Hypertrophic scars in a patient with Turner's syndrome treated with recombinant growth hormone
Identifieur interne : 001B09 ( Pmc/Checkpoint ); précédent : 001B08; suivant : 001B10Hypertrophic scars in a patient with Turner's syndrome treated with recombinant growth hormone
Auteurs : Andrzej K Dzia ; Mariola Pawlaczyk ; El Bieta PetriczkoSource :
- Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii [ 1642-395X ] ; 2014.
Abstract
Turner's syndrome is a common genetic disorder of girls and women, for which characteristic clinical symptoms encompass short stature, gonadal dysgenesis, systemic defects, multiple dysmorphic features and skin changes, including an increased number of melanocytic nevi, hypertrophic scars and keloids. The affected girls are treated with recombinant human growth hormone to improve the height. We present a case of a 15-year-old girl with Turner's syndrome, hypertrophic scars and a keloid. At the age of 12 years and 8 months, the girl started recombinant human growth hormone treatment. During the therapy, a surgical excision of 4 out of 42 benign melanocytic nevi was performed. After 2 months the hypertrophic scars as well as a keloid were noted at sites of excision. Parents of girls with Turner's syndrome undertake various attempts to improve not only the height and maturity of their daughters, but also their appearance by commonly performed surgical corrections of the webbed neck and pigmented nevi. The presented case suggests an increased risk of scars hypertrophy and keloid formations after surgical intervention in Turner's syndrome patients who are treated with recombinant human growth hormone at the same time. Due to that it should be advised to postpone all planned surgical procedures until the therapy has been completed.
Url:
DOI: 10.5114/pdia.2014.40917
PubMed: 25097479
PubMed Central: 4112245
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Hypertrophic scars in a patient with Turner's syndrome treated with recombinant growth hormone</title><author><name sortKey="K Dzia, Andrzej" sort="K Dzia, Andrzej" uniqKey="K Dzia A" first="Andrzej" last="K Dzia">Andrzej K Dzia</name><affiliation><nlm:aff id="AF0001">Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ass. Prof. Andrzej Kędzia</nlm:aff><wicri:noCountry code="subfield">Poland. Head of Department: Ass. Prof. Andrzej Kędzia</wicri:noCountry></affiliation></author><author><name sortKey="Pawlaczyk, Mariola" sort="Pawlaczyk, Mariola" uniqKey="Pawlaczyk M" first="Mariola" last="Pawlaczyk">Mariola Pawlaczyk</name><affiliation><nlm:aff id="AF0002">Department of Geriatric Medicine and Gerontology, Division of Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ass. Prof. Mariola Pawlaczyk</nlm:aff><wicri:noCountry code="subfield">Poland. Head of Department: Ass. Prof. Mariola Pawlaczyk</wicri:noCountry></affiliation></author><author><name sortKey="Petriczko, El Bieta" sort="Petriczko, El Bieta" uniqKey="Petriczko E" first="El Bieta" last="Petriczko">El Bieta Petriczko</name><affiliation><nlm:aff id="AF0003">Clinic of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Children, Pomeranian Medical University, Szczecin, Poland. 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Head of Department: Ass. Prof. Andrzej Kędzia</nlm:aff><wicri:noCountry code="subfield">Poland. Head of Department: Ass. Prof. Andrzej Kędzia</wicri:noCountry></affiliation></author><author><name sortKey="Pawlaczyk, Mariola" sort="Pawlaczyk, Mariola" uniqKey="Pawlaczyk M" first="Mariola" last="Pawlaczyk">Mariola Pawlaczyk</name><affiliation><nlm:aff id="AF0002">Department of Geriatric Medicine and Gerontology, Division of Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ass. Prof. Mariola Pawlaczyk</nlm:aff><wicri:noCountry code="subfield">Poland. Head of Department: Ass. Prof. Mariola Pawlaczyk</wicri:noCountry></affiliation></author><author><name sortKey="Petriczko, El Bieta" sort="Petriczko, El Bieta" uniqKey="Petriczko E" first="El Bieta" last="Petriczko">El Bieta Petriczko</name><affiliation><nlm:aff id="AF0003">Clinic of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Children, Pomeranian Medical University, Szczecin, Poland. Head of Clinic: Prof. Mieczysław Walczak MD, PhD</nlm:aff><wicri:noCountry code="subfield">PhD</wicri:noCountry></affiliation></author></analytic><series><title level="j">Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii</title><idno type="ISSN">1642-395X</idno><idno type="eISSN">2299-0046</idno><imprint><date when="2014">2014</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Turner's syndrome is a common genetic disorder of girls and women, for which characteristic clinical symptoms encompass short stature, gonadal dysgenesis, systemic defects, multiple dysmorphic features and skin changes, including an increased number of melanocytic nevi, hypertrophic scars and keloids. The affected girls are treated with recombinant human growth hormone to improve the height. We present a case of a 15-year-old girl with Turner's syndrome, hypertrophic scars and a keloid. At the age of 12 years and 8 months, the girl started recombinant human growth hormone treatment. During the therapy, a surgical excision of 4 out of 42 benign melanocytic nevi was performed. After 2 months the hypertrophic scars as well as a keloid were noted at sites of excision. Parents of girls with Turner's syndrome undertake various attempts to improve not only the height and maturity of their daughters, but also their appearance by commonly performed surgical corrections of the webbed neck and pigmented nevi. The presented case suggests an increased risk of scars hypertrophy and keloid formations after surgical intervention in Turner's syndrome patients who are treated with recombinant human growth hormone at the same time. Due to that it should be advised to postpone all planned surgical procedures until the therapy has been completed.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Hook, E" uniqKey="Hook E">E Hook</name></author><author><name sortKey="Warburton, D" uniqKey="Warburton D">D Warburton</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Gibbs, P" uniqKey="Gibbs P">P Gibbs</name></author><author><name sortKey="Brady, B" uniqKey="Brady B">B Brady</name></author><author><name sortKey="Gonzalez, R" uniqKey="Gonzalez R">R Gonzalez</name></author><author><name sortKey="Robinson, W" uniqKey="Robinson W">W Robinson</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Becker, B" uniqKey="Becker B">B Becker</name></author><author><name sortKey="Jospe, N" uniqKey="Jospe N">N Jospe</name></author><author><name sortKey="Goldschmith, L" uniqKey="Goldschmith L">L 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Rabinowitz</name></author><author><name sortKey="Esterly, N" uniqKey="Esterly N">N Esterly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Wyatt, D" uniqKey="Wyatt D">D Wyatt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Noto, G" uniqKey="Noto G">G Noto</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="case-report"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Postepy Dermatol Alergol</journal-id><journal-id journal-id-type="iso-abbrev">Postepy Dermatol Alergol</journal-id><journal-id journal-id-type="publisher-id">PDIA</journal-id><journal-title-group><journal-title>Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii</journal-title></journal-title-group><issn pub-type="ppub">1642-395X</issn><issn pub-type="epub">2299-0046</issn><publisher><publisher-name>Termedia Publishing House</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">25097479</article-id><article-id pub-id-type="pmc">4112245</article-id><article-id pub-id-type="publisher-id">22323</article-id><article-id pub-id-type="doi">10.5114/pdia.2014.40917</article-id><article-categories><subj-group subj-group-type="heading"><subject>Case Report</subject></subj-group></article-categories><title-group><article-title>Hypertrophic scars in a patient with Turner's syndrome treated with recombinant growth hormone</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Kędzia</surname><given-names>Andrzej</given-names></name><xref ref-type="aff" rid="AF0001">1</xref></contrib><contrib contrib-type="author" corresp="yes"><name><surname>Pawlaczyk</surname><given-names>Mariola</given-names></name><xref ref-type="aff" rid="AF0002">2</xref></contrib><contrib contrib-type="author"><name><surname>Petriczko</surname><given-names>Elżbieta</given-names></name><xref ref-type="aff" rid="AF0003">3</xref></contrib></contrib-group><aff id="AF0001"><label>1</label>Department of Clinical Auxology and Pediatric Nursing, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ass. Prof. Andrzej Kędzia</aff><aff id="AF0002"><label>2</label>Department of Geriatric Medicine and Gerontology, Division of Skin Diseases Prophylaxis, Poznan University of Medical Sciences, Poznan, Poland. Head of Department: Ass. Prof. Mariola Pawlaczyk</aff><aff id="AF0003"><label>3</label>Clinic of Pediatrics, Endocrinology, Diabetology, Metabolic Diseases and Cardiology of the Children, Pomeranian Medical University, Szczecin, Poland. Head of Clinic: Prof. Mieczysław Walczak MD, PhD</aff><author-notes><corresp id="cor1"><bold>Address for correspondence:</bold> Mariola Pawlaczyk MD, PhD, Department of Geriatric Medicine and Gerontology, Division of Skin Diseases Prophylaxis, Poznan University of Medical Science, 34 Dojazd St, 60-631 Poznan, Poland. phone: +48 61601747 670. e-mail: <email xlink:href="mariolapawlaczyk@o2.pl">mariolapawlaczyk@o2.pl</email></corresp></author-notes><pub-date pub-type="epub"><day>22</day><month>4</month><year>2014</year></pub-date><pub-date pub-type="ppub"><month>5</month><year>2014</year></pub-date><volume>31</volume><issue>2</issue><fpage>117</fpage><lpage>120</lpage><history><date date-type="received"><day>21</day><month>4</month><year>2013</year></date><date date-type="rev-recd"><day>09</day><month>5</month><year>2013</year></date><date date-type="accepted"><day>23</day><month>5</month><year>2013</year></date></history><permissions><copyright-statement>Copyright © 2014 Termedia</copyright-statement><copyright-year>2014</copyright-year><license license-type="open-access" xlink:href="http://creativecommons.org/licenses/by-nc-nd/3.0/"><license-p>This is an Open Access article distributed under the terms of the Creative Commons Attribution-Noncommercial 3.0 Unported License, permitting all non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.</license-p></license></permissions><abstract><p>Turner's syndrome is a common genetic disorder of girls and women, for which characteristic clinical symptoms encompass short stature, gonadal dysgenesis, systemic defects, multiple dysmorphic features and skin changes, including an increased number of melanocytic nevi, hypertrophic scars and keloids. The affected girls are treated with recombinant human growth hormone to improve the height. We present a case of a 15-year-old girl with Turner's syndrome, hypertrophic scars and a keloid. At the age of 12 years and 8 months, the girl started recombinant human growth hormone treatment. During the therapy, a surgical excision of 4 out of 42 benign melanocytic nevi was performed. After 2 months the hypertrophic scars as well as a keloid were noted at sites of excision. Parents of girls with Turner's syndrome undertake various attempts to improve not only the height and maturity of their daughters, but also their appearance by commonly performed surgical corrections of the webbed neck and pigmented nevi. The presented case suggests an increased risk of scars hypertrophy and keloid formations after surgical intervention in Turner's syndrome patients who are treated with recombinant human growth hormone at the same time. Due to that it should be advised to postpone all planned surgical procedures until the therapy has been completed.</p></abstract><kwd-group><kwd>Turner's syndrome</kwd><kwd>scar</kwd><kwd>hypertrophy</kwd><kwd>growth hormone</kwd></kwd-group></article-meta></front></pmc><affiliations><list></list><tree><noCountry><name sortKey="K Dzia, Andrzej" sort="K Dzia, Andrzej" uniqKey="K Dzia A" first="Andrzej" last="K Dzia">Andrzej K Dzia</name><name sortKey="Pawlaczyk, Mariola" sort="Pawlaczyk, Mariola" uniqKey="Pawlaczyk M" first="Mariola" last="Pawlaczyk">Mariola Pawlaczyk</name><name sortKey="Petriczko, El Bieta" sort="Petriczko, El Bieta" uniqKey="Petriczko E" first="El Bieta" last="Petriczko">El Bieta Petriczko</name></noCountry></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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