LYMPHATIC VESSELS IN HEALTH AND DISEASE
Identifieur interne : 002935 ( Pmc/Checkpoint ); précédent : 002934; suivant : 002936LYMPHATIC VESSELS IN HEALTH AND DISEASE
Auteurs : Cristina T. Kesler ; Shan Liao ; Lance L. Munn ; Timothy P. PaderaSource :
- Wiley interdisciplinary reviews. Systems biology and medicine [ 1939-5094 ] ; 2012.
Abstract
The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism and cancer metastasis. In adults, lymphatic vessel formation and remodeling occurs primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth. Unlike the blood circulation, where unidirectional flow is sustained by the pumping actions of the heart, pumping actions intrinsic to the lymphatic vessels themselves are important drivers of lymphatic flow. This review summarizes critical components that control lymphatic physiology.
Url:
DOI: 10.1002/wsbm.1201
PubMed: 23209022
PubMed Central: 3527689
Affiliations:
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PMC:3527689Le document en format XML
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<front><div type="abstract" xml:lang="en"><p id="P1">The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism and cancer metastasis. In adults, lymphatic vessel formation and remodeling occurs primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth. Unlike the blood circulation, where unidirectional flow is sustained by the pumping actions of the heart, pumping actions intrinsic to the lymphatic vessels themselves are important drivers of lymphatic flow. This review summarizes critical components that control lymphatic physiology.</p>
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<title-group><article-title>LYMPHATIC VESSELS IN HEALTH AND DISEASE</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Kesler</surname>
<given-names>Cristina T.</given-names>
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<contrib contrib-type="author"><name><surname>Liao</surname>
<given-names>Shan</given-names>
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<contrib contrib-type="author"><name><surname>Munn</surname>
<given-names>Lance L.</given-names>
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<contrib contrib-type="author"><name><surname>Padera</surname>
<given-names>Timothy P.</given-names>
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<xref rid="FN1" ref-type="author-notes">*</xref>
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<aff id="A1">E. L. Steele Laboratory, Department of Radiation Oncology, Harvard Medical School and Massachusetts General Hospital, Boston, MA 02114</aff>
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<author-notes><corresp id="FN1"><label>*</label>
Correspondence: <email>tpadera@steele.mgh.harvard.edu</email>
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<year>2013</year>
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<pub-date pub-type="pmc-release"><day>01</day>
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<year>2014</year>
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<volume>5</volume>
<issue>1</issue>
<fpage>111</fpage>
<lpage>124</lpage>
<abstract><p id="P1">The lymphatic vasculature plays vital roles in tissue fluid balance, immune defense, metabolism and cancer metastasis. In adults, lymphatic vessel formation and remodeling occurs primarily during inflammation, development of the corpus luteum, wound healing, and tumor growth. Unlike the blood circulation, where unidirectional flow is sustained by the pumping actions of the heart, pumping actions intrinsic to the lymphatic vessels themselves are important drivers of lymphatic flow. This review summarizes critical components that control lymphatic physiology.</p>
</abstract>
<funding-group><award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>T32 CA073479 || CA</award-id>
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<award-group><funding-source country="United States">National Institute of Allergy and Infectious Diseases Extramural Activities : NIAID</funding-source>
<award-id>R21 AI097745 || AI</award-id>
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<award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source>
<award-id>R01 HL106584 || HL</award-id>
</award-group>
<award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R01 CA149285 || CA</award-id>
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<award-group><funding-source country="United States">National Cancer Institute : NCI</funding-source>
<award-id>R00 CA137167 || CA</award-id>
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<award-group><funding-source country="United States">Office of the Director : NIH</funding-source>
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<name sortKey="Munn, Lance L" sort="Munn, Lance L" uniqKey="Munn L" first="Lance L." last="Munn">Lance L. Munn</name>
<name sortKey="Padera, Timothy P" sort="Padera, Timothy P" uniqKey="Padera T" first="Timothy P." last="Padera">Timothy P. Padera</name>
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