Transcriptional Regulation oa Endothelial Cell And Vascular Development
Identifieur interne : 001E91 ( Pmc/Checkpoint ); précédent : 001E90; suivant : 001E92Transcriptional Regulation oa Endothelial Cell And Vascular Development
Auteurs : Changwon Park ; Tae Min Kim ; Asrar B. MalikSource :
- Circulation research [ 0009-7330 ] ; 2013.
Abstract
The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the etiology of vascular diseases. Here we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling molecules that specify the differentiation of vascular endothelial cells. We also discuss recent progress on reprogramming of somatic cells towards distinct endothelial cell lineages and its promise in regenerative vascular medicine.
Url:
DOI: 10.1161/CIRCRESAHA.113.301078
PubMed: 23661712
PubMed Central: 3730491
Affiliations:
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<front><div type="abstract" xml:lang="en"><p id="P1">The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the etiology of vascular diseases. Here we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling molecules that specify the differentiation of vascular endothelial cells. We also discuss recent progress on reprogramming of somatic cells towards distinct endothelial cell lineages and its promise in regenerative vascular medicine.</p>
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<pmc article-type="research-article"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
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<contrib-group><contrib contrib-type="author"><name><surname>Park</surname>
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<contrib contrib-type="author"><name><surname>Kim</surname>
<given-names>Tae Min</given-names>
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<contrib contrib-type="author"><name><surname>Malik</surname>
<given-names>Asrar B.</given-names>
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<aff id="A1">Department of Pharmacology and Center for Lung and Vascular Biology, The University of Illinois College of Medicine, Chicago, IL USA</aff>
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<author-notes><corresp id="FN1">Correspondence: Asrar B. Malik (<email>abmalik@uic.edu</email>
)</corresp>
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<pub-date pub-type="nihms-submitted"><day>19</day>
<month>7</month>
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<pub-date pub-type="ppub"><day>10</day>
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<year>2013</year>
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<volume>112</volume>
<issue>10</issue>
<fpage>1380</fpage>
<lpage>1400</lpage>
<abstract><p id="P1">The establishment and maintenance of the vascular system is critical for embryonic development and postnatal life. Defects in endothelial cell development and vessel formation and function lead to embryonic lethality and are important in the etiology of vascular diseases. Here we review the underlying molecular mechanisms of endothelial cell differentiation, plasticity, and the development of the vasculature. This review focuses on the interplay among transcription factors and signaling molecules that specify the differentiation of vascular endothelial cells. We also discuss recent progress on reprogramming of somatic cells towards distinct endothelial cell lineages and its promise in regenerative vascular medicine.</p>
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<kwd-group><kwd>endothelial cells</kwd>
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<funding-group><award-group><funding-source country="United States">National Heart, Lung, and Blood Institute : NHLBI</funding-source>
<award-id>R01 HL090152 || HL</award-id>
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<award-id>R01 HL045638 || HL</award-id>
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<award-id>P01 HL077806 || HL</award-id>
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<name sortKey="Park, Changwon" sort="Park, Changwon" uniqKey="Park C" first="Changwon" last="Park">Changwon Park</name>
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