Tobacco Assessment in Actively Accruing National Cancer Institute Cooperative Group Program Clinical Trials
Identifieur interne : 002633 ( Pmc/Checkpoint ); précédent : 002632; suivant : 002634Tobacco Assessment in Actively Accruing National Cancer Institute Cooperative Group Program Clinical Trials
Auteurs : Erica N. Peters ; Essie Torres ; Benjamin A. Toll ; K. Michael Cummings ; Ellen R. Gritz ; Andrew Hyland ; Roy S. Herbst ; James R. Marshall ; Graham W. WarrenSource :
- Journal of Clinical Oncology [ 0732-183X ] ; 2012.
Abstract
Substantial evidence suggests that tobacco use has adverse effects on cancer treatment outcomes; however, routine assessment of tobacco use has not been fully incorporated into standard clinical oncology practice. The purpose of this study was to evaluate tobacco use assessment in patients enrolled onto actively accruing cancer clinical trials.
Protocols and forms for 155 actively accruing trials in the National Cancer Institute's (NCI's) Clinical Trials Cooperative Group Program were evaluated for tobacco use assessment at enrollment and follow-up by using a structured coding instrument.
Of the 155 clinical trials reviewed, 45 (29%) assessed any form of tobacco use at enrollment, but only 34 (21.9%) assessed current cigarette use. Only seven trials (4.5%) assessed any form of tobacco use during follow-up. Secondhand smoke exposure was captured in 2.6% of trials at enrollment and 0.6% during follow-up. None of the trials assessed nicotine dependence or interest in quitting at any point during enrollment or treatment. Tobacco status assessment was higher in lung/head and neck trials as well as phase III trials, but there was no difference according to year of starting accrual or cooperative group.
Most actively accruing cooperative group clinical trials do not assess tobacco use, and there is no observable trend in improvement over the past 8 years. Failure to incorporate standardized tobacco assessments into NCI-funded Cooperative Group Clinical Trials will limit the ability to provide evidence-based cessation support and will limit the ability to accurately understand the precise effect of tobacco use on cancer treatment outcomes.
Url:
DOI: 10.1200/JCO.2011.40.8815
PubMed: 22689794
PubMed Central: 3410402
Affiliations:
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Tobacco Assessment in Actively Accruing National Cancer Institute Cooperative Group Program Clinical Trials</title>
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<author><name sortKey="Toll, Benjamin A" sort="Toll, Benjamin A" uniqKey="Toll B" first="Benjamin A." last="Toll">Benjamin A. Toll</name>
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<author><name sortKey="Herbst, Roy S" sort="Herbst, Roy S" uniqKey="Herbst R" first="Roy S." last="Herbst">Roy S. Herbst</name>
<affiliation><nlm:aff id="aff1">Erica N. Peters and Roy S. Herbst, Yale University School of Medicine; Benjamin A. Toll and Roy S. Herbst, Smilow Cancer Hospital at Yale-New Haven and Yale Cancer Center, New Haven, CT; Essie Torres, Andrew Hyland, James R. Marshall, and Graham W. Warren, Roswell Park Cancer Institute, Buffalo, NY; K. Michael Cummings, Medical University of South Carolina, Charleston, SC; and Ellen R. Gritz, The University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:aff>
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<author><name sortKey="Marshall, James R" sort="Marshall, James R" uniqKey="Marshall J" first="James R." last="Marshall">James R. Marshall</name>
<affiliation><nlm:aff id="aff1">Erica N. Peters and Roy S. Herbst, Yale University School of Medicine; Benjamin A. Toll and Roy S. Herbst, Smilow Cancer Hospital at Yale-New Haven and Yale Cancer Center, New Haven, CT; Essie Torres, Andrew Hyland, James R. Marshall, and Graham W. Warren, Roswell Park Cancer Institute, Buffalo, NY; K. Michael Cummings, Medical University of South Carolina, Charleston, SC; and Ellen R. Gritz, The University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:aff>
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<author><name sortKey="Warren, Graham W" sort="Warren, Graham W" uniqKey="Warren G" first="Graham W." last="Warren">Graham W. Warren</name>
<affiliation><nlm:aff id="aff1">Erica N. Peters and Roy S. Herbst, Yale University School of Medicine; Benjamin A. Toll and Roy S. Herbst, Smilow Cancer Hospital at Yale-New Haven and Yale Cancer Center, New Haven, CT; Essie Torres, Andrew Hyland, James R. Marshall, and Graham W. Warren, Roswell Park Cancer Institute, Buffalo, NY; K. Michael Cummings, Medical University of South Carolina, Charleston, SC; and Ellen R. Gritz, The University of Texas MD Anderson Cancer Center, Houston, TX.</nlm:aff>
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<series><title level="j">Journal of Clinical Oncology</title>
<idno type="ISSN">0732-183X</idno>
<idno type="eISSN">1527-7755</idno>
<imprint><date when="2012">2012</date>
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<front><div type="abstract" xml:lang="en"><sec><title>Purpose</title>
<p>Substantial evidence suggests that tobacco use has adverse effects on cancer treatment outcomes; however, routine assessment of tobacco use has not been fully incorporated into standard clinical oncology practice. The purpose of this study was to evaluate tobacco use assessment in patients enrolled onto actively accruing cancer clinical trials.</p>
</sec>
<sec><title>Methods</title>
<p>Protocols and forms for 155 actively accruing trials in the National Cancer Institute's (NCI's) Clinical Trials Cooperative Group Program were evaluated for tobacco use assessment at enrollment and follow-up by using a structured coding instrument.</p>
</sec>
<sec><title>Results</title>
<p>Of the 155 clinical trials reviewed, 45 (29%) assessed any form of tobacco use at enrollment, but only 34 (21.9%) assessed current cigarette use. Only seven trials (4.5%) assessed any form of tobacco use during follow-up. Secondhand smoke exposure was captured in 2.6% of trials at enrollment and 0.6% during follow-up. None of the trials assessed nicotine dependence or interest in quitting at any point during enrollment or treatment. Tobacco status assessment was higher in lung/head and neck trials as well as phase III trials, but there was no difference according to year of starting accrual or cooperative group.</p>
</sec>
<sec><title>Conclusion</title>
<p>Most actively accruing cooperative group clinical trials do not assess tobacco use, and there is no observable trend in improvement over the past 8 years. Failure to incorporate standardized tobacco assessments into NCI-funded Cooperative Group Clinical Trials will limit the ability to provide evidence-based cessation support and will limit the ability to accurately understand the precise effect of tobacco use on cancer treatment outcomes.</p>
</sec>
</div>
</front>
</TEI>
<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<front><journal-meta><journal-id journal-id-type="nlm-ta">J Clin Oncol</journal-id>
<journal-id journal-id-type="iso-abbrev">J. Clin. Oncol</journal-id>
<journal-id journal-id-type="hwp">jco</journal-id>
<journal-id journal-id-type="pmc">jco</journal-id>
<journal-id journal-id-type="publisher-id">JCO</journal-id>
<journal-title-group><journal-title>Journal of Clinical Oncology</journal-title>
</journal-title-group>
<issn pub-type="ppub">0732-183X</issn>
<issn pub-type="epub">1527-7755</issn>
<publisher><publisher-name>American Society of Clinical Oncology</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">22689794</article-id>
<article-id pub-id-type="pmc">3410402</article-id>
<article-id pub-id-type="publisher-id">08815</article-id>
<article-id pub-id-type="doi">10.1200/JCO.2011.40.8815</article-id>
<article-categories><subj-group subj-group-type="hwp-journal-coll"><subject>Epid3</subject>
<subject>Psc12</subject>
</subj-group>
<subj-group subj-group-type="heading"><subject>Original Reports</subject>
<subj-group><subject>Cancer Prevention and Control</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Tobacco Assessment in Actively Accruing National Cancer Institute Cooperative Group Program Clinical Trials</article-title>
<alt-title alt-title-type="short">Tobacco Assessment in Clinical Trials</alt-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Peters</surname>
<given-names>Erica N.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Torres</surname>
<given-names>Essie</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Toll</surname>
<given-names>Benjamin A.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Cummings</surname>
<given-names>K. Michael</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Gritz</surname>
<given-names>Ellen R.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Hyland</surname>
<given-names>Andrew</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Herbst</surname>
<given-names>Roy S.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Marshall</surname>
<given-names>James R.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
</contrib>
<contrib contrib-type="author"><name><surname>Warren</surname>
<given-names>Graham W.</given-names>
</name>
<xref ref-type="aff" rid="aff1"></xref>
<xref ref-type="corresp" rid="cor1"></xref>
</contrib>
<aff id="aff1">Erica N. Peters and Roy S. Herbst, Yale University School of Medicine; Benjamin A. Toll and Roy S. Herbst, Smilow Cancer Hospital at Yale-New Haven and Yale Cancer Center, New Haven, CT; Essie Torres, Andrew Hyland, James R. Marshall, and Graham W. Warren, Roswell Park Cancer Institute, Buffalo, NY; K. Michael Cummings, Medical University of South Carolina, Charleston, SC; and Ellen R. Gritz, The University of Texas MD Anderson Cancer Center, Houston, TX.</aff>
</contrib-group>
<author-notes><corresp id="cor1">Corresponding author: Graham W. Warren, MD, PhD, Department of Radiation Medicine, Roswell Park Cancer Institute, Elm & Carlton St, Buffalo, NY 14052; e-mail: <email>graham.warren@roswellpark.org</email>
.</corresp>
</author-notes>
<pub-date pub-type="ppub"><day>10</day>
<month>8</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="epub"><day>11</day>
<month>6</month>
<year>2012</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>10</day>
<month>8</month>
<year>2013</year>
</pub-date>
<pmc-comment> PMC Release delay is 12 months and 0 days and was based on the
. </pmc-comment>
<volume>30</volume>
<issue>23</issue>
<fpage>2869</fpage>
<lpage>2875</lpage>
<history><date date-type="received"><day>23</day>
<month>11</month>
<year>2011</year>
</date>
<date date-type="accepted"><day>27</day>
<month>4</month>
<year>2012</year>
</date>
</history>
<permissions><copyright-statement>© 2012 by American Society of Clinical Oncology</copyright-statement>
<copyright-year>2012</copyright-year>
</permissions>
<self-uri xlink:title="pdf" xlink:type="simple" xlink:href="zlj02312002869.pdf"></self-uri>
<abstract><sec><title>Purpose</title>
<p>Substantial evidence suggests that tobacco use has adverse effects on cancer treatment outcomes; however, routine assessment of tobacco use has not been fully incorporated into standard clinical oncology practice. The purpose of this study was to evaluate tobacco use assessment in patients enrolled onto actively accruing cancer clinical trials.</p>
</sec>
<sec><title>Methods</title>
<p>Protocols and forms for 155 actively accruing trials in the National Cancer Institute's (NCI's) Clinical Trials Cooperative Group Program were evaluated for tobacco use assessment at enrollment and follow-up by using a structured coding instrument.</p>
</sec>
<sec><title>Results</title>
<p>Of the 155 clinical trials reviewed, 45 (29%) assessed any form of tobacco use at enrollment, but only 34 (21.9%) assessed current cigarette use. Only seven trials (4.5%) assessed any form of tobacco use during follow-up. Secondhand smoke exposure was captured in 2.6% of trials at enrollment and 0.6% during follow-up. None of the trials assessed nicotine dependence or interest in quitting at any point during enrollment or treatment. Tobacco status assessment was higher in lung/head and neck trials as well as phase III trials, but there was no difference according to year of starting accrual or cooperative group.</p>
</sec>
<sec><title>Conclusion</title>
<p>Most actively accruing cooperative group clinical trials do not assess tobacco use, and there is no observable trend in improvement over the past 8 years. Failure to incorporate standardized tobacco assessments into NCI-funded Cooperative Group Clinical Trials will limit the ability to provide evidence-based cessation support and will limit the ability to accurately understand the precise effect of tobacco use on cancer treatment outcomes.</p>
</sec>
</abstract>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Cummings, K Michael" sort="Cummings, K Michael" uniqKey="Cummings K" first="K. Michael" last="Cummings">K. Michael Cummings</name>
<name sortKey="Gritz, Ellen R" sort="Gritz, Ellen R" uniqKey="Gritz E" first="Ellen R." last="Gritz">Ellen R. Gritz</name>
<name sortKey="Herbst, Roy S" sort="Herbst, Roy S" uniqKey="Herbst R" first="Roy S." last="Herbst">Roy S. Herbst</name>
<name sortKey="Hyland, Andrew" sort="Hyland, Andrew" uniqKey="Hyland A" first="Andrew" last="Hyland">Andrew Hyland</name>
<name sortKey="Marshall, James R" sort="Marshall, James R" uniqKey="Marshall J" first="James R." last="Marshall">James R. Marshall</name>
<name sortKey="Peters, Erica N" sort="Peters, Erica N" uniqKey="Peters E" first="Erica N." last="Peters">Erica N. Peters</name>
<name sortKey="Toll, Benjamin A" sort="Toll, Benjamin A" uniqKey="Toll B" first="Benjamin A." last="Toll">Benjamin A. Toll</name>
<name sortKey="Torres, Essie" sort="Torres, Essie" uniqKey="Torres E" first="Essie" last="Torres">Essie Torres</name>
<name sortKey="Warren, Graham W" sort="Warren, Graham W" uniqKey="Warren G" first="Graham W." last="Warren">Graham W. Warren</name>
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