Comparison of Three Quality of Life Instruments in Lymphatic Filariasis: DLQI, WHODAS 2.0, and LFSQQ
Identifieur interne : 001C64 ( Pmc/Checkpoint ); précédent : 001C63; suivant : 001C65Comparison of Three Quality of Life Instruments in Lymphatic Filariasis: DLQI, WHODAS 2.0, and LFSQQ
Auteurs : Cristina Thomas [États-Unis] ; Saravu R. Narahari [Inde] ; Kuthaje S. Bose [Inde] ; Kuthaje Vivekananda [Inde] ; Steven Nwe [États-Unis] ; Dennis P. West [États-Unis] ; Mary Kwasny [États-Unis] ; Roopal V. Kundu [États-Unis]Source :
- PLoS Neglected Tropical Diseases [ 1935-2727 ] ; 2014.
Abstract
The Global Program to Eliminate Lymphatic Filariasis aims to interrupt transmission of lymphatic filariasis and manage morbidity in people currently living with the disease. A component of morbidity management is improving health-related quality of life (HRQoL) in patients. Measurement of HRQoL in current management programs is varied because of the lack of a standard HRQoL tool for use in the lymphatic filariasis population.
In this study, the psychometric properties of three health status measures were compared when used in a group of lymphatic filariasis patients and healthy controls. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), the Dermatology Life Quality Index (DLQI), and the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ) were administered to 36 stage II and stage III lymphatic filariasis subjects and 36 age and sex matched controls in Kerala, India. All three tools yielded missing value rates lower than 10%, suggesting high feasibility. Highest internal consistency was seen in the LFSQQ (α = 0.97). Discriminant validity analysis demonstrated that HRQoL was significantly lower in the LF group than in controls for the WHODAS 2.0, DLQI, and LFSQQ, but total HRQoL scores did not differ between stage II and stage III lymphedema subjects. The LFSQQ total score correlated most strongly with the WHODAS 2.0 (r = 0.91, p<0.001) and DLQI (r = 0.81, p<0.001).
The WHODAS 2.0, DLQI, and LFSQQ demonstrate acceptable feasibility, internal consistency, discriminate validity, and construct validity. Based on our psychometric analyses, the LFSQQ performs the best and is recommended for use in the lymphatic filariasis population.
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DOI: 10.1371/journal.pntd.0002716
PubMed: 24587467
PubMed Central: 3930502
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Narahari</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Bose, Kuthaje S" sort="Bose, Kuthaje S" uniqKey="Bose K" first="Kuthaje S." last="Bose">Kuthaje S. 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Narahari</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Bose, Kuthaje S" sort="Bose, Kuthaje S" uniqKey="Bose K" first="Kuthaje S." last="Bose">Kuthaje S. Bose</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Vivekananda, Kuthaje" sort="Vivekananda, Kuthaje" uniqKey="Vivekananda K" first="Kuthaje" last="Vivekananda">Kuthaje Vivekananda</name><affiliation wicri:level="1"><nlm:aff id="aff2"><addr-line>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala, India</addr-line></nlm:aff><country xml:lang="fr">Inde</country><wicri:regionArea>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala</wicri:regionArea><wicri:noRegion>Kerala</wicri:noRegion></affiliation></author><author><name sortKey="Nwe, Steven" sort="Nwe, Steven" uniqKey="Nwe S" first="Steven" last="Nwe">Steven Nwe</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="West, Dennis P" sort="West, Dennis P" uniqKey="West D" first="Dennis P." last="West">Dennis P. West</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Kwasny, Mary" sort="Kwasny, Mary" uniqKey="Kwasny M" first="Mary" last="Kwasny">Mary Kwasny</name><affiliation wicri:level="2"><nlm:aff id="aff3"><addr-line>Department of Preventative Medicine Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Preventative Medicine Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author><author><name sortKey="Kundu, Roopal V" sort="Kundu, Roopal V" uniqKey="Kundu R" first="Roopal V." last="Kundu">Roopal V. Kundu</name><affiliation wicri:level="2"><nlm:aff id="aff1"><addr-line>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America</addr-line></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois</wicri:regionArea><placeName><region type="state">Illinois</region></placeName></affiliation></author></analytic><series><title level="j">PLoS Neglected Tropical Diseases</title><idno type="ISSN">1935-2727</idno><idno type="eISSN">1935-2735</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><sec><title>Background</title><p>The Global Program to Eliminate Lymphatic Filariasis aims to interrupt transmission of lymphatic filariasis and manage morbidity in people currently living with the disease. A component of morbidity management is improving health-related quality of life (HRQoL) in patients. Measurement of HRQoL in current management programs is varied because of the lack of a standard HRQoL tool for use in the lymphatic filariasis population.</p></sec><sec><title>Methodology/Principal Findings</title><p>In this study, the psychometric properties of three health status measures were compared when used in a group of lymphatic filariasis patients and healthy controls. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), the Dermatology Life Quality Index (DLQI), and the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ) were administered to 36 stage II and stage III lymphatic filariasis subjects and 36 age and sex matched controls in Kerala, India. All three tools yielded missing value rates lower than 10%, suggesting high feasibility. Highest internal consistency was seen in the LFSQQ (α = 0.97). Discriminant validity analysis demonstrated that HRQoL was significantly lower in the LF group than in controls for the WHODAS 2.0, DLQI, and LFSQQ, but total HRQoL scores did not differ between stage II and stage III lymphedema subjects. The LFSQQ total score correlated most strongly with the WHODAS 2.0 (r = 0.91, p<0.001) and DLQI (r = 0.81, p<0.001).</p></sec><sec><title>Conclusions/Significance</title><p>The WHODAS 2.0, DLQI, and LFSQQ demonstrate acceptable feasibility, internal consistency, discriminate validity, and construct validity. Based on our psychometric analyses, the LFSQQ performs the best and is recommended for use in the lymphatic filariasis population.</p></sec></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Michael, E" uniqKey="Michael E">E Michael</name></author><author><name sortKey="Bundy, Da" uniqKey="Bundy D">DA Bundy</name></author><author><name sortKey="Grenfell, Bt" uniqKey="Grenfell B">BT Grenfell</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ottesen, Ea" uniqKey="Ottesen E">EA Ottesen</name></author><author><name sortKey="Hooper, Pj" uniqKey="Hooper P">PJ Hooper</name></author><author><name sortKey="Bradley, M" uniqKey="Bradley M">M Bradley</name></author><author><name sortKey="Biswas, G" uniqKey="Biswas G">G Biswas</name></author></analytic></biblStruct><biblStruct></biblStruct><biblStruct><analytic><author><name sortKey="Krishna Kumari, A" uniqKey="Krishna Kumari A">A Krishna 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<front><journal-meta><journal-id journal-id-type="nlm-ta">PLoS Negl Trop Dis</journal-id><journal-id journal-id-type="iso-abbrev">PLoS Negl Trop Dis</journal-id><journal-id journal-id-type="publisher-id">plos</journal-id><journal-id journal-id-type="pmc">plosntds</journal-id><journal-title-group><journal-title>PLoS Neglected Tropical Diseases</journal-title></journal-title-group><issn pub-type="ppub">1935-2727</issn><issn pub-type="epub">1935-2735</issn><publisher><publisher-name>Public Library of Science</publisher-name><publisher-loc>San Francisco, USA</publisher-loc></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">24587467</article-id><article-id pub-id-type="pmc">3930502</article-id><article-id pub-id-type="publisher-id">PNTD-D-13-01390</article-id><article-id pub-id-type="doi">10.1371/journal.pntd.0002716</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="Discipline-v2"><subject>Medicine</subject><subj-group><subject>Infectious diseases</subject><subj-group><subject>Neglected tropical diseases</subject><subj-group><subject>Lymphatic filariasis</subject></subj-group></subj-group><subj-group><subject>Parasitic diseases</subject><subj-group><subject>Filariasis</subject><subject>Lymphatic filariasis</subject></subj-group></subj-group><subj-group><subject>Tropical diseases (non-neglected)</subject><subj-group><subject>Filariasis</subject></subj-group></subj-group></subj-group></subj-group></article-categories><title-group><article-title>Comparison of Three Quality of Life Instruments in Lymphatic Filariasis: DLQI, WHODAS 2.0, and LFSQQ</article-title><alt-title alt-title-type="running-head">QoL Tool Comparison in Lymphatic Filariasis</alt-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Thomas</surname><given-names>Cristina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Narahari</surname><given-names>Saravu R.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Bose</surname><given-names>Kuthaje S.</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Vivekananda</surname><given-names>Kuthaje</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref></contrib><contrib contrib-type="author"><name><surname>Nwe</surname><given-names>Steven</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>West</surname><given-names>Dennis P.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kwasny</surname><given-names>Mary</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref></contrib><contrib contrib-type="author"><name><surname>Kundu</surname><given-names>Roopal V.</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="cor1"><sup>*</sup></xref></contrib></contrib-group><aff id="aff1"><label>1</label><addr-line>Department of Dermatology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America</addr-line></aff><aff id="aff2"><label>2</label><addr-line>Department of Integrative Dermatology, Institute of Applied Dermatology, Uliyathadka, Kasaragod, Kerala, India</addr-line></aff><aff id="aff3"><label>3</label><addr-line>Department of Preventative Medicine Biostatistics Collaboration Center, Northwestern University Feinberg School of Medicine, Chicago, Illinois, United States of America</addr-line></aff><contrib-group><contrib contrib-type="editor"><name><surname>Specht</surname><given-names>Sabine</given-names></name><role>Editor</role><xref ref-type="aff" rid="edit1"></xref></contrib></contrib-group><aff id="edit1"><addr-line>University Clinic Bonn, Germany</addr-line></aff><author-notes><corresp id="cor1">* E-mail: <email>rkundu@nmff.org</email></corresp><fn fn-type="conflict"><p>I have read the journal's policy and have the following conflicts: the Lymphatic Filariasis-Specific Quality of Life Questionnaire was developed at the Institute of Applied Dermatology. This does not alter our adherence to all PLOS policies on sharing data and materials.</p></fn><fn fn-type="con"><p>Conceived and designed the experiments: CT SRN KSB DPW RVK. Performed the experiments: CT KV. Analyzed the data: CT MK. Contributed reagents/materials/analysis tools: CT SRN SN DPW RVK. Wrote the paper: CT MK RVK.</p></fn></author-notes><pub-date pub-type="collection"><month>2</month><year>2014</year></pub-date><pub-date pub-type="epub"><day>20</day><month>2</month><year>2014</year></pub-date><volume>8</volume><issue>2</issue><elocation-id>e2716</elocation-id><history><date date-type="received"><day>11</day><month>9</month><year>2013</year></date><date date-type="accepted"><day>10</day><month>1</month><year>2014</year></date></history><permissions><copyright-year>2014</copyright-year><copyright-holder>Thomas et al</copyright-holder><license><license-p>This is an open-access article distributed under the terms of the <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by/4.0/">Creative Commons Attribution License</ext-link>, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.</license-p></license></permissions><abstract><sec><title>Background</title><p>The Global Program to Eliminate Lymphatic Filariasis aims to interrupt transmission of lymphatic filariasis and manage morbidity in people currently living with the disease. A component of morbidity management is improving health-related quality of life (HRQoL) in patients. Measurement of HRQoL in current management programs is varied because of the lack of a standard HRQoL tool for use in the lymphatic filariasis population.</p></sec><sec><title>Methodology/Principal Findings</title><p>In this study, the psychometric properties of three health status measures were compared when used in a group of lymphatic filariasis patients and healthy controls. The World Health Organization Disability Assessment Schedule 2.0 (WHODAS 2.0), the Dermatology Life Quality Index (DLQI), and the Lymphatic Filariasis Quality of Life Questionnaire (LFSQQ) were administered to 36 stage II and stage III lymphatic filariasis subjects and 36 age and sex matched controls in Kerala, India. All three tools yielded missing value rates lower than 10%, suggesting high feasibility. Highest internal consistency was seen in the LFSQQ (α = 0.97). Discriminant validity analysis demonstrated that HRQoL was significantly lower in the LF group than in controls for the WHODAS 2.0, DLQI, and LFSQQ, but total HRQoL scores did not differ between stage II and stage III lymphedema subjects. The LFSQQ total score correlated most strongly with the WHODAS 2.0 (r = 0.91, p<0.001) and DLQI (r = 0.81, p<0.001).</p></sec><sec><title>Conclusions/Significance</title><p>The WHODAS 2.0, DLQI, and LFSQQ demonstrate acceptable feasibility, internal consistency, discriminate validity, and construct validity. Based on our psychometric analyses, the LFSQQ performs the best and is recommended for use in the lymphatic filariasis population.</p></sec></abstract><abstract abstract-type="summary"><title>Author Summary</title><p>Lymphatic filariasis affects approximately 120 million people and is the second leading cause of life-long disability worldwide. Because lymphatic filariasis is one of the World Health Organization's six eradicable diseases, much effort has been placed into reducing transmission of the disease and managing morbidity. Novel interventions frequently use health-related quality of life as an outcome measure to monitor efficacy of the intervention. In an effort to delineate the strengths and weaknesses of health status measures and recommend use of a single tool in the lymphatic filariasis population, we compared the use of three health status tools (The World Health Organization Disability Assessment Schedule 2.0, the Dermatology Life Quality Index, and the Lymphatic Filariasis Quality of Life Questionnaire) in lymphatic filariasis subjects and healthy controls in Kerala, India. The Lymphatic Filariasis Quality of Life Questionnaire performed the best by discriminating well between subjects and controls, possessing significant content overlap with the other two tools, yielding a low missing value rate, and being internally consistent. This is the first study to compare health status measures in lymphatic filariasis subjects and provides insight into the use of the tools in quality of life analysis.</p></abstract><funding-group><funding-statement>This study was funded by the Center for Global Health at Northwestern University Feinberg School of Medicine. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.</funding-statement></funding-group><counts><page-count count="8"></page-count></counts></article-meta></front></pmc><affiliations><list><country><li>Inde</li><li>États-Unis</li></country><region><li>Illinois</li></region></list><tree><country name="États-Unis"><region name="Illinois"><name sortKey="Thomas, Cristina" sort="Thomas, Cristina" uniqKey="Thomas C" first="Cristina" last="Thomas">Cristina Thomas</name></region><name sortKey="Kundu, Roopal V" sort="Kundu, Roopal V" uniqKey="Kundu R" first="Roopal V." last="Kundu">Roopal V. Kundu</name><name sortKey="Kwasny, Mary" sort="Kwasny, Mary" uniqKey="Kwasny M" first="Mary" last="Kwasny">Mary Kwasny</name><name sortKey="Nwe, Steven" sort="Nwe, Steven" uniqKey="Nwe S" first="Steven" last="Nwe">Steven Nwe</name><name sortKey="West, Dennis P" sort="West, Dennis P" uniqKey="West D" first="Dennis P." last="West">Dennis P. West</name></country><country name="Inde"><noRegion><name sortKey="Narahari, Saravu R" sort="Narahari, Saravu R" uniqKey="Narahari S" first="Saravu R." last="Narahari">Saravu R. Narahari</name></noRegion><name sortKey="Bose, Kuthaje S" sort="Bose, Kuthaje S" uniqKey="Bose K" first="Kuthaje S." last="Bose">Kuthaje S. Bose</name><name sortKey="Vivekananda, Kuthaje" sort="Vivekananda, Kuthaje" uniqKey="Vivekananda K" first="Kuthaje" last="Vivekananda">Kuthaje Vivekananda</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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