Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and Inflammation
Identifieur interne : 002809 ( Pmc/Checkpoint ); précédent : 002808; suivant : 002810Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and Inflammation
Auteurs : Li-Chin Yao [États-Unis] ; Peter Baluk [États-Unis] ; R. Sathish Srinivasan [États-Unis] ; Guillermo Oliver [États-Unis] ; Donald M. Mcdonald [États-Unis]Source :
- The American Journal of Pathology [ 0002-9440 ] ; 2012.
Abstract
Endothelial cells of initial lymphatics have discontinuous button-like junctions (buttons), unlike continuous zipper-like junctions (zippers) of collecting lymphatics and blood vessels. Buttons are thought to act as primary valves for fluid and cell entry into lymphatics. To learn when and how buttons form during development and whether they change in disease, we examined the appearance of buttons in mouse embryos and their plasticity in sustained inflammation. We found that endothelial cells of lymph sacs at embryonic day (E)12.5 and tracheal lymphatics at E16.5 were joined by zippers, not buttons. However, zippers in initial lymphatics decreased rapidly just before birth, as buttons appeared. The proportion of buttons increased from only 6% at E17.5 and 12% at E18.5 to 35% at birth, 50% at postnatal day (P)7, 90% at P28, and 100% at P70. In inflammation, zippers replaced buttons in airway lymphatics at 14 and 28 days after
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DOI: 10.1016/j.ajpath.2012.02.019
PubMed: 22538088
PubMed Central: 3378913
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Endothelial cells of initial lymphatics have discontinuous button-like junctions (buttons), unlike continuous zipper-like junctions (zippers) of collecting lymphatics and blood vessels. Buttons are thought to act as primary valves for fluid and cell entry into lymphatics. To learn when and how buttons form during development and whether they change in disease, we examined the appearance of buttons in mouse embryos and their plasticity in sustained inflammation. We found that endothelial cells of lymph sacs at embryonic day (E)12.5 and tracheal lymphatics at E16.5 were joined by zippers, not buttons. However, zippers in initial lymphatics decreased rapidly just before birth, as buttons appeared. The proportion of buttons increased from only 6% at E17.5 and 12% at E18.5 to 35% at birth, 50% at postnatal day (P)7, 90% at P28, and 100% at P70. In inflammation, zippers replaced buttons in airway lymphatics at 14 and 28 days after <italic>Mycoplasma pulmonis</italic>
infection of the respiratory tract. The change in lymphatic junctions was reversed by dexamethasone but not by inhibition of vascular endothelial growth factor receptor-3 signaling by antibody mF4-31C1. Dexamethasone also promoted button formation during early postnatal development through a direct effect involving glucocorticoid receptor phosphorylation in lymphatic endothelial cells. These findings demonstrate the plasticity of intercellular junctions in lymphatics during development and inflammation and show that button formation can be promoted by glucocorticoid receptor signaling in lymphatic endothelial cells.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Am J Pathol</journal-id>
<journal-id journal-id-type="iso-abbrev">Am. J. Pathol</journal-id>
<journal-title-group><journal-title>The American Journal of Pathology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0002-9440</issn>
<issn pub-type="epub">1525-2191</issn>
<publisher><publisher-name>American Society for Investigative Pathology</publisher-name>
</publisher>
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<article-id pub-id-type="pmc">3378913</article-id>
<article-id pub-id-type="publisher-id">AJPA860</article-id>
<article-id pub-id-type="doi">10.1016/j.ajpath.2012.02.019</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Regular Article</subject>
<subj-group><subject>Vascular Biology, Atherosclerosis, and Endothelium Biology</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Plasticity of Button-Like Junctions in the Endothelium of Airway Lymphatics in Development and Inflammation</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Yao</surname>
<given-names>Li-Chin</given-names>
</name>
<xref rid="aff1" ref-type="aff">⁎</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baluk</surname>
<given-names>Peter</given-names>
</name>
<xref rid="aff1" ref-type="aff">⁎</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Srinivasan</surname>
<given-names>R. Sathish</given-names>
</name>
<xref rid="aff2" ref-type="aff">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Oliver</surname>
<given-names>Guillermo</given-names>
</name>
<xref rid="aff2" ref-type="aff">†</xref>
</contrib>
<contrib contrib-type="author"><name><surname>McDonald</surname>
<given-names>Donald M.</given-names>
</name>
<email>donald.mcdonald@ucsf.edu</email>
<xref rid="aff1" ref-type="aff">⁎</xref>
<xref rid="cor1" ref-type="corresp">⁎</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>⁎</label>
Department of Anatomy, Cardiovascular Research Institute, and the Comprehensive Cancer Center, University of California, San Francisco, California</aff>
<aff id="aff2"><label>†</label>
Department of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, Tennessee</aff>
<author-notes><corresp id="cor1"><label>⁎</label>
Address reprint requests to Donald M. McDonald, M.D., Ph.D., Department of Anatomy, University of California, 513 Parnassus Ave., Room S1349, San Francisco, CA 94143-0452 <email>donald.mcdonald@ucsf.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="ppub"><month>6</month>
<year>2012</year>
</pub-date>
<volume>180</volume>
<issue>6</issue>
<fpage>2561</fpage>
<lpage>2575</lpage>
<history><date date-type="accepted"><day>9</day>
<month>2</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© 2012 American Society for Investigative Pathology. Published by Elsevier Inc. All rights reserved.</copyright-statement>
<copyright-year>2012</copyright-year>
<copyright-holder>American Society for Investigative Pathology</copyright-holder>
<license><license-p>This document may be redistributed and reused, subject to <ext-link ext-link-type="uri" xlink:href="http://www.elsevier.com/wps/find/authorsview.authors/supplementalterms1.0">certain conditions</ext-link>
.</license-p>
</license>
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<abstract><p>Endothelial cells of initial lymphatics have discontinuous button-like junctions (buttons), unlike continuous zipper-like junctions (zippers) of collecting lymphatics and blood vessels. Buttons are thought to act as primary valves for fluid and cell entry into lymphatics. To learn when and how buttons form during development and whether they change in disease, we examined the appearance of buttons in mouse embryos and their plasticity in sustained inflammation. We found that endothelial cells of lymph sacs at embryonic day (E)12.5 and tracheal lymphatics at E16.5 were joined by zippers, not buttons. However, zippers in initial lymphatics decreased rapidly just before birth, as buttons appeared. The proportion of buttons increased from only 6% at E17.5 and 12% at E18.5 to 35% at birth, 50% at postnatal day (P)7, 90% at P28, and 100% at P70. In inflammation, zippers replaced buttons in airway lymphatics at 14 and 28 days after <italic>Mycoplasma pulmonis</italic>
infection of the respiratory tract. The change in lymphatic junctions was reversed by dexamethasone but not by inhibition of vascular endothelial growth factor receptor-3 signaling by antibody mF4-31C1. Dexamethasone also promoted button formation during early postnatal development through a direct effect involving glucocorticoid receptor phosphorylation in lymphatic endothelial cells. These findings demonstrate the plasticity of intercellular junctions in lymphatics during development and inflammation and show that button formation can be promoted by glucocorticoid receptor signaling in lymphatic endothelial cells.</p>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
<li>Tennessee</li>
</region>
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</region>
<name sortKey="Baluk, Peter" sort="Baluk, Peter" uniqKey="Baluk P" first="Peter" last="Baluk">Peter Baluk</name>
<name sortKey="Mcdonald, Donald M" sort="Mcdonald, Donald M" uniqKey="Mcdonald D" first="Donald M." last="Mcdonald">Donald M. Mcdonald</name>
<name sortKey="Oliver, Guillermo" sort="Oliver, Guillermo" uniqKey="Oliver G" first="Guillermo" last="Oliver">Guillermo Oliver</name>
<name sortKey="Srinivasan, R Sathish" sort="Srinivasan, R Sathish" uniqKey="Srinivasan R" first="R. Sathish" last="Srinivasan">R. Sathish Srinivasan</name>
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