Possible Genetic Predisposition to Lymphedema after Breast Cancer
Identifieur interne : 002806 ( Pmc/Checkpoint ); précédent : 002805; suivant : 002807Possible Genetic Predisposition to Lymphedema after Breast Cancer
Auteurs : Beth Newman ; Felicity Lose ; Mary-Anne Kedda ; Mathias Francois ; Kaltin Ferguson ; Monika Janda ; Patsy Yates ; Amanda B. Spurdle ; Sandra C. HayesSource :
- Lymphatic Research and Biology [ 1539-6851 ] ; 2012.
Abstract
Known risk factors for secondary lymphedema only partially explain who develops lymphedema following cancer, suggesting that inherited genetic susceptibility may influence risk. Moreover, identification of molecular signatures could facilitate lymphedema risk prediction prior to surgery or lead to effective drug therapies for prevention or treatment. Recent advances in the molecular biology underlying development of the lymphatic system and related congenital disorders implicate a number of potential candidate genes to explore in relation to secondary lymphedema.
We undertook a nested case-control study, with participants who had developed lymphedema after surgical intervention within the first 18 months of their breast cancer diagnosis serving as cases (
These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets.
Url:
DOI: 10.1089/lrb.2011.0024
PubMed: 22404826
PubMed Central: 3311400
Affiliations:
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Spurdle</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Hayes, Sandra C" sort="Hayes, Sandra C" uniqKey="Hayes S" first="Sandra C." last="Hayes">Sandra C. Hayes</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">22404826</idno><idno type="pmc">3311400</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3311400</idno><idno type="RBID">PMC:3311400</idno><idno type="doi">10.1089/lrb.2011.0024</idno><date when="2012">2012</date><idno type="wicri:Area/Pmc/Corpus">003019</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">003019</idno><idno type="wicri:Area/Pmc/Curation">003018</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">003018</idno><idno type="wicri:Area/Pmc/Checkpoint">002806</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002806</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Possible Genetic Predisposition to Lymphedema after Breast Cancer</title><author><name sortKey="Newman, Beth" sort="Newman, Beth" uniqKey="Newman B" first="Beth" last="Newman">Beth Newman</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Lose, Felicity" sort="Lose, Felicity" uniqKey="Lose F" first="Felicity" last="Lose">Felicity Lose</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Kedda, Mary Anne" sort="Kedda, Mary Anne" uniqKey="Kedda M" first="Mary-Anne" last="Kedda">Mary-Anne Kedda</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Francois, Mathias" sort="Francois, Mathias" uniqKey="Francois M" first="Mathias" last="Francois">Mathias Francois</name><affiliation><nlm:aff id="aff3"></nlm:aff></affiliation></author><author><name sortKey="Ferguson, Kaltin" sort="Ferguson, Kaltin" uniqKey="Ferguson K" first="Kaltin" last="Ferguson">Kaltin Ferguson</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Janda, Monika" sort="Janda, Monika" uniqKey="Janda M" first="Monika" last="Janda">Monika Janda</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author><author><name sortKey="Yates, Patsy" sort="Yates, Patsy" uniqKey="Yates P" first="Patsy" last="Yates">Patsy Yates</name><affiliation><nlm:aff id="aff4"></nlm:aff></affiliation></author><author><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><affiliation><nlm:aff id="aff2"></nlm:aff></affiliation></author><author><name sortKey="Hayes, Sandra C" sort="Hayes, Sandra C" uniqKey="Hayes S" first="Sandra C." last="Hayes">Sandra C. Hayes</name><affiliation><nlm:aff id="aff1"></nlm:aff></affiliation></author></analytic><series><title level="j">Lymphatic Research and Biology</title><idno type="ISSN">1539-6851</idno><idno type="eISSN">1557-8585</idno><imprint><date when="2012">2012</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>Abstract</title><sec><title>Background</title><p>Known risk factors for secondary lymphedema only partially explain who develops lymphedema following cancer, suggesting that inherited genetic susceptibility may influence risk. Moreover, identification of molecular signatures could facilitate lymphedema risk prediction prior to surgery or lead to effective drug therapies for prevention or treatment. Recent advances in the molecular biology underlying development of the lymphatic system and related congenital disorders implicate a number of potential candidate genes to explore in relation to secondary lymphedema.</p></sec><sec><title>Methods and Results</title><p>We undertook a nested case-control study, with participants who had developed lymphedema after surgical intervention within the first 18 months of their breast cancer diagnosis serving as cases (<italic>n</italic>=22) and those without lymphedema serving as controls (<italic>n</italic>=98), identified from a prospective, population-based, cohort study in Queensland, Australia. TagSNPs that covered all known genetic variation in the genes <italic>SOX18</italic>, <italic>VEGFC</italic>, <italic>VEGFD</italic>, <italic>VEGFR2, VEGFR3</italic>, <italic>RORC</italic>, <italic>FOXC2, LYVE1, ADM,</italic> and <italic>PROX1</italic> were selected for genotyping. Multiple SNPs within three receptor genes, <italic>VEGFR2, VEGFR3,</italic> and <italic>RORC</italic>, were associated with lymphedema defined by statistical significance (<italic>p</italic><0.05) or extreme risk estimates (OR <0.5 or >2.0).</p></sec><sec><title>Conclusions</title><p>These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets.</p></sec></div></front></TEI><pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Lymphat Res Biol</journal-id><journal-id journal-id-type="iso-abbrev">Lymphat Res Biol</journal-id><journal-id journal-id-type="publisher-id">lrb</journal-id><journal-title-group><journal-title>Lymphatic Research and Biology</journal-title></journal-title-group><issn pub-type="ppub">1539-6851</issn><issn pub-type="epub">1557-8585</issn><publisher><publisher-name>Mary Ann Liebert, Inc.</publisher-name><publisher-loc>140 Huguenot Street, 3rd FloorNew Rochelle, NY 10801USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">22404826</article-id><article-id pub-id-type="pmc">3311400</article-id><article-id pub-id-type="publisher-id">10.1089/lrb.2011.0024</article-id><article-id pub-id-type="doi">10.1089/lrb.2011.0024</article-id><article-categories><subj-group subj-group-type="heading"><subject>Original Articles</subject></subj-group></article-categories><title-group><article-title>Possible Genetic Predisposition to Lymphedema after Breast Cancer</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Newman</surname><given-names>Beth</given-names></name><degrees>Ph.D.</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Lose</surname><given-names>Felicity</given-names></name><degrees>Ph.D.</degrees><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kedda</surname><given-names>Mary-Anne</given-names></name><degrees>Ph.D.</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Francois</surname><given-names>Mathias</given-names></name><degrees>Ph.D.</degrees><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ferguson</surname><given-names>Kaltin</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Janda</surname><given-names>Monika</given-names></name><degrees>Ph.D.</degrees><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Yates</surname><given-names>Patsy</given-names></name><degrees>Ph.D.</degrees><xref ref-type="aff" rid="aff4"><sup>4</sup></xref></contrib><contrib contrib-type="author"><name><surname>Spurdle</surname><given-names>Amanda B.</given-names></name><degrees>Ph.D.</degrees><xref ref-type="aff" rid="aff2"><sup>2,</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>*</sup></xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Hayes</surname><given-names>Sandra C.</given-names></name><degrees>PhD</degrees><xref ref-type="aff" rid="aff1"><sup>1,</sup></xref><xref ref-type="author-notes" rid="fn1"><sup>*</sup></xref></contrib><aff id="aff1"><label><sup>1</sup></label>Institute of Health and Biomedical Innovation and School of Public Health,<institution>Queensland University of Technology</institution>, Brisbane,<country>Australia</country>.</aff><aff id="aff2"><label><sup>2</sup></label>Molecular Cancer Epidemiology Laboratory, Genetics and Population Health Division,<institution>Queensland Institute of Medical Research</institution>, Brisbane,<country>Australia</country>.</aff><aff id="aff3"><label><sup>3</sup></label>Institute of Molecular Bioscience,<institution>University of Queensland</institution>, Brisbane,<country>Australia</country>.</aff><aff id="aff4"><label><sup>4</sup></label>Institute of Health and Biomedical Innovation and School of Nursing,<institution>Queensland University of Technology</institution>, Brisbane,<country>Australia</country>.</aff></contrib-group><author-notes><corresp>Address correspondence to: <italic>Sandra C. Hayes, Ph.D., School of Public Health, Queensland University of Technology, Victoria Park Road, Kelvin Grove, Brisbane, Queensland, 4059, Australia. E-mail:</italic><email xlink:href="mailto:sc.hayes@qut.edu.au">sc.hayes@qut.edu.au</email></corresp><fn id="fn1" fn-type="other"><label><sup>*</sup></label><p>ABS led laboratory-related activities, while SCH led field-related activities.</p></fn></author-notes><pub-date pub-type="ppub"><month>3</month><year>2012</year><pmc-comment>string-date: March 2012</pmc-comment>
</pub-date><pub-date pub-type="pmc-release"><month>3</month><year>2012</year><pmc-comment>string-date: March 2012</pmc-comment>
</pub-date><pmc-comment> PMC Release delay is 0 months and 0 days and was based on the
<volume>10</volume><issue>1</issue><fpage>2</fpage><lpage>13</lpage><permissions><copyright-statement>Copyright 2012, Mary Ann Liebert, Inc.</copyright-statement><copyright-year>2012</copyright-year></permissions><self-uri xlink:type="simple" xlink:href="lrb.2011.0024.pdf"></self-uri><abstract><title>Abstract</title><sec><title>Background</title><p>Known risk factors for secondary lymphedema only partially explain who develops lymphedema following cancer, suggesting that inherited genetic susceptibility may influence risk. Moreover, identification of molecular signatures could facilitate lymphedema risk prediction prior to surgery or lead to effective drug therapies for prevention or treatment. Recent advances in the molecular biology underlying development of the lymphatic system and related congenital disorders implicate a number of potential candidate genes to explore in relation to secondary lymphedema.</p></sec><sec><title>Methods and Results</title><p>We undertook a nested case-control study, with participants who had developed lymphedema after surgical intervention within the first 18 months of their breast cancer diagnosis serving as cases (<italic>n</italic>=22) and those without lymphedema serving as controls (<italic>n</italic>=98), identified from a prospective, population-based, cohort study in Queensland, Australia. TagSNPs that covered all known genetic variation in the genes <italic>SOX18</italic>, <italic>VEGFC</italic>, <italic>VEGFD</italic>, <italic>VEGFR2, VEGFR3</italic>, <italic>RORC</italic>, <italic>FOXC2, LYVE1, ADM,</italic> and <italic>PROX1</italic> were selected for genotyping. Multiple SNPs within three receptor genes, <italic>VEGFR2, VEGFR3,</italic> and <italic>RORC</italic>, were associated with lymphedema defined by statistical significance (<italic>p</italic><0.05) or extreme risk estimates (OR <0.5 or >2.0).</p></sec><sec><title>Conclusions</title><p>These provocative, albeit preliminary, findings regarding possible genetic predisposition to secondary lymphedema following breast cancer treatment warrant further attention for potential replication using larger datasets.</p></sec></abstract><counts><table-count count="3"></table-count><ref-count count="47"></ref-count><page-count count="12"></page-count></counts></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="Ferguson, Kaltin" sort="Ferguson, Kaltin" uniqKey="Ferguson K" first="Kaltin" last="Ferguson">Kaltin Ferguson</name><name sortKey="Francois, Mathias" sort="Francois, Mathias" uniqKey="Francois M" first="Mathias" last="Francois">Mathias Francois</name><name sortKey="Hayes, Sandra C" sort="Hayes, Sandra C" uniqKey="Hayes S" first="Sandra C." last="Hayes">Sandra C. Hayes</name><name sortKey="Janda, Monika" sort="Janda, Monika" uniqKey="Janda M" first="Monika" last="Janda">Monika Janda</name><name sortKey="Kedda, Mary Anne" sort="Kedda, Mary Anne" uniqKey="Kedda M" first="Mary-Anne" last="Kedda">Mary-Anne Kedda</name><name sortKey="Lose, Felicity" sort="Lose, Felicity" uniqKey="Lose F" first="Felicity" last="Lose">Felicity Lose</name><name sortKey="Newman, Beth" sort="Newman, Beth" uniqKey="Newman B" first="Beth" last="Newman">Beth Newman</name><name sortKey="Spurdle, Amanda B" sort="Spurdle, Amanda B" uniqKey="Spurdle A" first="Amanda B." last="Spurdle">Amanda B. Spurdle</name><name sortKey="Yates, Patsy" sort="Yates, Patsy" uniqKey="Yates P" first="Patsy" last="Yates">Patsy Yates</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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