva M" sort="Sevick Muraca, Eva M" uniqKey="Sevick Muraca E" first="Eva M." last="Sevick-Muraca">Eva M. Sevick-Muraca</name><name sortKey="Tan, I Chih" sort="Tan, I Chih" uniqKey="Tan I" first="I-Chih" last="Tan">I-Chih Tan</name><name sortKey="Xiang, Xiaoyan" sort="Xiang, Xiaoyan" uniqKey="Xiang X" first="Xiaoyan" last="Xiang">Xiaoyan Xiang</name><name sortKey="Zhou, Shaohua Kevin" sort="Zhou, Shaohua Kevin" uniqKey="Zhou S" first="Shaohua Kevin" last="Zhou">Shaohua Kevin Zhou</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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