Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis
Identifieur interne : 002503 ( Pmc/Checkpoint ); précédent : 002502; suivant : 002504Anti-Wolbachia drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis
Auteurs : Mark J. Taylor [Royaume-Uni] ; Achim Hoerauf [Allemagne] ; Simon Townson [Royaume-Uni] ; Barton E. Slatko [États-Unis] ; Stephen A. Ward [Royaume-Uni]Source :
- Parasitology [ 0031-1820 ] ; 2013.
Abstract
Anti-
Url:
DOI: 10.1017/S0031182013001108
PubMed: 23866958
PubMed Central: 3884836
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3884836Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-<italic>Wolbachia</italic> drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis</title><author><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J." last="Taylor">Mark J. Taylor</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Liverpool School of Tropical Medicine</institution>,<addr-line>Pembroke Place, Liverpool, L3 5QA</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute for Medical Microbiology, Immunology and Parasitology</addr-line>,<institution>University Hospital Bonn</institution>,<addr-line>Sigmund-Freud-Strasse 25, 53105 Bonn</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Townson, Simon" sort="Townson, Simon" uniqKey="Townson S" first="Simon" last="Townson">Simon Townson</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Tropical Parasitic Diseases Unit</addr-line>,<institution>Northwick Park Institute for Medical Research</institution>,<addr-line>Watford Road, Harrow, Middlesex HA1 3UJ</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slatko, Barton E" sort="Slatko, Barton E" uniqKey="Slatko B" first="Barton E." last="Slatko">Barton E. Slatko</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>New England Biolabs, Inc., 240 County Road, Ipswich, MA 01938</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Liverpool School of Tropical Medicine</institution>,<addr-line>Pembroke Place, Liverpool, L3 5QA</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23866958</idno><idno type="pmc">3884836</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3884836</idno><idno type="RBID">PMC:3884836</idno><idno type="doi">10.1017/S0031182013001108</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">004554</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">004554</idno><idno type="wicri:Area/Pmc/Curation">004553</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">004553</idno><idno type="wicri:Area/Pmc/Checkpoint">002503</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002503</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-<italic>Wolbachia</italic> drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis</title><author><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J." last="Taylor">Mark J. Taylor</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Liverpool School of Tropical Medicine</institution>,<addr-line>Pembroke Place, Liverpool, L3 5QA</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Institute for Medical Microbiology, Immunology and Parasitology</addr-line>,<institution>University Hospital Bonn</institution>,<addr-line>Sigmund-Freud-Strasse 25, 53105 Bonn</addr-line>,<country>Germany</country></nlm:aff><country xml:lang="fr">Allemagne</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Townson, Simon" sort="Townson, Simon" uniqKey="Townson S" first="Simon" last="Townson">Simon Townson</name><affiliation wicri:level="1"><nlm:aff id="aff3"><addr-line>Tropical Parasitic Diseases Unit</addr-line>,<institution>Northwick Park Institute for Medical Research</institution>,<addr-line>Watford Road, Harrow, Middlesex HA1 3UJ</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Slatko, Barton E" sort="Slatko, Barton E" uniqKey="Slatko B" first="Barton E." last="Slatko">Barton E. Slatko</name><affiliation wicri:level="1"><nlm:aff id="aff4"><addr-line>New England Biolabs, Inc., 240 County Road, Ipswich, MA 01938</addr-line>,<country>USA</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Liverpool School of Tropical Medicine</institution>,<addr-line>Pembroke Place, Liverpool, L3 5QA</addr-line>,<country>UK</country></nlm:aff><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Parasitology</title><idno type="ISSN">0031-1820</idno><idno type="eISSN">1469-8161</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><title>SUMMARY</title><p>Anti-<italic>Wolbachia</italic> therapy delivers safe macrofilaricidal activity with superior therapeutic outcomes compared to all standard anti-filarial treatments, with the added benefit of substantial improvements in clinical pathology. These outcomes can be achieved, in principle, with existing registered drugs, e.g. doxycycline, that are affordable, available to endemic communities and have well known, albeit population-limiting, safety profiles. The key barriers to using doxycycline as an mass drug administration (MDA) strategy for widespread community-based control are the logistics of a relatively lengthy course of treatment (4–6 weeks) and contraindications in children under eight years and pregnancy. Therefore, the primary goal of the anti-<italic>Wolbachia</italic> (A·WOL) consortium is to find drugs and regimens that reduce the period of treatment from weeks to days (7 days or less), and to find drugs which would be safe in excluded target populations (pregnancy and children). A secondary goal is to refine regimens of existing antibiotics suitable for a more restricted use, prior to the availability of a regimen that is compatible with MDA usage. For example, for use in the event of the emergence of drug-resistance, in individuals with high loiasis co-infection and at risk of severe adverse events (SAE) to ivermectin, or in post-MDA ‘endgame scenarios’, where test and treat strategies become more cost effective and deliverable.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Amazigo, U" uniqKey="Amazigo U">U. Amazigo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ash, L R" uniqKey="Ash L">L. R. Ash</name></author><author><name sortKey="Riley, J M" uniqKey="Riley J">J. M. Riley</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bockarie, M J" uniqKey="Bockarie M">M. J. Bockarie</name></author><author><name sortKey="Deb, R" uniqKey="Deb R">R. Deb</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chu, B K" uniqKey="Chu B">B. K. 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Harry</name></author><author><name sortKey="Dailey, H A" uniqKey="Dailey H">H. A. Dailey</name></author><author><name sortKey="Landmann, F" uniqKey="Landmann F">F. Landmann</name></author><author><name sortKey="Ford, L" uniqKey="Ford L">L. Ford</name></author><author><name sortKey="Taylor, M J" uniqKey="Taylor M">M. J. Taylor</name></author><author><name sortKey="Carlow, C K S" uniqKey="Carlow C">C. K. S. Carlow</name></author><author><name sortKey="Foster, J M" uniqKey="Foster J">J. M. Foster</name></author><author><name sortKey="Slatko, B E" uniqKey="Slatko B">B. E. Slatko</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Parasitology</journal-id><journal-id journal-id-type="iso-abbrev">Parasitology</journal-id><journal-id journal-id-type="publisher-id">PAR</journal-id><journal-title-group><journal-title>Parasitology</journal-title></journal-title-group><issn pub-type="ppub">0031-1820</issn><issn pub-type="epub">1469-8161</issn><publisher><publisher-name>Cambridge University Press</publisher-name><publisher-loc>Cambridge, UK</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23866958</article-id><article-id pub-id-type="pmc">3884836</article-id><article-id pub-id-type="doi">10.1017/S0031182013001108</article-id><article-id pub-id-type="pii">S0031182013001108</article-id><article-id pub-id-type="publisher-id">00110</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group></article-categories><title-group><article-title>Anti-<italic>Wolbachia</italic> drug discovery and development: safe macrofilaricides for onchocerciasis and lymphatic filariasis</article-title><alt-title alt-title-type="left-running">Mark J. Taylor and others</alt-title><alt-title alt-title-type="right-running">A·WOL drug discovery and development</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>TAYLOR</surname><given-names>MARK J.</given-names></name><xref ref-type="aff" rid="aff1">1</xref><xref ref-type="corresp" rid="cor1">*</xref></contrib><contrib contrib-type="author"><name><surname>HOERAUF</surname><given-names>ACHIM</given-names></name><xref ref-type="aff" rid="aff2">2</xref></contrib><contrib contrib-type="author"><name><surname>TOWNSON</surname><given-names>SIMON</given-names></name><xref ref-type="aff" rid="aff3">3</xref></contrib><contrib contrib-type="author"><name><surname>SLATKO</surname><given-names>BARTON E.</given-names></name><xref ref-type="aff" rid="aff4">4</xref></contrib><contrib contrib-type="author"><name><surname>WARD</surname><given-names>STEPHEN A.</given-names></name><xref ref-type="aff" rid="aff1">1</xref></contrib></contrib-group><contrib-group><contrib contrib-type="editor"><name><surname>Barrett</surname><given-names>Michael P.</given-names></name></contrib><contrib contrib-type="editor"><name><surname>Croft</surname><given-names>Simon L.</given-names></name></contrib><role>Guest Editors</role></contrib-group><aff id="aff1"><label>1</label><institution>Liverpool School of Tropical Medicine</institution>,<addr-line>Pembroke Place, Liverpool, L3 5QA</addr-line>,<country>UK</country></aff><aff id="aff2"><label>2</label><addr-line>Institute for Medical Microbiology, Immunology and Parasitology</addr-line>,<institution>University Hospital Bonn</institution>,<addr-line>Sigmund-Freud-Strasse 25, 53105 Bonn</addr-line>,<country>Germany</country></aff><aff id="aff3"><label>3</label><addr-line>Tropical Parasitic Diseases Unit</addr-line>,<institution>Northwick Park Institute for Medical Research</institution>,<addr-line>Watford Road, Harrow, Middlesex HA1 3UJ</addr-line>,<country>UK</country></aff><aff id="aff4"><label>4</label><addr-line>New England Biolabs, Inc., 240 County Road, Ipswich, MA 01938</addr-line>,<country>USA</country></aff><author-notes><corresp id="cor1"><label>*</label><addr-line>Corresponding author: Head of Parasitology Department</addr-line>, <institution>Liverpool School of Tropical Medicine</institution>, <addr-line>Liverpool, L3 5QA</addr-line>, <country>UK</country>. Tel: <phone>0044 (0)151 705 3112</phone>. Fax: <fax>0044 (0)151 705 3371</fax>. E-mail: <email>mark.taylor@liv.ac.uk</email></corresp></author-notes><pub-date pub-type="ppub"><month>1</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>18</day><month>7</month><year>2013</year></pub-date><volume>141</volume><issue>1</issue><issue-title content-type="special_issue">Symposia of the British Society for Parasitology volume 49 Emerging paradigms in anti-infective drug design</issue-title><fpage>119</fpage><lpage>127</lpage><history><date date-type="received"><day>08</day><month>4</month><year>2013</year></date><date date-type="rev-recd"><day>05</day><month>6</month><year>2013</year></date><date date-type="accepted"><day>05</day><month>6</month><year>2013</year></date></history><permissions><copyright-statement>© Cambridge University Press 2013</copyright-statement><copyright-year>2013</copyright-year><copyright-holder>Cambridge University Press</copyright-holder><license license-type="open-access"><license-p><pmc-comment>CREATIVE COMMONS</pmc-comment>The online version of this article is published within an Open Access environment subject to the conditions of the Creative Commons Attribution licence <<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/3.0/">http://creativecommons.org/licenses/by/3.0/</ext-link></license-p></license></permissions><self-uri xlink:title="pdf" xlink:type="simple" xlink:href="S0031182013001108a.pdf"></self-uri><abstract abstract-type="normal"><title>SUMMARY</title><p>Anti-<italic>Wolbachia</italic> therapy delivers safe macrofilaricidal activity with superior therapeutic outcomes compared to all standard anti-filarial treatments, with the added benefit of substantial improvements in clinical pathology. These outcomes can be achieved, in principle, with existing registered drugs, e.g. doxycycline, that are affordable, available to endemic communities and have well known, albeit population-limiting, safety profiles. The key barriers to using doxycycline as an mass drug administration (MDA) strategy for widespread community-based control are the logistics of a relatively lengthy course of treatment (4–6 weeks) and contraindications in children under eight years and pregnancy. Therefore, the primary goal of the anti-<italic>Wolbachia</italic> (A·WOL) consortium is to find drugs and regimens that reduce the period of treatment from weeks to days (7 days or less), and to find drugs which would be safe in excluded target populations (pregnancy and children). A secondary goal is to refine regimens of existing antibiotics suitable for a more restricted use, prior to the availability of a regimen that is compatible with MDA usage. For example, for use in the event of the emergence of drug-resistance, in individuals with high loiasis co-infection and at risk of severe adverse events (SAE) to ivermectin, or in post-MDA ‘endgame scenarios’, where test and treat strategies become more cost effective and deliverable.</p></abstract><kwd-group><title>Key words</title><kwd><italic>Wolbachia</italic></kwd><kwd>onchocerciasis</kwd><kwd>lymphatic filariasis</kwd><kwd>drug discovery</kwd><kwd>macrofilaricide</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><ref-count count="37"></ref-count><page-count count="9"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Allemagne</li><li>Royaume-Uni</li><li>États-Unis</li></country></list><tree><country name="Royaume-Uni"><noRegion><name sortKey="Taylor, Mark J" sort="Taylor, Mark J" uniqKey="Taylor M" first="Mark J." last="Taylor">Mark J. Taylor</name></noRegion><name sortKey="Townson, Simon" sort="Townson, Simon" uniqKey="Townson S" first="Simon" last="Townson">Simon Townson</name><name sortKey="Ward, Stephen A" sort="Ward, Stephen A" uniqKey="Ward S" first="Stephen A." last="Ward">Stephen A. Ward</name></country><country name="Allemagne"><noRegion><name sortKey="Hoerauf, Achim" sort="Hoerauf, Achim" uniqKey="Hoerauf A" first="Achim" last="Hoerauf">Achim Hoerauf</name></noRegion></country><country name="États-Unis"><noRegion><name sortKey="Slatko, Barton E" sort="Slatko, Barton E" uniqKey="Slatko B" first="Barton E." last="Slatko">Barton E. Slatko</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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