Flow control in our vessels: vascular valves make sure there is no way back
Identifieur interne : 002998 ( Pmc/Checkpoint ); précédent : 002997; suivant : 002999Flow control in our vessels: vascular valves make sure there is no way back
Auteurs : Eleni Bazigou ; Taija MakinenSource :
- Cellular and Molecular Life Sciences [ 1420-682X ] ; 2012.
Abstract
The efficient transport of blood and lymph relies on competent intraluminal valves that ensure unidirectional fluid flow through the vessels. In the lymphatic vessels, lack of luminal valves causes reflux of lymph and can lead to lymphedema, while dysfunction of venous valves is associated with venous hypertension, varicose veins, and thrombosis that can lead to edema and ulcerations. Despite their clinical importance, the mechanisms that regulate valve formation are poorly understood and have only recently begun to be characterized. Here, we discuss new findings regarding the development of venous and lymphatic valves that indicate the involvement of common molecular mechanisms in regulating valve formation in different vascular beds.
Url:
DOI: 10.1007/s00018-012-1110-6
PubMed: 22922986
PubMed Central: 3578722
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Flow control in our vessels: vascular valves make sure there is no way back</title><author><name sortKey="Bazigou, Eleni" sort="Bazigou, Eleni" uniqKey="Bazigou E" first="Eleni" last="Bazigou">Eleni Bazigou</name><affiliation><nlm:aff id="Aff1">Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3LY UK</nlm:aff><wicri:noCountry code="subfield">WC2A 3LY UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Cardiovascular Mechanics Lab, Department of Bioengineering, Imperial College London, London, SW7 2AZ UK</nlm:aff><wicri:noCountry code="subfield">SW7 2AZ UK</wicri:noCountry></affiliation></author><author><name sortKey="Makinen, Taija" sort="Makinen, Taija" uniqKey="Makinen T" first="Taija" last="Makinen">Taija Makinen</name><affiliation><nlm:aff id="Aff1">Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3LY UK</nlm:aff><wicri:noCountry code="subfield">WC2A 3LY UK</wicri:noCountry></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22922986</idno><idno type="pmc">3578722</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3578722</idno><idno type="RBID">PMC:3578722</idno><idno type="doi">10.1007/s00018-012-1110-6</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">000F31</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000F31</idno><idno type="wicri:Area/Pmc/Curation">000F30</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000F30</idno><idno type="wicri:Area/Pmc/Checkpoint">002998</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002998</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Flow control in our vessels: vascular valves make sure there is no way back</title><author><name sortKey="Bazigou, Eleni" sort="Bazigou, Eleni" uniqKey="Bazigou E" first="Eleni" last="Bazigou">Eleni Bazigou</name><affiliation><nlm:aff id="Aff1">Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3LY UK</nlm:aff><wicri:noCountry code="subfield">WC2A 3LY UK</wicri:noCountry></affiliation><affiliation><nlm:aff id="Aff2">Cardiovascular Mechanics Lab, Department of Bioengineering, Imperial College London, London, SW7 2AZ UK</nlm:aff><wicri:noCountry code="subfield">SW7 2AZ UK</wicri:noCountry></affiliation></author><author><name sortKey="Makinen, Taija" sort="Makinen, Taija" uniqKey="Makinen T" first="Taija" last="Makinen">Taija Makinen</name><affiliation><nlm:aff id="Aff1">Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3LY UK</nlm:aff><wicri:noCountry code="subfield">WC2A 3LY UK</wicri:noCountry></affiliation></author></analytic><series><title level="j">Cellular and Molecular Life Sciences</title><idno type="ISSN">1420-682X</idno><idno type="eISSN">1420-9071</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>The efficient transport of blood and lymph relies on competent intraluminal valves that ensure unidirectional fluid flow through the vessels. In the lymphatic vessels, lack of luminal valves causes reflux of lymph and can lead to lymphedema, while dysfunction of venous valves is associated with venous hypertension, varicose veins, and thrombosis that can lead to edema and ulcerations. Despite their clinical importance, the mechanisms that regulate valve formation are poorly understood and have only recently begun to be characterized. Here, we discuss new findings regarding the development of venous and lymphatic valves that indicate the involvement of common molecular mechanisms in regulating valve formation in different vascular beds.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Alimi, Ys" uniqKey="Alimi Y">YS Alimi</name></author><author><name sortKey="Barthelemy, P" uniqKey="Barthelemy P">P Barthelemy</name></author><author><name sortKey="Juhan, C" uniqKey="Juhan C">C Juhan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kugler, C" uniqKey="Kugler C">C Kugler</name></author><author><name sortKey="Strunk, M" uniqKey="Strunk M">M Strunk</name></author><author><name sortKey="Rudofsky, G" uniqKey="Rudofsky G">G Rudofsky</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Meissner, Mh" uniqKey="Meissner M">MH Meissner</name></author><author><name sortKey="Moneta, G" uniqKey="Moneta G">G 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Cell Mol Life Sci</journal-id><journal-id journal-id-type="iso-abbrev">Cell. Mol. Life Sci</journal-id><journal-title-group><journal-title>Cellular and Molecular Life Sciences</journal-title></journal-title-group><issn pub-type="ppub">1420-682X</issn><issn pub-type="epub">1420-9071</issn><publisher><publisher-name>SP Birkhäuser Verlag Basel</publisher-name><publisher-loc>Basel</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22922986</article-id><article-id pub-id-type="pmc">3578722</article-id><article-id pub-id-type="publisher-id">1110</article-id><article-id pub-id-type="doi">10.1007/s00018-012-1110-6</article-id><article-categories><subj-group subj-group-type="heading"><subject>Review</subject></subj-group></article-categories><title-group><article-title>Flow control in our vessels: vascular valves make sure there is no way back</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Bazigou</surname><given-names>Eleni</given-names></name><address><email>e.bazigou@imperial.ac.uk</email></address><xref ref-type="aff" rid="Aff1"></xref><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Makinen</surname><given-names>Taija</given-names></name><address><phone>+44-207-2693459</phone><fax>+44-207-2693417</fax><email>taija.makinen@cancer.org.uk</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Lymphatic Development Laboratory, Cancer Research UK London Research Institute, 44 Lincoln’s Inn Fields, London, WC2A 3LY UK</aff><aff id="Aff2"><label></label>Cardiovascular Mechanics Lab, Department of Bioengineering, Imperial College London, London, SW7 2AZ UK</aff></contrib-group><pub-date pub-type="epub"><day>25</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="pmc-release"><day>25</day><month>8</month><year>2012</year></pub-date><pub-date pub-type="ppub"><month>3</month><year>2013</year></pub-date><volume>70</volume><issue>6</issue><fpage>1055</fpage><lpage>1066</lpage><history><date date-type="received"><day>28</day><month>6</month><year>2012</year></date><date date-type="rev-recd"><day>24</day><month>7</month><year>2012</year></date><date date-type="accepted"><day>26</day><month>7</month><year>2012</year></date></history><permissions><copyright-statement>© The Author(s) 2012</copyright-statement></permissions><abstract id="Abs1"><p>The efficient transport of blood and lymph relies on competent intraluminal valves that ensure unidirectional fluid flow through the vessels. In the lymphatic vessels, lack of luminal valves causes reflux of lymph and can lead to lymphedema, while dysfunction of venous valves is associated with venous hypertension, varicose veins, and thrombosis that can lead to edema and ulcerations. Despite their clinical importance, the mechanisms that regulate valve formation are poorly understood and have only recently begun to be characterized. Here, we discuss new findings regarding the development of venous and lymphatic valves that indicate the involvement of common molecular mechanisms in regulating valve formation in different vascular beds.</p></abstract><kwd-group xml:lang="en"><title>Keywords</title><kwd>Valve</kwd><kwd>Lymphatic vessel</kwd><kwd>Vein</kwd><kwd>Endothelium</kwd><kwd>Morphogenesis</kwd></kwd-group><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© Springer Basel 2013</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Bazigou, Eleni" sort="Bazigou, Eleni" uniqKey="Bazigou E" first="Eleni" last="Bazigou">Eleni Bazigou</name><name sortKey="Makinen, Taija" sort="Makinen, Taija" uniqKey="Makinen T" first="Taija" last="Makinen">Taija Makinen</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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