Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing
Identifieur interne : 002361 ( Pmc/Checkpoint ); précédent : 002360; suivant : 002362Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing
Auteurs : Yukari Takeno [Japon] ; Hiromi Arita [Japon] ; Etsuko Fujimoto [Japon]Source :
- SpringerPlus [ 2193-1801 ] ; 2013.
Abstract
Although complete decongestive therapy (CDT) is considered to reduce the volume of lymphedema, there is no concrete evidence to sustain its efficacy. The purpose of the present study was to find new evidence of CDT based on visualizing the changes of lymph fluid accumulating in an edematous limb using indocyanine green (ICG) fluorescent lymphography in real time.Twelve lymphedema rats were divided randomly into two groups. On the first day, ICG was injected into an edematous limb of rats, and no-intervention and CDT was applied to groups 1 and 2, respectively, for two weeks. ICG lymphography and circumferential measurements were done every two days in each two-week observation. The results indicates that a fluorescent flow to the ipsilateral axillary fossa was identified in all rats. In addition, network-like and dermal backflow patterns were observed in the lower legs and thighs. While manual lymph drainage was applied in the CDT group, the flow moved more rapidly through this pathway than that in the no-intervention group. An area of high-intensity fluorescent signals concentrated around the injection sites diminished in the CDT group more than that in the no-intervention-group after two weeks. Circumferential lengths of the edematous limbs were longer than the non-edematous limbs in both groups 1 and 2 on the day of ICG injection. The no-intervention group 1 showed no significance differences during 14 days, whereas the CDT group 2 exhibited very significant differences. These results suggest that CDT has beneficial effects in lymphedema treatment.
Url:
DOI: 10.1186/2193-1801-2-225
PubMed: 23795339
PubMed Central: 3683139
Affiliations:
Links toward previous steps (curation, corpus...)
Links to Exploration step
PMC:3683139Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing</title><author><name sortKey="Takeno, Yukari" sort="Takeno, Yukari" uniqKey="Takeno Y" first="Yukari" last="Takeno">Yukari Takeno</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken, 461-0047 Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken</wicri:regionArea><wicri:noRegion>Aichi-Ken</wicri:noRegion></affiliation></author><author><name sortKey="Arita, Hiromi" sort="Arita, Hiromi" uniqKey="Arita H" first="Hiromi" last="Arita">Hiromi Arita</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Nursing Science, Fukui Prefectural University, 4-1-1,Matsuoka-Kenjojima, Eiheiji-Machi, Yoshida-Gun, Fukui-Ken, 910-1195 Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Nursing Science, Fukui Prefectural University, 4-1-1,Matsuoka-Kenjojima, Eiheiji-Machi, Yoshida-Gun, Fukui-Ken</wicri:regionArea><wicri:noRegion>Fukui-Ken</wicri:noRegion></affiliation></author><author><name sortKey="Fujimoto, Etsuko" sort="Fujimoto, Etsuko" uniqKey="Fujimoto E" first="Etsuko" last="Fujimoto">Etsuko Fujimoto</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken, 461-0047 Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken</wicri:regionArea><wicri:noRegion>Aichi-Ken</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">23795339</idno><idno type="pmc">3683139</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3683139</idno><idno type="RBID">PMC:3683139</idno><idno type="doi">10.1186/2193-1801-2-225</idno><date when="2013">2013</date><idno type="wicri:Area/Pmc/Corpus">000E47</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000E47</idno><idno type="wicri:Area/Pmc/Curation">000E46</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000E46</idno><idno type="wicri:Area/Pmc/Checkpoint">002361</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">002361</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing</title><author><name sortKey="Takeno, Yukari" sort="Takeno, Yukari" uniqKey="Takeno Y" first="Yukari" last="Takeno">Yukari Takeno</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken, 461-0047 Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken</wicri:regionArea><wicri:noRegion>Aichi-Ken</wicri:noRegion></affiliation></author><author><name sortKey="Arita, Hiromi" sort="Arita, Hiromi" uniqKey="Arita H" first="Hiromi" last="Arita">Hiromi Arita</name><affiliation wicri:level="1"><nlm:aff id="Aff2">Department of Nursing Science, Fukui Prefectural University, 4-1-1,Matsuoka-Kenjojima, Eiheiji-Machi, Yoshida-Gun, Fukui-Ken, 910-1195 Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Nursing Science, Fukui Prefectural University, 4-1-1,Matsuoka-Kenjojima, Eiheiji-Machi, Yoshida-Gun, Fukui-Ken</wicri:regionArea><wicri:noRegion>Fukui-Ken</wicri:noRegion></affiliation></author><author><name sortKey="Fujimoto, Etsuko" sort="Fujimoto, Etsuko" uniqKey="Fujimoto E" first="Etsuko" last="Fujimoto">Etsuko Fujimoto</name><affiliation wicri:level="1"><nlm:aff id="Aff1">Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken, 461-0047 Japan</nlm:aff><country xml:lang="fr">Japon</country><wicri:regionArea>Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken</wicri:regionArea><wicri:noRegion>Aichi-Ken</wicri:noRegion></affiliation></author></analytic><series><title level="j">SpringerPlus</title><idno type="eISSN">2193-1801</idno><imprint><date when="2013">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Although complete decongestive therapy (CDT) is considered to reduce the volume of lymphedema, there is no concrete evidence to sustain its efficacy. The purpose of the present study was to find new evidence of CDT based on visualizing the changes of lymph fluid accumulating in an edematous limb using indocyanine green (ICG) fluorescent lymphography in real time.Twelve lymphedema rats were divided randomly into two groups. On the first day, ICG was injected into an edematous limb of rats, and no-intervention and CDT was applied to groups 1 and 2, respectively, for two weeks. ICG lymphography and circumferential measurements were done every two days in each two-week observation. The results indicates that a fluorescent flow to the ipsilateral axillary fossa was identified in all rats. In addition, network-like and dermal backflow patterns were observed in the lower legs and thighs. While manual lymph drainage was applied in the CDT group, the flow moved more rapidly through this pathway than that in the no-intervention group. An area of high-intensity fluorescent signals concentrated around the injection sites diminished in the CDT group more than that in the no-intervention-group after two weeks. Circumferential lengths of the edematous limbs were longer than the non-edematous limbs in both groups 1 and 2 on the day of ICG injection. The no-intervention group 1 showed no significance differences during 14 days, whereas the CDT group 2 exhibited very significant differences. These results suggest that CDT has beneficial effects in lymphedema treatment.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Abe, H" uniqKey="Abe H">H Abe</name></author><author><name sortKey="Mori, T" uniqKey="Mori T">T Mori</name></author><author><name sortKey="Umeda, T" uniqKey="Umeda T">T Umeda</name></author><author><name sortKey="Tanaka, M" uniqKey="Tanaka M">M Tanaka</name></author><author><name sortKey="Kawai, Y" uniqKey="Kawai Y">Y Kawai</name></author><author><name sortKey="Shimizu, T" uniqKey="Shimizu T">T Shimizu</name></author><author><name sortKey="Cho, H" uniqKey="Cho H">H Cho</name></author><author><name sortKey="Kubota, Y" uniqKey="Kubota Y">Y Kubota</name></author><author><name sortKey="Kurumi, Y" uniqKey="Kurumi Y">Y Kurumi</name></author><author><name sortKey="Tani, T" uniqKey="Tani T">T Tani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferlay, J" uniqKey="Ferlay J">J Ferlay</name></author><author><name sortKey="Shin, Hr" uniqKey="Shin H">HR Shin</name></author><author><name sortKey="Bray, F" uniqKey="Bray F">F Bray</name></author><author><name sortKey="Forman, D" uniqKey="Forman D">D Forman</name></author><author><name sortKey="Mathers, C" uniqKey="Mathers C">C Mathers</name></author><author><name sortKey="Parkin, Dm" uniqKey="Parkin D">DM Parkin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Hirche, C" uniqKey="Hirche C">C Hirche</name></author><author><name sortKey="Murawa, D" uniqKey="Murawa D">D Murawa</name></author><author><name sortKey="Mohr, Z" uniqKey="Mohr Z">Z Mohr</name></author><author><name sortKey="Kneif, S" uniqKey="Kneif S">S Kneif</name></author><author><name sortKey="Hunerbein, M" uniqKey="Hunerbein M">M Hunerbein</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Kitai, T" uniqKey="Kitai T">T Kitai</name></author><author><name sortKey="Inoue, T" uniqKey="Inoue T">T Inoue</name></author><author><name sortKey="Miwa, M" uniqKey="Miwa M">M Miwa</name></author><author><name sortKey="Shikayama, T" uniqKey="Shikayama T">T Shikayama</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Koul, R" uniqKey="Koul R">R Koul</name></author><author><name sortKey="Dufan, T" uniqKey="Dufan T">T Dufan</name></author><author><name sortKey="Russell, C" uniqKey="Russell C">C Russell</name></author><author><name sortKey="Guenther, W" uniqKey="Guenther W">W Guenther</name></author><author><name sortKey="Nugent, Z" uniqKey="Nugent Z">Z Nugent</name></author><author><name sortKey="Sun, X" uniqKey="Sun X">X Sun</name></author><author><name sortKey="Cooke, Al" uniqKey="Cooke A">AL Cooke</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Loprinizi, Cl" uniqKey="Loprinizi C">CL Loprinizi</name></author><author><name sortKey="Kugler, Jw" uniqKey="Kugler J">JW Kugler</name></author><author><name sortKey="Sloan, Ja" uniqKey="Sloan J">JA Sloan</name></author><author><name sortKey="Rooke, Tw" uniqKey="Rooke T">TW Rooke</name></author><author><name sortKey="Quella, Sk" uniqKey="Quella S">SK Quella</name></author><author><name sortKey="Novotny, P" uniqKey="Novotny P">P Novotny</name></author><author><name sortKey="Mowat, Rb" uniqKey="Mowat R">RB Mowat</name></author><author><name sortKey="Michala, Jc" uniqKey="Michala J">JC Michala</name></author><author><name sortKey="Stella, Pj" uniqKey="Stella P">PJ Stella</name></author><author><name sortKey="Levitt, R" uniqKey="Levitt R">R Levitt</name></author><author><name sortKey="Tschetter, Lk" uniqKey="Tschetter L">LK Tschetter</name></author><author><name sortKey="Windschitl, H" uniqKey="Windschitl H">H Windschitl</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mondry, Te" uniqKey="Mondry T">TE Mondry</name></author><author><name sortKey="Riffenburgh, Rh" uniqKey="Riffenburgh R">RH Riffenburgh</name></author><author><name sortKey="Johnstone, P" uniqKey="Johnstone P">P Johnstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ogata, F" uniqKey="Ogata F">F Ogata</name></author><author><name sortKey="Azuma, R" uniqKey="Azuma R">R Azuma</name></author><author><name sortKey="Kikuchi, M" uniqKey="Kikuchi M">M Kikuchi</name></author><author><name sortKey="Koshima, I" uniqKey="Koshima I">I Koshima</name></author><author><name sortKey="Morimoto, Y" uniqKey="Morimoto Y">Y Morimoto</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pinell, Xa" uniqKey="Pinell X">XA Pinell</name></author><author><name sortKey="Kirkpatrick, Sh" uniqKey="Kirkpatrick S">SH Kirkpatrick</name></author><author><name sortKey="Hawkins, K" uniqKey="Hawkins K">K Hawkins</name></author><author><name sortKey="Mondry, Te" uniqKey="Mondry T">TE Mondry</name></author><author><name sortKey="Johnstone, Pas" uniqKey="Johnstone P">PAS Johnstone</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sitzia, J" uniqKey="Sitzia J">J Sitzia</name></author><author><name sortKey="Woods, M" uniqKey="Woods M">M Woods</name></author><author><name sortKey="Hine, P" uniqKey="Hine P">P Hine</name></author><author><name sortKey="William, A" uniqKey="William A">A William</name></author><author><name sortKey="Eaton, K" uniqKey="Eaton K">K Eaton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Szuba, A" uniqKey="Szuba A">A Szuba</name></author><author><name sortKey="Rockson, Sg" uniqKey="Rockson S">SG Rockson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Towers, A" uniqKey="Towers A">A Towers</name></author><author><name sortKey="Carnevale, Fa" uniqKey="Carnevale F">FA Carnevale</name></author><author><name sortKey="Baker, Me" uniqKey="Baker M">ME Baker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Unno, N" uniqKey="Unno N">N Unno</name></author><author><name sortKey="Nishiyama, M" uniqKey="Nishiyama M">M Nishiyama</name></author><author><name sortKey="Suzuki, M" uniqKey="Suzuki M">M Suzuki</name></author><author><name sortKey="Yamamoto, N" uniqKey="Yamamoto N">N Yamamoto</name></author><author><name sortKey="Inuzuka, K" uniqKey="Inuzuka K">K Inuzuka</name></author><author><name sortKey="Sagara, D" uniqKey="Sagara D">D Sagara</name></author><author><name sortKey="Tanaka, H" uniqKey="Tanaka H">H Tanaka</name></author><author><name sortKey="Konno, H" uniqKey="Konno H">H Konno</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Springerplus</journal-id><journal-id journal-id-type="iso-abbrev">Springerplus</journal-id><journal-title-group><journal-title>SpringerPlus</journal-title></journal-title-group><issn pub-type="epub">2193-1801</issn><publisher><publisher-name>Springer International Publishing AG</publisher-name><publisher-loc>Cham</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">23795339</article-id><article-id pub-id-type="pmc">3683139</article-id><article-id pub-id-type="publisher-id">318</article-id><article-id pub-id-type="doi">10.1186/2193-1801-2-225</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research</subject></subj-group></article-categories><title-group><article-title>Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing</article-title></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name><surname>Takeno</surname><given-names>Yukari</given-names></name><address><email>takeno.yukari@a.mbox.nagoya-u.ac.jp</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><contrib contrib-type="author"><name><surname>Arita</surname><given-names>Hiromi</given-names></name><address><email>arita@fpu.ac.jp</email></address><xref ref-type="aff" rid="Aff2"></xref></contrib><contrib contrib-type="author"><name><surname>Fujimoto</surname><given-names>Etsuko</given-names></name><address><email>fujimoto@met.nagoya-u.ac.jp</email></address><xref ref-type="aff" rid="Aff1"></xref></contrib><aff id="Aff1"><label></label>Graduate School of medicine, Nagoya University, 1-1-20 Daiko- Minami, Higashi-Ku, Nagoya-Shi, Aichi-Ken, 461-0047 Japan</aff><aff id="Aff2"><label></label>Department of Nursing Science, Fukui Prefectural University, 4-1-1,Matsuoka-Kenjojima, Eiheiji-Machi, Yoshida-Gun, Fukui-Ken, 910-1195 Japan</aff></contrib-group><pub-date pub-type="epub"><day>16</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="pmc-release"><day>16</day><month>5</month><year>2013</year></pub-date><pub-date pub-type="collection"><year>2013</year></pub-date><volume>2</volume><elocation-id>225</elocation-id><history><date date-type="received"><day>22</day><month>1</month><year>2013</year></date><date date-type="accepted"><day>16</day><month>4</month><year>2013</year></date></history><permissions><copyright-statement>© Takeno et al.; licensee Springer. 2013</copyright-statement><license license-type="open-access"><license-p>This article is published under license to BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (<ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/2.0">http://creativecommons.org/licenses/by/2.0</ext-link>), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract id="Abs1"><p>Although complete decongestive therapy (CDT) is considered to reduce the volume of lymphedema, there is no concrete evidence to sustain its efficacy. The purpose of the present study was to find new evidence of CDT based on visualizing the changes of lymph fluid accumulating in an edematous limb using indocyanine green (ICG) fluorescent lymphography in real time.Twelve lymphedema rats were divided randomly into two groups. On the first day, ICG was injected into an edematous limb of rats, and no-intervention and CDT was applied to groups 1 and 2, respectively, for two weeks. ICG lymphography and circumferential measurements were done every two days in each two-week observation. The results indicates that a fluorescent flow to the ipsilateral axillary fossa was identified in all rats. In addition, network-like and dermal backflow patterns were observed in the lower legs and thighs. While manual lymph drainage was applied in the CDT group, the flow moved more rapidly through this pathway than that in the no-intervention group. An area of high-intensity fluorescent signals concentrated around the injection sites diminished in the CDT group more than that in the no-intervention-group after two weeks. Circumferential lengths of the edematous limbs were longer than the non-edematous limbs in both groups 1 and 2 on the day of ICG injection. The no-intervention group 1 showed no significance differences during 14 days, whereas the CDT group 2 exhibited very significant differences. These results suggest that CDT has beneficial effects in lymphedema treatment.</p></abstract><custom-meta-group><custom-meta><meta-name>issue-copyright-statement</meta-name><meta-value>© The Author(s) 2013</meta-value></custom-meta></custom-meta-group></article-meta></front></pmc><affiliations><list><country><li>Japon</li></country></list><tree><country name="Japon"><noRegion><name sortKey="Takeno, Yukari" sort="Takeno, Yukari" uniqKey="Takeno Y" first="Yukari" last="Takeno">Yukari Takeno</name></noRegion><name sortKey="Arita, Hiromi" sort="Arita, Hiromi" uniqKey="Arita H" first="Hiromi" last="Arita">Hiromi Arita</name><name sortKey="Fujimoto, Etsuko" sort="Fujimoto, Etsuko" uniqKey="Fujimoto E" first="Etsuko" last="Fujimoto">Etsuko Fujimoto</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Pmc/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002361 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd -nk 002361 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Pmc
|étape= Checkpoint
|type= RBID
|clé= PMC:3683139
|texte= Efficacy of complete decongestive therapy (CDT) on edematous rat limb after lymphadenectomy demonstrated by real time lymphatic fluid tracing
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Pmc/Checkpoint/RBID.i -Sk "pubmed:23795339" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Pmc/Checkpoint/biblio.hfd \
| NlmPubMed2Wicri -a LymphedemaV1
| This area was generated with Dilib version V0.6.31. |  |