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Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery

Identifieur interne : 001D32 ( Pmc/Checkpoint ); précédent : 001D31; suivant : 001D33

Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery

Auteurs : Sy-Huey Doong [États-Unis] ; Anand Dhruva [États-Unis] ; Laura B. Dunn [États-Unis] ; Claudia West [États-Unis] ; Steven M. Paul [États-Unis] ; Bruce A. Cooper [États-Unis] ; Charles Elboim [États-Unis] ; Gary Abrams [États-Unis] ; John D. Merriman [États-Unis] ; Dale J. Langford [États-Unis] ; Heather Leutwyler [États-Unis] ; Christina Baggott [États-Unis] ; Kord Kober [États-Unis] ; Bradley E. Aouizerat [États-Unis] ; Christine Miaskowski [États-Unis]

Source :

Biological research for nursing [ 1099-8004 ] ; 2014.

RBID : PMC:5486211

Abstract

Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of pro-inflammatory cytokines. The purposes of this study were to determine whether distinct latent classes of patients with breast cancer (n = 398) could be identified based on their experience with this symptom cluster, whether patients in these latent classes differed on demographic and clinical characteristics, and whether variations in cytokine genes were associated with latent class membership. Three distinct latent classes were identified: All Low (61.0%), Low Pain and High Fatigue (31.6%), All High (7.1%). Compared to patients in the All Low class, patients in the ALL High class were significantly younger, had less education, were more likely to be non-White, had a lower annual income, were more likely to live alone, had a lower functional status, had a higher comorbidity score, and had more advanced disease. Significant associations were found between interleukin (IL) 6 rs2069845, IL13 rs1295686, and tumor necrosis factor alpha rs18800610 and latent class membership. Findings suggest that variations in pro- and anti-inflammatory cytokine genes are associated with this symptom cluster in breast cancer patients.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5486211

DOI: 10.1177/1099800414550394
PubMed: 25304131
PubMed Central: 5486211

Affiliations:

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PMC:5486211

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<front><div type="abstract" xml:lang="en"><p id="P1">Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of pro-inflammatory cytokines. The purposes of this study were to determine whether distinct latent classes of patients with breast cancer (<italic>n</italic>
 = 398) could be identified based on their experience with this symptom cluster, whether patients in these latent classes differed on demographic and clinical characteristics, and whether variations in cytokine genes were associated with latent class membership. Three distinct latent classes were identified: All Low (61.0%), Low Pain and High Fatigue (31.6%), All High (7.1%). Compared to patients in the All Low class, patients in the ALL High class were significantly younger, had less education, were more likely to be non-White, had a lower annual income, were more likely to live alone, had a lower functional status, had a higher comorbidity score, and had more advanced disease. Significant associations were found between interleukin (IL) 6 rs2069845, IL13 rs1295686, and tumor necrosis factor alpha rs18800610 and latent class membership. Findings suggest that variations in pro- and anti-inflammatory cytokine genes are associated with this symptom cluster in breast cancer patients.</p>
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<title-group><article-title>Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery</article-title>
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<contrib-group><contrib contrib-type="author"><name><surname>Doong</surname>
<given-names>Sy-Huey</given-names>
</name>
<degrees>RN, MS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Dhruva</surname>
<given-names>Anand</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Dunn</surname>
<given-names>Laura B.</given-names>
</name>
<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>West</surname>
<given-names>Claudia</given-names>
</name>
<degrees>RN, MS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Paul</surname>
<given-names>Steven M.</given-names>
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<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Cooper</surname>
<given-names>Bruce A.</given-names>
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<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Elboim</surname>
<given-names>Charles</given-names>
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<degrees>MD</degrees>
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<contrib contrib-type="author"><name><surname>Abrams</surname>
<given-names>Gary</given-names>
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<degrees>MD</degrees>
<xref ref-type="aff" rid="A2">2</xref>
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<contrib contrib-type="author"><name><surname>Merriman</surname>
<given-names>John D.</given-names>
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<degrees>RN, PhD(c)</degrees>
<xref ref-type="aff" rid="A1">1</xref>
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<contrib contrib-type="author"><name><surname>Langford</surname>
<given-names>Dale J.</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Leutwyler</surname>
<given-names>Heather</given-names>
</name>
<degrees>RN, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Baggott</surname>
<given-names>Christina</given-names>
</name>
<degrees>RN, PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Kober</surname>
<given-names>Kord</given-names>
</name>
<degrees>PhD</degrees>
<xref ref-type="aff" rid="A1">1</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Aouizerat</surname>
<given-names>Bradley E.</given-names>
</name>
<degrees>PhD, MAS</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref ref-type="aff" rid="A4">4</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Miaskowski</surname>
<given-names>Christine</given-names>
</name>
<degrees>RN, PhD, FAAN</degrees>
<xref ref-type="aff" rid="A1">1</xref>
<xref rid="FN2" ref-type="author-notes">*</xref>
</contrib>
</contrib-group>
<aff id="A1"><label>1</label>
School of Nursing, University of California, San Francisco, CA</aff>
<aff id="A2"><label>2</label>
School of Medicine, University of California, San Francisco, CA</aff>
<aff id="A3"><label>3</label>
Redwood Regional Medical Group, Santa Rosa, CA</aff>
<aff id="A4"><label>4</label>
Institute for Human Genetics, University of California, San Francisco, CA</aff>
<author-notes><corresp id="FN1">Address correspondence to: Christine Miaskowski, RN, PhD, FAAN, Professor, Department of Physiological Nursing, University of California, 2 Koret Way – N631Y, San Francisco, CA 94143-0610, 415-476-9407 (phone), 415-476-8899 (fax), <email>chris.miaskowski@nursing.ucsf.edu</email>
</corresp>
<fn id="FN2"><label>*</label>
<p>Dual senior authorship</p>
</fn>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>17</day>
<month>4</month>
<year>2017</year>
</pub-date>
<pub-date pub-type="epub"><day>10</day>
<month>10</month>
<year>2014</year>
</pub-date>
<pub-date pub-type="ppub"><month>5</month>
<year>2015</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>27</day>
<month>6</month>
<year>2017</year>
</pub-date>
<volume>17</volume>
<issue>3</issue>
<fpage>237</fpage>
<lpage>247</lpage>
<pmc-comment>elocation-id from pubmed: 10.1177/1099800414550394</pmc-comment>
      <abstract><p id="P1">Pain, fatigue, sleep disturbance, and depression are common and frequently co-occurring symptoms in oncology patients. This symptom cluster is often attributed to the release of pro-inflammatory cytokines. The purposes of this study were to determine whether distinct latent classes of patients with breast cancer (<italic>n</italic>
 = 398) could be identified based on their experience with this symptom cluster, whether patients in these latent classes differed on demographic and clinical characteristics, and whether variations in cytokine genes were associated with latent class membership. Three distinct latent classes were identified: All Low (61.0%), Low Pain and High Fatigue (31.6%), All High (7.1%). Compared to patients in the All Low class, patients in the ALL High class were significantly younger, had less education, were more likely to be non-White, had a lower annual income, were more likely to live alone, had a lower functional status, had a higher comorbidity score, and had more advanced disease. Significant associations were found between interleukin (IL) 6 rs2069845, IL13 rs1295686, and tumor necrosis factor alpha rs18800610 and latent class membership. Findings suggest that variations in pro- and anti-inflammatory cytokine genes are associated with this symptom cluster in breast cancer patients.</p>
</abstract>
<kwd-group><kwd>pain</kwd>
<kwd>fatigue</kwd>
<kwd>sleep disturbance</kwd>
<kwd>depression</kwd>
<kwd>symptom cluster</kwd>
<kwd>cytokines</kwd>
<kwd>candidate genes</kwd>
<kwd>interleukin</kwd>
<kwd>tumor necrosis factor alpha</kwd>
</kwd-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>États-Unis</li>
</country>
<region><li>Californie</li>
</region>
</list>
<tree><country name="États-Unis"><region name="Californie"><name sortKey="Doong, Sy Huey" sort="Doong, Sy Huey" uniqKey="Doong S" first="Sy-Huey" last="Doong">Sy-Huey Doong</name>
</region>
<name sortKey="Abrams, Gary" sort="Abrams, Gary" uniqKey="Abrams G" first="Gary" last="Abrams">Gary Abrams</name>
<name sortKey="Aouizerat, Bradley E" sort="Aouizerat, Bradley E" uniqKey="Aouizerat B" first="Bradley E." last="Aouizerat">Bradley E. Aouizerat</name>
<name sortKey="Aouizerat, Bradley E" sort="Aouizerat, Bradley E" uniqKey="Aouizerat B" first="Bradley E." last="Aouizerat">Bradley E. Aouizerat</name>
<name sortKey="Baggott, Christina" sort="Baggott, Christina" uniqKey="Baggott C" first="Christina" last="Baggott">Christina Baggott</name>
<name sortKey="Cooper, Bruce A" sort="Cooper, Bruce A" uniqKey="Cooper B" first="Bruce A." last="Cooper">Bruce A. Cooper</name>
<name sortKey="Dhruva, Anand" sort="Dhruva, Anand" uniqKey="Dhruva A" first="Anand" last="Dhruva">Anand Dhruva</name>
<name sortKey="Dunn, Laura B" sort="Dunn, Laura B" uniqKey="Dunn L" first="Laura B." last="Dunn">Laura B. Dunn</name>
<name sortKey="Elboim, Charles" sort="Elboim, Charles" uniqKey="Elboim C" first="Charles" last="Elboim">Charles Elboim</name>
<name sortKey="Kober, Kord" sort="Kober, Kord" uniqKey="Kober K" first="Kord" last="Kober">Kord Kober</name>
<name sortKey="Langford, Dale J" sort="Langford, Dale J" uniqKey="Langford D" first="Dale J." last="Langford">Dale J. Langford</name>
<name sortKey="Leutwyler, Heather" sort="Leutwyler, Heather" uniqKey="Leutwyler H" first="Heather" last="Leutwyler">Heather Leutwyler</name>
<name sortKey="Merriman, John D" sort="Merriman, John D" uniqKey="Merriman J" first="John D." last="Merriman">John D. Merriman</name>
<name sortKey="Miaskowski, Christine" sort="Miaskowski, Christine" uniqKey="Miaskowski C" first="Christine" last="Miaskowski">Christine Miaskowski</name>
<name sortKey="Paul, Steven M" sort="Paul, Steven M" uniqKey="Paul S" first="Steven M." last="Paul">Steven M. Paul</name>
<name sortKey="West, Claudia" sort="West, Claudia" uniqKey="West C" first="Claudia" last="West">Claudia West</name>
</country>
</tree>
</affiliations>
</record>

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Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery

Associations Between Cytokine Genes and a Symptom Cluster of Pain, Fatigue, Sleep Disturbance, and Depression in Patients Prior to Breast Cancer Surgery

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